scholarly journals Hemolysis risk after packed red blood cells transfusion with infusion pumps

2018 ◽  
Vol 26 (0) ◽  
Author(s):  
Ana Maria Miranda Martins Wilson ◽  
Maria Angélica Sorgini Peterlini ◽  
Mavilde da Luz Gonçalves Pedreira
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Infusion Pump ◽  
Randomized Study ◽  
Transfusion Practice ◽  
Free Hemoglobin ◽  
Infusion Pumps ◽  
Packed Red Blood Cells ◽  
Total Hemoglobin ◽  
Before And After

ABSTRACT Objective: To evaluate the hemolysis biomarkers of packed red blood cells transfused by two different linear peristaltic infusion pumps at two infusion rates. Method: An experimental and randomized study was designed simulating the clinical practice of transfusion. Two linear peristaltic infusion pumps from different manufactures were studied in triplicate at 100 mL/h and 300mL/h infusion rates. The chosen hemolysis biomarkers were total hemoglobin, free hemoglobin, hematocrit, potassium and degree of hemolysis. They were analyzed before and after each infusion. Results: Potassium showed statistically significant variations in all scenarios of the experiment (P<0.010). In a separated analysis, potassium increased mainly at 300mL/h rate (P=0.021) and free hemoglobin had significant variation when comparing infusion pumps from different manufacturers (P=0.026). Although hematocrit, total hemoglobin and degree of hemolysis had increased after infusion, no statistically significance variations were identified. Conclusions: Hemolysis risk induced by a linear peristaltic infusion pump was identified by an increase in free hemoglobin and potassium markers. As the potassium biomarker is often increased in aged packed red blood cells, we do not recommend using them in this scenario. Additional studies should be performed about other markers and using larger samples in order to reinforce the transfusion practice in nursing.

Administration of whole blood, packed red blood cells, and platelets using a multipurpose infusion pump

1991 ◽  
Vol 48 (9) ◽  
pp. 1970-1972
Author(s):  
Andy H. Strayer ◽  
David W. Henry ◽  
Allen Erenberg ◽  
Richard D. Leff
Keyword(s):  
Red Blood Cells ◽  
Whole Blood ◽  
Blood Cells ◽  
Infusion Pump ◽  
Packed Red Blood Cells

Implementation of Perioperative Point-of-Care Platelet Function Analyses Reduces Transfusion Requirements in Cardiac Surgery: A Retrospective Cohort Study

2020 ◽  
Author(s):  
Lihui Wang ◽  
Oswaldo Valencia ◽  
Simon Phillips ◽  
Vivek Sharma
Keyword(s):  
Blood Loss ◽  
Red Blood Cells ◽  
Platelet Function ◽  
Blood Cells ◽  
Platelet Transfusion ◽  
Postoperative Blood Loss ◽  
Transfusion Rate ◽  
Cabg Surgery ◽  
Packed Red Blood Cells ◽  
Before And After

Abstract Background Platelet dysfunction is a common cause of bleeding, perioperative blood transfusion, and surgical re-exploration in cardiac surgical patients. We evaluated the effect of incorporating a platelet function analyzer utilizing impedance aggregometry (Multiplate, Roche, Munich, Germany) into our local transfusion algorithm on the rate of platelet transfusion and postoperative blood loss in patients undergoing coronary artery bypass grafting (CABG) surgery. Methods Data were collected on patients undergoing CABG surgery from January 2015 to April 2017. Patients who underwent surgery before and after introduction of this algorithm were classified into prealgorithm and postalgorithm groups, respectively. The primary outcome was the rate of platelet transfusion before and after implementation of the Multiplate-based transfusion algorithm. Secondary outcomes included transfusion rate of packed red blood cells, postoperative blood loss at 12 and 24 hours, length of stay in the intensive care unit, and the hospital and mortality. Results A total of 726 patients were included in this analysis with 360 and 366 patients in the pre- and postalgorithm groups, respectively. Transfusion rates of platelets (p = 0.01) and packed red blood cells (p = 0.0004) were significantly lower following introduction of the algorithm in patients (n = 257) who had insufficient time to withhold antiplatelet agents. Receiver operating characteristic curves defined optimal cutoff points of arachidonic acid and adenosine diphosphate assays on the Multiplate to predict future platelet transfusion were 23AU and 43AU, respectively. Conclusions The introduction of a Multiplate-based platelet transfusion algorithm showed a statistically significant reduction in the administration of platelets to patients undergoing urgent CABG surgery.

scholarly journals RELATIONSHIP BETWEEN TRANSFUSION OF PACKED RED BLOOD CELLS, PLASMA FREE HEMOGLOBIN AND STORAGE TIME IN PATIENTS WITH SEVERE TRAUMA

