scholarly journals Clinical case of endometrial cancer in a patient with complete doubling of the uterus and cervix

2021 ◽  
Vol 17 (2) ◽  
pp. 100-103
Author(s):  
A. L. Chernyshova ◽  
L. A. Коlomiets ◽  
Yu. M. Truschuk
Keyword(s):  
Endometrial Cancer ◽  
Clinical Case ◽  
Clinical Course ◽  
Combined Treatment ◽  
Morphological Characteristics ◽  
The Body ◽  
Choice Of Treatment ◽  
Similarities And Differences ◽  
Satisfactory Quality

A clinical case of endometrial cancer in a patient with complete doubling of the cervix and the body of the uterus is presented. The combination of this pathology is quite rare and is often accompanied by difficulties in timely diagnosis and choice of treatment tactics. The article presents an analysis of studies to identify similarities and differences in the clinical and morphological characteristics and prognosis of endometrial cancer associated with uterine abnormalities. This clinical case clearly demonstrates the features of the clinical course of endometrial cancer against the background of a congenital abnormality of the uterus. The standard combined treatment performed showed a good result and a satisfactory quality of life for the patient.

scholarly journals Endovascular Treatment of Renal Artery Stenosis Caused by Fibromuscular Dysplasia. A Clinical Case Report

2019 ◽  
Vol 9 (3) ◽  
pp. 223-228 ◽  
Author(s):  
D. S. Chigidinova ◽  
N. E. Gavrilova ◽  
B. A. Rudenko ◽  
A. S. Shanoyan ◽  
V. P. Mazaev ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Renal Artery ◽  
Endovascular Treatment ◽  
Renal Artery Stenosis ◽  
Balloon Angioplasty ◽  
Clinical Case ◽  
Fibromuscular Dysplasia ◽  
The Body ◽  
Artery Stenosis

Introduction. Fibromuscular dysplasia (FMD) is an idiopathic, non-atherosclerotic, non-inflammatory disease of arteries. Careful research into this disorder showed that FMD has been found in every arterial bed in the body; the most common arteries affected are renal arteries and extracranial sections of carotid and vertebral arteries. The clinical presentation is determined by the localization of the vasculature affected and the stenosis severity. Today FMD is a very rare disease with the incidence of 4 per 1000 people. The diagnosis today is difficult and may take a long time. According to the latest European Society of Cardiology guidelines renal artery balloon angioplasty is indicated for patients with FMD; if a good angiographic result is achieved (no dissection, TIMI 3 flow) no renal artery stenting required. The treatment success depends on the early diagnosis.Materials and Methods. This paper presents a clinical case of renal artery stenosis caused by fibromuscular dysplasia that was treated successfully with balloon angioplasty without stenting.Results and discussion. Protracted process of diagnosing this disease may result in deteriorating quality of life and poor outcomes such as difficult-to-control hypertension and its sequelae, TIA, stroke, aneurism dissection or rupture. It is worth pointing out that FMD diagnosis may be incidental when imaging is performed for other reasons, or when there is a systolic murmur at arteries in an asymptomatic patient who does not have classic atherosclerosis risk factors. According to the latest guidelines endovascular treatment is indicated for patients with FMD to manage the hypertension; this has proven very effective in improving quality of life.

scholarly journals PHOTOHEMOTHERAPY IN THE COMBINED TREATMENT OF THE PATIENTS PRESENTING WITH BRONCHIAL ASTHMA

2017 ◽  
Vol 16 (2) ◽  
pp. 89-93
Author(s):  
E. I Ostrovskiy ◽  
N. P Aleksandrova ◽  
V. I Karandashov ◽  
B. V Zubov
Keyword(s):  
Bronchial Asthma ◽  
Clinical Course ◽  
Combined Treatment ◽  
Red Light ◽  
Blood Rheology ◽  
Signs And Symptoms ◽  
The Body ◽  
Rheological Parameters ◽  
Therapeutic Modalities ◽  
The Impact

