scholarly journals Design, synthesis & evaluation of human Aurora kinase and phosphodiesterase inhibitors for anti-trypanosomal drug discovery via target repurposing

2012 ◽  
Author(s):  
Stefan O. Ochiana
Keyword(s):  
Drug Discovery ◽  
Phosphodiesterase Inhibitors ◽  
Aurora Kinase ◽  
Design Synthesis ◽  
Target Repurposing

scholarly journals The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing

2013 ◽  
Vol 62 ◽  
pp. 777-784 ◽  
Author(s):  
Stefan O. Ochiana ◽  
Vidya Pandarinath ◽  
Zhouxi Wang ◽  
Rishika Kapoor ◽  
Mary Jo Ondrechen ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Kinase Inhibitor ◽  
Aurora Kinase ◽  
Lead Compound ◽  
Aurora Kinase Inhibitor ◽  
Target Repurposing

Design, Synthesis and Docking Studies of Some Novel Fluoroquinolone Compounds with Antibacterial Activity

2018 ◽  
Vol 69 (4) ◽  
pp. 815-822 ◽  
Author(s):  
Lucia Pintilie ◽  
Amalia Stefaniu ◽  
Alina Ioana Nicu ◽  
Maria Maganu ◽  
Miron Teodor Caproiu
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Molecular Docking ◽  
Drug Discovery ◽  
Elemental Analysis ◽  
Docking Studies ◽  
Receptor Protein ◽  
Chemical Methods ◽  
Design Synthesis ◽  
Gram Negative

A new series of fluoroquinolone compounds have been obtained by Gould-Jacobs method. The compounds have been characterized by physic-chemical methods (elemental analysis, FTIR, NMR, UV-Vis) and by antimicrobial activity against Gram-positive and Gram-negative microorganisms. For the synthesized compounds have been performed calculations of characteristics and molecular properties, using Spartan�14 Software from Wavefunction, Inc. Irvine, CA. and molecular docking studies using CLC Drug Discovery Workbench 2.4 software, to identify and visualize the most likely interaction ligand (fluoroquinolone) with the receptor protein.

scholarly journals Computational drug discovery of potential phosphodiesterase inhibitors using in silico studies

2012 ◽  
Vol 2 ◽  
pp. S822-S826 ◽  
Author(s):  
Arumugam Madeswaran ◽  
Muthuswamy Umamaheswari ◽  
Kuppusamy Asokkumar ◽  
Thirumalaisamy Sivashanmugam ◽  
Varadharajan Subhadradevi ◽  
...  
Keyword(s):  
Drug Discovery ◽  
In Silico ◽  
Phosphodiesterase Inhibitors ◽  
In Silico Studies ◽  
Computational Drug Discovery

Design, Synthesis and Biological Activity of β-Carboline-Based Type-5 Phosphodiesterase Inhibitors.

ChemInform ◽  
2003 ◽  
Vol 34 (29) ◽  
Author(s):  
Graham N. Maw ◽  
Charlotte M. N. Allerton ◽  
Eugene Gbekor ◽  
William A. Million
Keyword(s):  
Biological Activity ◽  
Phosphodiesterase Inhibitors ◽  
Design Synthesis ◽  
Type 5 Phosphodiesterase Inhibitors

Exploration of a library of triazolothiadiazole and triazolothiadiazine compounds as a highly potent and selective family of cholinesterase and monoamine oxidase inhibitors: design, synthesis, X-ray diffraction analysis and molecular docking studies

RSC Advances ◽  
2015 ◽  
Vol 5 (27) ◽  
pp. 21249-21267 ◽  
Author(s):  
Imtiaz Khan ◽  
Syeda Mahwish Bakht ◽  
Aliya Ibrar ◽  
Saba Abbas ◽  
Shahid Hameed ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Drug Discovery ◽  
Monoamine Oxidase ◽  
Organic Molecules ◽  
Docking Studies ◽  
X Ray Diffraction ◽  
High Demand ◽  
Design Synthesis ◽  
Small Organic Molecules ◽  
X Ray

There is a high demand for the collection of small organic molecules (especially N-heterocycles) with diversity and complexity in the process of drug discovery.

scholarly journals Fragment-Based Drug Discovery of Phosphodiesterase Inhibitors

2017 ◽  
Vol 61 (4) ◽  
pp. 1415-1424 ◽  
Author(s):  
Fredrik Svensson ◽  
Andreas Bender ◽  
David Bailey
Keyword(s):  
Drug Discovery ◽  
Phosphodiesterase Inhibitors ◽  
Fragment Based Drug Discovery
Sign in / Sign up

Export Citation Format

Share Document