scholarly journals Validation of the Argentine version of the Memory Binding Test (MBT) for Early Detection of Mild Cognitive Impairment

2016 ◽  
Vol 10 (3) ◽  
pp. 217-226 ◽  
Author(s):  
Fabian Roman ◽  
Mónica Iturry ◽  
Galeno Rojas ◽  
Ernesto Barceló ◽  
Herman Buschke ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Detection ◽  
Episodic Memory ◽  
Latin American ◽  
Memory Test ◽  
Control Group ◽  
Operating Characteristics ◽  
Memory Binding ◽  
Significant Difference

ABSTRACT Background: "Forgetfulness" is frequent in normal aging and characteristic of the early stages of dementia syndromes. The episodic memory test is central for detecting amnestic mild cognitive impairment (MCI). The Memory Binding Test (MBT) is a simple, easy and brief memory test to detect the early stage of episodic memory impairment. Objective: To validate the Argentine version of the MBT in a Latin American population and to estimate the diagnostic accuracy as a tool for early detection of MCI. Methods: 88 subjects (46 healthy controls and 42 patients with amnestic MCI) matched for age and educational level were evaluated by an extensive neuropsychological battery and the memory binding test. Results: A significantly better performance was detected in the control group; all MBT scales were predictive of MCI diagnosis (p<.01). The MBT showed high sensitivity (69%) and high specificity (88%), with a PPV of 93% and a NPV of 55% for associative paired recall. A statistically significant difference (c2=14,164, p<.001) was obtained when comparing the area under the curve (AUC) of the MBT (0.88) and the MMSE (0.70). Conclusion: The Argentine version of the MBT correlated significantly with the MMSE and the memory battery and is a useful tool in the detection of MCI. The operating characteristics of the MBT are well suited, surpassing other tests commonly used for detecting MCI.

scholarly journals Donepezil for mild cognitive impairment in Parkinson’s disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kyoungwon Baik ◽  
Seon Myeong Kim ◽  
Jin Ho Jung ◽  
Yang Hyun Lee ◽  
Seok Jong Chung ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Treatment Group ◽  
Outcome Measures ◽  
Rating Scale ◽  
Secondary Outcome ◽  
Control Group ◽  
Significant Difference

AbstractWe investigated the efficacy of donepezil for mild cognitive impairment in Parkinson’s disease (PD-MCI). This was a prospective, non-randomized, open-label, two-arm study. Eighty PD-MCI patients were assigned to either a treatment or control group. The treatment group received donepezil for 48 weeks. The primary outcome measures were the Korean version of Mini-Mental State Exam and Montreal Cognitive Assessment scores. Secondary outcome measures were the Clinical Dementia Rating, Unified Parkinson’s Disease Rating Scale part III, Clinical Global Impression scores. Progression of dementia was assessed at 48-week. Comprehensive neuropsychological tests and electroencephalography (EEG) were performed at baseline and after 48 weeks. The spectral power ratio of the theta to beta2 band (TB2R) in the electroencephalogram was analyzed. There was no significant difference in the primary and secondary outcome measures between the two groups. However, the treatment group showed a significant decrease in TB2R at bilateral frontotemporoparietal channels compared to the control group. Although we could not demonstrate improvements in the cognitive functions, donepezil treatment had a modulatory effect on the EEG in PD-MCI patients. EEG might be a sensitive biomarker for detecting changes in PD-MCI after donepezil treatment.

Working memory binding and episodic memory formation in aging, mild cognitive impairment, and Alzheimer’s dementia

2015 ◽  
Vol 37 (5) ◽  
pp. 538-548 ◽  
Author(s):  
Bonnie van Geldorp ◽  
Sophie M. Heringa ◽  
Esther van den Berg ◽  
Marcel G. M. Olde Rikkert ◽  
Geert Jan Biessels ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Episodic Memory ◽  
Memory Formation ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia ◽  
Memory Binding

scholarly journals Psychometric characteristics of the Rivermead Behavioural Memory Test (RBMT) as an early detection instrument for dementia and mild cognitive impairment in Brazil

