scholarly journals PRAVASTATIN IN CORRECTION OF VESSEL WALL ANTIPLATELET CONTROL OVER THE BLOOD CELLS IN PATIENTS WITH ARTERIAL HYPERTENSION AND DYSLIPIDEMIA

2014 ◽  
Vol 13 (6) ◽  
pp. 18-22 ◽  
Author(s):  
I. N. Medvedev ◽  
I. A. Skoryatina I.A
Keyword(s):  
Arterial Hypertension ◽  
Blood Cells ◽  
Vessel Wall ◽  
Blood Count ◽  
Plasma Lipids ◽  
Middle Age ◽  
Peroxidation Of Lipids ◽  
Night Sleep ◽  
Neutrophil Aggregation ◽  
In The Beginning

Aim. To evaluate in patients with arterial hypertension (AH) and dyslipidemia (DL) a grade of correction influence of pravastatin on antiaggregation activity of vessel wall for erythrocytes, platelets and leukocytes.Material and methods. Totally 47 patients observed with 1-2 levels of AH and the risk 3, with DL IIb type, middle age. Controls were 26 healthy people of the same age. To correct DL all patients were prescribed pravastatin 20 mg before night sleep with already being taken enalapril 10 mg BID. Chemistry, blood count and statistics used. Evaluation of clinical and laboratory parameters was performed in the beginning of treatment, in 4, 12 and 52 weeks.Results. An enforced in AH with DLP erythrocyte, platelet neutrophil aggregation was linked with a control decrease over it by vessel wall and as result of lipid metabolism changes, peroxide oxydation of plasma lipids, lowering of NO generation and of prostacycline as well. After 52-week use of pravastatine in AH with DLP there was significantly better in lipid profile and there was weakening of peroxidation of lipids in plasma, that followed by significant positive dynamics of antiplatelet properties of vessel wall.Conclusion. In AH patients with DLP there is weakening of antiplatlet control by vessels over blood cells, which becomes slightly improved after 52-week pravastatine treatment. 

scholarly journals Dementia in elderly patients as a consequence of arterial hypertension (literature review)

2021 ◽  
Author(s):  
Sergey S Mikhailov ◽  
Kirill L. Kozlov ◽  
Andrey N Shishkevich ◽  
Evgeniy Yu. Bessonov ◽  
Nikolai G. Lukjanov ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Brain Function ◽  
Middle Age ◽  
The Elderly ◽  
World Population ◽  
Old People ◽  
Aged People ◽  
Number Of Patients ◽  
Elderly And Old People

Alzheimer's disease and vascular dementia are important causes of cognitive decline in the elderly and senile. This problem is becoming increasingly important in connection with the general aging of the world population and an increase in the number of patients with concomitant pathology, among which arterial hypertension plays an important role. There are a number of studies proving the link between arterial hypertension in middle age and dementia in the elderly. It is hoped that the normalization of blood pressure among middle-aged people will reduce the incidence of cognitive dysfunction. It is also known that maintaining blood pressure at acceptable levels in elderly and old people can improve brain function and reduce the prevalence of dementia, but it is not entirely clear which blood pressure numbers are optimal.

scholarly journals CLINICAL AND FUNCTIONAL STATE OF KIDNEYS IN MIDDLE AGE PATIENTS WITH ARTERIAL HYPERTENSION

2018 ◽  
Vol 11 (4) ◽  
pp. 63-67
Author(s):  
OLGA B. OSHCHEPKOVA ◽  
◽  
EVGENII V. ARKHIPOV ◽  
OLGA YU. MIKHOPAROVA ◽  
GULNARA R. KAMASHEVA ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Functional State ◽  
Middle Age

METHOD OF ERYTHROCYTE PROTECTION IN URGENT CARDIAC SURGERY

2021 ◽  
Vol 8 (2) ◽  
pp. 68-74
Author(s):  
Volodymyr І. Cherniy ◽  
Lada O. Sobanska
Keyword(s):  
Cardiac Surgery ◽  
Blood Cells ◽  
Blood Count ◽  
Negative Impact ◽  
Hemoglobin Concentration ◽  
Negative Influence ◽  
Control Group ◽  
Extracorporeal Circuit ◽  
Free Hemoglobin ◽  
Erythrocyte Membrane Permeability

Aim: The use of a simple, safe and convenient method of treatment extracorporeal circuit with «adaptation composition » (AdC) for the reduction of negative impact on the state of erythrocytes and tissue hypoxia. Material and methods: The research included 150 patients. They were divided into two groups. The first group included patients who underwent surgery with the treatment of an extracorporeal circuit by AdC, the second group was the control group. Сomplete blood count parameters, plasma free hemoglobin concentration, erythrocyte mechanical and osmotic resistance, erythrocyte membrane permeability and acid hemolysis were studied. Results: Use of AdC prevents adsorption the blood cells on the surface of the extracorporeal circuit and protects the erythrocytes during cardiopulmonary bypass in urgent cardiac surgery. Conclusions: The treatment of oxygenator with AdC reduces the negative influence СРВ on state of RBC. Membranes of erythrocytes were more resistant to traumatic factors in the group with AdC.

