scholarly journals Study of leucine-rich alpha-2-glycoprotein-1 marker serum level in cases of malignant epithelial ovarian tumors

2020 ◽  
Vol 10 (1) ◽  
pp. 12
Author(s):  
Abd Elfatah Agameia ◽  
Rania Shafik Swelem ◽  
Hossam Hassan El Sokkary ◽  
Ghada Shehata Elsayed
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Tumor Marker ◽  
Histopathological Examination ◽  
Mean Value ◽  
Ovarian Tumors ◽  
Controlled Study ◽  
Control Group ◽  
Group I ◽  
Significant Difference

Background: The aim of this study was to compare the level of LRG1 in epithelial ovarian cancer (EOC) cases with benign ovarian masses and to evaluate results in relation to CA125.Methods: An observational prospective controlled study was done on 70 patients admitted to El Shatby Maternity University Hospital, Oncology department categorized as follows: study group (group I) included 35 patients, with epithelial ovarian malignancy confirmed by histopathological examination and control group (group Il) included 35 patients with benign ovarian tumors confirmed by histopathological examination. Determination of Serum LRGI level by using enzyme-linked immuno sorbent assay with CA125 tumor marker analysis were done for all cases of both groups.Results: As regard comparison between the two studied groups according to CA125 and LRGI. CA125 in group I ranged from 14.90 to 4600 with a mean value 856.73±1104.03, in group II ranged from 7.45 to 523 with a mean value of 51.97±86.14. LRGI in group I ranged from 62.46 to 653.98 with a mean value of 130.86±119.78, in group Il ranged from 47.73 to 261.78 with a mean value of 77.35±38.75. There was statistically significant difference between the two studied groups regarding CA125 and LRGI (p≤0.05).Conclusions: LRG1 can be used as promising tumor marker to diagnose epithelial malignant ovarian cancer with or without CA125 tumor marker as it was significantly higher in epithelial ovarian cancer patients.

scholarly journals The effect of prophylactic bilateral salpingectomy on ovarian reserve in patients who underwent laparoscopic hysterectomy

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Shizhuo Wang ◽  
Jiahui Gu
Keyword(s):  
Ovarian Cancer ◽  
Ovarian Reserve ◽  
Premenopausal Women ◽  
Laparoscopic Hysterectomy ◽  
Ovarian Tumors ◽  
Reproductive Age ◽  
Control Group ◽  
Significant Difference ◽  
Bilateral Salpingectomy ◽  
The Impact

Abstract Background Bilateral salpingectomy has been proposed to reduce the risk of ovarian cancer, but it is not clear whether the surgery affects ovarian reserve. This study compares the impact of laparoscopic hysterectomy for benign disease with or without prophylactic bilateral salpingectomy on ovarian reserve. Methods Records were reviewed for 373 premenopausal women who underwent laparoscopic hysterectomy with ovarian reserve for benign uterine diseases. The serum anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and three-dimensional antral follicle count (AFC) were assessed before surgery and 3 and 9 months postoperatively to evaluate ovarian reserve. Patients were divided into two groups according to whether they underwent prophylactic bilateral salpingectomy. The incidence of pelvic diseases was monitored until the ninth month after surgery. Results There was no significant difference between the two surgery groups in terms of baseline AMH, E2, FSH, LH, and AFC (all P > 0.05). There was no difference in potential bias factors, including patient age, operative time, and blood loss (all P > 0.05). There was also no significant difference between the two groups 3 months after surgery with respect to AMH (P = 0.763), E2 (P = 0.264), FSH (P = 0.478), LH (P = 0.07), and AFC (P = 0.061). Similarly, there were no differences between groups 9 months after surgery for AMH (P = 0.939), E2 (P = 0.137), FSH (P = 0.276), LH (P = 0.07) and AFC (P = 0.066). At 9 months after the operation, no patients had malignant ovarian tumors. The incidences of benign ovarian tumors in the salpingectomy group were 0 and 2.68 % at 3 and 9 months after surgery, respectively, and the corresponding values in the control group were 0 and 5.36 %. The incidences of pelvic inflammatory disease in the salpingectomy group were 10.72 and 8.04 % at 3 and 9 months after surgery, respectively, while corresponding values in the control group were 24.13 and 16.09 %. Conclusions Prophylactic bilateral salpingectomy did not damage the ovarian reserve of reproductive-age women who underwent laparoscopic hysterectomy. Prophylactic bilateral salpingectomy might be a good method to prevent the development of ovarian cancer. Larger clinical trials with longer follow-up times are needed to further evaluate the risks and benefits.

