scholarly journals Pharmacological potential strengthening of drug therapy in treating patients with chronic pancreatitis by using therapeutic physical factors

2021 ◽  
Vol 19 (5) ◽  
pp. 293-298
Author(s):  
Raziyat M. Mallaeva ◽  
Anna N. Makhinko ◽  
Marat B. Uzdenov
Keyword(s):  
Quality Of Life ◽  
Chronic Pancreatitis ◽  
Drug Therapy ◽  
Clinical Manifestations ◽  
Medical Rehabilitation ◽  
Control Group ◽  
Physical Factors ◽  
Standard Drug ◽  
Pharmacological Potential

Background. The steady increase in the incidence of chronic pancreatitis, its aggressive course in recent years, as well as the insufficient therapeutic effect of standard techniques determine the relevance of the search for new approaches to the treatment and medical rehabilitation of this category of patients. Aims. To improve rehabilitation treatment of patients with chronic pancreatitis (CP) at inpatient stage by strengthening pharmacological potential of drug therapy due to inclusion of therapeutic physical factors (TPF) in therapeutic programs. Materials and methods. 159 patients with acute CP were observed. By simple randomization, 4 groups were formed: the control group (MG; n=39) received standard drug therapy; 1st comparison group (GC1; n=38) additionally received TPF; (GC2, n=40) in addition to treatment in GC1 had drinking mineral water "Slavyanovskaya"; in main group (n=42) in addition to the treatment in GC2 got preformed peloidotherapy on the cervical-collar zone. All the patients underwent the evaluation of clinical score and quality of life before and after medical rehabilitation. Results. In MG, clinical symptomatology leveling was by 78.2% (р 0.01), in GC1 by 71.5% (р 0.01), GC2 by 62.3% (р 0.01), CG by 57.2% (р 0.01) on average immediately after the treatment, which was in a clear correlation with indicators of quality of life. In the long term (in 6 and 12 months), the advantage of combination therapy was noted with the same validity, the preservation of the achieved positive result was mostly noted in the MG: after 6 months the improvement in physical health compared to the initial values was noted by 34.4% (р 0.01), after 12 months by 24.0% (р 0.05); mental by 32.3% (р 0.01) and 22.5% (р 0.05), respectively. In both comparison groups, positive dynamics was 1012% lower, and in the control group, after 6 months, there was only a tendency to improve quality of life indicators. Conclusion. The inclusion of TPF in the programs of the inpatient stage of medical rehabilitation of patients with chronic pancreatitis by strengthening the pharmacological potential of drug therapy contributes to the leveling of clinical manifestations (abdominal pain, dyspepsia and diarrhea), the result of which is an improvement in the quality of life of this category of patients.

Strengthening the pharmacological potential of drug therapy in treatment of patients with chronic pancreatitis by using therapeutic physical factors

2020 ◽  
pp. 8-14
Author(s):  
R. M. Mallaeva ◽  
A. N. Makhinko ◽  
M. B. Uzdenov
Keyword(s):  
Quality Of Life ◽  
Chronic Pancreatitis ◽  
Drug Therapy ◽  
Clinical Manifestations ◽  
Medical Rehabilitation ◽  
Control Group ◽  
Physical Factors ◽  
Standard Drug ◽  
Pharmacological Potential

