scholarly journals EFFECTS OF PSYCHOPHYSIOLOGICAL NEUROTHERAPY IN REGULATION IMMUNE RESPONSE COMBINED WITH STANDARD ANTITUBERCULOSIS DRUG THERAPY IN ACUTE PULMONARY TUBERCULOSIS

2019 ◽  
Vol 21 (1) ◽  
pp. 129-136
Author(s):  
O. V. Kolesnikova ◽  
T. I. Petrenko ◽  
T. A. Kolpakova ◽  
V. A. Trufakin
Keyword(s):  
Drug Therapy ◽  
Pulmonary Tuberculosis ◽  
Combined Therapy ◽  
Antituberculosis Drug ◽  
Vibrotactile Stimulation ◽  
Lung Tuberculosis ◽  
Healthy Control ◽  
Phagocyte Activity ◽  
Stress Therapy ◽  
Additional Therapy

The aim of this study was to assess optimizing effects of antistress neurotechnologies on the clinical course of acute pulmonary tuberculosis. The study was performed in three steps: upon admission before treatment, followed by repeated examination at 2 and 4 months. The patients before study were divided into the two groups: (1) 33 patients received standard antituberculosis drug therapy (SDT) and (2) 35 cases after standard antituberculosis drug therapy accompanied by neurothechnological anti-stress therapy (NAT). Patients from the NAT group received a regular audio-visual-vibrotactile stimulation as additional therapy (2 to 3 30-min sessions per week during 4 months). By the time of hospitalization, the groups did not differ in their general immune state. The percentages of CD3+, CD4+, CD8+, CD16+, CD19+as well as indexes of phagocyte activity showed some changes after 2 and 4 months of therapy. The patients from both groups before treatment exhibited lymphocytosis, decreased phagocyte activity, when compared to healthy individuals. By the end of therapy (4 months), the patients from the NAT group showed increased phagocytosis by monocytes (p < 0.01) and granulocytes (p < 0.05) which approached values of healthy control. The study demonstrated also that efficiency of combined therapy was higher in the NAT vs. SDT group: closure of lung destruction cavities was observed in 90.5% of patients from the NAT group vs 45% of patients from the STD group. The results present evidence for combined implementation of neurothechnological anti-stress therapies as a supplementary method for the standard specific drug therapy in primary infiltrative lung tuberculosis.

COMBINATION OF POTASSIUM PERCHLORATE AND PROPYLTHIOURACIL IN THE TREATMENT OF THYROTOXICOSIS

1968 ◽  
Vol 57 (4) ◽  
pp. 565-577 ◽  
Author(s):  
K. E. Røkke ◽  
J. H. Vogt
Keyword(s):  
Drug Therapy ◽  
Side Effects ◽  
Metabolic Rate ◽  
Total Cholesterol ◽  
Basal Metabolic Rate ◽  
Combined Therapy ◽  
Combined Treatment ◽  
Control Measures ◽  
Potassium Perchlorate ◽  
Plasma Total Cholesterol

ABSTRACT A report is given on 95 thyrotoxic patients treated with a combination of 400 mg propylthiouracil and 400 mg of potassium perchlorate. Perchlorate was stopped when a marked remission of symptoms was obtained, on an average after less than 7 weeks. Euthyroidism was found on an average after 7.2 weeks. The basal metabolic rate, PBI, plasma total cholesterol and weight showed a fairly rapid normalization. Thirteen of the 95 patients were given radio-iodine therapy shortly before drug therapy was started. The remaining 82 cases were grouped together with the 23 cases previously reported. Of the total of 105 cases, 96 became euthyroid on combined therapy. For the frequency of side-effects, the thirteen cases mentioned above were included, giving a total of 118 cases. Eight cases showed an increase in goitre size and 15 cases had other side-effects, of which three were granulocytopenia due to propylthiouracil. The possibility of a higher frequency of mainly minor side-effects on combined therapy has to be balanced against the seemingly rapid and reliable therapeutic effect. Combined treatment, perhaps with even smaller doses than reported here, can be recommended in selected cases of thyrotoxicosis where a shortening of the thyrotoxic state seems of importance, or possibly where difficulties due to iodine exposure may be anticipated, provided adequate control measures are taken.

