scholarly journals Activity of the brain isoenzyme creatine kinase in newborns with intrauterine growth retardation

2003 ◽  
Vol 52 (4) ◽  
pp. 28-32
Author(s):  
D. S. Dodkhoev ◽  
I. I. Evsyukova ◽  
Z. N. Tumasova ◽  
А. V. Harutyunyan
Keyword(s):  
Creatine Kinase ◽  
Growth Retardation ◽  
Clinical Condition ◽  
Intrauterine Growth Retardation ◽  
Neonatal Period ◽  
Placental Insufficiency ◽  
Intrauterine Growth ◽  
Early Neonatal Period ◽  
The Brain

The CK-BB activity in neonates with intrauterine growth retardation (IUGR) was investi-gated and the results were compared to their clinical condition in early neonatal period. The re-sults of the study have shown that the CK-BB activity was increased in neonates with symmetric IUGR and in the presence of chronic placental insufficiency of infectious genesis.

scholarly journals Neonatal hypoglycemia in children with risk factors

2022 ◽  
pp. 80-84
Author(s):  
E. V. Antsiferova ◽  
T. E. Taranushenko ◽  
N. G. Kiseleva ◽  
E. A. Belyaeva ◽  
T. I. Donskaya
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Blood Glucose ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Neonatal Period ◽  
Large Body ◽  
Neonatal Hypoglycemia ◽  
Intrauterine Growth ◽  
Early Neonatal Period

Objective: The analysis of clinical-laboratory peculiarities and the dynamics of glycemia clarifying the terms of blood glucose stabilization during the early neonatal period in children having risk factors of the development of such state.Methods: Open, retrospective , continuous, single-center study was conducted. It was aimed at getting preliminary data that is important for planning further tactics of examining newborns having risk factors on hypoglycemia development (kids having large body weight at birth, children whose mothers have diabetes, newborns having intrauterine growth retardation).The target group of the survey included 522 newborns of both genders in the early neonatal period (from 0 to 7 days of life).Results: There is data on the frequency of first indicated hypoglycemia in newborns having risk factors of the development of such state, clinicallaboratory peculiarities, the dynamics of glycemia during early neonatal period, and also the period of blood glucose stabilization (the age of reaching normoglycemia). Neonatal hypoglycemia was detected in 40.2% of examined children. Laboratory manifestation during the first day of life was noticed 62.9% of cases with the further normalization of glucose level in blood in 24 hours in 73.3% of newborns. Significant reduction of blood glucose was observed in 54.8% of cases requiring hypoglycemia therapy with parenteral prescription of 10% glucose solution. Hypoglycemia jugulated against oral correction of 5% glucoses solution in 40.5 % of cases. 4.8% of children got the level of glucose stabilized after introduction of supplementary feeding.Conclusion: The results of the newborns having risk factors on hypoglycemia development (kids having large body weight at birth, children whose mothers have diabetes, newborns having intrauterine growth retardation) examinations are presented. The peculiarities of neonatal hypoglycemia are: the absence of a typical clinical symptoms among 89% of children. Asymptomatic course of hypoglycemia confirms the importance and necessity of glycemia monitoring in the early neonatal period in order to conduct timely and adequate therapy.

scholarly journals Some health aspects of children born with different types of intrauterine growth restriction during the early neonatal period

2017 ◽  
Vol 98 (1) ◽  
pp. 44-52 ◽  
Author(s):  
V V Derevtsov
Keyword(s):  
Growth Retardation ◽  
Intrauterine Growth Restriction ◽  
Intrauterine Growth Retardation ◽  
Neonatal Period ◽  
Growth Restriction ◽  
Past Medical History ◽  
Intrauterine Growth ◽  
Septal Defects ◽  
Early Neonatal Period ◽  
Different Types

