scholarly journals Anosmin-1 Modulates Fibroblast Growth Factor Receptor 1 Signaling in Human Gonadotropin-Releasing Hormone Olfactory Neuroblasts through a Heparan Sulfate-Dependent Mechanism

2004 ◽  
Vol 24 (46) ◽  
pp. 10384-10392 ◽  
Author(s):  
D. Gonzalez-Martinez
Keyword(s):  
Growth Factor ◽  
Heparan Sulfate ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Fibroblast Growth ◽  
Releasing Hormone ◽  
Dependent Mechanism

scholarly journals Binding of Heparin/Heparan Sulfate to Fibroblast Growth Factor Receptor 4

2001 ◽  
Vol 276 (20) ◽  
pp. 16868-16876 ◽  
Author(s):  
Britt-Marie Loo ◽  
Johan Kreuger ◽  
Markku Jalkanen ◽  
Ulf Lindahl ◽  
Markku Salmivirta
Keyword(s):  
Growth Factor ◽  
Heparan Sulfate ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth

Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development

Development ◽  
1999 ◽  
Vol 126 (17) ◽  
pp. 3715-3723 ◽  
Author(s):  
X. Lin ◽  
E.M. Buff ◽  
N. Perrimon ◽  
A.M. Michelson
Keyword(s):  
Growth Factor ◽  
Heparan Sulfate ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Growth Factor Receptors ◽  
Fibroblast Growth ◽  
Receptor Signaling ◽  
Fibroblast Growth Factor Receptors ◽  
Growth Factor Receptor Signaling

The Drosophila sugarless and sulfateless genes encode enzymes required for the biosynthesis of heparan sulfate glycosaminoglycans. Biochemical studies have shown that heparan sulfate glycosaminoglycans are involved in signaling by fibroblast growth factor receptors, but evidence for such a requirement in an intact organism has not been available. We now demonstrate that sugarless and sulfateless mutant embryos have phenotypes similar to those lacking the functions of two Drosophila fibroblast growth factor receptors, Heartless and Breathless. Moreover, both Heartless- and Breathless-dependent MAPK activation is significantly reduced in embryos which fail to synthesize heparan sulfate glycosaminoglycans. Consistent with an involvement of Sulfateless and Sugarless in fibroblast growth factor receptor signaling, a constitutively activated form of Heartless partially rescues sugarless and sulfateless mutants, and dosage-sensitive interactions occur between heartless and the heparan sulfate glycosaminoglycan biosynthetic enzyme genes. We also find that overexpression of Branchless, the Breathless ligand, can partially overcome the requirement of Sugarless and Sulfateless for Breathless activity. These results provide the first genetic evidence that heparan sulfate glycosaminoglycans are essential for fibroblast growth factor receptor signaling in a well defined developmental context, and support a model in which heparan sulfate glycosaminoglycans facilitate fibroblast growth factor ligand and/or ligand-receptor oligomerization.

scholarly journals N-Glycosylation of Fibroblast Growth Factor Receptor 1 Regulates Ligand and Heparan Sulfate Co-receptor Binding

2006 ◽  
Vol 281 (37) ◽  
pp. 27178-27189 ◽  
Author(s):  
Laurence Duchesne ◽  
Bérangère Tissot ◽  
Timothy R. Rudd ◽  
Anne Dell ◽  
David G. Fernig
Keyword(s):  
Growth Factor ◽  
Heparan Sulfate ◽  
Fibroblast Growth Factor ◽  
Receptor Binding ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth
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