Evaluation of red cell distribution width (RDW) as a septic marker in comparison with clinical scores and C-reactive protein

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ali Ahmed Naga ◽  
Mohammed Ismaeil Abdel Fattah ◽  
Walid Hamed Nofal ◽  
Mohammed Abd-elsalam AlMenshawe
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Controlled Study ◽  
Control Group ◽  
Study Group ◽  
Distribution Width ◽  
Clinical Scores ◽  
Group I ◽  
Significant Difference ◽  
Sepsis And Septic Shock

Abstract Background Challenges of diagnosing and treating sepsis only seem more difficult as incidence increases, patients become older and sicker, and pathogenic organisms evolve. New understanding of inflammatory mediators and pathways, immunity, and genetic variability in this disease state suggests that the current definitions of SIRS, sepsis, severe sepsis, and septic shock are oversimplified. Objective The aim of our study is to evaluate the level of RDW, CRP and clinical scores "SOFA and APACHI" as markers in patients with sepsis and their levels on the outcome and resolution of sepsis in ICU. Methodology We conducted a prospective observational controlled study on 90 adult persons of both sex, 45 of them are adult patients and served as the study group (Group I), and the other 45 are healthy adult volunteers and served as the control group (Group II). The study group represented patients admitted to the ICU of Intensive Care Unit at Damanhour Medical National Institute who fulfilled the diagnostic criteria for sepsis, severe sepsis and septic shock on arrival to ICU according to the SCCM/ ESICM/ ACCP/ ATS/SIS International Sepsis Definitions Conference. Results. In the present study we found that CRP measured on admission was not a predictor of mortality, while that measured at day 5 and day 10 predicted mortality, where there was no statistically significant difference in CRP levels between survivors and non-survivors at the day of admission while there were statistically significant differences between survivors and non survivors according to CRP levels at day 5 (p = 0.001*) and at day 10 (p = 0.001*). It was found also that there were statistically significant differences between survivors and non-survivors according to RDW at day 1(p = 0.011*) and at day 5(p = 0.009*), at day 10 was found there was no statistically significant difference between survivors and non-survivors (p = 0.338). Conclusion RDW is a new promising cheap and readily available biomarker that can be able to diagnose patients with sepsis with accuracy comparable to CRP. Also, RDW at admission is able to predict mortality.

scholarly journals Hypodontia phenotype in patients with epithelial ovarian cancer

2015 ◽  
Vol 49 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Anita Fekonja ◽  
Andrej Cretnik ◽  
Danijel Zerdoner ◽  
Iztok Takac
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Figo Stage ◽  
Clinicopathological Characteristics ◽  
Control Group ◽  
Malignant Tumours ◽  
Cancer Group ◽  
Significant Difference ◽  
The University ◽  
And Control

Abstract Background. Ovarian cancer is usually diagnosed in an advanced stage and the present clinical and diagnostic molecular markers for early OC screening are insufficient. The aim of this study was to identify potential relationship between the hypodontia and epithelial ovarian cancer (EOC). Patients and methods. A retrospective study was conducted on 120 patients with EOC treated at the Department of Gynaecologic and Breast Oncology at the University Clinical Centre and 120 gynaecological healthy women (control group) of the same mean age. Women in both groups were reviewed for the presence of hypodontia and the patients with EOC also for clinicopathological characteristics of EOC according to hypodontia phenotype. Results. Hypodontia was diagnosed in 23 (19.2%) of patients with EOC and 8 (6.7%) controls (p = 0.004; odds ratio [OR] = 3.32; confidence interval [CI], 1.42-7.76). There was no statistically significant difference in patients with EOC with or without hypodontia regarding histological subtype (p = 0.220); they differed in regard to FIGO stage (p = 0.014; OR =3.26; CI, 1.23-8.64) and tumour differentiation grade (p = 0.042; OR = 3.1; CI, 1.01-9.53). Also, bilateral occurrence of EOC was more common than unilateral occurrence in women with hypodontia (p = 0.021; OR = 2.9; CI, 1.15-7.36). We also found statistically significant difference between the ovarian cancer group and control group in presence of other malignant tumours in subjects (p < 0.001). Conclusions. The results of the study suggest a statistical association between EOC and hypodontia phenotype. Hypodontia might serve as a risk factor for EOC detection.

