scholarly journals The MX Beamlines BL14.1-3 at BESSY II

2016 ◽  
Vol 2 ◽  
Author(s):  
Martin Gerlach ◽  
Uwe Mueller ◽  
Manfred S. Weiss
Keyword(s):  
State Of The Art ◽  
Beam Line ◽  
Macromolecular Crystallography ◽  
Research Groups ◽  
Regular User ◽  
Safety Level ◽  
Wavelength Shifter ◽  
Fixed Energy ◽  
Level 1 ◽  
Biology Laboratory

The Macromolecular Crystallography (MX) group at the Helmholtz-Zentrum Berlin (HZB) is operating three state-of-the-art synchrotron beamlines for MX at BESSY II in Berlin (Heinemann et al., 2003; Mueller et al., 2012, 2015). The radiation source for all three beamlines BL14.1-3 is a superconducting 7T-wavelength shifter. Currently, the three beam lines are the most productive stations for MX in Germany, with about 250 PDB depositions per year and over 1500 PDB depositions in total (Status 10/2015). BL14.1 and BL14.2 are energy tuneable in the range 5.5-15.5 keV, while beam line BL14.3 is a fixed-energy side station operated at 13.8 keV. The HZB-MX beamlines are in regular user operation providing close to 200 beam days per year and about 600 user shifts to approximately 100 research groups across Europe. Additional user facilities include office space adjacent to the beam lines, a sample preparation laboratory, a biology laboratory (safety level 1) and high-end computing resources.

scholarly journals Facilities for Macromolecular Crystallography at the HZB

2014 ◽  
Vol 70 (a1) ◽  
pp. C1681-C1681
Author(s):  
Ronald Förster ◽  
Michael Hellmig ◽  
Martin Röwer ◽  
Karine Sparta ◽  
Michael Steffien ◽  
...  
Keyword(s):  
State Of The Art ◽  
Beam Line ◽  
Macromolecular Crystallography ◽  
Test Beam ◽  
Regular User ◽  
Safety Level ◽  
User Community ◽  
Ccd Detectors ◽  
Biology Laboratory ◽  
Ancillary Equipment

The Macromolecular Crystallography (MX) group at the Helmholtz-Zentrum Berlin (HZB) has been in operation since 2003. Since then, three state-of-the-art synchrotron beam lines (BL14.1-3) for MX have been built up on a 7T-wavelength shifter source [1,2]. Currently, the three beam lines represent the most productive MX-stations in Germany, with more than 1100 PDB depositions (Status 02/2014). BLs14.1 and 14.2 are energy tuneable in the range 5.5-15.5 keV, while beam line 14.3 is a fixed-energy side station operated at 13.8 keV. All three beam lines are equipped with state-of-the-art detectors: BL14.1 with a PILATUS 6M detector and BLs14.2 and 14.3 with large CCD-detectors. BL14.1 and BL14.2 are in regular user operation providing about 200 beam days per year and about 600 user shifts to approximately 70 research groups across Europe. BL14.3 has been equipped with a HC1 crystal dehydration device in 2011. In addition to serving the user community mainly as a screening and test beam line, it is currently the only MX beamline in Europe with a HC1 device permanently installed. Additional user facilities include office space adjacent to the beam lines, a sample preparation laboratory, a biology laboratory (safety level 1) and high-end computing resources. On the poster, a summary on the experimental possibilities of the beam lines and the ancillary equipment provided to the user community will be given.

Bugscope: A Practical Approach to Providing Remote Microscopy for Science Education Outreach

2001 ◽  
Vol 7 (3) ◽  
pp. 249-252 ◽  
Author(s):  
Clinton S. Potter ◽  
Bridget Carragher ◽  
Liana Carroll ◽  
Charles Conway ◽  
Benjamin Grosser ◽  
...  
Keyword(s):  
State Of The Art ◽  
Low Cost ◽  
Educational Outreach ◽  
Outreach Program ◽  
High Magnification ◽  
Research Groups ◽  
Web Browser ◽  
Classroom Activities ◽  
K 12 ◽  
Education Outreach

AbstractThe Bugscope project is an educational outreach program for kindergarten to grade 12 (K–12) classrooms. The project provides a resource to classrooms so that they may remotely operate a scanning electron microscope to image insects at high magnification. The microscope is remotely controlled in real time from a classroom computer over the Internet using a Web browser. Bugscope provides a state-of-the-art microscope resource for teachers that can be readily integrated into classroom activities. The Bugscope project provides a low-cost, sustainable model for research groups to support K–12 education outreach projects.