The purpose of the study is to improve rehabilitation treatment of patients with chronic pancreatitis (CP) at inpatient stage by strengthening pharmacological potential of drug therapy due to inclusion of therapeutic physical factors (TPF) in therapeutic programs. Materials and methods. 159 patients with acute CP were observed. By simple randomization, 4 groups were formed: the control group (MG, 39 people) received standard drug therapy; 1st comparison group (GC1; 38 people) additionally received TPF; GC2 (40 people) in addition to treatment in GC1 had drinking mineral water «Slavyanovskaya»; in main group (42 people) in addition to the treatment in GC2 got preformed peloidotherapy on the cervical-collar zone. All the patients underwent the evaluation of clinical score and quality of life before and after medical rehabilitation. Results. In MG, clinical symptomatology leveling was by 78,2% (p<0,01), in GC1 — by 71,5% (p<0,01), GC2 — by 62,3% (p<0,01), CG — by 57,2% (p<0,01) on average immediately after the treatment, which was in a clear correlation with indicators of quality of life. In the long term (in 6 and 12 months), the advantage of combination therapy was noted with the same validity, the preservation of the achieved positive result was mostly noted in the MG: after 6 months the improvement in physical health compared to the initial values was noted by 34,4% (p<0,01), after 12 months — by 24,0% (p<0,05); mental — by 32,3% (p<0,01) and 22,5% (p<0,05), respectively. In both comparison groups, positive dynamics was 10–12% lower, and in the control group, after 6 months, there was only a tendency to improve quality of life indicators. Conclusion. The inclusion of TPF in the programs of the inpatient stage of medical rehabilitation of patients with chronic pancreatitis by strengthening the pharmacological potential of drug therapy contributes to the leveling of clinical manifestations (abdominal pain, dyspepsia and diarrhea), the result of which is an improvement in the quality of life of this category of patients.

scholarly journals New approaches to medical rehabilitation of patients with chronic pancreatitis at hospital stage

2019 ◽  
Vol 18 (2) ◽  
pp. 81-85
Author(s):  
Anna N. Makhinko
Keyword(s):  
Quality Of Life ◽  
Chronic Pancreatitis ◽  
Physical Therapy ◽  
Mineral Water ◽  
Main Group ◽  
Medical Rehabilitation ◽  
Control Group ◽  
Therapeutic Factors ◽  
Standard Drug

The research objective is to study therapeutic effectiveness of the medical rehabilitation program of patients suffering from chronic pancreatitis at the stationary stage with combined use of physical therapeutic factors against the background of standard pharmacotherapy. Materials and methods. In the therapeutic department of City Clinical Hospital No. 1 in Krasnodar there have been examined and treated 159 patients with acute chronic pancreatitis. By simple randomization, 4 groups were formed: the main group (39 people) received a standard drug therapy; the 1st group of comparison (38 people) additionally received physical therapy; the 2nd group of comparison (40 people) got drinking mineral water Slavyanovskaya in addition to the treatment in the 1st group of comparison; in the main group (42 people) the patients received preformed peloido-therapy (PPT) on the cervical collar zone in addition to the treatment in the 2nd group of comparison. All the patients before and after medical rehabilitation underwent clinical and laboratory research, the assessment of quality of life). Results. In the main group leveling of clinical symptoms occurred by 78.2% (p 0.01) on average, in the 1st group of comparison by 71.5% (р 0,01), in the 2nd group of comparison by 62.3% (p 0.01), in the control group by 57.2%. Decrease in anxiety intensity with patients suffering from chronic pancreatitis in case of complex medical rehabilitation (main group) occurred by 47.6% (p 0.01) compared with the data before medical rehabilitation; after additional inclusion physical therapy and drinking mineral water in the treatment complex by 42.6% (p 0.01); in the main group after inclusion complex pharmacotherapy and physical therapy by 34% (p 0.01) and in the control group by 30.7% (p 0.01) after using only standard pharmacotherapy. Positive dynamics of clinical and laboratory indicators was accompanied by significant improvement of quality of life at combined medical rehabilitation. Conclusion. The inclusion of physical therapeutic factors in the programs of the inpatient stage of medical rehabilitation of patients with chronic pancreatitis contributes to levelling of clinical manifestations (abdominal pain, dyspepsia, and diarrhoea), significant improvement of excretory function of pancreas, which results in the improvement of quality of life of this category of patients.

scholarly journals ОПТИМІЗАЦІЯ КОМПЛЕКСНОГО ЛІКУВАННЯ ІЗ ЗАСТОСУВАННЯМ ПРЕФОРМОВАНИХ ФАКТОРІВ У ЖІНОК У ПОСТМЕНОПАУЗАЛЬНОМУ ПЕРІОДІ, ХВОРИХ НА ОСТЕОАРТРОЗ КОЛІННИХ СУГЛОБІВ