The article presents the results of the application of photochemotherapy for the combined rehabilitation treatment of the patients suffering from bronchial asthma. The assessment of the effectiveness and the impact of this treatment was made on the basis of changes of the indicators of blood rheology as one of the components of pathogenesis of this disease with due regard for the signs and symptoms characterizing the clinical course of this condition. It has been demonstrated that 74 patients presenting with bronchial asthma experienced the statistically significant restoration of the altered rheological parameters of blood and the general improvement of the clinical course of the disease under the influence of photochemotherapy in comparison with the results of the baseline treatment obtained in the remaining 42 patients. The effect of optical radiation of blue and red light on the clinical course of bronchial asthma was more pronounced than that of the conventional treatment. The two therapeutic modalities were virtually identical when evaluated based on the effectiveness criteria, but differed in terms of the mechanism of action on the body.

scholarly journals THE RATIONALE FOR DIAGNOSTIC AND TREATMENT TACTICS IN PATIENTS WITH NEUROENDOCRINE TUMORS OF THE SMALL INTESTINE

2018 ◽  
Vol 177 (4) ◽  
pp. 28-37
Author(s):  
P. N. Romashchenko ◽  
N. A. Maistrenko ◽  
R. V. Orlova ◽  
M. V. Lysanyuk
Keyword(s):  
Small Intestine ◽  
Neuroendocrine Tumors ◽  
Morphological Characteristics ◽  
Main Method ◽  
Medical Centers ◽  
Increased Risk ◽  
Choice Of Treatment ◽  
Complicated Course ◽  
Generalized Net

The  OBJECTIVE  of the  study  was  to clarify the  rational  program of diagnosis and  choice  of treatment tactics  for patients with neuroendocrine tumors  (NET) of the  small  intestine, taking  into account their clinical and  morphological characteristics. MATERIAL AND METHODS.  We  studied the  results of examination and  treatment of 39  patients. RESULTS.  CT is the main  method of topical  diagnosis, the  sensitivity  of which  in the  detection of NET of the  small  intestine is 96.4  %. Sign of  the  localization   of  NET  in  the  small  intestine is  the  tumor  conglomerate of  its  mesentery, which  includes diffuse-infiltrative  and   nodular   variant   of  changes.  The   diffuse-infiltrative  variant   of  tumor   conglomerate  is  characterized   by increased risk  of complicated course of tumor  process.  Cytoreductive surgical  treatment allows  to  increase the  survival rate   of  patients with  generalized NET  of  the  small  intestine in  1.7  times.   CONCLUSION.  Treatment of  patients with NET  of  the  small  intestine should   be  carried   out  in  specialized medical   centers that  have   the  ability  to  implement   a multidisciplinary  approach that  can  significantly  increase the  duration   and  quality  of  life of  patients.

scholarly journals The development of severe osteomalacia following biliopancreatic diversion surgery for the management of morbid obesity

2012 ◽  
Vol 58 (3) ◽  
pp. 16-21
Author(s):  
G A Mel'nichenko ◽  
E A Troshina ◽  
N V Mazurina ◽  
N A Ogneva ◽  
Iu I Iashkov
Keyword(s):  
Morbid Obesity ◽  
Biliopancreatic Diversion ◽  
Clinical Case ◽  
Surgical Intervention ◽  
Clinical Course ◽  
The Body ◽  
Beneficial Action ◽  
Biliopancreatic Diversion Surgery ◽  
Stable Reduction ◽  
Regular Intake

Biliopancreatic diversion (BPD) surgery is one of the most efficacious bariatric procedures employed to manage morbid obesity. However, apart from a stable reduction of the body weight and beneficial action on the clinical course of various diseases associated with obesity, this method creates the risk of inducing osteometabolic disorders following the surgical intervention. We present here a clinical case of osteomalacia that developed in the late post-BPD period in the absence of regular intake of medicines and adequate medical care.

scholarly journals COMBINATION OF LENVATINIB AND PEMBROLISUMAB IN THE TREATMENT OF ADVANCED ENDOMETRIAL CANCER: A CASE REPORT

2021 ◽  
Vol 20 (1) ◽  
pp. 162-168
Author(s):  
O. N. Churuksaeva ◽  
L. A. Kolomiets ◽  
A. B. Villert
Keyword(s):  
Endometrial Cancer ◽  
Clinical Approach ◽  
Repair System ◽  
Female Reproductive System ◽  
Standard Chemotherapy ◽  
Metastatic Lesions ◽  
Third Line ◽  
Common Malignancy ◽  
Satisfactory Quality

