scholarly journals Human mucocutaneous leishmaniasis in Três Braços, Bahia - Brazil: an area of Leishmania braziliensis braziliensis transmission. II. Cutaneous disease. Presentation and evolution

1984 ◽  
Vol 17 (4) ◽  
pp. 169-177 ◽  
Author(s):  
Elmer A. Llanos-Cuentas ◽  
Philip D. Marsden ◽  
Edinaldo L. Lago ◽  
Air C. Barreto ◽  
César C. Cuba ◽  
...  
Keyword(s):  
Fluorescent Antibody ◽  
Age Groups ◽  
Skin Lesions ◽  
Skin Tests ◽  
Leishmania Braziliensis ◽  
Mucocutaneous Leishmaniasis ◽  
Anterior Tibial ◽  
Antibody Titres ◽  
Size Ofthe ◽  
Clinical Records

The clinical records of 182 patients with cutaneous leishmaniasis probably due to Leishmania braziliensis braziliensis are analysed. 68% had a single lesion which was usually an ulceron the lower anterior tibial third. Many had short histories of one to two months and all age groups were represented 13% had closed lesions of a verrucose or plaque like nature. Evolution of these skin lesions after treatment was related to the regularity of antimony therapy. Although healing usually occurred in three months, the time to scarring after commencing treatment was variable and related to the size ofthe lesion (p < 0.01). Usually if sufficient antimony treatment was given the lesion closed. Seven of the ten patients with initially negative leishmanin skin tests converted to positive after treatment. A significant decline of indirect fluorescent antibody titres occurred in patients followed, during and after therapy.

VZV myelitis with secondary HIV CSF escape

2021 ◽  
Vol 14 (6) ◽  
pp. e241738
Author(s):  
Julian J Weiss ◽  
Serena Spudich ◽  
Lydia Barakat
Keyword(s):  
Rare Complication ◽  
Fluorescent Antibody ◽  
Central Nervous System Infection ◽  
Skin Lesions ◽  
Antibody Testing ◽  
Hiv Viral Load ◽  
Varicella Zoster ◽  
Intravenous Acyclovir ◽  
Immunosuppressed Patients ◽  
Csf Escape

A 52-year-old woman with HIV and recent antiretroviral therapy non-adherence presented with a 5-day history of widespread painful vesicular skin lesions. Direct fluorescent antibody testing of the skin lesions was positive for varicella zoster virus (VZV). On day 3, she developed profound right upper extremity weakness. MRI of the brain and cervical spine was suggestive of VZV myelitis. Lumbar puncture was positive for VZV PCR in the cerebrospinal fluid (CSF) and CSF HIV viral load was detected at 1030 copies/mL, indicating ‘secondary’ HIV CSF escape. She was treated with intravenous acyclovir for 4 weeks and subsequent oral therapy with famciclovir then valacyclovir for 6 weeks. She also received dexamethasone. The patient had an almost full recovery at 6 months. Myelitis is a rare complication of reactivated VZV infection that can have atypical presentation in immunocompromised patients. Such ‘secondary’ HIV CSF escape should be considered in immunosuppressed patients with concomitant central nervous system infection.

scholarly journals Regulatory T-Cell Dynamics in Cutaneous and Mucocutaneous Leishmaniasis due to Leishmania braziliensis

2018 ◽  
Vol 98 (3) ◽  
pp. 753-758 ◽  
Author(s):  
Nicolas Barros ◽  
Nestor Vasquez ◽  
Fernando Woll ◽  
Cesar Sanchez ◽  
Braulio Valencia ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Leishmania Braziliensis ◽  
Cell Dynamics ◽  
Mucocutaneous Leishmaniasis

Case Report: Miltefosine Failure and Spontaneous Resolution of Cutaneous Leishmaniasis braziliensis

2021 ◽  
Author(s):  
Sheridan Joseph ◽  
Timothy J. Whitman ◽  
Frederick S. Buckner ◽  
Anna L. Cogen
Keyword(s):  
Case Report ◽  
South America ◽  
Treatment Failure ◽  
Cutaneous Leishmaniasis ◽  
Young Woman ◽  
Spontaneous Resolution ◽  
Clinical Monitoring ◽  
Leishmania Braziliensis ◽  
Oral Medications ◽  
Mucocutaneous Leishmaniasis

Cutaneous leishmaniasis (CL) is often caused by Leishmania braziliensis (L. braziliensis) in South America. Because of the risk for mucocutaneous leishmaniasis, L. braziliensis is frequently treated with parenteral or oral medications. Here, we present a case of a young woman with L. braziliensis (CL) that did not respond to miltefosine but eventually experienced spontaneous resolution. This case highlights the potential for treatment failure and the importance of clinical monitoring in the setting of cutaneous leishmaniasis caused by L. braziliensis.

scholarly journals Trends in Poliovirus Seroprevalence in Kano State, Northern Nigeria

2018 ◽  
Vol 67 (suppl_1) ◽  
pp. S103-S109
Author(s):  
Harish Verma ◽  
Zubairu Iliyasu ◽  
Kehinde T Craig ◽  
Natalie A Molodecky ◽  
Utibeabasi Urua ◽  
...  
Keyword(s):  
Old Age ◽  
Age Groups ◽  
Significant Risk ◽  
Immunization Coverage ◽  
Neutralizing Antibody ◽  
Age Group ◽  
Parental Consent ◽  
Population Immunity ◽  
Antibody Titres ◽  
The Impact

