A multifunctional poly(acrylic acid)/gelatin hydrogel

2009 ◽  
Vol 24 (5) ◽  
pp. 1653-1661 ◽  
Author(s):  
Qunwei Tang ◽  
Jihuai Wu ◽  
Jianming Lin ◽  
Shijun Fan ◽  
De Hu
Keyword(s):  
Acrylic Acid ◽  
Transport Model ◽  
Interpenetrating Network ◽  
Hybrid Hydrogel ◽  
Elongation At Break ◽  
Gelatin Hydrogel ◽  
Preparation Conditions ◽  
Aqueous Solution Polymerization ◽  
Poly Acrylic Acid

A poly(acrylic acid)/gelatin interpenetrating network hydrogel was synthesized by aqueous solution polymerization. The influences of preparation conditions including cross-linker, initiator, gelatin content, and neutralization degree on the swelling ratios of the hydrogels are investigated. The swelling, mechanical strength, biodegradability, and drug-release properties of poly(acrylic acid)/gelatin hydrogel are evaluated. The hydrogel has excellent mechanical properties; tensile strength is 1500 kPa, and elongation at break is 887%, respectively. The in vitro biodegradation shows that an interpenetrating network structure exists in the poly(acrylic acid)/gelatin hybrid hydrogel. A release study indicates that the theophylline release from the hydrogel depends on the cross-linking density of the hydrogel and pH of the medium, and the drug diffusion obeys an anomalous transport model.

scholarly journals Superabsorbent poly(acrylic acid) and antioxidant poly(ester amide) hybrid hydrogel for enhanced wound healing

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Jianhua Zhang ◽  
Junfei Hu ◽  
Baoshu Chen ◽  
Tianbao Zhao ◽  
Zhipeng Gu
Keyword(s):  
Wound Healing ◽  
Acrylic Acid ◽  
Protein Denaturation ◽  
Healing Process ◽  
Antioxidant Properties ◽  
Skin Damage ◽  
Hybrid Hydrogel ◽  
Hydrogel Scaffolds ◽  
Hybrid Hydrogels ◽  
Poly Acrylic Acid

Abstract Wound healing dressing is increasingly needed in clinical owing to the large quantity of skin damage annually. Excessive reactive oxygen species (ROS) produced through internal or external environmental influences can lead to lipid peroxidation, protein denaturation, and even DNA damage, and ultimately have harmful effects on cells. Aiming to sufficiently contact with the wound microenvironment and scavenge ROS, superabsorbent poly (acrylic acid) and antioxidant poly (ester amide) (PAA/PEA) hybrid hydrogel has been developed to enhance wound healing. The physical and chemical properties of hybrid hydrogels were studied by Fourier-transform infrared (FTIR) absorption spectrum, compression, swelling, degradation, etc. Besides, the antioxidant properties of hybrid hydrogels can be investigated through the free radical scavenging experiment, and corresponding antioxidant indicators have been tested at the cellular level. Hybrid hydrogel scaffolds supported the proliferation of human umbilical vein endothelial cells and fibroblasts, as well as accelerated angiogenesis and skin regeneration in wounds. The healing properties of wounds in vivo were further assessed on mouse skin wounds. Results showed that PAA/PEA hybrid hydrogel scaffolds significantly accelerated the wound healing process through enhancing granulation formation and re-epithelialization. In summary, these superabsorbent and antioxidative hybrid hydrogels could be served as an excellent wound dressing for full-thickness wound healing.

In Vitro Response of Osteoblast-Like Cells to Hydroxyapatite-Zinc Oxide-Poly(Acrylic Acid) Cements

2001 ◽  
Vol 218-220 ◽  
pp. 347-352 ◽  
Author(s):  
S. Kenny ◽  
Martin Buggy ◽  
T. Pembroke ◽  
R. Hill ◽  
P.V. Hatton
Keyword(s):  
Zinc Oxide ◽  
Acrylic Acid ◽  
In Vitro Response ◽  
Poly Acrylic Acid

Synthesis and assessment of poly(acrylic acid)/polyvinylpyrrolidone interpenetrating network as a matrix for oral mucosa cells

2019 ◽  
Vol 34 (7) ◽  
pp. 998-1008 ◽  
Author(s):  
Carolina Oliver Urrutia ◽  
Raúl Rosales-Ibáñez ◽  
Ma Victoria Dominguez García ◽  
Jaime Flores-Estrada ◽  
Miriam V Flores-Merino
Keyword(s):  
Acrylic Acid ◽  
Oral Mucosa ◽  
Interpenetrating Network ◽  
Poly Acrylic Acid
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