Anatomycal features of the ethmoidal labyrinth and nasal cavity structures in childhood

2020 ◽  
Vol 22 (4) ◽  
pp. 95-99
Author(s):  
M. V. Markeeva ◽  
O. Yu. Aleshkina ◽  
N. V. Tarasova ◽  
I. V. Gaivoronsky
Keyword(s):  
Early Childhood ◽  
High Risk ◽  
Nasal Cavity ◽  
Age Groups ◽  
Physiological Model ◽  
Lower Edge ◽  
Old Growth ◽  
Ethmoid Bone ◽  
Iatrogenic Complications ◽  
Front Section

The morphotopometric variability of the ethmoidal labyrinth and the parameters of the nasal cavity for 87 childrens cranium (121 years) has been determined. The growth of the ethmoidal labyrinth and the nasal cavity occurs undulating and unevenly. The increase of the height of the ethmoidal labyrinth begins earlier than its width and length from 23 years to 1316 years old. Growth periods the height of ethmoidal labyrinth occur for 23 years, 812 and 1316 years; widths 47, 812 and 1721 years; length 47, 812 and 1316 years. At the ethmoidotomy in the infant and early childhood, the smallest size of the ethmoidal labyrinth should be taken into account: width 78 mm, height 1416 mm, length 2729 mm, so in these age periods there is a high risk of damage of the cribriform and orbital plates ethmoid bone with the development of iatrogenic complications. The nasal cavity штchildren expands posteriorly as well as in adults. In the infancy, the width of the nasal cavity at the back corresponds to the width in the front section, from 2 years prevails than in front and by adolescence becomes larger for 33,5 mm. Knowing these agerelated features of the structure of the childrens nasal cavity, during surgery the rhinosurgeon when shifting the middle nasal shells medially or laterally should ensure to maintain the physiological model of the nasal cavity. In infancy, the width of the ethmoidal labyrinth is larger than the width of the nasal cavity by 38,5%, and by adolescence this ratio increases to 76,8%. The length of the nasal cavity increases from 47 years to adolescence, the length of the ethmoidal labyrinth grows parallel to the maximum length of the nasal cavity and it is less for more than a half in all childrens age groups: in the infancy by 74%, in adolescence by 85.1%. The height of the nasal cavity is twice the height of the labyrinth in any childhood age, the distance from the bottom of the nasal cavity to the lower edge of the middle nasal shell must be correlated with the distance above the level of the average nasal shell during intranasal surgeries and do not exceed it for the introduction of tools.

Clinical consequences of untreated early childhood caries in urban population of children with high risk of caries in Poland

2016 ◽  
Vol 69 (6) ◽  
pp. 620-630
Author(s):  
Piotr Rożniatowski ◽  
Anna Piróg-Bednarska ◽  
Angelika Kobylińska ◽  
Dariusz Gozdowski ◽  
Dorota Olczak-Kowalczyk
Keyword(s):  
Early Childhood ◽  
High Risk ◽  
Urban Population ◽  
Early Childhood Caries ◽  
Age Groups ◽  
Significance Level ◽  
High Caries Risk ◽  
Clinical Consequences ◽  
Untreated Caries ◽  
Childhood Caries

Background. The anatomy and low mineral content of primary teeth, especially soon after their eruption, predispose to acute progression of caries. Untreated early childhood caries (ECC) can rapidly lead to destruction of the crown and to pulpal involvement. It is, therefore, important to depict its clinical consequences in relation to caries intensity and age. Aim of the study. To assess the correlation of clinical consequences of ECC with its intensity and age in urban population of children with high risk of caries in Poland. Material and methods. In a group of high caries risk children from Warsaw aged below 6 years the following were evaluated: dental health (decayed, filled, missing teeth due to caries (dmft/dmfs), carious pulp exposure) and mucosal health (ulcerations caused by decayed teeth, fistulae, abscesses (pufa). Four age groups were distinguished: less than 3 years, 3-4 years, 4-5 years and 5-6 years. Statistical analysis: Kruskal-Wallis test (significance level p=0.05). Results. Among 223 children (mean age 4.30±1.154 years) dmft>0 was found in 80% (mean dmft=6.14±5.49, dmfs=11.60±12.92), restorative index was 0.23±0.33. Pufa >0 was observed in 26% (mean 0.853±1.839) with the highest value in the youngest age group (mean 1.20±2.222). Correlations between dmft, dmfs and pufa were observed. Statistically significant correlations were found between teeth missing due to caries and the clinical consequences of untreated caries. Conclusions. The younger the child affected by caries, the more severe the consequences of untreated caries. It has been observed that the rate of consequences increases with caries intensity.

