scholarly journals Impact of malignant neoplasms on musculoskeletal system in children (literature review)

2019 ◽  
Vol 13 (4) ◽  
pp. 60-66
Author(s):  
O. A. Tikhonova ◽  
N. Yu. Krutikova ◽  
A. F. Karelin ◽  
E. V. Zhukovskaya ◽  
A. G. Rumyantsev
Keyword(s):  
Musculoskeletal System ◽  
Mineral Metabolism ◽  
Bone Mineralization ◽  
Disease Free Survival ◽  
Underlying Disease ◽  
Late Complications ◽  
Malignant Neoplasms ◽  
Successful Implementation ◽  
Actual Problem

Because of the successful implementation of modern treatment technologies at any stage of therapy of children with oncohematological diseases, their overall and disease-free survival has increased significantly. According to recent observations, 80 % of children after the completion of a special antitumor treatment continue to have changes of different organs. Almost all patients are at risk for late complications from the musculoskeletal system but little attention is paid to this issue. Evaluation of long-term complications from the musculoskeletal system and mineral metabolism in patients, development of their complex rehabilitation and prevention is an actual problem of pediatric oncology and hematology. This review summarizes data on long-term complications from the musculoskeletal system after special therapy. The necessity of diagnostics approaches harmonization and correction of not only the most common complications, but also little studied conditions, such as reduction of bone mineralization, is shown. It is noted that multidisciplinary rehabilitation treatment of children in remission can not only correct the consequences of the underlying disease, concomitant pathology and the consequences of special therapy but also reduce the disability of children.

scholarly journals Late effects of antitumor treatment on the musculoskeletal system

2019 ◽  
Vol 6 (3) ◽  
pp. 86-93
Author(s):  
G. M. Muftakhova ◽  
N. A. Bolshakov ◽  
E. Yu. Ilyina
Keyword(s):  
Musculoskeletal System ◽  
Late Effects ◽  
The State ◽  
Limb Amputation ◽  
Malignant Neoplasms ◽  
Pathological Changes ◽  
Treatment And Prevention ◽  
Pathological Conditions ◽  
Long Term Consequences

This article is devoted to the analysis of problems associated with the state of the musculoskeletal system in patients who survived malignant neoplasms in childhood. The main diseases and pathological conditions that can develop in this population are considered. The risks of pathological changes in the musculoskeletal system, treatment and prevention are described. The issues of long-term consequences after limb amputation, organ-preserving operations, osteonecrosis, scoliosis, osteoporosis are separately analyzed.

Treatment-Specific Risks of Second Malignancies and Cardiovascular Disease in 5-Year Survivors of Testicular Cancer

2007 ◽  
Vol 25 (28) ◽  
pp. 4370-4378 ◽  
Author(s):  
Alexandra W. van den Belt-Dusebout ◽  
Ronald de Wit ◽  
Jourik A. Gietema ◽  
Simon Horenblas ◽  
Marieke W.J. Louwman ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Cox Regression ◽  
Late Complication ◽  
Late Complications ◽  
Malignant Neoplasms ◽  
Second Malignancies ◽  
Similar Extent ◽  
Second Malignant Neoplasms

Purpose To compare radiotherapy and chemotherapy effects on long-term risks of second malignant neoplasms (SMNs) and cardiovascular diseases (CVDs) in testicular cancer (TC) survivors. Patients and Methods In our nationwide cohort comprising 2,707 5-year TC survivors, incidences of SMNs and CVDs were compared with general-population rates by calculating standardized incidence ratios (SIRs) and absolute excess risks (AERs). Treatment effects on risks of SMN and CVD were quantified in multivariable Cox regression and competing risks analyses. Results After a median follow-up time of 17.6 years, 270 TC survivors developed SMNs. The SIR of SMN overall was 1.7 (95% CI, 1.5 to 1.9), with an AER of 32.3 excess occurrences per 10,000 person-years. SMN risk was 2.6-fold (95% CI, 1.7- to 4.0-fold) increased after subdiaphragmatic radiotherapy and 2.1-fold (95% CI, 1.4- to 3.1-fold) increased after chemotherapy, compared with surgery only. Subdiaphragmatic radiotherapy increased the risk of a major late complication (SMN or CVD) 1.8-fold (95% CI, 1.3- to 2.4-fold), chemotherapy increased the risk of a major late complication 1.9-fold (95% CI, 1.4- to 2.5-fold), and smoking increased the risk of a major late complication 1.7-fold (95% CI, 1.4- to 2.1-fold), compared with surgery only. The median survival time was 1.4 years after SMN and 4.7 years after CVD. Conclusion Radiotherapy and chemotherapy increased the risk of developing SMN or CVD to a similar extent as smoking. Subdiaphragmatic radiotherapy strongly increases the risk of SMNs but not of CVD, whereas chemotherapy increases the risks of both SMNs and CVDs. Prolonged follow-up after chemotherapy is needed to reliably compare the late complications of radiotherapy and chemotherapy after 20 years.

