scholarly journals Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?

Metabolites ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 771
Author(s):  
Lourdes Balcázar-Hernandez ◽  
Lourdes Basurto ◽  
Leticia Manuel-Apolinar ◽  
Sara Vega-García ◽  
Norma Basurto-Acevedo ◽  
...  
Keyword(s):  
Body Size ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
The Body ◽  
Metabolic Phenotype ◽  
Obese Women ◽  
Middle Aged ◽  
Cross Sectional ◽  
Metabolically Healthy Obese ◽  
Metabolically Healthy

Variations in levels of some adipokines, myokines, osteokines, hepatokines and inflammatory cytokines contribute to abnormal glucose and lipid metabolism. The aim of this study was to determine the pattern of adiponectin, osteocalcin (OCN), irisin, FGF-21, and MCP-1 according to the body size phenotype of middle-aged women, and their associations with BMI, visceral adipose tissue (VAT), and HOMA-IR. A cross-sectional study in 265 women aged from 40 to 65 years was performed. The biochemical characteristics were evaluated in metabolically healthy normal weight, metabolically unhealthy normal weight, metabolically healthy obese, and metabolically unhealthy obese women. There was an association of OCN with BMI (r = −0.107; p = 0.047); adiponectin with BMI (r = −0.217; p = 0.001), insulin (r = −0.415; p = 0.0001), HOMA-IR (r = −0.429; p = 0.0001), and VAT (r = −0.134; p = 0.025); irisin with BMI (r = 0.604; p = 0.001), insulin (r = 0.446; p = 0.0001), HOMA-IR (r = 0.452; p = 0.0001), and VAT (r = 0.645; p = 0.0001); FGF−21 with insulin (r = −0.337; p= 0.030) and HOMA-IR (r = −0.341; p = 0.03); and MCP-1 with BMI (r = 0.481; p = 0.0001), VAT (r = 0.497; p = 0.001), insulin (r = 0.298; p= 0.001), and HOMA-IR (r = 0.255; p = 0.004). A multivariate analysis showed that an elevation of OCN (OR 1.4 (95%CI 1.06–1.81)) and a reduction of adiponectin (OR 0.9 (0.84–0.96)) were associated factors for a metabolic unhealthy phenotype in normal weight participants. Likewise, higher irisin (OR 1.007 (1.003–1.011)) and MCP-1 (1.044 (1.008–1.083)) were risk factors for a metabolic unhealthy phenotype in woman with obesity. OCN, adiponectin, irisin, FGF-21, and MCP-1 are associated with some metabolic parameters such as BMI, HOMA-IR, and VAT, and could be possible biomarkers of an unhealthy metabolic phenotype in middle-aged women.

scholarly journals Determinants of IGF1 and GH across the weight spectrum: from anorexia nervosa to obesity

2010 ◽  
Vol 163 (2) ◽  
pp. 185-191 ◽  
Author(s):  
D J Brick ◽  
A V Gerweck ◽  
E Meenaghan ◽  
E A Lawson ◽  
M Misra ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Free Testosterone ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
The Body ◽  
Obese Women ◽  
Significant Determinant ◽  
Serum Samples ◽  
Cross Sectional ◽  
Gh Secretion

ContextChronic starvation is characterized by GH resistance, and obesity is characterized by decreased GH secretion. In both extremes, IGF1 levels may be low and androgen levels may be abnormal.ObjectiveTo investigate the determinants of IGF1 and GH across the weight spectrum in women.DesignCross-sectional study.SettingClinical research center.Study participantsIn total, 32 women had participated in the study: 11 women with anorexia nervosa (AN), 11 normal-weight women, and 10 obese women of comparable mean age.InterventionNone.Main outcome measuresPooled hourly overnight serum samples assayed for IGF1, GH, estradiol (E2), testosterone, SHBG, insulin, free fatty acids, and trunk fat.ResultsFree testosterone was higher in obese women and lower in women with AN than in normal-weight women, and was the only independent (and positive) predictor of IGF1 levels, accounting for 14% of the variability (P=0.032) in the group as a whole. This relationship was stronger when obese women were excluded, with free testosterone accounting for 36% of the variability (P=0.003). Trunk fat accounted for 49% of the variability (P<0.0001) of GH, with an additional 7% of the variability attributable to E2 (P=0.042) in the group as a whole, but was not a significant determinant of GH secretion when obese women were excluded.ConclusionsFree testosterone is a significant determinant of IGF1 levels in women across the body weight spectrum. In contrast, GH secretion is differentially regulated at the extremes of the weight spectrum.