Background. Endometrial cancer is the most common malignancy of the female reproductive system. Patients with metastatic endometrial cancer have the overall 5-year survival rate of less than 20 %. The efficacy of treatment of advanced endometrial cancer remains low; therefore, the search for novel approaches for treating endometrial cancer is of great importance.Case description. We report a case of a 68-year-old female who presented with advanced endometrial cancer with metastatic lesions found in the axillary and lumbar lymph nodes, liver and lungs. The disease progressed after third-line chemotherapy, with no deficiency in the DNA repair system. The patient was successfully treated with lenvatinib and pembrolisumab. The treatment was characterized by controlled minimal toxicity and a satisfactory quality of life. At 5 months, the patient is alive with stable disease.Conclusion. Despite the progress in treating endometrial cancer including chemotherapy and hormone therapy, the prognosis of patients with metastatic endometrial cancer is poor. The discovery of new molecular markers (MSI , PD -L1) made it possible to develop a clinical approach using a combination of pembrolizumab and lenvatinib for patients with no deficiency in the repair system, for whom, the standard chemotherapy is ineffective. The presented case gives hope for the treatment of this category of patients.

scholarly journals Study on the importance of medical treatment and physical methods in recovering patients with knee osteoarthritis

2019 ◽  
Vol 10 (10.2) ◽  
pp. 90-97 ◽  
Author(s):  
Sinziana Calina Silisteanu ◽  
Elisabeta Antonescu ◽  
Maria Totan
Keyword(s):  
Knee Osteoarthritis ◽  
Combined Treatment ◽  
Cyclooxygenase 2 ◽  
The Body ◽  
Key Words Osteoarthritis ◽  
Osteoarthritis Pain ◽  
Recovery Treatment ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Intrduction.Etoricoxibum belongs to the group of non-steroidal anti-inflammatory inhibitors selective of cyclooxygenase-2. The non-steroidal anti-inflammatory drugs are used to treat acute musculoskeletal disorders as they result in pain-relieving therapeutical effect. Etoricoxibum intervenes by blocking cyclooxygenase-2 and by reducing the painful and inflammatory phenomena. Material and method. The trial focused on the evolution of patients diagnosed with knee osteoarthritis after making the treatment by etoricoxibum. This study was conducted in the ambulatory regime for a period of 6 months and included 77 patients. Results and discussions It was assessed the efficacy of the complex recovery treatment for the patients diagnosed by knee osteoarthritis wich use of Etoricoxibum, in a dose of 60 mg /day, in order to improve the pain and the inflammation. The pursued objectives were: the assessment of the effects by using Etoricoxibum for the reduction of the pain and inflammation, the increase of the articular mobility and stability, the recovery of the walk and motor control, the decrease of the body weight, the increase of the quality of life. Conclusions. This trial show that, by making a combined treatment of medication and recovery, there was an reducing the pain and the inflammation as well as increasing the articular mobility. Key words: osteoarthritis, pain, ultrasound, recovery, disability,

scholarly journals Сombine therapy of patients with acne vulgaris comorbidity with functional disorder of hepatobiliary system and demodecosis

2019 ◽  
Keyword(s):  
Quality Of Life ◽  
Laser Therapy ◽  
Acne Vulgaris ◽  
Combined Treatment ◽  
Treatment Algorithm ◽  
The Body ◽  
Functional Disorders ◽  
Hepatobiliary System ◽  
Group 1

Introduction. One of the common chronic dermatoses that have a direct impact on the quality of life of patients is acne. The occurrence of psycho-emotional disorders due to the location of elements in the open areas of the body. Given the high prevalence of acne in puberty (up to 85 % of adolescents have episodes of acne of varying severity), there is a need to find new algorithms for acne treatment to prevent the progression of social maladaptation and depressive states. Materials and methods. The study included 140 patients who were divided into 3 groups depending on the presence of comorbid pathology and treatment methods: group 1 — patients with acne who were underwent standard treatment for 60 days, group 2 — patients with acne in comorbidity with demodecosis, group 3 — patients with acne in comorbidity with demodecosis and functional disorders of the digestive system, who were additionally treated with a laser therapy. Treatment efficacy was evaluated using the GAGS scale and the DLQI questionnaire on days 14, 28 and 60 of therapy. Results. Evaluation of the results on day 60 shows a decrease in the manifestations of inflammation by 50 % in groups 2 and 3, and by 29 % in the standard therapy group. Improving of the quality of life in groups 2 and 3 was by 70 %, while in the group 1 — by 35 %. The following correlations were established: r = + 0.9 — between the severity of VC manifestations and the presence of comorbid pathology, r = + 0.71 — between the severity of VC and the assessment of quality of life, r = + 0.69 — between the presence of acne comorbidity with demodecosis and FDGBS and the effect on quality of life (p < 0.005). Conclusions. Optimization of the treatment algorithm for acne patients in comorbidity with demodecosis and functional disorders of the hepatobiliary system is achieved by the use of combined treatment using laser therapy, which significantly improves the quality of life of patients.