HISTOPATHOLOGICAL AND BIOMECHANICAL INVESTIGATION OF THE EFFECT OF MOMORDICA CHARANTIA ON FRACTURE HEALING, KIDNEY, AND LIVER: AN EXPERIMENTAL RAT MODEL

2021 ◽  
Vol 21 (03) ◽  
pp. 2150019
Author(s):  
BURHAN OZTURK ◽  
SERMET INAL ◽  
T. CIHAN DULGEROGLU ◽  
A. OKTAR UZUMCUGIL ◽  
AYSENUR DEGER ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Momordica Charantia ◽  
Control Group ◽  
Albino Rats ◽  
Oral Gavage ◽  
Fracture Union ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
The Right

Momordica charantia (MC) is a plant belonging to the family Cucurbitaceae. MC has antidiabetic, antibacterial, antioxidant, antimutagenic, antiulcerative, antiinflammatory and antilipidemic effects. However, information on the effect of MC on fracture union is lacking. This study aimed to examine the effect of MC on fracture union histopathologically and biomechanically. A total of 42 male Wistar-Albino rats were randomly divided into 3 groups, 14 in each group. A diaphyseal fracture was created on the right tibia of all rats. All fractures were fixed with a Kirschner (K) wire. The rats in Group I did not undergo any further procedures (Control group). Group II rats were treated with 0.9% saline oral gavage at a dose of [Formula: see text]L/day for 28 days [Saline (S) group]. The rats in Group III were given 300[Formula: see text]mg/kg MC extract per day, dissolved in [Formula: see text]L 0.9% saline by oral gavage for 28 days [MC (Extract) group]. After 28 days, all rats were sacrificed. Each group was randomly divided into two subgroups. The histopathological examination was performed on the right tibia of rats in the first subgroup and the biomechanical examination in the second subgroup. The kidneys and livers of all rats were evaluated histopathologically. Fracture union was significantly better in the Extract group compared with the Control and S groups histopathologically. The fracture inflammation values were lower in the Extract group than in the other groups. No statistically significant difference was found between the groups in terms of possible side effects to kidneys and livers. In terms of biomechanics, fracture union was significantly better in the Extract group compared with the Control and S groups except yield displacement values. MC had a positive effect on fracture union histopathologically and biomechanically.

Comparison of serum vascular endothelial growth levels between patients with and without ovarian malignancies

2002 ◽  
Vol 12 (6) ◽  
pp. 715-719 ◽  
Author(s):  
K. Dehaven ◽  
D. D. Taylor ◽  
C. Gercel-Taylor
Keyword(s):  
Ovarian Cancer ◽  
Mean Value ◽  
Control Group ◽  
Vascular Endothelial ◽  
Serum Samples ◽  
Ovarian Cancer Screening ◽  
Significant Difference ◽  
The Us ◽  
The Mean ◽  
Endothelial Growth Factor