scholarly journals Protocol for a family-centered behavioral intervention to reduce early childhood caries: the MySmileBuddy program efficacy trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Christie L. Lumsden ◽  
Burton L. Edelstein ◽  
Charles E. Basch ◽  
Randi L. Wolf ◽  
Pamela A. Koch ◽  
...  
Keyword(s):  
Early Childhood ◽  
High Risk ◽  
Behavioral Intervention ◽  
Early Childhood Caries ◽  
Text Messages ◽  
Trial Registration ◽  
Control Group ◽  
Causal Pathways ◽  
Family Centered ◽  
Childhood Caries

Abstract Background Although largely preventable through diet management and topical fluoride use, early childhood caries (ECC) often progresses to severity that necessitates surgical repair. Yet repair often fails to mitigate caries progression. Needed is an effective behavioral intervention to address underlying behavioral causes. Methods This randomized controlled trial will evaluate the efficacy of a behaviorally focused, family-centered intervention, the MySmileBuddy Program (MSB Program), to reduce ECC progression in high-risk preschoolers in New York City. Recruitment will target 858 children ages 24–71 months with ECC and their parents from primary care medical and dental clinics. The study aims to assess the MSB Program’s efficacy to: (1) decrease ECC progression measured 12-months post-randomization; and (2) enhance adoption of a low cariogenic diet and twice-daily fluoridated toothpaste use compared to control group. Potential causal pathways (mediators and moderators) will be explored. The MSB Program equips community health workers (CHWs) with an app that facilitates multilevel risk assessment and provides motivational interviewing-based counseling to inform parents about the caries process, develop personalized goals, and create family-level action plans to achieve targeted behaviors. Social support from CHWs (4 interactions during the 6-month intervention, supplemented by up to 4 in-person/remote contacts throughout the 12-month study period, based on need) is bolstered by automated text messages. Participants will be randomized to a Control Group (paper-based educational handout plus toothbrushes and fluoridated toothpaste for the child) or Intervention Group (MSB Program, two tooth-brushing observations with feedback and instruction, and toothbrushes and toothpaste for the entire family). All children will receive visual ICDAS dental examinations and parents will complete study measures at baseline and 12-months. An incentive up to $150 plus round-trip transit cards ($5.50 value) will be provided. Discussion This study hypothesizes that the MSB Program can reduce ECC progression in a high-risk population. Sufficient incentives and a focus on establishing rapport between participants and CHWs are anticipated to mitigate recruitment and retention challenges. If successful, this study will advance the long-term goal of reducing pediatric oral health disparities by demonstrating the efficacy of an acceptable and feasible intervention that shifts attention from dental repair to behavioral risk mitigation. Trial registration: Trial registration was completed on 4/13/2021 through the U.S. National Library of Medicine ClinicalTrials.gov website (Identifier: NCT04845594).

scholarly journals Physical Activity of Serbian Children in Daycare

Children ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 161
Author(s):  
Milenko Janković ◽  
Maja Batez ◽  
Dušan Stupar ◽  
Jelena Obradović ◽  
Nebojša Trajković
Keyword(s):  
Physical Activity ◽  
Early Childhood ◽  
Urban Environment ◽  
Educational Institution ◽  
Univariate Analysis ◽  
Age Groups ◽  
Preschool Age ◽  
Variance Test ◽  
Significant Difference ◽  
Novi Sad

Background: Monitoring of physical activity within the educational institution is of great importance, primarily because of the orientation and content implemented in the daycare. This research aimed to examine the number of steps children took during their stay in daycare with regards to age, gender and the frequency of going out. Methods: The research was conducted in four daycares in the urban environment of Novi Sad (Republic of Serbia), where 231 children, aged 5 to 7, were monitored (129 boys and 102 girls). Data on the number of steps were obtained using the pedometers. Results: The result of the univariate analysis of the variance test confirmed a statistically significant difference in the number of steps in relation to the age of children (p = 0.04). Boys were more active than girls in both age groups (p = 0.001). Children who were going to the daycare yard three to five times a week took drastically more steps than children who went up to twice a week (p = 0.001). Conclusion: The results of the current study show that age, gender, and time spent outdoors are significant determinants of physical activity in preschool age. Therefore, interventions regarding physical activity should be made during early childhood in order to promote health and prevent disease.

scholarly journals Early Childhood Gut Microbiomes Show Strong Geographic Differences Among Subjects at High Risk for Type 1 Diabetes: Figure 1

Diabetes Care ◽  
2014 ◽  
Vol 38 (2) ◽  
pp. 329-332 ◽  
Author(s):  
Kaisa M. Kemppainen ◽  
Alexandria N. Ardissone ◽  
Austin G. Davis-Richardson ◽  
Jennie R. Fagen ◽  
Kelsey A. Gano ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Early Childhood ◽  
High Risk ◽  
Geographic Differences