scholarly journals ID30A-3 (MASSIF-3) – a beamline for macromolecular crystallography at the ESRF with a small intense beam

2020 ◽  
Vol 27 (3) ◽  
pp. 844-851 ◽  
Author(s):  
David von Stetten ◽  
Philippe Carpentier ◽  
David Flot ◽  
Antonia Beteva ◽  
Hugo Caserotto ◽  
...  
Keyword(s):  
Photon Counting ◽  
European Synchrotron Radiation Facility ◽  
One Dimension ◽  
Macromolecular Crystallography ◽  
Focus Beam ◽  
Photon Counting Detector ◽  
Fixed Energy ◽  
Small Crystals ◽  
Intense Beam ◽  
Current Characteristics

ID30A-3 (or MASSIF-3) is a mini-focus (beam size 18 µm × 14 µm) highly intense (2.0 × 1013 photons s−1), fixed-energy (12.81 keV) beamline for macromolecular crystallography (MX) experiments at the European Synchrotron Radiation Facility (ESRF). MASSIF-3 is one of two fixed-energy beamlines sited on the first branch of the canted undulator setup on the ESRF ID30 port and is equipped with a MD2 micro-diffractometer, a Flex HCD sample changer, and an Eiger X 4M fast hybrid photon-counting detector. MASSIF-3 is recommended for collecting diffraction data from single small crystals (≤15 µm in one dimension) or for experiments using serial methods. The end-station has been in full user operation since December 2014, and here its current characteristics and capabilities are described.

scholarly journals Risk Assessment Proposal In HydrauliC Presses With Fuzzy Logic

2021 ◽  
Vol 9 (5) ◽  
pp. 349-368
Author(s):  
Patricia Sluce
Keyword(s):  
At Risk ◽  
Hydraulic Press ◽  
Risk Level ◽  
Safety Level ◽  
Before And After ◽  
Level 3 ◽  
Machine Safety ◽  
Level 1 ◽  
Object Of Study ◽  
Risk Categories

The aim of this study was to evaluate the safety level of industrial machines, in particular hydraulic press. The dissertation used hydraulic presses as the object of study. The research instruments used were machine safety analyzes based on normative items pre-established in ABNT NBR: 12100, possible accidents that these machineries can cause. The results show that hydraulic presses cause many accidents, in some situations dying. Through Annex B of ABNT NBR 14153: 2013, there are 4 risk categories for machinery, the greater the degree of risk, the more unsafe the machine is. The appraiser's experience is very important to analyze the machine and reach the level of risk level before and after the adjustment. Finally, it appears that the machine analyzed in this study was at risk level 3, after analysis and adaptations the same machine was at risk level 1, totally acceptable to maintain the operator's safety level.

scholarly journals Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Solveig K. Sieberts ◽  
◽  
Fan Zhu ◽  
Javier García-García ◽  
Eli Stahl ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
State Of The Art ◽  
Heritability Estimate ◽  
Predictive Performance ◽  
Genetic Contribution ◽  
Research Groups ◽  
Community Based ◽  
Snp Data ◽  
Genetic Heritability ◽  
Wide Range

Abstract Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, treatment fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment of the utility of SNP data for predicting anti-TNF treatment efficacy in RA patients was performed in the context of a DREAM Challenge (http://www.synapse.org/RA_Challenge). An open challenge framework enabled the comparative evaluation of predictions developed by 73 research groups using the most comprehensive available data and covering a wide range of state-of-the-art modelling methodologies. Despite a significant genetic heritability estimate of treatment non-response trait (h 2=0.18, P value=0.02), no significant genetic contribution to prediction accuracy is observed. Results formally confirm the expectations of the rheumatology community that SNP information does not significantly improve predictive performance relative to standard clinical traits, thereby justifying a refocusing of future efforts on collection of other data.

scholarly journals Nanoarchitectonics: Complexes and Conjugates of Platinum Drugs with Silicon Containing Nanocarriers. An Overview