2010 ◽  
Vol 22 (8) ◽  
pp. 1362-1362
Author(s):  
Mônica Sanches Yassuda ◽  
Mariana Kneese Flaks ◽  
Luciane Fátima Viola ◽  
Fernanda Speggiorin Pereira ◽  
Claudia Maia Memória ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Detection ◽  
Sao Paulo ◽  
Memory Test ◽  
Title Page ◽  
São Paulo ◽  
Psychometric Characteristics ◽  
Rivermead Behavioural Memory Test ◽  
Detection Instrument

On the title page, the authors' affiliations need to be reversed. The first author is affiliated to the Gerontology Department at the School of Arts, Sciences and Humanities (EACH), University of São Paulo, and the remaining authors are affiliated to the Psychogeriatric Unit, Laboratory of Neuroscience (LIM 27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo.

scholarly journals Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment

2018 ◽  
Vol 15 (5) ◽  
pp. 482-492 ◽  
Author(s):  
Kiyomi Nishimaki ◽  
Takashi Asada ◽  
Ikuroh Ohsawa ◽  
Etsuko Nakajima ◽  
Chiaki Ikejima ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Clinical Study ◽  
Molecular Hydrogen ◽  
Word Recall ◽  
Control Group ◽  
Stress Model ◽  
Randomized Clinical Study ◽  
Significant Difference

Background: Oxidative stress is one of the causative factors in the pathogenesis of neurodegenerative diseases including mild cognitive impairment (MCI) and dementia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant. Objective: We assess the effects of drinking H2-water (water infused with H2) on oxidative stress model mice and subjects with MCI. Methods: Transgenic mice expressing a dominant-negative form of aldehyde dehydrogenase 2 were used as a dementia model. The mice with enhanced oxidative stress were allowed to drink H2-water. For a randomized double-blind placebo-controlled clinical study, 73 subjects with MCI drank ~300 mL of H2-water (H2-group) or placebo water (control group) per day, and the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) scores were determined after 1 year. Results: In mice, drinking H2-water decreased oxidative stress markers and suppressed the decline of memory impairment and neurodegeneration. Moreover, the mean lifespan in the H2-water group was longer than that of the control group. In MCI subjects, although there was no significant difference between the H2- and control groups in ADAS-cog score after 1 year, carriers of the apolipoprotein E4 (APOE4) genotype in the H2-group were improved significantly on total ADAS-cog score and word recall task score (one of the sub-scores in the ADAS-cog score). Conclusion: H2-water may have a potential for suppressing dementia in an oxidative stress model and in the APOE4 carriers with MCI.

scholarly journals Textual Inference Comprehension in Mild Cognitive Impairment: The Influence of Semantic Processing and Verbal Episodic Memory

2021 ◽  
Vol 13 ◽  
Author(s):  
Maria Paula Maziero ◽  
Ariella Fornachari Ribeiro Belan ◽  
Marina von Zuben de Arruda Camargo ◽  
Marcela Lima Silagi ◽  
Orestes Vicente Forlenza ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Episodic Memory ◽  
Semantic Processing ◽  
Semantic Knowledge ◽  
Amnestic Mild Cognitive Impairment ◽  
Control Group ◽  
Inference Making ◽  
Healthy Elderly ◽  
Verbal Episodic Memory

Language complaints, especially in complex tasks, may occur in mild cognitive impairment (MCI). Various language measures have been studied as cognitive predictors of MCI conversion to Alzheimer's type dementia. Understanding textual inferences is considered a high-demanding task that recruits multiple cognitive functions and, therefore, could be sensitive to detect decline in the early stages of MCI. Thus, we aimed to compare the performance of subjects with MCI to healthy elderly in a textual inference comprehension task and to determine the best predictors of performance in this ability considering one verbal episodic memory and two semantic tasks. We studied 99 individuals divided into three groups: (1) 23 individuals with amnestic mild cognitive impairment (aMCI), (2) 42 individuals with non-amnestic mild cognitive impairment (naMCI), (3), and (4) 34 cognitively healthy individuals for the control group (CG). A reduced version of The Implicit Management Test was used to assess different types of inferential reasoning in text reading. MCI patients performed poorer than healthy elderly, and there were no differences between MCI subgroups (amnestic and non-amnestic). The best predictors for inference-making were verbal memory in the aMCI and semantic tasks in the naMCI group. The results confirmed that the failure to understand textual inferences can be present in MCI and showed that different cognitive skills like semantic knowledge and verbal episodic memory are necessary for inference-making.