Development of the Paranasal Sinuses in Children: Implications for Paranasal Sinus Surgery

1993 ◽  
Vol 102 (9) ◽  
pp. 705-711 ◽  
Author(s):  
Gerald Wolf ◽  
Wolfgang Anderhuber ◽  
Frederick Kuhn
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinus ◽  
Paranasal Sinuses ◽  
Age Groups ◽  
Clinical Importance ◽  
Sinus Surgery ◽  
Clinical Anatomy ◽  
Surgical Interventions ◽  
Stage Of Development ◽  
Paranasal Sinus Surgery

The pediatric nasal cavity and paranasal sinuses, when compared to those in adults, differ not only in size but also in proportion. Knowledge of the unique anatomy and pneumatization of children's sinuses is an important prerequisite to understanding the pathogenesis of sinusitis and its complications. It is also important in evaluation of radiographs and in planning surgical interventions. In order to study the development of the paranasal sinuses in children and relate clinical anatomy to sinus surgery, the sinuses in 102 pediatric skulls and cadaver heads were measured. The results were classified by stage of development into 4 different age groups: newborn and 1 to 4, 4 to 8, and 8 to 12 years. The characteristics of each group and their clinical importance for paranasal sinus surgery are described.

scholarly journals The Family Check-Up With High-Risk Indigent Families: Preventing Problem Behavior by Increasing Parents’ Positive Behavior Support in Early Childhood

2008 ◽  
Vol 79 (5) ◽  
pp. 1395-1414 ◽  
Author(s):  
Thomas J. Dishion ◽  
Daniel Shaw ◽  
Arin Connell ◽  
Frances Gardner ◽  
Chelsea Weaver ◽  
...  
Keyword(s):  
Early Childhood ◽  
High Risk ◽  
Problem Behavior ◽  
Positive Behavior Support ◽  
Positive Behavior ◽  
Behavior Support ◽  
The Family

scholarly journals High-risk HPV genotypes and cervical lesions association in postmenopausal women

2021 ◽  
Vol 31 (Supplement_2) ◽  
Author(s):  
Ana Rita Fernandes Miranda da Costa ◽  
Cláudia Sousa ◽  
Erica Isidoro ◽  
Regina Silva ◽  
Cristiana Mourato
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Postmenopausal Women ◽  
Age Groups ◽  
Low Grade ◽  
High Grade ◽  
Cervical Lesions ◽  
Intraepithelial Lesion ◽  
The Bethesda System ◽  
High Risk Hpv

Abstract Background Persistent infection by high-risk Human Papillomavirus (hrHPV) are the major cause of cervical cancer. Studies report disparities in the incidence of infection and the various genotypes of this virus in different age groups, suggesting a higher frequency of hrHPV in young women and low-risk subtypes being predominant in older women. This study aimed to investigate the incidence and distribution of hrHPV genotypes in postmenopausal women as well as the correlation with the cytological findings. Methods 16 859 women, aged 50–64 years, performed cervical cancer screening test in Friuri Venezia Giulia region, Italy. The infection was evaluated by the Polymerase Chain Reaction methodology and the positive samples were evaluated by Liquid Based Cytology according to the Bethesda System from 2014. A statistical analysis was performed to study the molecular and cytological data of this population. Results hrHPV infection were found in 5.8% of the women and 78.3% of these were caused by hrHPV other than HPV16 and HPV18 (). Also, 65.7% of the positive samples were negative for intraepithelial lesion or malignancy while low grade squamous intraepithelial lesion was the most frequent (22.4%). There was an increase in the number of high-grade intraepithelial lesions in the presence of HPV16 compared to that recorded when this genotype was absent (20.8% vs. 8.5%). No cervical cancers were detected. Conclusions Infection with hrHPV is uncommon in postmenopausal women and it is mostly caused by subtypes less associated with the development of cervical cancer. Yet, HPV16 infection triggers the development of high-grade lesions.

scholarly journals Features of in-hospital clinical course of pulmonary embolism in patients of different age groups

2020 ◽  
Vol 19 (5) ◽  
pp. 2423
Author(s):  
E. A. Shmidt ◽  
S. A. Berns ◽  
A. G. Neeshpapa ◽  
P. A. Talyzin ◽  
I. I. Zhidkova ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
High Risk ◽  
Clinical Course ◽  
Diastolic Pressure ◽  
Age Groups ◽  
Statistical Processing ◽  
Severity Index ◽  
Cardiovascular Comorbidity ◽  
Vein Thrombosis ◽  
Comorbidity Status