scholarly journals IL-4 Level in Rifampicin-Sensitive and Rifampicin-Resistant Lung Tuberculosis Patients

2020 ◽  
Vol 27 (1) ◽  
Author(s):  
Joko Susanto ◽  
Jusak Nugraha ◽  
Soedarsono Soedarsono
Keyword(s):  
Pulmonary Tuberculosis ◽  
Operating Characteristics ◽  
Mycobacterium Tuberculosis Infection ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Lung Tuberculosis ◽  
Characteristics Analysis ◽  
Resistant Group ◽  
The Difference ◽  
Sensitive Group

Tuberculosis remains a global health burden. Mycobacterium tuberculosis infection causes humoral and cellularresponses. Macrophages of patients with pulmonary tuberculosis evolve M1 polarization that blocks infection orimmunosuppressive M2, promoting tissue repair mediated by IL-4, IL-10, and IL-13. Previous research showed a decrease ofIL-4R and IL-10 expression in lung macrophages of anti-TB drug resistance. A molecular test can detectrifampicin- resistance. There has been no study, which showed the difference in serum IL-4 levels in rifampicin-sensitive andrifampicin-resistant tuberculosis patients. This study aimed to determine the difference between circulating IL-4 levels inrifampicin-sensitive and rifampicin-resistant pulmonary tuberculosis patients. This cross-sectional observational studyconsecutively recruited subjects based on positive molecular and acid-fast bacilli microscopic examination from MDR-TBClinic of the Dr. Soetomo Hospital between December 2018 to March 2019. Subjects were classified into arifampicin-sensitive and rifampicin-resistant group. On ELISA measurement, IL-4 data were analyzed with SPSS version 17.Mann-Whitney U test and ROC analysis tests were performed, and p < 0.05 was significant for α=0.05 (95% CI). There wassignificant difference between rifampicin-sensitive group (420±281 pg/mL) and rifampicin-resistant group(253±279 pg/mL) (p=0.014). Receiver operating characteristics analysis showed AUC 0.70, the sensitivity of 81.5%, thespecificity of 63.6%, and the cut-off value of 235.6 pg/mL. There was a significantly higher level of circulating IL-4 in therifampicin-sensitive group than the rifampicin-resistant group. IL-4 level in healthy subjects should be measured as thenormal value in the population. Immunology and metabolic parameters should be performed to increase samplehomogeneity. Further study was also needed to understand the IL-4 role in rifampicin resistance of lung tuberculosispatients in the Indonesia population.

scholarly journals Determinan Kepatuhan Minum Obat Pasien Tuberkulosis Paru

2019 ◽  
Vol 1 (2) ◽  
pp. 176-185
Author(s):  
Christine Vita Gloria ◽  
Zulmeliza Rasyid ◽  
Sherly Vermita W ◽  
Elmia Kursani ◽  
Bizanti Umayyah
Keyword(s):  
Pulmonary Tuberculosis ◽  
Health Center ◽  
Family Support ◽  
Health Workers ◽  
Treatment Compliance ◽  
P Value ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Lung Tuberculosis

This study aims to see whether the determinants are related to treatment compliance for pulmonary tuberculosis patients at the 2019 health center. This type of research is a quantitative observational cross-sectional design. The results showed that with a P value of 0.05, there was a significant relationship between knowledge (P value = 0.005 and POR = 14.276), attitudes (P value = 0.506 and POR = 1.615), family support (P value = 0.038 and POR = 1,961), the role of health workers (P values = 0.026 and POR = 4.440), with medication adherence for pulmonary tuberculosis patients. Conclusions, of the 4 variables there are 3 variables related to adherence to taking pulmonary TB drugs in the Work Area of the Siak Hulu II Health Center, namely knowledge, family support, and the role of health workers and 1 unrelated variable, attitude.   Keywords: Obedience, Medicine, Lung Tuberculosis