scholarly journals Associação entre obesidade, risco de quedas e medo de cair em mulheres idosas

2017 ◽  
Vol 19 (4) ◽  
pp. 450 ◽  
Author(s):  
Silvia Gonçalves Ricci Neri ◽  
André Bonadias Gadelha ◽  
Ana Luiza Matias Correia ◽  
Juscélia Cristina Pereira ◽  
Marisete Peralta Safons ◽  
...  
Keyword(s):  
Fear Of Falling ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
The Body ◽  
Obese Women ◽  
Chi Square ◽  
Cross Sectional ◽  
Significance Level ◽  
Risk Of Falls ◽  
Overweight Subjects

DOI: http://dx.doi.org/10.5007/1980-0037.2017v19n4p450 The aim of this cross-sectional study was to investigate the association between obesity, risk of falls and fear of falling in older women. Two hundred and twenty-six volunteers (68.05 ± 6.22 years, 68.06 ± 11.79 kg, 1.56 ± 0.06 m) were classified as normal weight, overweight or obese, according to the body mass index. Risk of falls and fear of falling were evaluated using QuickScreen Clinical Falls Risk Assessment and Falls Efficiency Scale – International (FES-I), respectively. Comparisons between groups were conducted using Chi-square and ANOVA One-way tests. The significance level was set at p< 0.05. Obesity was associated with greater probability of falls (p< 0.001), which may be partly explained by decreased muscle strength (p< 0.001) and reaction time (p< 0.001). In addition, significant differences between groups was observed in FES-I score (p< 0.01), with obese women showing more pronounced fear of falling (30.10 ± 8.4) than normal weigh (25. 33 ± 7.11, p< 0.01) and overweight subjects (26.97 ± 7.05, p< 0.05). These findings corroborate previous evidence pointing obesity as a major risk factor for falls. Therefore, health professionals dealing with fall prevention should consider the effects of overweight.

scholarly journals Can Gamma Glutamyle Transferase Predict Unhealthy Metabolic Phenotype in Healthcare Workers in Azar Cohort Study?

2020 ◽  
Author(s):  
Mohammadhossein Somi ◽  
Sina Zakavi ◽  
Alireza Ostadrahimi ◽  
Negin Frounchi ◽  
Neda Gilani ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Cross Sectional Study ◽  
Metabolic Phenotype ◽  
P Value ◽  
Cross Sectional ◽  
Metabolically Healthy Obese ◽  
The Metabolic Syndrome ◽  
Healthy Obese ◽  
Metabolically Healthy ◽  
The Relationship

