scholarly journals Determinants of IGF1 and GH across the weight spectrum: from anorexia nervosa to obesity

2010 ◽  
Vol 163 (2) ◽  
pp. 185-191 ◽  
Author(s):  
D J Brick ◽  
A V Gerweck ◽  
E Meenaghan ◽  
E A Lawson ◽  
M Misra ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Free Testosterone ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
The Body ◽  
Obese Women ◽  
Significant Determinant ◽  
Serum Samples ◽  
Cross Sectional ◽  
Gh Secretion

ContextChronic starvation is characterized by GH resistance, and obesity is characterized by decreased GH secretion. In both extremes, IGF1 levels may be low and androgen levels may be abnormal.ObjectiveTo investigate the determinants of IGF1 and GH across the weight spectrum in women.DesignCross-sectional study.SettingClinical research center.Study participantsIn total, 32 women had participated in the study: 11 women with anorexia nervosa (AN), 11 normal-weight women, and 10 obese women of comparable mean age.InterventionNone.Main outcome measuresPooled hourly overnight serum samples assayed for IGF1, GH, estradiol (E2), testosterone, SHBG, insulin, free fatty acids, and trunk fat.ResultsFree testosterone was higher in obese women and lower in women with AN than in normal-weight women, and was the only independent (and positive) predictor of IGF1 levels, accounting for 14% of the variability (P=0.032) in the group as a whole. This relationship was stronger when obese women were excluded, with free testosterone accounting for 36% of the variability (P=0.003). Trunk fat accounted for 49% of the variability (P<0.0001) of GH, with an additional 7% of the variability attributable to E2 (P=0.042) in the group as a whole, but was not a significant determinant of GH secretion when obese women were excluded.ConclusionsFree testosterone is a significant determinant of IGF1 levels in women across the body weight spectrum. In contrast, GH secretion is differentially regulated at the extremes of the weight spectrum.

scholarly journals Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?

Metabolites ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 771
Author(s):  
Lourdes Balcázar-Hernandez ◽  
Lourdes Basurto ◽  
Leticia Manuel-Apolinar ◽  
Sara Vega-García ◽  
Norma Basurto-Acevedo ◽  
...  
Keyword(s):  
Body Size ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
The Body ◽  
Metabolic Phenotype ◽  
Obese Women ◽  
Middle Aged ◽  
Cross Sectional ◽  
Metabolically Healthy Obese ◽  
Metabolically Healthy

Variations in levels of some adipokines, myokines, osteokines, hepatokines and inflammatory cytokines contribute to abnormal glucose and lipid metabolism. The aim of this study was to determine the pattern of adiponectin, osteocalcin (OCN), irisin, FGF-21, and MCP-1 according to the body size phenotype of middle-aged women, and their associations with BMI, visceral adipose tissue (VAT), and HOMA-IR. A cross-sectional study in 265 women aged from 40 to 65 years was performed. The biochemical characteristics were evaluated in metabolically healthy normal weight, metabolically unhealthy normal weight, metabolically healthy obese, and metabolically unhealthy obese women. There was an association of OCN with BMI (r = −0.107; p = 0.047); adiponectin with BMI (r = −0.217; p = 0.001), insulin (r = −0.415; p = 0.0001), HOMA-IR (r = −0.429; p = 0.0001), and VAT (r = −0.134; p = 0.025); irisin with BMI (r = 0.604; p = 0.001), insulin (r = 0.446; p = 0.0001), HOMA-IR (r = 0.452; p = 0.0001), and VAT (r = 0.645; p = 0.0001); FGF−21 with insulin (r = −0.337; p= 0.030) and HOMA-IR (r = −0.341; p = 0.03); and MCP-1 with BMI (r = 0.481; p = 0.0001), VAT (r = 0.497; p = 0.001), insulin (r = 0.298; p= 0.001), and HOMA-IR (r = 0.255; p = 0.004). A multivariate analysis showed that an elevation of OCN (OR 1.4 (95%CI 1.06–1.81)) and a reduction of adiponectin (OR 0.9 (0.84–0.96)) were associated factors for a metabolic unhealthy phenotype in normal weight participants. Likewise, higher irisin (OR 1.007 (1.003–1.011)) and MCP-1 (1.044 (1.008–1.083)) were risk factors for a metabolic unhealthy phenotype in woman with obesity. OCN, adiponectin, irisin, FGF-21, and MCP-1 are associated with some metabolic parameters such as BMI, HOMA-IR, and VAT, and could be possible biomarkers of an unhealthy metabolic phenotype in middle-aged women.

