scholarly journals Reduced Anxiety, Conditioned Fear, and Hippocampal Long-Term Potentiation in Transient Receptor Potential Vanilloid Type 1 Receptor-Deficient Mice

2007 ◽  
Vol 27 (4) ◽  
pp. 832-839 ◽  
Author(s):  
R. Marsch ◽  
E. Foeller ◽  
G. Rammes ◽  
M. Bunck ◽  
M. Kossl ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Conditioned Fear ◽  
Receptor Potential ◽  
Long Term Potentiation ◽  
Transient Receptor Potential Vanilloid ◽  
Term Potentiation ◽  
Transient Receptor ◽  
Deficient Mice

scholarly journals Lack of the Transient Receptor Potential Vanilloid 1 Shifts Cannabinoid-Dependent Excitatory Synaptic Plasticity in the Dentate Gyrus of the Mouse Brain Hippocampus

2021 ◽  
Vol 15 ◽  
Author(s):  
Jon Egaña-Huguet ◽  
Miquel Saumell-Esnaola ◽  
Svein Achicallende ◽  
Edgar Soria-Gomez ◽  
Itziar Bonilla-Del Río ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Long Term Potentiation ◽  
Perforant Path ◽  
Transient Receptor Potential Vanilloid ◽  
Functional Changes ◽  
Nitric Oxide Signaling ◽  
Transient Receptor

The transient receptor potential vanilloid 1 (TRPV1) participates in synaptic functions in the brain. In the dentate gyrus, post-synaptic TRPV1 in the granule cell (GC) dendritic spines mediates a type of long-term depression (LTD) of the excitatory medial perforant path (MPP) synapses independent of pre-synaptic cannabinoid CB1 receptors. As CB1 receptors also mediate LTD at these synapses, both CB1 and TRPV1 might be influencing the activity of each other acting from opposite synaptic sites. We tested this hypothesis in the MPP–GC synapses of mice lacking TRPV1 (TRPV1-/-). Unlike wild-type (WT) mice, low-frequency stimulation (10 min at 10 Hz) of TRPV1-/- MPP fibers elicited a form of long-term potentiation (LTP) that was dependent on (1) CB1 receptors, (2) the endocannabinoid 2-arachidonoylglycerol (2-AG), (3) rearrangement of actin filaments, and (4) nitric oxide signaling. These functional changes were associated with an increase in the maximum binding efficacy of guanosine-5′-O-(3-[35S]thiotriphosphate) ([35S]GTPγS) stimulated by the CB1 receptor agonist CP 55,940, and a significant decrease in receptor basal activation in the TRPV1-/- hippocampus. Finally, TRPV1-/- hippocampal synaptosomes showed an augmented level of the guanine nucleotide-binding (G) Gαi1, Gαi2, and Gαi3 protein alpha subunits. Altogether, the lack of TRPV1 modifies CB1 receptor signaling in the dentate gyrus and causes the shift from CB1 receptor-mediated LTD to LTP at the MPP–GC synapses.

scholarly journals Activation of Transient Receptor Potential Vanilloid Type-1 Channel Prevents Adipogenesis and Obesity

2007 ◽  
Vol 100 (7) ◽  
pp. 1063-1070 ◽  
Author(s):  
Li Li Zhang ◽  
Dao Yan Liu ◽  
Li Qun Ma ◽  
Zhi Dan Luo ◽  
Ting Bing Cao ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Transient Receptor Potential Vanilloid ◽  
Transient Receptor
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