scholarly journals THE DIFFICULTIES OF DIAGNOSIS AND CHOICE OF TREATMENT TACTICS OF NEUROENDOCRINE TUMORS OF THE SMALL INTESTINE

2018 ◽  
Vol 177 (4) ◽  
pp. 76-80
Author(s):  
M. V. Lysanyuk ◽  
N. A. Maistrenko ◽  
P. N. Romashchenko
Keyword(s):  
Quality Of Life ◽  
Small Intestine ◽  
Surgical Treatment ◽  
Neuroendocrine Tumor ◽  
Neuroendocrine Tumors ◽  
Clinical Case ◽  
Surgical Intervention ◽  
Diagnostic Methods ◽  
Choice Of Treatment

The paper presents the clinical case that reflects the difficulties of diagnosis and choice of treatment tactics of patients with neuroendocrine tumors   of the  small  intestine. The  sequence of instrumental diagnostic methods  made  it possible to determine the localization of the tumor in small intestine and to clarify the prevalence of the tumor process. The implementation of active surgical treatment tactics allowed performing cytoreductive surgical intervention, eliminating the risk of complications of the  tumor  process and  improving  the  quality of life of the  patient  with generalized neuroendocrine tumor of the small intestine.

scholarly journals Clinical cases of mastocytosis in clinical practice

2015 ◽  
Vol 96 (4) ◽  
pp. 598-601
Author(s):  
N M Rakhmatullina ◽  
G Z Garifullina
Keyword(s):  
Clinical Case ◽  
Clinical Effect ◽  
Clinical Observation ◽  
Clinical Course ◽  
Age Groups ◽  
Clinical Observations ◽  
Clinical Presentations ◽  
Rare Group ◽  
Clinical Cases

Mastocytosis is a relatively rare group of diseases caused by the proliferation of mast cells in various organs and tissues. The article presents data on the etiology, pathogenesis, clinical presentations, diagnosis and differential diagnosis of mastocytosis, and own clinical observations. Presented clinical cases picture the features of the clinical course of the disease in different age groups. The first clinical case clearly shows the onset of the disease in early childhood (6 months), and misdiagnosis of this disease. The clinical picture of mastocytosis was wrongly assessed as a manifestation of atopic dermatitis, for which the patient received topical treatment without clinical effect. The second clinical observation is in 30 year old patient. The nature and spreading of the disease were assessed, proper treatment was administered. Both patients improved after treatment. Presented clinical observations reflect the importance of the problem in medical practice. Early diagnosis improves the prognosis of the disease and improves the quality of life.

scholarly journals Anaplastic Carcinoma of the Pancreas: Clinical and Morphological Characteristics

2020 ◽  
Vol 14 (3) ◽  
pp. 624-631
Author(s):  
Valery I. Podzolkov ◽  
Anna E. Pokrovskaya ◽  
Tatyana S. Vargina ◽  
Andrey B. Ponomarev ◽  
Yevgenia A. Kogan ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Pancreatic Carcinoma ◽  
Clinical Case ◽  
Clinical Course ◽  
Morphological Characteristics ◽  
Anaplastic Carcinoma ◽  
Ductal Adenocarcinoma ◽  
Histological Subtype ◽  
Fast Disease Progression ◽  
Morphological Picture

Anaplastic pancreatic carcinoma is a very rare histological subtype of pancreatic cancer, which is characterized by a more aggressive course than for conventional ductal adenocarcinoma. In this article, we consider the features of the clinical course, the difficulties of diagnosis in connection with the absence of pathognomonic signs of pancreatic cancer, and the morphological picture of this disease in a patient 60 years of age. This clinical case clearly demonstrates the complexities of the pancreatic carcinoma diagnosis, fast disease progression, and extremely unfavorable prognosis. It is important for clinicians to remember that this pathology often has a subclinical course, and the oncomarker levels are not always true.

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