The objective of this study was to determine if there was a relationship between serum vascular endothelial growth factor (VEGF) levels and ovarian malignancies by contrasting a population with ovarian malignancies and a population free of gynecological neoplasms. Two hundred forty four serum samples were obtained from the US National Cancer Institute's Prostate, Lung, Colon, and Ovarian Cancer Screening Project. These samples were analyzed by enzyme-linked immunosorbent assays in duplicate, and on completion of the assays, the samples were decoded for age and disease type. Average VEGF values for the nongynecological control group was 4.399 ng/ml; for benign gynecologic cases, 2.515 ng/ml; and for patients with malignancies, 4.287 ng/ml. Specifically, there was no difference between the mean value of VEGF in patients with ovarian malignancies and the patients with benign gynecological tumors (P = 0.8823). Also, there was no difference between the mean value of VEGF in patients with ovarian malignancies and the control patients who did not have gynecological disease (P = 0.3110). Using the Mann–Whitney U-test, no significant differences were found between the three populations of this study. Based on our data, due to the lack of significant difference in mean serum VEGF values between patients with and without ovarian malignancies, we feel that serum VEGF cannot be used as a possible screening tool for ovarian cancer.

scholarly journals The effect of prophylactic bilateral salpingectomy on ovarian reserve in patients who underwent laparoscopic hysterectomy

2021 ◽  
Author(s):  
Shizhuo Wang ◽  
jiahui gu
Keyword(s):  
Ovarian Cancer ◽  
Ovarian Reserve ◽  
Premenopausal Women ◽  
Laparoscopic Hysterectomy ◽  
Ovarian Tumors ◽  
Reproductive Age ◽  
Control Group ◽  
Significant Difference ◽  
Bilateral Salpingectomy ◽  
The Impact

Abstract Background Bilateral salpingectomy has been proposed to reduce the risk of ovarian cancer, but it is not clear whether the surgery affects ovarian reserve. This study compares the impact of laparoscopic hysterectomy for benign disease with or without prophylactic bilateral salpingectomy on ovarian reserve. Methods Records were reviewed for 373 premenopausal women who underwent laparoscopic hysterectomy with ovarian reserve for benign uterine diseases. The serum anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and three-dimensional antral follicle count (AFC) were assessed before surgery and 3 and 9 months postoperatively to evaluate ovarian reserve. Patients were divided into two groups according to whether they underwent prophylactic bilateral salpingectomy. The incidence of pelvic diseases was monitored until the ninth month after surgery. Results There was no significant difference between the two surgery groups in terms of baseline AMH, E2, FSH, LH, and AFC (all P > 0.05). There was no difference in potential bias factors, including patient age, operative time, and blood loss (all P > 0.05). There was also no significant difference between the two groups 3 months after surgery with respect to AMH (P = 0.763), E2 (P = 0.264), FSH (P = 0.478), LH (P = 0.07), and AFC (P = 0.061). Similarly, there were no differences between groups 9 months after surgery for AMH (P = 0.939), E2 (P = 0.137), FSH (P = 0.276), LH (P = 0.07) and AFC (P = 0.066). At 9 months after the operation, no patients had malignant ovarian tumors. The incidences of benign ovarian tumors in the salpingectomy group were 0% and 2.68% at 3 and 9 months after surgery, respectively, and the corresponding values in the control group were 0% and 5.36%. The incidences of pelvic inflammatory disease in the salpingectomy group were 10.72% and 8.04% at 3 and 9 months after surgery, respectively, while corresponding values in the control group were 24.13% and 16.09%. Conclusion Prophylactic bilateral salpingectomy did not damage the ovarian reserve of reproductive-age women who underwent laparoscopic hysterectomy. Prophylactic bilateral salpingectomy might be a good method to prevent the development of ovarian cancer. Larger clinical trials with longer follow-up times are needed to further evaluate the risks and benefits.

scholarly journals Effect of IV Infusion of Magnesium Sulfate on Postoperative Pain after Spinal Anesthesia: A Prospective Randomized Trial

2021 ◽  
Author(s):  
Shubhi Singhal ◽  
Devang Bharti ◽  
Sangeeta Yadav ◽  
Nitin Hayaran
Keyword(s):  
Postoperative Pain ◽  
Magnesium Sulfate ◽  
Spinal Anesthesia ◽  
Lower Limb ◽  
Controlled Study ◽  
Control Group ◽  
Analgesic Requirement ◽  
Group I ◽  
Significant Difference ◽  
Vas Scores