World Science ◽  
2019 ◽  
Vol 2 (11(51)) ◽  
pp. 47-51
Author(s):  
Якименко О. О. ◽  
Кравчук О. Є. ◽  
Коломієць С. М. ◽  
Богдан Н. М.
Keyword(s):  
Quality Of Life ◽  
Drug Therapy ◽  
Effective Treatment ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Knee Joints ◽  
Osteoarthritis Of The Knee ◽  
Complex Treatment ◽  
Standard Drug

The article presents the issues of complex treatment of osteoarthritis of the knee with the use of preformed factors in postmenopausal women compared to standard drug therapy. The study included 60 women aged 50 to 75 years with clinical manifestations of osteoarthritis of the knee joints in the postmenopausal period. Complex treatment with preformed factors has been found to be an effective treatment for this category of patients, improving the clinical course of osteoarthritis by 53% and improving quality of life.

scholarly journals 1% ivermectin in combination therapy regimens for rosacea

2020 ◽  
pp. 17-23
Author(s):  
E. A. Khlystova ◽  
A. L. Savastenko
Keyword(s):  
Quality Of Life ◽  
Comparative Analysis ◽  
Combination Therapy ◽  
Combination Treatment ◽  
Clinical Manifestations ◽  
Life Quality ◽  
Clinical Results ◽  
Control Group ◽  
Before And After

Introduction. The article provides latest data on modern methods of treating rosacea. The results of own clinical observations of patients with moderate to severe papulopustular rosacea receiving combination treatment and a comparative analysis of the efficacy of various therapy regimens are presented.Objective of the study. The aim of the study was to conduct a comparative analysis of the therapeutic efficacy of combination therapy using the ivermectin 1% topical drug combined with systemic therapy drugs (doxycycline, minocycline, isotretinoin).Materials and methods. We observed 37 patients with moderate to severe papulo-pustular rosacea subtype. The patients were divided into 4 groups (A, B, C, D). Patients in the control group received monotherapy with 1% ivemectin topical drug, patients in the other groups received combination therapy (1% ivermectin combined with low-dose doxycycline, minocycline and isotretinoin). The efficacy of the therapy was evaluated by measuring rosacea severity on the Scale for Diagnostic Assessment of Rosacea (SDAR), clinical manifestations according to the IGA (Investigator Global Assessment) criteria, and by assessing the patients' quality of life using the DLQI (Dermatology Life Quality Index) questionnaire before and after 3-month treatment.Results. The comparative analysis of changes in severity indicators of the skin process and quality of life in patients with moderate to severe papulopustular rosacea after topical and combination therapy showed that the results of the treatment in patients receiving combination therapy were more significant than those in the group receiving monotherapy.Conclusion. The concomitant use of 1% ivermectin and systemic drugs is most effective in patients with severe papulopustular rosacea subtype. The combination treatment tailored to the clinical forms and severity of rosacea allows to optimize the clinical results of the therapy, which significantly affects the patients' quality of life and opens up potential for an individual approach in the algorithms for the treatment of rosacea.

scholarly journals Elimination of pain syndrome in patients with advanced pancreatic head cancer

2019 ◽  
Vol 42 (1) ◽  
pp. 46-52
Author(s):  
T. G. Gevorkyan ◽  
I. A. Feinstein
Keyword(s):  
Quality Of Life ◽  
Pancreatic Cancer ◽  
Drug Therapy ◽  
Cancer Patients ◽  
Clinical Manifestations ◽  
Pancreatic Head ◽  
Pain Syndrome ◽  
Pancreatic Head Cancer ◽  
Surgical Methods