Microarray Analysis of Peripheral Blood Cells in Pulmonary Arterial Hypertension, Surrogate to Biopsy

CHEST Journal ◽  
2005 ◽  
Vol 128 (6) ◽  
pp. 584S ◽  
Author(s):  
Todd M. Bull ◽  
Chris D. Coldren ◽  
Patrick Nana-Sinkam ◽  
Sylk M. Sotto-Santiago ◽  
Mark Moore ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Microarray Analysis ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Peripheral Blood Cells ◽  
Pulmonary Arterial

The Use of Wavelets for Wall Removal and Scatter Enhancement in Ultrasound Blood Velocity Profile Measurements

2011 ◽  
Author(s):  
Nathalie Bijnens ◽  
Gregory Koutsouridis ◽  
Marcel Rutten ◽  
Frans van de Vosse ◽  
Peter Brands
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Vessel Wall ◽  
Blood Velocity ◽  
Velocity Estimation ◽  
The Body ◽  
Flow Measurements ◽  
Pass Filter ◽  
Ultrasound Waves ◽  
Blood Flow Measurements

Ultrasound waves, transmitted by a transducer into a body, are reflected and scattered by the materials they encounter in the body. In case of blood flow measurements in an artery, the received signal will contain the information not only from the moving red blood cells, but the reflections from the vessel wall of other soft tissue structures as well. The discrimination between ultrasound signals originating from scattering of red blood cells and reflection of tissue is one of the major problems for blood velocity assessment. Traditionally, in Doppler processing, where the highest blood velocities in the middle of the vessel are estimated, this discrimination is obtained via a high pass filter with a static cut-off frequency related to the maximum frequency content of the reflections. This is illustrated in Fig.1 (top). As illustrated in Fig. 1 (bottom), problems occur for velocity estimation of slowly moving blood cells close to the vessel wall and in case of perpendicular insonification [1]. In these cases, there is no frequency shift in the signal received from scattering on blood cells. Furthermore, the intensity of the reflections from the vessel wall is highest in case of perpendicular insonification. Filtering in these cases is very challenging since it allows the assessment of blood velocity profiles without contrast agents.

scholarly journals Can Haematological Indices Predict Positive Findings at Endoscopy in Anaemic Patients?

2007 ◽  
Vol 89 (3) ◽  
pp. 221-225
Author(s):  
AMP Schizas ◽  
R Reid ◽  
ML George
Keyword(s):  
Cell Volume ◽  
Blood Cells ◽  
Blood Count ◽  
Haematological Parameters ◽  
Full Blood Count ◽  
Mean Cell Volume ◽  
Upper Gi ◽  
Significant Difference ◽  
Significant Pathology ◽  
Haematological Indices

INTRODUCTION Patients with anaemia are commonly referred for bidirectional endoscopy. The aim of this study was to determine if any haematological parameters could predict positive findings at endoscopy. PATIENTS AND METHODS A total of 209 patients had bidirectional endoscopies performed for anaemia between September 2002 and March 2004. The endoscopy reports, histology and full blood count results (haemoglobin [Hb], red blood cells [RBCs], packed cell volume [PCV], mean cell volume [MCV] and mean cell haemoglobin [MCH]) were then reviewed. Statistical analysis was performed using non-parametric tests. RESULTS Overall, 197 patients had successful bidirectional endoscopies with 12 requiring completion barium enema. In 48 (23%) of these patients, a cause of anaemia was found with 15 (7.2%) carcinomas detected (2 upper GI and 13 lower GI). There was a significant difference in haemoglobin (9.2 g/dl versus 10.1 g/dl; P = 0.0044), RBCs (3.56 × 1012/l versus 3.83 × 1012/l; P = 0.0325) and PCV (0.279 l/l versus 0.31 l/l; P = 0.0112) between patients with positive findings at endoscopy and those with a normal investigation. Cancer patients had significantly lower haemoglobin (8.65 g/dl versus 10.1 g/dl; P = 0.0103), RBCs (3.45 × 1012/l versus 3.83 × 1012/l; P = 0.0179) and PCV (0.27 l/l versus 0.31 l/l; P = 0.0298) compared with patients with normal endoscopies. There was no significant difference in the other haematological parameters between those found to have positive findings and those that had normal endoscopies. CONCLUSIONS Based on this study, the yield of bidirectional endoscopy is low, with haemoglobin and PCV being the most useful haematological indices of significant pathology. Ferritin and MCV did not predict the likelihood of finding a gastrointestinal cause for the anaemia.

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