Background: The current study attempts to evaluate the effect of intravenous (IV) infusion of magnesium sulfate during spinal anesthesia on postoperative pain and postoperative analgesic requirements in lower limb surgeries. Methods: In this double blind, randomized controlled study, 60 patients undergoing elective lower limb surgeries, were selected and randomly divided into two groups. Group I received isotonic saline and group II was administered magnesium sulfate 50 mg Kg-1 IV for 15 min and then 15 mg Kg-1 h-1 by continuous IV infusion till the end of surgery or 2 hours, whichever was earlier. Ramsay sedation scores, VAS scores for pain, time of first administration of rescue analgesic and total analgesic requirement were noted in both the groups. Results: Statistically significant difference was observed in the VAS score between the two groups at 1st, 2nd, 3rd, 6th, 9th and 12th hour intervals; with VAS scores being lower in the magnesium group (p<0.05). The mean time of first rescue analgesic requirement in control group was 144.00 mins, while in magnesium group was 246.00 mins (p<0.05). The total rescue analgesic requirement was found to be 251.67 mg and 181.67 mg at the end of 24 hours, in control and magnesium groups, respectively (p<0.05). Conclusion: This study demonstrates statistically significant lowering of postoperative VAS scores, delayed need of postoperative analgesia and reduced total postoperative analgesic requirement in patients receiving intraoperative IV magnesium sulfate compared to the control group. Magnesium sulfate did not cause sedation or any other significant adverse effect in the doses used in the study.

scholarly journals Acute Toxicity Test of Gedi (Abelmoschus manihot L.) Ethanol Leaves Extract to Histopatology of Liver Mice

MEDULA ◽  
2019 ◽  
Vol 6 (3) ◽  
Author(s):  
Mutmainna Mutmainna ◽  
Yenti Purnamasari ◽  
Parawansah Parawansah
Keyword(s):  
Treatment Group ◽  
Acute Toxicity ◽  
Liver Tissue ◽  
Histopathological Examination ◽  
Liver Cells ◽  
Control Treatment ◽  
Control Group ◽  
Group I ◽  
Significant Difference ◽  
Mice Liver

ABSTRACTBackground: Abelmoschus manihot L.are widely used  as a daily dish  of dishes and traditional medicine to treat various diseases. It contains alkaloids, triterpenoids, saponins, and flavonoids wich can be toxic agent at variable dose. Purpose: This study aimed determine the effect of ethanol extract of abelmoschus manihot L. on histopatologic image of mice liver tissue.  Methods: This is quasi experimental study  with post test only control group design. Fourty five mice  (mus musculus)  as the subject of this research, they divided into 5 groups, group I threated by 50 mg /kgBB extract, group II threated by 200 mg / kgBB extract, group III threated by 800 mg / kgBB extract, group IV threated by 3,200 mg / kgBB extract, and group V as negative control. Treatment was done for 14 days and terminated at next day for histopatology examination use them liver tissue. Result: Histopathological examination of liver cells within normal limits. In the treatment group of 50 mg liver tissue of mice who died during treatment on day 7 and day 10 showed liver tissue necrosis. In the treatment group of 200 mg and 800 mg of liver tissue showed the presence of liver cell necrosis, and cell boundaries appeared unclear. In the treatment group of 3200 mg liver tissue showed necrotic cells, lysi s cells, unclear  cell  boundaries  and  necrotic  cells  more  widely.Conclusion:  As  a  conclusion  there  an histopatologic changes of  microscopic examination of mice liver cells in the form of necrosis and, there is not significant difference in ALT and AST  between the control group.Keywords : Abelmoschus manihot L. extract, acute toxicity, liver histopathology

scholarly journals The Effect of Incorporating Different Concentrations of Octenidine Dihydrochloride on the Degree of Conversion of an Experimental Flowable Resin Composite

2021 ◽  
Vol 9 (D) ◽  
pp. 196-201
Author(s):  
Mahitab Mansour ◽  
Tarek Salah Hussein ◽  
Haidy Salem
Keyword(s):  
Antibacterial Agent ◽  
Resin Composite ◽  
Mean Value ◽  
Degree Of Conversion ◽  
Control Group ◽  
Experimental Conditions ◽  
Flowable Composite ◽  
Group I ◽  
Octenidine Dihydrochloride ◽  
Significant Difference