The Effects of Exposure to Recent Autobiographical Events on Declarative Memory in Amnestic Mild Cognitive Impairment: A Preliminary Pilot Study

2020 ◽  
Vol 17 (2) ◽  
pp. 158-167
Author(s):  
Olga Gelonch ◽  
Neus Cano ◽  
Marta Vancells ◽  
Marc Bolaños ◽  
Laia Farràs-Permanyer ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Episodic Memory ◽  
Autobiographical Memory ◽  
Cognitive Reserve ◽  
Statistical Significance ◽  
Cognitive Intervention ◽  
Amnestic Mild Cognitive Impairment ◽  
Post Treatment ◽  
Control Group

Background: Individuals with amnestic Mild Cognitive Impairment (aMCI) are at heightened risk of developing Alzheimer's dementia. In recent years, much attention has been given to the search for new interventions to slow down the progression of cognitive decline of these patients. Wearable digital camera devices are one form of new technology that captures images of one’s life events, so they constitute a promising method to be used as a means to stimulate recent autobiographical memory. Objective: This preliminary study investigates the ability of a new cognitive intervention based on exposure to recent autobiographical memory captured by wearable cameras to improve episodic memory in patients with aMCI. Method: Seventeen subjects wore a wearable camera while they went about their daily activities. The images captured were converted into eight different 3-minute films containing the most relevant information of each event. The intervention involved eight individualized weekly sessions during which patients were exposed to a different autobiographical event each week. Besides, several specific questions were formulated within each session. Clinical questionnaires assessing cognitive reserve, premorbid intelligence, depression, and anxiety were administered at baseline. Measures of objective episodic memory were applied at baseline and at post-treatment. Results: Significant improvements were observed at post-treatment in memory measures, and significant associations were found between memory change scores and age and cognitive reserve. Anyway, these associations did not reach statistical significance after adjusting for multiple comparisons. Conclusion: The present study provides preliminary evidence that aMCI patients may benefit from a cognitive intervention program based on re-experiencing recent autobiographical events. However, future studies incorporating a control group will be needed to confirm these preliminary findings.

scholarly journals Comparative Effectiveness of Interventions for Global Cognition in Patients With Mild Cognitive Impairment: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

2021 ◽  
Vol 13 ◽  
Author(s):  
Zijun Xu ◽  
Wen Sun ◽  
Dexing Zhang ◽  
Vincent Chi-Ho Chung ◽  
Regina Wing-Shan Sit ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Physical Exercise ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Control Group ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Significant Difference ◽  
Global Cognition

Background: There is a lack of study comprehensively comparing the effects of all existing types of interventions on global cognition among patients with mild cognitive impairment (MCI).Aims: To conduct a network meta-analysis to evaluate the effectiveness of different types of interventions in improving global cognition among MCI patients.Methods: Randomized controlled trials (RCTs) assessing the effects of pharmacological or non-pharmacological interventions on the Mini-Mental State Examination (MMSE) in MCI patients were included. Two authors independently screened the studies and extracted the data. Random-effects network meta-analysis was used to synthesize the data. Results were summarized as mean difference (MD) and corresponding 95% CIs of MMSE in forest plots.Results: Fifty RCTs with 5,944 MCI patients met the inclusion criteria and 49 were included in the network meta-analysis. Compared with the control group, cognition-based intervention (MD = 0.80, 95% CI 0.04–1.57), physical exercise (MD = 1.92, 95% CI 1.19–2.64), combined physical exercise and cognition-based intervention (MD = 1.86, 95% CI 0.60–3.12), and antioxidants (MD = 0.94, 95% CI 0.04–1.83) had positive effects on MMSE in participants with MCI. There was no significant difference between all other interventions included and the control group.Conclusions: This study suggested that cognition-based intervention, physical exercise, combined physical exercise and cognition-based intervention, and antioxidants could be among the most effective interventions on global cognition in older adults with MCI. The availability, acceptability, and cost-effectiveness of interventions should also be taken into consideration when selecting interventions.Registration: PROSPERO CRD42020171985.