Pain syndrome, along with mechanical jaundice, is one of the most evident clinical manifestations of pancreatic cancer and is often a sign of tumor neglecting. Existing treatment options for chronic pain in cancer patients are diverse and include the various ways of impact on the different links of pathological pain: medicinal, endoscopic, surgical. With this pathology, drug therapy using analgesics, weak and strong opioids, is usually not effective enough. In such cases, preference is given to chemical neurolysis — denervation of the autonomic structures of the retroperitoneal space, carried out under the guidance of ultrasound or computed tomography. Conducting percutaneous neurolysis of the celiac plexus with the use of alcohol or phenol is prescribed upon insufficient effectiveness of pharmacotherapy. Surgical methods of anesthesia are used extremely rarely, as they considerably worsen the patient’s condition, without significantly affecting the quality of life or the prognosis. Thoracoscopic splanchnicectomy is considered a modern and effective method of endoscopic treatment of pain in unresectable pancreatic cancer, the conduction of which can significantly decrease the intensity of pain, reduce the number of narcotic analgesics and improve the quality of life of cancer patients. This minimally invasive intervention is the basis for the subsequent lifelong systemic drug therapy.

scholarly journals Alcoholic chronic pancreatitis: A quality of life study

2016 ◽  
Vol 29 (1) ◽  
pp. 23-31
Author(s):  
Simone Carla BENINCÁ ◽  
Angelica de Freitas MELHEM ◽  
Renato Duffles MARTINS ◽  
Ermelindo Della LIBERA JÚNIOR
Keyword(s):  
Quality Of Life ◽  
Chronic Pancreatitis ◽  
Body Fat ◽  
Pancreatic Surgery ◽  
Control Group ◽  
Diabetic Patients ◽  
Alcoholic Chronic Pancreatitis ◽  
Percentage Of Body Fat ◽  
Smoking Duration

ABSTRACT Objective: To compare the quality of life between patients with alcoholic chronic pancreatitis and controls, and between diabetic and non-diabetic patients, correlating clinical, sociodemographic, and nutritional factors with their quality of life scores. Methods: Forty-three outpatients of the pancreas and biliary tract clinic diagnosed with alcoholic chronic pancreatitis were assessed. Quality of life was measured by the Brazilian version of the Short Form-36. The control group consisted of 43 healthy companions. Nutritional status was classified according to body mass index and triceps, biceps, suprailiac, and subscapular skinfold thicknesses, using the appropriate methods. The percentage of body fat was given by adding the four skinfold thicknesses and by bioelectrical impedance analysis. The statistical tests included the Chi-square, Mann-Whitney, and Spearman's correlation tests, with the significance level set at p<0.05. Results: The sociodemographic variables of the case and control groups did not differ. Quality of life was lower in alcoholic chronic pancreatitis patients than in controls. The only quality of life domain that differed between diabetics and non-diabetics was functional capacity, lower in diabetics (p=0.022). Smoking duration, alcohol intake in grams, and time since pancreatic surgery correlated negatively with the quality of life of alcoholic chronic pancreatitis patients. Old age, skinfold thicknesses, and percentage of body fat correlated positively with quality of life. Conclusion: Quality of life is low in alcoholic chronic pancreatitis patients because of the negative influence of certain factors, such as smoking duration, amount of alcohol consumed, and time since pancreatic surgery.

scholarly journals Results of the Preformed Physical Factors Application in the Rehabilitation Treatment of Corneal Ulcerative Defects

2021 ◽  
Vol 20 (4) ◽  
pp. 126-132
Author(s):  
Olga V. Yurova ◽  
Yaroslav A. Soloviev ◽  
Tatiana V. Konchugova
Keyword(s):  
Visual Acuity ◽  
Drug Therapy ◽  
Low Frequency ◽  
Pain Syndrome ◽  
Control Group ◽  
Physical Factors ◽  
Standard Drug ◽  
Corneal Ulcers ◽  
Combined Use