scholarly journals Associação entre obesidade, risco de quedas e medo de cair em mulheres idosas

2017 ◽  
Vol 19 (4) ◽  
pp. 450 ◽  
Author(s):  
Silvia Gonçalves Ricci Neri ◽  
André Bonadias Gadelha ◽  
Ana Luiza Matias Correia ◽  
Juscélia Cristina Pereira ◽  
Marisete Peralta Safons ◽  
...  
Keyword(s):  
Fear Of Falling ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
The Body ◽  
Obese Women ◽  
Chi Square ◽  
Cross Sectional ◽  
Significance Level ◽  
Risk Of Falls ◽  
Overweight Subjects

DOI: http://dx.doi.org/10.5007/1980-0037.2017v19n4p450 The aim of this cross-sectional study was to investigate the association between obesity, risk of falls and fear of falling in older women. Two hundred and twenty-six volunteers (68.05 ± 6.22 years, 68.06 ± 11.79 kg, 1.56 ± 0.06 m) were classified as normal weight, overweight or obese, according to the body mass index. Risk of falls and fear of falling were evaluated using QuickScreen Clinical Falls Risk Assessment and Falls Efficiency Scale – International (FES-I), respectively. Comparisons between groups were conducted using Chi-square and ANOVA One-way tests. The significance level was set at p< 0.05. Obesity was associated with greater probability of falls (p< 0.001), which may be partly explained by decreased muscle strength (p< 0.001) and reaction time (p< 0.001). In addition, significant differences between groups was observed in FES-I score (p< 0.01), with obese women showing more pronounced fear of falling (30.10 ± 8.4) than normal weigh (25. 33 ± 7.11, p< 0.01) and overweight subjects (26.97 ± 7.05, p< 0.05). These findings corroborate previous evidence pointing obesity as a major risk factor for falls. Therefore, health professionals dealing with fall prevention should consider the effects of overweight.

scholarly journals Avaliação dos Níveis de Atividade Física em Estudantes Universitários do Ensino a Distância

2017 ◽  
Vol 19 (3) ◽  
pp. 143
Author(s):  
Stefany Hulda Primo ◽  
Mario Molari ◽  
Amanda Alcântara Luna ◽  
Nuno de Noronha Da Costa Bispo ◽  
Vinicius Aparecido Yoshio Ossada ◽  
...  
Keyword(s):  
Physical Activity ◽  
Morbid Obesity ◽  
Health Promotion ◽  
University Students ◽  
Physical Inactivity ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
The Body ◽  
Cross Sectional ◽  
The Mean