scholarly journals Comparison of Resistance and Chair Yoga Training on Subjective Sleep Quality in MCI Women

2017 ◽  
Vol 5 (1) ◽  
pp. 26 ◽  
Author(s):  
Maria Karydaki ◽  
Eleni Dimakopoulou ◽  
Eleni Margioti ◽  
Vassilios Lyras ◽  
Xenofon Apostolopoulos ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Resistance Training ◽  
Sleep Quality ◽  
Control Group ◽  
Sleep Onset Latency ◽  
Subjective Sleep Quality ◽  
Resistance Training Program ◽  
Subjective Sleep ◽  
Significant Difference

Background: Self-rated sleep disorders are common in older adults, resulting in various health problems. Two types of exercise are suggested as an affordable and accessible non-pharmacological treatment and are being compared and discussed. Objectives: This randomized, controlled, 12-week trial investigates the effects of different types of exercise (resistance vs chair yoga training) on subjective sleep quality, in women with Mild Cognitive Impairment (MCI). Methods: In order to measure cognitive function, the Mini-Mental State Examination (MMSE) was used. Forty nine participants enrolled in the study were randomized to a resistance training program (n=16), or a chair yoga program (n=15), or a control group (n=18). All participants engaged in cognitive activities. Results: At baseline, PSQI scores for CYG, RTG and CG (8.2±5.1, 6.1±4.3, 7.4±4.1, respectively) and MMSE (28.3±1.4, 27.8±1.2, 28.0±2.3, respectively) did not differ statistically between the three groups (F2,46= 1.993, p= 0.143). After the intervention, a significant improvement in PSQI total score was noted in resistance training group (t=2.335, df15, p=0.03). Conclusions: There were no significant differences between groups before and after test for the PSQI subscale scores (sleep onset latency (h), time spent in bed before sleep (min), morning waking up (h) and sleep duration (h)). No significant difference was found in PSQI subscales scores within each group. This study proposes that resistance training is an effective treatment approach to improve sleep quality in women with mild cognitive impairment. 

Identifying Brain Connectivity Using Network-Based Statistics in Amnestic Mild Cognitive Impairment Stratified by β-Amyloid Positivity

2018 ◽  
Vol 34 (2) ◽  
pp. 104-111 ◽  
Author(s):  
Ji Eun Kim ◽  
Sung-Woo Kim ◽  
Minsuk Choi ◽  
Joon-Kyung Seong ◽  
Jae-Hong Lee
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Amnestic Mild Cognitive Impairment ◽  
Control Group ◽  
Whole Brain ◽  
Brain White Matter ◽  
Significant Difference ◽  
Β Amyloid ◽  
Structural Networks

Background: The aim of this study was to identify white matter structural networks of amnestic mild cognitive impairment (aMCI) dichotomized by β amyloid (Aβ) status and compare them using network-based statistics (NBS). Methods: Patients underwent whole-brain diffusion-weighted magnetic resonance imaging, detailed neuropsychological test and [18F]-Florbetaben amyloid positron emission tomography. We performed the NBS analysis to compare the whole-brain white matter structural networks extracted from diffusion tensor images. Results: One hundred sixteen participants (Aβ− cognitively normal [CN], n = 35; Aβ− aMCI, n = 42; Aβ+ aMCI, n = 39) were included. There was no subnetwork showing significant difference between Aβ+ aMCI and Aβ− aMCI. However, by comparing each aMCI group with control group, we found that supplementary motor areas were common hub regions. Intriguingly, Aβ+ aMCI showed reduced connectivity mainly in the medial frontal regions, while Aβ− aMCI showed somewhat uniform disruption when compared to CN. Conclusion: Structural network analysis using network-based approach in aMCI may shed light on further understanding of white matter disruption in the prodromal stage of Alzheimer’s disease.

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