Abstract Background: There is a close connection between serum gamma-glutamyltransferase (GGT), insulin resistance, and the increased number of the components of the metabolic syndrome (MetS). However, there are no studies evaluating the correlation between GGT and cardiometabolic phenotype. Thus, the main objective of the current study is to evaluate the relationship between GGT and cardiometabolic phenotypes among healthcare workers in Azar Cohort Study.Method: In this cross-sectional study, anthropometric measurements, fasting blood sugar (FBS), triglyceride (TG), cholesterol, high lipoprotein density (HDL), GGT, and blood pressure of 1458 healthcare workers were evaluated. MetS was determined according to the report by the National Cholesterol Education Program Adult Treatment Panel III (ATP III). We classified participants into four cardiometabolic phenotypes. These phenotypes consist of metabolically-healthy lean (MHL) (no MetS and BMI < 25 kg/m2), metabolically-unhealthy lean (MUHL) (MetS present and BMI < 25 kg/m2), metabolically-healthy obese (MHO) (no MetS and BMI ≥25 kg/m2), and metabolically-unhealthy obese (MUHO) (MetS present and BMI ≥ 25 kg/m2).Results: The first and third GGT tertiles have the highest prevalence of MHL (31%) and MHO (65.1%), respectively, which is statistically significant (P-value ≤ 0.001). In comparison with the lowest GGT tertile, the odds of MHO and MUHO increased by 2.84 (95% CI 2.01-4.01) and 9.12 (95%CI 5.54-15), respectively. However, the correlation between MUHL and GGT tertile does not show a similar trend. According to the ROC curve, the cutoff value of 18.5 U/l for GGT allowed us to distinguish between MHO and MUHO.Conclusions: Based on the findings of the study, the GGT can be used as a biomarker to reveal the risk of MetS, and we believe that the GGT level can be used for the early detection of MHO at risk of MetS and for administering proper interventions.

scholarly journals Characterization of Differentially Expressed Circulating miRNAs in Metabolically Healthy versus Unhealthy Obesity

Biomedicines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 321
Author(s):  
Susana Rovira-Llopis ◽  
Rubén Díaz-Rúa ◽  
Carmen Grau-del Valle ◽  
Francesca Iannantuoni ◽  
Zaida Abad-Jimenez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Insulin Signalling ◽  
Cross Sectional Study ◽  
Differentially Expressed ◽  
Circulating Mirnas ◽  
Oxidative Stress Biomarkers ◽  
Cross Sectional ◽  
Metabolically Healthy Obese ◽  
Metabolically Healthy

Obese individuals without metabolic comorbidities are categorized as metabolically healthy obese (MHO). MicroRNAs (miRNAs) may be implicated in MHO. This cross-sectional study explores the link between circulating miRNAs and the main components of metabolic syndrome (MetS) in the context of obesity. We also examine oxidative stress biomarkers in MHO vs. metabolically unhealthy obesity (MUO). We analysed 3536 serum miRNAs in 20 middle-aged obese individuals: 10 MHO and 10 MUO. A total of 159 miRNAs were differentially expressed, of which, 72 miRNAs (45.2%) were higher and 87 miRNAs (54.7%) were lower in the MUO group. In addition, miRNAs related to insulin signalling and lipid metabolism pathways were upregulated in the MUO group. Among these miRNAs, hsa-miR-6796-5p and hsa-miR-4697-3p, which regulate oxidative stress, showed significant correlations with glucose, triglycerides, HbA1c and HDLc. Our results provide evidence of a pattern of differentially expressed miRNAs in obesity according to MetS, and identify those related to insulin resistance and lipid metabolism pathways.

scholarly journals Interaction patterns on body size and health on Instagram and associated factors in nutrition students: an exploratory study

2021 ◽  
Vol 34 ◽  
Author(s):  
Pabyle Alves FLAUZINO ◽  
Antonio Augusto Ferreira CARIOCA
Keyword(s):  
Body Size ◽  
Associated Factors ◽  
Educational Institution ◽  
Cross Sectional Study ◽  
Female Students ◽  
The Body ◽  
Interaction Patterns ◽  
Cross Sectional ◽  
Main Component ◽  
High Engagement