Atualmente tem se observado que as incidências de mortes são ocasionadas por fatores relacionados ao comportamento humano, como no caso da inatividade física. Esta pesquisa se objetivou em avaliar o nível de atividade física habitual - AF em relação ao índice de massa corpórea - IMC em universitários do Ensino a distância - EaD, por meio do Questionário Internacional de Atividade Física - IPAQ. É um estudo do tipo transversal com o total de 107 universitários do EaD. Para as coletas de dados foi utilizado o questionário geral e o questionário IPAQ. O IMC foi calculado pela equação IMC= peso corporal (Kg)/ altura (m)2, considerando os valores <18,5 kg abaixo do peso; e entre 18,5-24,9 kg peso normal; 25-29,9 kg sobrepeso; 30-34,9 kg obesidade leve; 35-39,9 kg obesidade moderada e obesidade mórbida >40 kg (CUNHA, 2009). A média de idade foi de 30,1±9,7 anos, prevalecendo o sexo feminino com 61,6%. Dos 107 entrevistados, 64,4% são praticantes de AF. Quanto ao IMC, 6,5% estão abaixo do peso; 46% estão no peso normal; 33% estão com sobrepeso; 9,3% estão com obesidade leve; 2% com obesidade moderada; 3,8% com obesidade mórbida, sendo 1,8%. Através dos dados analisados por meio do questionário GERAL, IPAQ e pelo programa de análise estatística SPSS se verificou que quanto maior o IMC, pior é a classificação quanto ao nível de atividade física. Sendo assim, nota-se a importância de ações voltadas para os universitários praticarem atividade física, além de estratégicas voltadas para a promoção da saúde e prevenção de doenças provenientes do sedentarismo.Palavras-chave: Exercício. Obesidade. Promoção da Saúde.AbstractIt has now been observed that the incidence of deaths is caused by factors related to human behavior, as in the case of physical inactivity. This study aimed to evaluate the level of habitual physical activity (FA) in relation to the body mass index (BMI) in distance learning university students (EAD), through the International Questionnaire of Physical Activity (IPAQ). It is a cross-sectional study with a total of 107 university students. For data collection, the general questionnaire and the IPAQ questionnaire were used. The BMI was calculated by the equation BMI = body weight (kg) / height (m) 2, considering values <18.5 kg below weight; And between 18.5-24.9 kg normal weight; 25-29.9 kg overweight; 30-34.9 kg light obesity; 35-39.9 kg moderate obesity and morbid obesity> 40 kg (CUNHA, 2009). The mean age was 30.1 ± 9.7 years, prevailing the female sex with 61.6%. Of the 107 interviewees, 64.4% are AF practitioners. Regarding BMI 6.5% are underweight; 46% are in normal weight; 33% are overweight; 9.3% are lightly obese; 2% with moderate obesity; 3.8% with morbid obesity, being 1.8%. Through the data analyzed through the questionnaire GENERAL, IPAQ and the program of statistical analysis SPSS, it was verified that the higher the BMI, the worse the classification concerning the level of physical activity. Thus, we notice the importance of actions aimed at university students to practice physical activity, as well as strategies aimed at health promotion and prevention of sedentrary individuals’ diseases.Keywords: Exercise. Obesity. Health Promotion.

scholarly journals Factors associated to usual physical activity in women

2015 ◽  
Vol 21 (2) ◽  
pp. 99-103 ◽  
Author(s):  
Paulo André Medeiros de Oliveira ◽  
Alexandrina Gomes de Oliveira ◽  
Ana Cristina Tillmann ◽  
Camila da Cruz Ramos de Araujo ◽  
Cecília Bertuol ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cross Sectional Study ◽  
Northern Region ◽  
Normal Weight ◽  
The Body ◽  
Western Region ◽  
Santa Catarina ◽  
Cross Sectional ◽  
Usual Practice ◽  
Factors Associated

INTRODUCTION: attention has been focused on investigating the prevalence of physical activity PA in different populations.OBJECTIVE: to analyze factors associated with the usual practice of PA in women from areas of Santa Catarina, Brazil.METHODS: the cross-sectional study enrolled a sample of 2750 women with a mean age of 32.97±10.9 years. PA was assessed by the International Physical Activity Questionnaire IPAQ. The sample was divided into six groups: Southern Region; Itajaí Valley; Northern Region; Western Region; Highlands Region and the Greater Florianópolis Region, SC, Brazil. Statistical analysis was descriptive and inferential.RESULTS: approximately 68.3% of women were considered sufficiently active active + very active, in particular the Greater Florianópolis Region, SC, Brazil. In the practice of moderate and moderate + vigorous activity, the women of Western Region presented the highest averages 65±64 min/d; 105±102 min/d, respectively, and those in the range of 20-32 years old showed 61% chance of being considered active compared with women in the range of 46-59 years old. As for the body mass index BMI, women with normal weight of the South Region and Itajaí Valley regions had 2.24 95% CI;1.15-4.35 and 1.76 95% CI; 1.14-2.73 times more chances to be active when compared to the overweight women.CONCLUSION: women in the regions of Santa Catarina were considered sufficiently active. Moderate + vigorous PA was the most prevalent in the six regions studied.