2021 ◽  
Vol 22 (17) ◽  
pp. 9264
Author(s):  
Kinga Piorecka ◽  
Jan Kurjata ◽  
Wlodzimierz A. Stanczyk
Keyword(s):  
Drug Delivery ◽  
Driving Force ◽  
State Of The Art ◽  
Platinum Drugs ◽  
Research Groups ◽  
Current State ◽  
Delivery Platform ◽  
Silicon Based ◽  
Intensive Search

The development in the area of novel anticancer prodrugs (conjugates and complexes) has attracted growing attention from many research groups. The dangerous side effects of currently used anticancer drugs, including cisplatin and other platinum based drugs, as well their systemic toxicity is a driving force for intensive search and presents a safer way in delivery platform of active molecules. Silicon based nanocarriers play an important role in achieving the goal of synthesis of the more effective prodrugs. It is worth to underline that silicon based platform including silica and silsesquioxane nanocarriers offers higher stability, biocompatibility of such the materials and pro-longed release of active platinum drugs. Silicon nanomaterials themselves are well-known for improving drug delivery, being themselves non-toxic, and versatile, and tailored surface chemistry. This review summarizes the current state-of-the-art within constructs of silicon-containing nano-carriers conjugated and complexed with platinum based drugs. Contrary to a number of other reviews, it stresses the role of nano-chemistry as a primary tool in the development of novel prodrugs.

scholarly journals Introduction: European Integrated project on Aerosol Cloud Climate and Air Quality interactions (EUCAARI) – integrating aerosol research from nano to global scales

2008 ◽  
Vol 8 (6) ◽  
pp. 19415-19455 ◽  
Author(s):  
M. Kulmala ◽  
A. Asmi ◽  
H. K. Lappalainen ◽  
K. S. Carslaw ◽  
U. Pöschl ◽  
...  
Keyword(s):  
Air Quality ◽  
State Of The Art ◽  
Global Scale ◽  
Research Groups ◽  
Global Models ◽  
Aerosol Cloud ◽  
Operational Systems ◽  
First Results ◽  
Integrated Project

Abstract. The European Aerosol Cloud Climate and Air Quality Interactions project EUCAARI is an EU Research Framework 6 integrated project focusing on understanding the interactions of climate and air pollution. EUCAARI works in an integrative and multidisciplinary way from nano- to global scale. EUCAARI brings together several leading European research groups, state-of-the-art infrastructure and some key scientists from third countries to investigate the role of aerosol on climate and air quality. Altogether 48 partners from 25 countries are participating in EUCAARI. During the first 16 months EUCAARI has built operational systems e.g. established pan-European measurement network for Lagrangian studies and four stations in developing countries. Also an improved understanding of nanoscale processes (like nucleation) has been implemented in global models. Here we present the research methods, organisation, operations and first results of EUCAARI.

Multivariate phase combination improves automated crystallographic model building

2010 ◽  
Vol 66 (7) ◽  
pp. 783-788 ◽  
Author(s):  
Pavol Skubák ◽  
Willem-Jan Waterreus ◽  
Navraj S. Pannu
Keyword(s):  
Model Building ◽  
State Of The Art ◽  
Standard Technique ◽  
Real Data ◽  
Data Sets ◽  
Macromolecular Crystallography ◽  
Current State ◽  
Phase Combination ◽  
Density Map ◽  
Electron Density Map

Density modification is a standard technique in macromolecular crystallography that can significantly improve an initial electron-density map. To obtain optimal results, the initial and density-modified map are combined. Current methods assume that these two maps are independent and propagate the initial map information and its accuracy indirectly through previously determined coefficients. A multivariate equation has been derived that no longer assumes independence between the initial and density-modified map, considers the observed diffraction data directly and refines the errors that can occur in a single-wavelength anomalous diffraction experiment. The equation has been implemented and tested on over 100 real data sets. The results are dramatic: the method provides significantly improved maps over the current state of the art and leads to many more structures being built automatically.

scholarly journals An overview of touchless 2D fingerprint recognition

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Jannis Priesnitz ◽  
Christian Rathgeb ◽  
Nicolas Buchmann ◽  
Christoph Busch ◽  
Marian Margraf
Keyword(s):  
High Performance ◽  
State Of The Art ◽  
Attack Detection ◽  
Fingerprint Recognition ◽  
Research Groups ◽  
Trade Offs ◽  
Reliable Detection ◽  
Recognition Systems ◽  
Open Issues ◽  
Research Resources