THE ROLE OF PSYCHOLOGICAL REHABILITATION IN THE TREATMENT OF PATIENTS WITH LUNG TUBERCULOSIS

2021 ◽  
Vol 2 (3) ◽  
pp. 16-22
Author(s):  
Mamura Saidova ◽  
◽  
Svetlana Khodjaeva
Keyword(s):  
Risk Factors ◽  
Pulmonary Tuberculosis ◽  
Personality Characteristics ◽  
Premorbid Personality ◽  
Psychological Risk Factors ◽  
Lung Tuberculosis ◽  
Psychological Assistance ◽  
Psychological Risk ◽  
The Relationship

The article is devoted to current issues of psychological rehabilitation of patients with pulmonary tuberculosis. The article focuses on the specifics of psychological assistance. Itsubstantiates the need to organize special psychocorrectional programs aimed at overcoming premorbid elements of the relationship system, which are considered as psychological risk factors for the occurrence of the tuberculous process and its relapses.Keywords:pulmonary tuberculosis, psychological rehabilitation, premorbid personality characteristics, relationship system, therapeutic targets

scholarly journals Mathematical model and tool to explore shorter multi-drug therapy options for active pulmonary tuberculosis

2020 ◽  
Vol 16 (8) ◽  
pp. e1008107
Author(s):  
John Fors ◽  
Natasha Strydom ◽  
William S. Fox ◽  
Ron J. Keizer ◽  
Radojka M. Savic
Keyword(s):  
Mathematical Model ◽  
Drug Therapy ◽  
Pulmonary Tuberculosis ◽  
Therapy Options ◽  
Active Pulmonary Tuberculosis

Impact of Psychosocial Factors on the Conduct of Combined Drug and Psychotherapy Research

1975 ◽  
Vol 127 (5) ◽  
pp. 432-439 ◽  
Author(s):  
W. N. Stone ◽  
B. L. Green ◽  
G. C. Gleser ◽  
R. M. Whitman ◽  
B. B. Foster
Keyword(s):  
Drug Therapy ◽  
Psychosocial Factors ◽  
Research Team ◽  
Combined Therapy ◽  
Psychotherapy Research ◽  
Outcome Data ◽  
Similar Percentage ◽  
And Training

SummaryThe effect of attitudes of therapists, patients and researchers on the conduct and outcome of combined drug and psychotherapy research was examined in a brief crisis-oriented psychotherapy clinic. Seventy-seven consecutive patients were given one of two anti-anxiety drugs or a placebo in conjunction with the typical psychoanalytically-oriented treatment used in the clinic. The therapists' attitudes favouring psychotherapy over drug therapy (and psychotherapy research) were clearly conveyed to the patients. Indicative of this are the following: (a) 82 per cent of the patients dropped out of drug taking, although a similar percentage remained in treatment; (b) only a third of the patients perceived it as being important to their therapists that they should take medication; (c) 87 per cent of the patients were rated as improved; and 75 per cent of patients completing forms considered that most or all of their improvement was attributable to talking.The research team, made up of members of the same department who therefore had similar values as the therapists, diligently collected outcome data, but ignored its responsibility to enforce drug-related portions of the protocol. Overall, patients remained in therapy, improved and participated in completing forms, so that only the research goals of combined therapy were thwarted, while traditional clinic service and training goals proceeded as usual.

Combined Therapy in Pulmonary Tuberculosis

1955 ◽  
Vol 28 (3) ◽  
pp. 290-300
Author(s):  
GEORGE G. ORNSTEIN ◽  
LAWRENCE LERCHER
Keyword(s):  
Pulmonary Tuberculosis ◽  
Combined Therapy

Roentgen Manifestations of Pulmonary Tuberculosis Under Drug Therapy

Radiology ◽  
1958 ◽  
Vol 70 (2) ◽  
pp. 247-251
Author(s):  
Lawrence A. Davis
Keyword(s):  
Drug Therapy ◽  
Pulmonary Tuberculosis
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