A Cross-sectional Study of the Prevalence of Dental Caries among 12- to 15-year-old Overweight Schoolchildren

2016 ◽  
Vol 17 (9) ◽  
pp. 750-754 ◽  
Author(s):  
Zeeshan H Ahmad ◽  
Sukumaran Anil ◽  
Sham S Bhat ◽  
K Sundeep Hegde ◽  
Faizal C Peedikayil ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Dental Caries ◽  
Body Mass ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
The Body ◽  
Overweight Children ◽  
Sectional Study ◽  
Cross Sectional

ABSTRACT Introduction Overweight and obesity are growing healthrelated problems worldwide, and it is currently the most prevalent nutritional disorder among children and adolescents. The objective of this study was to assess the association between overweight and dental caries among 12- to 15-year-old schoolchildren in Mangaluru district, Karnataka, India. Materials and methods Data were obtained from 2000 schoolgoing children aged 12 to 15 years. The children were categorized as overweight and normal-weight group by assessing the body mass index (BMI). Body mass index was categorized using the classification system given by the International Obesity Task Force (IOTF) and obtained in units of kg/m2. The dental caries was assessed by detection and was performed according to decayed, missing, and filled teeth (DMFT) index. Results Of the 2000 children examined, the mean BMI recorded was 26.87 ± 2.26 for the overweight children and 20.82 ± 1.48 for the normal-weight children. Even though the DMFT (3.90 ± 2.95) in the overweight children was slightly higher than the control group (3.36 ± 2.73), it was not statistically significant. Conclusion Within the confines of the present study, it can be concluded that there is no significant association between overweight and dental caries among the schoolchildren of Mangaluru district in Karnataka. Longitudinal studies are necessary to substantiate the possible relationships between dental caries and overweight in children. Knowledge of these relationships could lead to preventive health measures designed to reduce the prevalence of both obesity and dental caries. How to cite this article Kottayi S, Bhat SS, Hegde KS, Peedikayil FC, Chandru TP, Anil S. A Cross-sectional Study on the Prevalence of Dental Caries among 12- to 15-year-old Overweight Schoolchildren. J Contemp Dent Pract 2016;17(9): 750-754.

scholarly journals Obesity and Multisite Pain in the Lower Limbs: Data from the Osteoarthritis Initiative

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Vishal Vennu ◽  
Aqeel M. Alenazi ◽  
Tariq A. Abdulrahman ◽  
Ahmad S. Binnasser ◽  
Saad M. Bindawas
Keyword(s):  
High Risk ◽  
Knee Osteoarthritis ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
The Body ◽  
Lower Limbs ◽  
Cross Sectional ◽  
Standards Of Practice ◽  
Multisite Pain ◽  
Osteoarthritis Initiative

Background. Although several studies investigated the relationship between obesity, osteoarthritis, and pain, no study examined the association between obesity and multijoint pain in the lower limbs. The purpose of this study was to address this gap. Method. This cross-sectional study was performed in Riyadh, Saudi Arabia, between March and April 2019. In this study, a total of 4,661 adults aged 45–79 years with or at high risk for knee osteoarthritis were included from the Osteoarthritis Initiative. The persons who had an elevated risk of developing symptoms of knee osteoarthritis during the study were defined as high risk for knee osteoarthritis. According to the body mass index, participants were categorized into three groups: normal weight (n = 1,068), overweight (n = 1,832), and obese (n = 1,761). Logistic regression was used to examine the association between obesity and multisite pain. Results. The odds of multisite pain was associated significantly (p<0.001) by 1.36 times higher with obesity than normal weight, no, or sigle-site pain, even after adjusting for sociodemographic and health variables Conclusion. Obesity is associated with an increased likelihood of multisite pain in the lower limbs. The results enable clinicians to adopt better standards of practice for the prevention and screening of multisite pain in this community.