Occupational Incidence of Employees of Enterprises State Corporation "Rosatom"

2017 ◽  
Vol 62 (1) ◽  
pp. 38-43
Author(s):  
Немков ◽  
A. Nemkov ◽  
Афонин ◽  
S. Afonin ◽  
Антоненков ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Musculoskeletal System ◽  
Occupational Diseases ◽  
Adhesive Capsulitis ◽  
Morbidity Rate ◽  
Malignant Neoplasms ◽  
Vibration Disease ◽  
Leading Position ◽  
State Corporation

Purpose: To analyze the incidence of occupational diseases of employees of factories and organizations in State Corporation «Rosatom». Material and methods: The study was conducted with the use of primary documents, containing information about the diseases and working conditions in the workplace. The calculation of this indicator is based on the standard and original software. Results: In 2014 leading position among professional pathologies adhesive capsulitis of the shoulder (26.1 %), a number enthesopathies (13.4 %), lateral and medial epicondylitis (4.2 % and 0.8 %, respectively) occupy. Pathologies associated with decrease in hearing (9.2 %). Cancers of the respiratory system, as well as malignant neoplasms unspecified localization (5.9 %). In the structure of occupational diseases employees from 50 to 59 years (36.9 %) is dominated; the lowest level of occupational diseases in the group under 39 years (5.9 %). 68.9 % of employees , registered in 2014, were over the age of 50. For the 2010–2014 long-term dynamics of occupational diseases shows its growth from 1.6 cases per 10,000 employees (2010) to 4.5 cases per 10,000 employees (2014). The negative long-term dynamics (2010–2014) observed for occupational diseases of the musculoskeletal system and connective tissue (from 0.1 to 2.57 cases per 10,000 employees), vibration disease (from 0.7 to 0.9 cases per 10,000 employees), malignant neoplasms (from 0.2 to 4.2 cases per 100,000 employees). Conclusion: During 2010–2014 there was an increase of the incidence, mainly due to professional pathology of the musculoskeletal system and connective tissue, cases of vibration disease and malignant neoplasms. The highest morbidity rate of professional diseases was observed in workers of Priargunsky Industrial Mining and Chemical Union.Analysis of the data showed that the greatest number of diseases was revealed at persons in the age range 50–59 years old.

1461: Local Control and Long Term Disease Free Survival Following Radical Prostatectomy for D1 Prostate Cancer In The PSA ERA

2004 ◽  
Vol 171 (4S) ◽  
pp. 385-385 ◽  
Author(s):  
Carl K. Gjertson ◽  
Kevin P. Asher ◽  
Joshua D. Sclar ◽  
Aaron E. Katz ◽  
Erik T. Goluboff ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Local Control ◽  
Disease Free Survival ◽  
Free Survival ◽  
Disease Free

Musikalisasi Syi’ir Aqoid Kiai Zaini Mun’im dan Budidaya Tanaman Obat Keluarga (Toga) di Pesantren Nurul Jadid Probolinggo

2020 ◽  
Vol 1 (1) ◽  
pp. 47-58
Author(s):  
Khodijatul Qodriyah
Keyword(s):  
Herbal Medicine ◽  
Herbal Medicines ◽  
Successful Implementation ◽  
Short Term ◽  
Middle Term

The lack of students’ knowledge of their teachers’ works and the less of their consciousness to the environment are crucial problems in some islamic boardingschool, especially in Nurul Jadid. These issues will be settled by implementation of religious preaching (dakwah) with poem (syi’ir) in Syu’abul Iman of Kiai Zaini Mun’im and prefentive action to the illness through herbal medicines of family crops medicine (tanaman obat keluarga). The program is undertaken with some phases, including planting family crops medicine, making herbal medicines, musicalisation of poem in book of Syu’abul Iman, socialization of the herbal medicine and musical poem of Syu’abul Iman. These phases have been structured with long-term, middle-term, and short-term programs which were finished during approximately 4 months (Augustus – November 2019). The involvement of many parties, such as activists of environment in Nurul Jadid, has strongly influenced on the successful implementation of these programs.Keywords: Family Crops Medicine, Nurul Jadid Islamic Boardingschool, Book of Syu’abul Iman