ABSTRACT Objective To identify interaction patterns on body size and health on Instagram and associated factors in nutrition students. Methods A total of 406 students (78% female) were included in this cross-sectional study. Instagram sociodemographic, academic and interaction data (Instagram time of use, exposure frequency to contents on body size and health, Instagram as a source of information and number of followers) were collected using a self-administered virtual questionnaire. A factor analysis by main component was used to derive the interaction patterns of Instagram as well as regression analyses to test the association of the patterns with the sociodemographic and academic factors. Results Three interaction patterns were observed on body size and health, named: “Fitness Pattern”; “Body Positivity Pattern” and “High Engagement Pattern”. Private Institutions’ Students who are on or have been on a diet and studying in the first semesters were associated with the “Fitness Pattern” (p<0.05). Female students, from public institutions, who changed their weight during the course and whose family’s head had higher education, were associated with the “Body Positivity Pattern” (p<0.05). Female students, younger and on a diet, were associated with the “High engagement Pattern” (p<0.05). Conclusion Gender, type of educational institution and diet practice of nutrition students are the factors that are most associated with different patterns of interaction on body size and health on Instagram.

Gender Differences in Cardiometabolic Risk Factors in Metabolically Healthy Normal Weight Adults with Central Obesity

2017 ◽  
Vol 126 (05) ◽  
pp. 309-315
Author(s):  
Katarína Šebeková ◽  
Melinda Csongová ◽  
Radana Gurecká ◽  
Zora Krivošíková ◽  
Jozef Šebek
Keyword(s):  
Blood Pressure ◽  
Waist Circumference ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Central Obesity ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Cross Sectional ◽  
Fasting Plasma ◽  
Metabolically Healthy

AbstractWe investigated whether metabolically healthy normal weight adults with central obesity display worse cardiometabolic profile compared with their centrally lean counterparts. This retrospective, cross-sectional study, comprised 1 135 subjects (64% females) aged 18-to-81 years, presenting ≤2 components of metabolic syndrome. They were classified as centrally lean (waist-to-height ratio (WHtR)<0.5 and waist circumference<80 cm in females and<94 cm in males) or presenting central obesity (WHtR ≥0.5, regardless of waist circumference). Data on blood pressure, glucose homeostasis, lipid profile, renal function, high-sensitive C-reactive protein (hsCRP), uric acid, adiponectin, leptin, and soluble receptor for advanced glycation end products were compared between the groups, separately in males and females. 5.7% of males and 6.9% of females presented WHtR ≥0.5. Compared with centrally lean subjects, those with central obesity had higher BMI-adjusted fasting plasma glucose (p<0.001), and leptin levels (p<0.05); females also presented higher blood pressure (p<0.001), while males had higher hsCRP concentrations (p=0.021). These changes associated with significantly higher BMI-adjusted odds to present fasting plasma glucose >5.6 mmol/l in both genders, higher odds to present hsCRP >3 mg/l in males, and those to present elevated blood pressure in females. Our analysis suggests that in metabolically healthy normal weight subjects WHtR ≥0.5 might indicate “early increased health risk”.

scholarly journals Cross-sectional study of associations between normal body weight with central obesity and hyperuricemia in Japan

2019 ◽  
Author(s):  
Takako Shirasawa ◽  
Hirotaka Ochiai ◽  
Takahiko Yoshimoto ◽  
Satsue Nagahama ◽  
Akihiro Watanabe ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Central Obesity ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Middle Aged ◽  
Cross Sectional ◽  
Men And Women ◽  
Japanese Adults