scholarly journals Clinical, ultrasonographical and hormonal correlation in women with polycystic ovarian syndrome

2018 ◽  
Vol 7 (12) ◽  
pp. 5134
Author(s):  
Ashwini Sidhmalswamy G. ◽  
Jyoti S. Ghongdemath ◽  
Sreedhar Venkatesh
Keyword(s):  
Testosterone Level ◽  
Polycystic Ovarian Syndrome ◽  
Free Testosterone ◽  
Cross Sectional Study ◽  
Obese Women ◽  
Cross Sectional ◽  
Ovarian Volume ◽  
The Mean ◽  
Free Testosterone Level ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of fertile age. The prevalence, time of onset and severity of clinical presentation vary among different ethnic and racial groups. Though there is significant reproductive, endocrine and metabolic morbidity of PCOS, very little is known about its different modes of presentation in Indian population. A cross sectional observational study. The objective To study the correlation between the clinical, ultrasonographical and hormonal features in women diagnosed as PCOS based on the revised diagnostic criteria, 2003.Methods: A cross-sectional study of 74 PCOS women who had oligo ovulatory cycles and polycystic ovarian morphology on ultrasound was done. Data about menstrual history and anthropometric measurements were collected. Clinical observations of acne and hirsutism were made.  Transvaginal ultrasonography and biochemical analysis for free testosterone was done.Results: In all, 74 PCOS women were studied and analyzed. The mean age was 24.884.03, mean BMI was 25.48 ±3.75 and mean free testosterone was 3.81±4.05. Among the PCOS women 39.8% were hirsute, 10.1% were obese, 2.3% had acne and 38% were hyperandrogenemic. Of the hyperandrogenemic women 61.2% were hirsute, 53.22% were obese and 36.54% had acne.  The association between BMI and free testosterone level was statistically significant (p=0.0023). BMI was moderately correlated with hyperandrogenemia (r=0.446). The mean left ovarian volume was higher in obese than in non-obese women, which was statistically significant (p=0.003). The mean left ovarian volume was high in hyperandrogenemic women which was statistically significant (p=0.00034).Conclusions: In the present study it was found that there is association between obesity and free testosterone level which was significant. There was statistically significant association between ovarian volume and obesity. Similarly, there was association between ovarian volume and hyperandrogenemia which was significant. Hirsutism and acne had no association with hyperandrogenemia.

scholarly journals Identifying Metabolomic Profiles of Insulinemic Dietary Patterns (OR31-03-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Fred Tabung ◽  
Raji Balasubramanian ◽  
Steven Clinton ◽  
Liming Liang ◽  
Clary Clish ◽  
...  
Keyword(s):  
Dietary Patterns ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Validation Dataset ◽  
Plasma Metabolites ◽  
Obese Women ◽  
Cross Sectional ◽  
Funding Sources ◽  
Secondary Analyses