Aim. To study the clinical course and management of patients with pulmonary embolism (PE) of various age groups hospitalized in a cardiology hospital.Material and methods. This prospective single-center study in the period from 2016 to 2018 included 154 patients with PE verified by computed tomography. Statistical processing was conducted using the MedCalcVersion 16.2.1 software package (Softwa, Belgium).Results. In all groups, female patients dominated, but the highest number of women (70,7%) belonged to the group of senile patients, while in the group <60 years, only half of patients with PE were women. Comorbid cardiovascular disease and deep vein thrombosis was diagnosed in eldest patients significantly more often than in those <60 years of age. The highest prevalence of cancer and recurrent PE were identified in the group of elderly patients. Thrombolytic therapy was performed most often in patients 60-75 years old, since these patients had a high risk of 30-day mortality according to Pulmonary Embolism Severity Index, but did not have severe comorbidities, as patients older than 75 years. An increase of right atrium size was found in the group of elderly and senile patients in comparison with patients <60 years. The highest pulmonary artery systolic and diastolic pressure was observed in the patients older than 75 years.Conclusion. In the Kemerovo Oblast, PE most often develops in patients aged 60-75 years and is characterized by a more severe clinical course compared with patients younger than 60 years. Patients over the 60 years of age have severe cardiovascular comorbidity status, atrial fibrillation/flutter and recurrent PE. Surgical treatment for senile patients is limited due to the high risk of postoperative complications, which specifies high mortality. Patients <60 years of age are a third of all patients hospitalized with PE. They have a low risk of mortality, but have an unfavorable course of the hospital period.

scholarly journals Transcriptomic Analysis of the Neurogenesis Signature suggests Continued but Minimal Neurogenesis in the Adult Human Hippocampus

2019 ◽  
Author(s):  
Ashutosh Kumar ◽  
Vikas Pareek ◽  
Muneeb A. Faiq ◽  
Pavan Kumar ◽  
Chiman Kumari ◽  
...  
Keyword(s):  
Early Childhood ◽  
Age Groups ◽  
Transcriptomic Analysis ◽  
Expression Data ◽  
Adult Age ◽  
Sharp Fall ◽  
Adult Human ◽  
Apoptotic Markers ◽  
Human Hippocampus ◽  
Late Maturation

AbstractPurposeSince immunohistological investigations have given rise to divergent perspectives about continued hippocampal neurogenesis in adult humans, a comprehensive transcriptomic analysis of the neurogenesis signature markers supplemented with insights from gliogenesis and apoptotic markers (in context to the developmental stages across age) may discern important aspects and may well be the appropriate methodology for resolving this conflict.Materials and MethodsRNA expression data for the salient neurogenesis, gliogenesis, and apoptotic marker genes in post-mortem human hippocampal tissue of the Prenatal (n=15), Infant/Early childhood (n= 5), Adolescence (n=4), and Adulthood (n=6) ages were downloaded from Allen Brain Atlas database (http://www.brainspan.org/rnaseq). Gene expression data was categorized, median values were computed, and age group specific differential expression was statistically analyzed (the confidence level of 95%, p value ≤ 0.05 is used).ResultsA sharp fall in prenatal to infant/early childhood expression was observed for all studied neurogenesis markers, except that for the post-mitotic late maturation (CALB1, CALB2, MAP2, NEUN, STMN2) which showed no significant differences in expression profiles. A continued post childhood decrease across advancing age was observed in the neural stem cells and progenitor markers with insignificant differences across close age groups. Uniquely, the postnatal sharp fall of KI67 and TBR2 continued across advancing age groups, reached near baseline until adolescent age. The immature granule cell, post mitotic early maturation, and late maturation markers showed a maintained or slightly increased (albeit insignificant) post childhood expression. The gliogenesis markers mostly showed a significant downregulation between prenatal and infant /early childhood age groups; this decline was persistent thereafter with insignificant differences between close age groups. A continued postnatal decrease occurred in apoptotic markers with observable, but insignificant, differences between adolescent and adult age.ConclusionsOur findings indicate a possibility of continued but minimal neurogenesis in the adult human hippocampus. A significant part of the newborn cells in the neurogenic niche may be glial cells.(Findings of this study were first presented at the Annual Meeting of Society for Neuroscience (SFN), 3rd-7th November, 2018, San Diego, USA.https://abstractsonline.com/pp8/#!/4649/presentation/37213)Graphical AbstractHighlightsA varying but continued fall in expression was observed for all studied neurogenesis markers across advancing age groups, except that for the immature granule cells, early and post-mitotic late neuronal maturation markers.A continued postnatal sharp fall of progenitor markers KI67 and TBR2 reached near baseline until adolescent age.Gliogenesis markers showed continued but insignificant fall in expression post infant/early childhood.Apoptotic markers showed continued post infant/early childhood downfall but changes were negligible between adolescent and adult age.

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