Aim. To evaluate some health aspects of children born with different types of intrauterine growth restriction during the early neonatal period.Methods. Clinical and anamnestic, physical, laboratory, electrophysiological, ultrasound and statistical methods were used. Children’s past medical history, development during early neonatal period, physical development, functioning of autonomic nervous system and cardiovascular system were assessed.Results. It was revealed that development of different types of intrauterine growth restriction is related to father and mother’s age at the time of pregnancy, women’s body mass before pregnancy, and time of pregnancy complication development (abortion risk, pre-eclampsia, arterial hypertension, Rh-immunization, edema). Fetuses with asymmetric type of intrauterine growth retardation had survived hypoxia more often (by 4.87 times). Children with symmetrical type of intrauterine growth retardation were more often born by C-section (by 2.66 times), with smaller anthropometric measurements, with more frequent and severe hypotrophy, moderate and severe cerebral ischemia and mild intracranial hemorrhage, cryptorchidism, kidney diseases, atrial septal defects, muscular ventricular septal defects, open arterial duct, and depleted reserves. Children with asymmetric type of intrauterine growth retardation more often had hypoglycemia, jaundice, polycythemia, restricted adaptation reserves, myocardial metabolic disorders, anterior mitral valve leaflet prolapse, posthypoxic changes similar to hypertrophic cardiopathy.Conclusion. Revealed features of past medical history, development during early neonatal period of life, physical development, functioning of autonomic nervous system and cardiovascular system in different types of children’s intrauterine growth restriction can promote formulation of criteria for early diagnosis of adaptive and reserve disorders and identification of dispensary groups.

scholarly journals Current trends in the treatment of chronic placental insufficiency

2020 ◽  
Vol 69 (1) ◽  
pp. 45-52
Author(s):  
Ekaterina V. Novitskaya ◽  
Vyacheslav M. Bolotskikh ◽  
Victoria O. Polyakova ◽  
Igor M. Kvetnoy
Keyword(s):  
Growth Retardation ◽  
Fetal Development ◽  
Intrauterine Growth Retardation ◽  
Experimental Studies ◽  
Placental Insufficiency ◽  
Melatonin Treatment ◽  
Successful Pregnancy ◽  
Intrauterine Growth ◽  
Current Trends

According to literature, intrauterine growth retardation complicates about 5% of pregnancies and is usually caused by chronic placental insufficiency. This article reviews literature data on modern views on the issue. Special attention is paid to the role of melatonin in chronic placental insufficiency and intrauterine growth. Examples of experimental studies demonstrate successful pregnancy course and functional fetal development in animals with melatonin treatment. The data obtained by other researchers on the effect of melatonin on pregnancy, in particular, on chronic placental insufficiency in women, are analyzed. Also in this review, we suggest that melatonin, which is a powerful antioxidant, can reduce morbidity and mortality associated with intrauterine growth retardation.

scholarly journals Peculiarities of hemodynamics and activity of myocardial isoenzyme of creatine kinase in neonates with intrauterine growth retardation

2004 ◽  
Vol 53 (3) ◽  
pp. 18-22
Author(s):  
A. A. Andreeva ◽  
D. S. Dodkhoev ◽  
D. S. Dodkhoev
Keyword(s):  
Heart Failure ◽  
Creatine Kinase ◽  
Early Detection ◽  
Cardiovascular System ◽  
High Activity ◽  
Growth Retardation ◽  
Early Treatment ◽  
Intrauterine Growth Retardation ◽  
Intrauterine Growth

It was investigated the hemodynamic condition and activity of myocardial band of creatine kinase (CK.-MB) in neonates with intrauterine growth retardation (IUGR). It was determined that neonates with grave condition of IUGR had echocardiography characters of heart failure and it was associated with high activity of CK.-MB. It was identified the neces-sity of meticulous examination of cardiovascular system of the same neonates for the early detection pathology and early treatment.

scholarly journals Experimental investigation of the lipin gravidoprotective action in the model of placental disfunction caused by oxidative stress

2014 ◽  
Vol 12 (2) ◽  
pp. 59-64
Author(s):  
Olesya Viktorovna Kudina
Keyword(s):  
Oxidative Stress ◽  
Experimental Investigation ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Morphological Changes ◽  
Placental Insufficiency ◽  
Pronounced Effect ◽  
Pregnant Rats ◽  
Reference Drug ◽  
Intrauterine Growth

In the model of placental insufficiency caused by tetrachlormethane during organogenesis in rats, a pronounced effect of the gravidoprotective drug lipin was found assessed in their ability to prevent intrauterine growth retardation of rats and to normalize the morphological changes in the liver, kidney and placenta of pregnant rats. The drug lipin exceeds the reference drug essentiale on the sum of these indicators.

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