Abstract Background Several studies have shown that normal weight with central obesity (NWCO) is associated with cardiovascular disease risk factors such as hypertension, dyslipidemia and diabetes. However, the relationship between NWCO and hyperuricemia has not been studied in detail. Methods We investigated the association between NWCO and hyperuricemia among Japanese adults aged 40-64 years who had undergone periodic health examinations between April 2013 and March 2014. Obesity was defined as a body mass index (BMI) ≥25 kg/m 2 and central obesity was determined as a waist-to-height ratio (WHtR) ≥0.5. We classified the participants into the following groups based according to having obesity and central obesity: normal weight (BMI 18.5-24.9 kg/m 2 ) without (NW; WHtR <0.5) and with (NWCO) central obesity, and obesity without (OB) and with (OBCO) central obesity. Hyperuricemia was defined as serum uric acid >7.0 and ≥6.0 mg/dL in men and women, respectively, or under medical treatment for hyperuricemia. Alcohol intake was classified as yes (daily and occasional consumption) and none (no alcohol consumption). Odds ratios (OR) and 95% confidence intervals (CI) for hyperuricemia were calculated using a logistic regression model. Results We analyzed data derived from 96,863 participants (69,241 men and 27,622 women). The prevalences of hyperuricemia in men and women were respectively, 21.4% and 11.0%, and of participants with NWCO respectively 15.6% and 30.0%. The adjusted OR for hyperuricemia was significantly increased in OBCO compared with NW, regardless of sex (men: OR, 2.12; 95%CI; 2.03-2.21; women: OR, 3.54; 95%CI, 3.21-3.90) and were statistically significant in NWCO compared with NW (men: OR, 1.44; 95%CI, 1.36-1.52; women: OR, 1.41; 95%CI, 1.27-1.57). The results were similar regardless of alcohol consumption. Conclusions We found that NWCO and OBCO were associated with hyperuricemia in middle-aged Japanese men and women. Middle-aged Japanese adults with normal weight but having central obesity should be screened using a combination of BMI and WHtR and educated about how to prevent hyperuricemia.

scholarly journals Avaliação dos Níveis de Atividade Física em Estudantes Universitários do Ensino a Distância

2017 ◽  
Vol 19 (3) ◽  
pp. 143
Author(s):  
Stefany Hulda Primo ◽  
Mario Molari ◽  
Amanda Alcântara Luna ◽  
Nuno de Noronha Da Costa Bispo ◽  
Vinicius Aparecido Yoshio Ossada ◽  
...  
Keyword(s):  
Physical Activity ◽  
Morbid Obesity ◽  
Health Promotion ◽  
University Students ◽  
Physical Inactivity ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
The Body ◽  
Cross Sectional ◽  
The Mean

Atualmente tem se observado que as incidências de mortes são ocasionadas por fatores relacionados ao comportamento humano, como no caso da inatividade física. Esta pesquisa se objetivou em avaliar o nível de atividade física habitual - AF em relação ao índice de massa corpórea - IMC em universitários do Ensino a distância - EaD, por meio do Questionário Internacional de Atividade Física - IPAQ. É um estudo do tipo transversal com o total de 107 universitários do EaD. Para as coletas de dados foi utilizado o questionário geral e o questionário IPAQ. O IMC foi calculado pela equação IMC= peso corporal (Kg)/ altura (m)2, considerando os valores <18,5 kg abaixo do peso; e entre 18,5-24,9 kg peso normal; 25-29,9 kg sobrepeso; 30-34,9 kg obesidade leve; 35-39,9 kg obesidade moderada e obesidade mórbida >40 kg (CUNHA, 2009). A média de idade foi de 30,1±9,7 anos, prevalecendo o sexo feminino com 61,6%. Dos 107 entrevistados, 64,4% são praticantes de AF. Quanto ao IMC, 6,5% estão abaixo do peso; 46% estão no peso normal; 33% estão com sobrepeso; 9,3% estão com obesidade leve; 2% com obesidade moderada; 3,8% com obesidade mórbida, sendo 1,8%. Através dos dados analisados por meio do questionário GERAL, IPAQ e pelo programa de análise estatística SPSS se verificou que quanto maior o IMC, pior é a classificação quanto ao nível de atividade física. Sendo assim, nota-se a importância de ações voltadas para os universitários praticarem atividade física, além de estratégicas voltadas para a promoção da saúde e prevenção de doenças provenientes do sedentarismo.Palavras-chave: Exercício. Obesidade. Promoção da Saúde.AbstractIt has now been observed that the incidence of deaths is caused by factors related to human behavior, as in the case of physical inactivity. This study aimed to evaluate the level of habitual physical activity (FA) in relation to the body mass index (BMI) in distance learning university students (EAD), through the International Questionnaire of Physical Activity (IPAQ). It is a cross-sectional study with a total of 107 university students. For data collection, the general questionnaire and the IPAQ questionnaire were used. The BMI was calculated by the equation BMI = body weight (kg) / height (m) 2, considering values <18.5 kg below weight; And between 18.5-24.9 kg normal weight; 25-29.9 kg overweight; 30-34.9 kg light obesity; 35-39.9 kg moderate obesity and morbid obesity> 40 kg (CUNHA, 2009). The mean age was 30.1 ± 9.7 years, prevailing the female sex with 61.6%. Of the 107 interviewees, 64.4% are AF practitioners. Regarding BMI 6.5% are underweight; 46% are in normal weight; 33% are overweight; 9.3% are lightly obese; 2% with moderate obesity; 3.8% with morbid obesity, being 1.8%. Through the data analyzed through the questionnaire GENERAL, IPAQ and the program of statistical analysis SPSS, it was verified that the higher the BMI, the worse the classification concerning the level of physical activity. Thus, we notice the importance of actions aimed at university students to practice physical activity, as well as strategies aimed at health promotion and prevention of sedentrary individuals’ diseases.Keywords: Exercise. Obesity. Health Promotion.