Abstract Objectives The empirical dietary index for hyperinsulinemia (EDIH) is a food-based score derived from correlations with plasma c-peptide. Our aim is to use the EDIH to discover metabolites associated with insulinemic dietary patterns. Methods This baseline cross-sectional study evaluated associations between continuous EDIH scores from food frequency questionnaires and 448 log-transformed plasma metabolites as outcomes in multivariable linear regression analyses. Metabolites were measured with liquid chromatography tandem mass spectroscopy. Metabolite discovery was conducted among 1109 Women's Health Initiative (WHI) Hormone Therapy trial participants and results replicated in an independent dataset of 810 WHI Observational Study participants. In both discovery and replication datasets statistical significance was based on false-discovery rate adjusted P < 0.05. Secondary analyses were conducted in body mass index (BMI: <25, >=25 kg/m2) categories. Results After adjustment for energy intake, BMI, physical activity, and other confounding variables, 26 metabolites were significantly associated with EDIH in the discovery dataset, and included: trigonelline, C14:0 CE, C16:1 CE, C18:1 CE, C18:3 CE, C20:3 CE. C20:5 CE, C36:1 PS plasmalogen and eicosapentaenoate were associated with lower dietary insulinemic potential, whereas C36:3 DAG, C51:3 TAG, C52:3 TAG, C52:4 TAG, C54:2 TAG, C54:3 TAG, C54:4 TAG, C54:6 TAG, C36:4 DAG-A, cystathionine, isoleucine, N4-acetylcytidine, C10:2 carnitine, cAMP, C18:2 SM, C4-OH carnitine, and myristoleic acid were associated with higher dietary insulinemic potential. 25 out of the 26 metabolites replicated in the validation dataset except myristoleic acid. In secondary analyses within BMI strata, Associations differed by BMI category: 12 metabolites were significant among normal weight women whereas 64 metabolites were associated with EDIH among overweight/obese women. Conclusions Cholesterol esters, triglycerides, carnitines and amino acids may constitute metabolites that are associated with insulinemic dietary patterns. Funding Sources R00CA207736, NHLBI HHSN268201300008C.

scholarly journals Ghrelin and Obestatin Circadian Levels Differentiate Bingeing-Purging from Restrictive Anorexia Nervosa

2010 ◽  
Vol 95 (6) ◽  
pp. 3057-3062 ◽  
Author(s):  
Natacha Germain ◽  
Bogdan Galusca ◽  
Dominique Grouselle ◽  
Delphine Frere ◽  
Stephane Billard ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Peptide Yy ◽  
Regulatory Peptides ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Acylated Ghrelin ◽  
Cross Sectional ◽  
Orexigenic Peptide ◽  
Purging Behavior ◽  
Total Ghrelin

Abstract Context: Anorexia nervosa (AN) patients present with restrictive food behavior (AN-R). Some of them develop episodes of bulimia (AN-BP) without any clear pathophysiological explanation to date. Their clinical differentiation is important but not easily performed. Orexigenic/anorexigenic peptides measurements could provide some clues for that matter. Objective: The objective of the study was to determine whether the circadian profile of total and acylated ghrelin, obestatin, and peptide YY (PYY) levels is different in AN-R subjects when compared with AN-BP patients. Design and Settings: This was a cross-sectional study in an endocrinological unit. Patients and Control Subjects: Four groups of age-matched young women: 22 AN-R, 10 AN-BP, 16 normal-weight bulimia nervosa (BN), and nine controls. Main Outcome Measures: Twelve-point circadian profiles of plasma total and acylated ghrelin, obestatin, and PYY were measured. Results: Total and acylated ghrelin and obestatin circadian levels were increased in AN-R when compared with controls but decreased in both AN-BP and BN groups (P &lt; 0.001). PYY was decreased in all groups with eating disorders. Acylated to total ghrelin ratio was decreased in AN-BP and BN (P &lt; 0.001), whereas obestatin to acylated ghrelin and PYY to acylated ghrelin ratios were increased in both groups with bingeing-purging behavior (P &lt; 0.0001). Conclusions: Patients with AN-associated bingeing-purging behavior present a very different profile of appetite regulatory peptides when compared with the pure restrictive type. The assessment of ghrelin (and eventually obestatin) could be of particular interest for differential diagnosis. Very low ghrelin levels and increased anorexigenic to orexigenic peptide ratios suggest either a lack of adaptation to a starvation state or a higher facility to cope with undernutrition.

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