BACKGROUND: One of the important parameters in assessing the definitive physical, mechanical, and biological characteristics of resin composites is the degree of conversion (DC), as composite qualities have been proven to improve with increasing the DC after photo-polymerization. Besides, fracture or secondary caries are the most common causes of composite resin failure. Accordingly, this reflects the need of formulating dental restorative materials possessing antibacterial activity. AIM: This study was designed to incorporate different concentrations of a new antibacterial agent (Octenidine dihydrochloride [OCT]) into an experimentally formulated flowable resin composite and evaluate its DC. MATERIALS AND METHODS: Four groups were tested in this study; group I was used as the control group, it’s a commercially available flowable composite “Herculite Ultra Flowable”. Group II was an experimental flowable composite with no antibacterial agent. During the preparation of the experimental flowable resin composite material, OCT antibacterial agent was added to the filler in special dark containers at a concentration of 1% wt. and 1.5% wt. respectively, in groups III and IV. The DC was measured and compared to the commercially available resin composite using the Fourier Transform Infrared spectroscopy method. RESULTS: Results of the current study showed that the mean values of DC ranged between (70.37 and 48.7), where Group1 showed the highest mean value, followed by Group 2 than Group 3, Group 4 specimens had the lowest mean value. The data showed that there is a statistically significant difference between all the tested groups. However, the DC was still within the accepted ranges for dental use. CONCLUSION: Based on the results obtained within the experimental conditions of this study it may be stated that the inclusion of the antibacterial OCT 1% and 1.5% wt., into the flowable resin composite showed satisfactory results for the DC as it met the ADA requirements for clinical use.

scholarly journals CPH-I and HE4 Are More Favorable Than CA125 in Differentiating Borderline Ovarian Tumors from Epithelial Ovarian Cancer at Early Stages

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Zhiheng Wang ◽  
Xiang Tao ◽  
Chunmei Ying
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Menopausal Status ◽  
Ovarian Tumors ◽  
Cancer Antigen 125 ◽  
Borderline Ovarian Tumors ◽  
Early Stages ◽  
Pathological Subtype ◽  
Benign Ovarian Tumor ◽  
Significant Difference

Aim. To evaluate the diagnosis value of serum human epididymis protein 4 (HE4), cancer antigen 125 (CA125), the Risk of Ovarian Malignancy Algorithm (ROMA), and Copenhagen Index (CPH-I) at early stages for differentiating borderline ovarian tumors from epithelial ovarian cancer. Methods. We recruited 144 borderline ovarian tumors in FIGO stages I and II (BOT I+II), 108 epithelial ovarian cancers in FIGO stages I and II (EOC I+II), and 238 benign ovarian tumor patients with surgical treatment in the retrospective study. The concentration of HE4 and CA125 and the values of CPH-I and ROMA were assessed separately. Results. The HE4 level and ROMA and CPH-I values of EOC I+II were all higher than that of BOT I+II and benign groups whether in all, pre-, or postmenopausal groups (P<0.01). When distinguishing BOT I+II from EOC I+II, the AUC-ROC of CPH-I and HE4 were bigger than CA125 (P<0.001), while the CPH-I has the highest sensitivities in all and postmenopausal groups (78.7%, 85.1%), and HE4 has the highest specificity and PPV (90.91%, 88.64%) in postmenopausal groups. Under pathological stratification, HE4, ROMA, and CPH-I of the serous EOC I+II were higher than that of BOT I+II (P<0.001) and the AUC of the three indices were significantly bigger than CA125 (P<0.001). However, the concentration of HE4 and CA125 and the values of CPH-I and ROMA have no significant difference between the two endometrioid subgroups. The index with the highest sensitivity and NPV among the four indices of different pathological subtype groups was CPH-I, and the index with the highest specificities and PPV was HE4. Conclusion. CPH-I was more valuable than CA125 for differentiating BOT I+II from EOC I+II regardless of menopausal status, while HE4 might be better than CA125 for postmenopausal subgroups. HE4 and CPH-I were more favorable than CA125 for differentiating BOT I+II from EOC I+II in the case of unknown pathology or in serous type.

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