Currently, an infectious corneal ulcer, a defect in the corneal epithelium, remains one of the main causes of monocular blindness,which necessitates the development of new effective methods of treatment. Aim. To develop and evaluate the effectiveness of the technique for the complex application of preformed physical factors of local andsegmental action in patients with corneal ulcers. Material and methods. The study involved 85 patients with corneal ulcers aged 18 to 60 years divided into three groups. Patients ofthe control group (29 people) received the standard drug therapy, the comparison group (29 people) underwent a course of magnetophoresiswith solcoseryl on closed eyelids against the background of standard drug therapy, patients of the main group (27 people)received standard drug therapy, magnetophoresis and low-frequency electrostatic fields on the collar area. All patients were evaluatedfor visual acuity, the size of the ulcer and the area of stromal infiltration. The subjective severity of pain syndrome (VAS scale),psychoemotional state (SAN test) were assessed. Statistical analysis of the data was performed using SPSS Statistics v.25. Results. Immediately after treatment, the use of preformed physical factors made it possible to shorten the period of the ulcer epithelializationand suppression of the inflammatory reaction in the cornea, which significantly improved the clinical and functionalparameters of the eye, as well as considerably reduced the severity of pain syndrome in comparison with standard drug treatment. Conclusion. In the long-term period, the use of preformed physical factors contributed to a significant decrease in the size of thecorneal infiltration area (residual opacities) and an improvement in the quality of life of patients according to the General MentalWellbeing scale, which exceeded the effectiveness of standard drug therapy, while the combined use of a low-frequency electrostaticfield and magnetophoresis allowed to noticeably improve the indicators of visual acuity in comparison with standard drug therapyand isolated use of magnetophoresis.

Possibilities of Complex Rehabilitation of Patients with Type 2 Diabetes and Concomitant Chronic Pancreatitis in Ambulatory Practice

2021 ◽  
Vol 63 (1) ◽  
pp. 33-37
Author(s):  
Liliya S. Babinets ◽  
Halyna M. Sasyk ◽  
Iryna M. Halabitska ◽  
Victoria R. Mykuliak
Keyword(s):  
Quality Of Life ◽  
Type 2 Diabetes ◽  
Chronic Pancreatitis ◽  
Control Group ◽  
Important Place ◽  
Sf 36 ◽  
Group 2 ◽  
Group 1

Introduction: An important place in the formation of the rehabilitation program is occupied by non-drug methods, such as physiotherapy, reflexology, spa treatment, the use of which improves the effectiveness of correction of complications, reduces drug load, allows to achieve sustainable compensation for diabetes and chronic pancreatitis (CP), and also improves life quality suffering from such comorbidity. Aim: to investigate the effectiveness of the use of acupuncture in the complex rehabilitation of patients with type 2 diabetes in combination with chronic pancreatitis based on an assessment of the quality of life (QOL) and clinical parameters. Material and Methods: 60 patients with type 2 diabetes in combination with CP were examined and divided into 2 groups. The average age of the patients was (52.86±0.83) years. Control group – 15 healthy persons. To evaluate QOL, a questionnaire was interviewed using the SF-36 questionnaire in treatment dynamics. All patients with type 2 diabetes in combination with CP received adequate conventional therapy. In addition to the treatment, the patients of group II received the acupuncture course according to the methodology, which was formed on the basis of the experience of the Kyiv School of reflexology (EL Macheret et al.) and the Beijing School (Kong Lin). Results: Faecal α-elastase levels increased by 14.9% in group 1, by 25.6% in group 2, blood glucose decreased by 9.2% in group 1 and by 19.5% in group 2, HbA1c level – by 4.9% in Group 1 and by 12.2% in Group 2, changes in coprogram parameters in points – by 24.5% in Group 1 and by 55.2% in Group 2. According to the SF-36 scales, there was a positive dynamics of quality of life in patients of both groups. In group 2, there was a more significant positive trend in the total indicator of mental status (increased by 17.75% (p <0.001) versus 8.71% (p <0.005) in the group 1, respectively) and physical status (increased by 2.59% ( p <0.05) versus 7.19% (p <0.05)). Conclusions: Improved exocrine and endocrine functions of the pancreas, as well as improved quality of life in patients treated with a course of acupuncture increase the efficiency of complex rehabilitation of patients with type 2 diabetes in combination with CP was found.

scholarly journals THE EFFECT OF THE TRACTION THERAPY ON PATIENTS WITH LUMBAR DISC DISEASE