2015 ◽  
Vol 3 (Suppl 1) ◽  
pp. A916
Author(s):  
S Chacón Alves ◽  
M Chico Fernández ◽  
C García Fuentes ◽  
A Del Pino Ramírez ◽  
N Zurera Plaza ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Storage Time ◽  
Severe Trauma ◽  
Free Hemoglobin ◽  
Packed Red Blood Cells ◽  
And Storage

scholarly journals Indicators of Erythrocyte Damage after Microwave Warming of Packed Red Blood Cells

2003 ◽  
Vol 49 (5) ◽  
pp. 792-799 ◽  
Author(s):  
Jan Hirsch ◽  
Axel Menzebach ◽  
Ingeborg Dorothea Welters ◽  
Gerald Volker Dietrich ◽  
Norbert Katz ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Room Temperature ◽  
Antibody Binding ◽  
Cellular Damage ◽  
Substantial Part ◽  
Packed Red Blood Cells ◽  
Before And After ◽  
Cellular Markers

Abstract Background: Localized overheating of packed red blood cells (PRBCs) after microwave warming with consequent damage to erythrocytes has been reported. We therefore compared possible cellular markers of erythrocyte damage, as measured by flow cytometry, with laboratory indicators of hemolysis to evaluate the effects of microwave warming on PRBCs. Methods: PRBC samples were warmed to room temperature or to 37, 42, 47, 52, or 57 °C in a water bath. Flow cytometry was performed after fluorescein labeling using antibodies to spectrin, Ca2+-ATPase, and Na+-K+-ATPase. The forward-to-sideward scatter (FSC/SSC) ratio and antibody binding were evaluated. Plasma free hemoglobin (FHb) and α-hydroxybutyrate dehydrogenase (HBDH) were measured immediately after heating and after 48 h. In addition, all measurements were made before and after the heating of PRBCs to 35 °C by a microwave blood warmer. Results: Analysis of 15 000 erythrocytes showed a decrease in the FSC/SSC ratio and antibody binding above 47 °C [at 37 °C, median (SD) of 94.2 (7.4) with 0.07 (0.05)% fluorescein-positive; at 52 °C, median (SD) of 177.0 (19.0) with 18.5 (6.4)% positively gated; P &lt;0.001]. FHb [room temperature, 0.3 (0.2) g/L] was increased 2-fold at 37 and 42 °C, 4-fold at 47 °C, and 25-fold at 52 °C. HBDH increased in parallel. Hemolysis markers showed an additional twofold increase 48 h after heating to 42 and 47 °C. Microwave heating to 35 °C did not produce significant changes of any marker. Conclusions: All markers of cellular damage were altered after heating to &gt;47 °C, and a substantial part of hemolysis was delayed. The methodology can be used for future testing of other blood warming devices.

scholarly journals Gender Differences in Neuromuscular, Haematological and Urinary Responses during Padel Matches

2021 ◽  
Vol 18 (11) ◽  
pp. 5864
Author(s):  
Francisco Pradas ◽  
Alejandro García-Giménez ◽  
Víctor Toro-Román ◽  
Nicolae Ochiana ◽  
Carlos Castellar
Keyword(s):  
Gender Differences ◽  
Red Blood Cells ◽  
Grip Strength ◽  
Blood Cells ◽  
Temporal Structure ◽  
Hand Grip Strength ◽  
Squat Jump ◽  
Hand Grip ◽  
Before And After ◽  
High Level

Research on the acute physiological response to a padel match is limited. The present study aimed to: (a) evaluate neuromuscular, urinary, and hematological responses after simulated padel competition (SC) and (b) analyze possible gender differences. In this study, 28 high-level padel players participated (men = 13, age = 26.83 ± 6.57 years; women = 15, age = 30.07 ± 4.36 years). The following parameters were analyzed before and after SC: neuromuscular (hand grip strength, squat jump (SJ), countermovement jump (CMJ), and Abalakov jump (ABK)), hematological (red blood cells, hemoglobin, and hematocrit), and urinary (pH, specific gravity, microalbuminuria, and red blood cells). Significant gender differences were found in neuromuscular and hematological responses, with men obtaining higher values (p < 0.05). For the SC influence, changes were noted in ABK and microalbuminuria (p < 0.05). The percentages of change in hand grip strength, SJ (height and watts), CMJ (height), and ABK (height) were higher for men than women (p < 0.05). SC negatively influenced the neuromuscular parameters to a greater extent in women. Our results could be related to gender differences in game actions, the temporal structure, and anthropometric and physiological characteristics. Game dynamics and a different organic response between male and female padel playing were confirmed.

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