Abstract Background Kano state has been a protracted reservoir of poliovirus in Nigeria. Immunity trends have been monitored through seroprevalence surveys since 2011. The survey in 2015 was, in addition, intended to assess the impact of use of inactivated poliovirus vaccine (IPV). Methods It was a health facility based seroprevalence survey. Eligible children aged 6-9, 12-15 and 19-22 months of age brought to the paediatrics outpatient department of Murtala Mohammad Specialist Hospital between 19 October and 6 November 2015, were screened for eligibility. Eligible children were enrolled after parental consent, history taken, physical examination conducted, and a blood sample collected to test for neutralizing antibody titres against the three poliovirus serotypes. Results Overall, 365 results were available in the three age groups. In the 6-9-month-old age group, the seroprevalence was 73% (95% confidence interval [CI] 64-80%), 83% (95% CI 75-88%), and 66% (95% CI 57-73%) for serotypes 1, 2, and 3, respectively. In the 12-15- and 19-22-month-old age groups, seroprevalence was higher but still remained <90% across serotypes. Seroprevalence to serotypes 1 and 3 in 2015 was similar to 2014; however, for serotype 2 there was a significant improvement. IPV received in supplemental immunization activities was found to be a significant predictor of seropositivity among 6-9-month-old infants for serotypes 1 and 2. Conclusions Seroprevalence for serotypes 1 and 3 remains low (<80%) in 6-9-month-olds. This poses a significant risk for poliovirus spread if reintroduced into the population. Efforts to strengthen immunization coverage are imperative to secure and sustain high population immunity.

scholarly journals Human mucocutaneous leishmaniasis in Três Braços, Bahia - Brazil: an area of Leishmania braziliensis braziliensis transmission. I. Laboratory diagnosis

1984 ◽  
Vol 17 (4) ◽  
pp. 161-167 ◽  
Author(s):  
César C. Cuba ◽  
Elmer A. Llanos-Cuentas ◽  
Air C. Barreto ◽  
Albino V. Magalhães ◽  
Edinaldo L. Lago ◽  
...  
Keyword(s):  
Skin Test ◽  
Antibody Test ◽  
Laboratory Diagnosis ◽  
Leishmania Braziliensis ◽  
Cutaneous Lesions ◽  
Positive Skin ◽  
Cutaneous Disease ◽  
Mucosal Disease ◽  
Mucocutaneous Leishmaniasis ◽  
Mucosal Lesions

Leishmanial parasites were detected in 71.2% of patients with cutaneous disease and 48% of patients with mucosal disease, using principally scanning of imprints mears and histological sections and hamster inoculation. Parasites were more frequent in early cutaneous lesions (p < 0.005) o fless than two month duration. Also they were more common in multiple than single mucosal lesions (p < 0.02) in spite of considerable prior glucan time therapy in the former group. 93% of cutaneous lesions had a positive leishmanin skin test and most of the negatives occurred in patients with lesions of less than one month duration. 97% of patients with single mucosal lesion and 79% with multiple mucosal lesions had a positive skin test. 86% of cutaneous disease and 90% of mucosal disease was associated with a positive indirect immunofluorescent antibody test at a ≥ 1/20 dilution. In both groups multiple lesions were associated with higher titres and titres were significantly higher in patients with mucosal disease compared with cutaneous disease (p < 0.01).

Fluorescent antibody titres after recovery from visceral leishmaniasis

Acta Tropica ◽  
1991 ◽  
Vol 50 (1) ◽  
pp. 87-88 ◽  
Author(s):  
Debasis Basu ◽  
K.K. Mallik ◽  
Amal Bhattacharya ◽  
Anil Kumar Ghosh
Keyword(s):  
Visceral Leishmaniasis ◽  
Fluorescent Antibody ◽  
Antibody Titres

Immunofluorescent and Morphologic Studies on Swinepox

1966 ◽  
Vol 3 (5) ◽  
pp. 556-564 ◽  
Author(s):  
N. F. Cheville
Keyword(s):  
Electron Microscopy ◽  
Infected Cell ◽  
Cell Cultures ◽  
Fluorescent Antibody ◽  
Antibody Test ◽  
Skin Lesions ◽  
Histologic Examination ◽  
Virus Particles ◽  
Naturally Occurring ◽  
Virus Isolates

Five virus isolates were obtained from pox-like lesions in swine. The respective skin lesions, infected cell cultures, virus particles and experimentally infected young swine were identical to that of swinepox by histologic examination, immunofluorescence and electron microscopy. The fluorescent antibody test provided a rapid and accurate means of diagnosis of naturally occurring lesions.

scholarly journals Toxoplasma antibodies in immigrants from Hong Kong

1974 ◽  
Vol 72 (1) ◽  
pp. 19-22 ◽  
Author(s):  
S. K. K. Seah
Keyword(s):  
Hong Kong ◽  
Toxoplasma Gondii ◽  
Indigenous Population ◽  
Fluorescent Antibody ◽  
Age Groups ◽  
Fluorescent Antibody Technique ◽  
Indirect Fluorescent Antibody ◽  
Chinese Adults ◽  
Antibody Technique ◽  
Total Incidence

SUMMARYThe sera of 200 Chinese adults recently immigrated to Canada from Hong Kong were examined for antibodies to Toxoplasma gondii by the indirect fluorescent antibody technique. It was found that the total incidence was 18·0%. This is significantly lower than that of the indigenous population of the same age groups in this area.

Mucocutaneous Leishmaniasis in Colombia: Leishmania Braziliensis Subspecies Diversity

1985 ◽  
Vol 34 (4) ◽  
pp. 714-720 ◽  
Author(s):  
Nancy G. Saravia ◽  
Ana Fernanda Holguín ◽  
Antonio D'Alessandro ◽  
Diane McMahon-Pratt
Keyword(s):  
Leishmania Braziliensis ◽  
Mucocutaneous Leishmaniasis
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