2021 ◽  
Author(s):  
Mariyana Mihaylova ◽  
◽  
Keyword(s):  
Quality Of Life ◽  
Lumbar Disc ◽  
Treatment Protocol ◽  
Control Group ◽  
Physical Factors ◽  
Disc Disease ◽  
Lumbar Disc Disease ◽  
Treatment Protocols ◽  
Before And After

The goal of this research is to examine the efficiency of a set of physical factors with the inclusion of traction therapy in treating lumbar static and dynamic pain and the opportunities to influence the quality of life of patients with lumbar disc disease (LDD).100 patients with lumber disc disease participated in the clinical study. They were equally divided into a control group (CG), which has been treated with basic therapy (LFMF and IFC) and experimental group (EG) where traction therapy was part of the treatment protocol. For evaluating the effectiveness of the treatment was used quantitative assessment for static and dynamic pain and the quality of life before and after thetreatment. Results of both treatment protocols have statistically significant effect (p<0,001) in reducing low back pain and improving the quality of life. In comparison between the two groups, EG has a statistically significant (p<0,001) advantage over the CG. The inclusion of extension therapy in basic physical therapy gives excellent results, contributes to a more significant reduction ofpain and improves the quality of life of patients.

scholarly journals Clinical efficiency of the combined application of physiotherapeutic technologies and drinking mineral waters in patients with curral skin changes under conditions of insulin resistance

2021 ◽  
Vol 20 (2) ◽  
pp. 147-154
Author(s):  
Christina V. Kazantseva ◽  
Sergey N. Nagornev ◽  
Valery K. Frolkov ◽  
Elena V. Gusakova ◽  
Maria S. Nagorneva
Keyword(s):  
Quality Of Life ◽  
Metabolic Syndrome ◽  
Laser Therapy ◽  
Mineral Water ◽  
Clinical Manifestations ◽  
Main Group ◽  
Mineral Waters ◽  
Control Group ◽  
Combined Application

BACKGROUND: One of the effective and pathogenetically substantiated methods of therapeutic action on cicatricial changes in the skin are laser technologies in combination with collagenases. However, as previous studies have shown, the presence of metabolic syndrome in patients significantly reduces the clinical efficacy of the combined use of laser therapy and phonophoresis of Fermencol. The most reasonable solution in this situation can be scientific research and experience in the practical use of drinking mineral waters, which have a high corrective efficiency in relation to metabolic processes, the course of which is significantly impaired in type II diabetes mellitus and metabolic syndrome. AIMS: Assessment of clinical indicators of cicatricial changes in the skin of patients with metabolic syndrome in the combined application of the method of phonophoresis Fermenkol, fractional photothermolysis and drinking mineral waters. MATERIAL AND METHODS: The study included 60 patients (49 men and 11 women) with cicatricial changes in the skin aged 19 to 50 years, with a confirmed diagnosis of metabolic syndrome. All patients by the method of simple fixed randomization were divided into two groups: the control group (30 people) and the main group (30 people). Both groups received treatment, which included a course of phonophoresis of 0.01% Fermencol gel in combination with the technique of fractional laser therapy. Patients of the main group, in contrast to the control group, in addition to the specified physiotherapeutic treatment received bottled sodium bicarbonate-chloride water Essentuki No. 17 (mineralization 11.8 g/l) at room temperature, 200250 ml three times a day for 1520 minutes before meals for 3 weeks. RESULTS: The addition of physiotherapeutic combined anti-scar therapy with a course of drinking mineral water Essentuki No. 17 in patients with cicatricial changes in the skin in combination with metabolic syndrome was accompanied by a significantly more pronounced clinical effect, assessed by the Vancouver scale and the Dermatological Index of Quality of Life. CONCLUSION: Additional course use of drinking mineral water Essentuki No. 17 is accompanied by a more pronounced dynamics of clinical manifestations of cicatricial deformities of the skin and an indicator of the quality of life of patients, due to the sanogenetic mechanisms of the drinking balneofactor.

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