AbstractTouchless fingerprint recognition represents a rapidly growing field of research which has been studied for more than a decade. Through a touchless acquisition process, many issues of touch-based systems are circumvented, e.g., the presence of latent fingerprints or distortions caused by pressing fingers on a sensor surface. However, touchless fingerprint recognition systems reveal new challenges. In particular, a reliable detection and focusing of a presented finger as well as an appropriate preprocessing of the acquired finger image represent the most crucial tasks. Also, further issues, e.g., interoperability between touchless and touch-based fingerprints or presentation attack detection, are currently investigated by different research groups. Many works have been proposed so far to put touchless fingerprint recognition into practice. Published approaches range from self identification scenarios with commodity devices, e.g., smartphones, to high performance on-the-move deployments paving the way for new fingerprint recognition application scenarios.This work summarizes the state-of-the-art in the field of touchless 2D fingerprint recognition at each stage of the recognition process. Additionally, technical considerations and trade-offs of the presented methods are discussed along with open issues and challenges. An overview of available research resources completes the work.

scholarly journals CRIATIVIDADE E EDUCAÇÃO: possibilidades de um campo de pesquisa

2018 ◽  
Vol 25 (4) ◽  
pp. 129
Author(s):  
Camila Nagem Marques Vieira ◽  
Maria Vitória Campos Mamede Maia
Keyword(s):  
Large Scale ◽  
State Of The Art ◽  
National Level ◽  
Research Groups ◽  
Creativity Research ◽  
The Subject ◽  
The Relationship ◽  
Theses And Dissertations ◽  
State Of Art ◽  
Formación Docente

O presente artigo tem por objetivo apresentar o estado da arte da temática criatividade e educação. De metodologia documental, este parte de levantamento das pesquisas acadêmicas desenvolvidas no Brasil, nos últimos seis anos. Os dados apresentados foram sistematizados a partir do Diretório de Grupos de Pesquisa da Capes, no Scielo, de maneira a constatar os artigos que tratam da temática, do Banco de teses e dissertações em âmbito nacional (Capes e BDTD-Biblioteca Digital de Teses e Dissertações) e demais sites e documentos que surgiram no decorrer dessa etapa, de maneira a garantir o rigor do referido estudo. Desta forma foram definidas como lacunas do conhecimento ainda pouco exploradas por pesquisas nacionais: o desenvolvimento de mapeamento em larga escala sobre a pesquisa em criatividade no país, o investimento na relação entre criatividade e formação docente e na formação continuada aplicada à criatividade.Palavras-chave: Criatividade e Educação. Estado da Arte. Pesquisa.CREATIVITY AND EDUCATION: possibilities of a research FieldAbstractThis article aims to present the state of the art of creativity and education. From documentary methodology, this part of survey of the academic researches developed in Brazil, in last six years. The data presented were systematized from the Directory of Research Groups of Capes, in Scielo, in order to verify the articles that deal with the subject, from the Bank of theses and dissertations at the national level (Capes and BDTD-Digital Library of Theses and Dissertations) and other sites and documents that appeared during this stage, in order to guarantee the rigor of this article. In this way, knowledge gaps that still unexplored by national research: the development of large-scale mapping on creativity research in the country, investment in the relationship between creativity and teacher training, and in continuing education applied to creativity.Keywords: Creativity and Education. State of art. Search.CREATIVIDAD Y EDUCACIÓN: posibilidades de um campo de investigaciónResumenEl presente artículo tiene por objetivo presentar el estado del arte de la temática creatividad y educación. De metodología documental, esta parte de levantamiento de las investigaciones académicas desarrolladas en Brasil, en los últimos seis años. Los datos presentados fueron sistematizados a partir del Directorio de Grupos de Investigación de Capes, en Scielo, de manera a constatar los artículos que tratan de la temática, del Banco de tesis y disertaciones a nivel nacional (Capes y BDTD-Biblioteca Digital de Tesis y Disertaciones y otros sitios y documentos que surgieron en el transcurso de esta etapa, de manera a garantizar el rigor del referido estudio. De esta forma se definieron como lagunas del conocimiento aún poco exploradas por investigaciones nacionales: el desarrollo de mapeo a gran escala sobre la investigación en creatividad en el país, la inversión en la relación entre creatividad y formación docente y en la formación continuada aplicada a la creatividad.Palabras clave: Creatividad y Educación. Estado del Arte. Investigación acadêmica.

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