Skull base aneurysmal bone cyst presenting with hydrocephalus: progressive residuum obliterated by Gamma Knife stereotactic radiosurgery in a pediatric patient

2020 ◽  
Vol 26 (1) ◽  
pp. 76-81
Author(s):  
George H. Tse ◽  
Feng Y. Jiang ◽  
Matthias W. R. Radatz ◽  
Saurabh Sinha ◽  
Hesham Zaki
Keyword(s):  
Skull Base ◽  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Pediatric Population ◽  
Bone Cyst ◽  
Disease Free Survival ◽  
Long Term Follow Up ◽  
Aneurysmal Bone Cysts ◽  
Gamma Knife Stereotactic Radiosurgery

Aneurysmal bone cysts (ABCs) are an uncommon entity predominantly encountered in the pediatric population. The skull is rarely involved, but these cysts have been reported to arise in the skull base. Traditional treatment has been with surgery alone; however, there is a gathering body of literature that reports alternative treatments that can achieve long-term disease-free survival. However, these therapies are predominantly directed at peripheral skeletal lesions. To the authors’ knowledge, this report is the first to describe long-term follow-up of the efficacy of Gamma Knife stereotactic radiosurgery for treatment of ABC residuum in the skull base that resulted in long-term patient stability and likely ABC obliteration.

scholarly journals Long-term oncologic outcomes of transanal TME compared with transabdominal TME for rectal cancer: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Jae Young Moon ◽  
Min Ro Lee ◽  
Gi Won Ha
Keyword(s):  
Rectal Cancer ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Distant Recurrence ◽  
Oncologic Outcomes ◽  
Cochrane Library ◽  
Transanal Total Mesorectal Excision ◽  
Random Effects Models ◽  
The Cochrane Library

Abstract Background Transanal total mesorectal excision (TaTME) appears to have favorable surgical and pathological outcomes. However, the evidence on survival outcomes remains unclear. We performed a meta-analysis to compare long-term oncologic outcomes of TaTME with transabdominal TME for rectal cancer. Methods PubMed, EMBASE, and the Cochrane Library were searched. Data were pooled, and overall effect size was calculated using random-effects models. Outcome measures were overall survival (OS), disease-free survival (DFS), and local and distant recurrence. Results We included 11 nonrandomized studies that examined 2,143 patients for the meta-analysis. There were no significant differences between the two groups in OS, DFS, and local and distant recurrence with a RR of 0.65 (95% CI 0.39–1.09, I2 = 0%), 0.79 (95% CI 0.57–1.10, I2 = 0%), 1.14 (95% CI 0.44–2.91, I2 = 66%), and 0.75 (95% CI 0.40–1.41, I2 = 0%), respectively. Conclusion In terms of long-term oncologic outcomes, TaTME may be an alternative to transabdominal TME in patients with rectal cancer. Well-designed randomized trials are warranted to further verify these results.

scholarly journals Long-term survival with multiple metastasectomies for pulmonary osteosarcoma: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Satoshi Takamori ◽  
Hiroyuki Oizumi ◽  
Jun Suzuki ◽  
Katsuyuki Suzuki
Keyword(s):  
Case Report ◽  
Pulmonary Metastases ◽  
Multidisciplinary Treatment ◽  
Underlying Disease ◽  
Pulmonary Metastasectomy ◽  
Extensive Resection ◽  
Term Survival ◽  
Long Term Survival ◽  
Primary Surgery

Abstract Background Repeat pulmonary metastasectomy (PM) considerably improves the prognosis of patients with pulmonary metastases of osteosarcoma. Reports have demonstrated a significantly improved prognosis in patients who have undergone repeat metastasectomy for osteosarcoma; however, there have been no reports with more than six metastasectomies. Herein, we describe the long-term survival of a patient following resection of multiple tumors and other treatments for metastatic osteosarcoma. Case presentation A 28-year-old woman underwent extensive resection and postoperative adjuvant chemotherapy for right tibial sarcoma. Over the years, she developed repeated pulmonary metastases. First, 116 metastases were removed from the bilateral lungs. After that, multiple PMs of approximately 250 tumors and other treatments for deep metastatic lesions were performed. The patient died of the underlying disease 24 years after the primary surgery. Conclusions This case report demonstrates the long-term survival benefit of a multidisciplinary treatment centered on multiple metastasectomies.

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