scholarly journals Cross-sectional study of associations between normal body weight with central obesity and hyperuricemia in Japan

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Takako Shirasawa ◽  
Hirotaka Ochiai ◽  
Takahiko Yoshimoto ◽  
Satsue Nagahama ◽  
Akihiro Watanabe ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Central Obesity ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Middle Aged ◽  
Cross Sectional ◽  
Men And Women ◽  
Japanese Adults

Abstract Background Several studies have shown that normal weight with central obesity (NWCO) is associated with cardiovascular disease risk factors such as hypertension, dyslipidemia and diabetes. However, the relationship between NWCO and hyperuricemia has not been studied in detail. Methods We investigated the association between NWCO and hyperuricemia among Japanese adults aged 40–64 years who had undergone periodic health examinations between April 2013 and March 2014. Obesity was defined as a body mass index (BMI) ≥25 kg/m2 and central obesity was determined as a waist-to-height ratio (WHtR) ≥0.5. We classified the participants into the following groups based according to having obesity and central obesity: normal weight (BMI 18.5–24.9 kg/m2) without (NW; WHtR < 0.5) and with (NWCO) central obesity, and obesity without (OB) and with (OBCO) central obesity. Hyperuricemia was defined as serum uric acid > 7.0 and ≥ 6.0 mg/dL in men and women, respectively, or under medical treatment for hyperuricemia. Alcohol intake was classified as yes (daily and occasional consumption) and none (no alcohol consumption). Odds ratios (OR) and 95% confidence intervals (CI) for hyperuricemia were calculated using a logistic regression model. Results We analyzed data derived from 96,863 participants (69,241 men and 27,622 women). The prevalences of hyperuricemia in men and women were respectively, 21.4 and 11.0%, and of participants with NWCO respectively 15.6 and 30.0%. The adjusted OR for hyperuricemia was significantly increased in OBCO compared with NW, regardless of sex (men: OR, 2.12; 95%CI; 2.03–2.21; women: OR, 3.54; 95%CI, 3.21–3.90) and were statistically significant in NWCO compared with NW (men: OR, 1.44; 95%CI, 1.36–1.52; women: OR, 1.41; 95%CI, 1.27–1.57). The results were similar regardless of alcohol consumption. Conclusions We found that NWCO and OBCO were associated with hyperuricemia in middle-aged Japanese men and women. Middle-aged Japanese adults with normal weight but having central obesity should be screened using a combination of BMI and WHtR and educated about how to prevent hyperuricemia.

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