scholarly journals A study of serum homocysteine and serum vitamin B12 levels in patients with retinal vein occlusion and its correlation

2020 ◽  
Vol 6 (2) ◽  
pp. 192-196
Author(s):  
Abhay Amrit Lune ◽  
◽  
Nikhil Navneet Toshniwal ◽  
Radhika R Paranjpe ◽  
Neha Kulkarni ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Retinal Vein Occlusion ◽  
Serum Vitamin ◽  
Vein Occlusion ◽  
Serum Homocysteine

Vitamin B12 and Folate as Risk Factors for Retinal Vein Occlusion: A Meta-Analysis

2021 ◽  
Author(s):  
Dimitrios Kazantzis ◽  
Panagiotis Theodossiadis ◽  
Christos Kroupis ◽  
George Theodossiadis ◽  
Irini Chatziralli
Keyword(s):  
Vitamin B12 ◽  
Retinal Vein Occlusion ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Mean Difference ◽  
Serum Folate ◽  
Case Control Studies ◽  
Vein Occlusion ◽  
Pubmed Database ◽  
Significant Difference

Abstract Purpose To evaluate the association between serum vitamin B12/folate and retinal vein occlusion (RVO). Methods A comprehensive search of the PubMed database was performed, which identified 271 abstracts to be screened. Ten studies met our inclusion criteria and a meta-analysis of these comparative case-control studies was performed on the mean ± standard deviation serum vitamin B12 and folate levels, without language restrictions. Nine studies with 720 patients with RVO and 613 controls were included in the meta-analysis for vitamin B12, and 10 studies with 784 patients with RVO and 677 controls in the meta-analysis for folate. Results There was no statistically significant difference between patients with RVO and controls in serum vitamin B12 levels (mean difference: − 40.25 pg/mL, p = 0.28), either central RVO (mean difference: − 18.24 pg/mL, p = 0.71) or branch RVO (mean difference: − 23.56 pg/mL, p = 0.48). On the contrary, the plasma folate level was significantly lower in RVO patients than in controls (mean difference: − 1.34 ng/mL, p = 0.001), as well as in patients with CRVO compared to controls (mean difference: − 1.48 ng/mL, p = 0.006), but not in BRVO patients (mean difference: − 0.72 ng/mL, p = 0.11). Conclusions RVO is associated with low serum folate levels, but not with serum vitamin B12 levels.

scholarly journals EFEK FORTIFIKASI VITAMIN B12 TERHADAP KADAR VITAMIN B12 SERUM DAN HOMOSISTEIN SERUM PADA VEGETARIAN

2020 ◽  
Vol 11 (1) ◽  
pp. 114-120
Author(s):  
Susianto Susianto
Keyword(s):  
Vitamin B12 ◽  
Homocysteine Level ◽  
Megaloblastic Anemia ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
Natural Sources ◽  
Serum Homocysteine ◽  
Microparticle Enzyme Immunoassay ◽  
B12 Deficiency ◽  
Community Trial

Introduction: Vegetarians consume plant-based foods with or without eggs and milk. Vegetarians are at risk of vitamin B12 deficiency, as natural sources of vitamin B12 are limited to animal-based foods. Vitamin B12 deficiency can lead to megaloblastic anemia, nerve damage and increase homocysteine level. Higher homocysteine level can increase the risk of coronary heart disease and stroke. The objective of this study was to investigate the effect of vitamin B12 fortification on the level of serum vitamin B12 and homocysteine in vegetarian. Method: The research design was an experimental study, community trial. The samples were 42 vegetarians with vitamin B12 deficiency (< 156 pmol/L) selected from 118 vegetarians as members of Indonesia Vegetarian Society (IVS) Pekanbaru, treated by vitamin B12 fortified oatmeal for three months from March to June 2010.  Serum vitamin B12 and homocysteine were measured by electrochemiluminescent immunoassay and microparticle enzyme immunoassay method respectively. Result: Prevalence of vitamin B12 deficiency in vegetarian was 35.6%. Statistical analysis showed a significant increase of serum vitamin B12 from 124.6 to 284.6 pmol/L (p=0.001) and significant decrease of serum homocysteine from 20.1 to 15.1 µmol/L (p=0.001). Conclusion: Consumption of vitamin B12 fortified oatmeal increases the level of serum vitamin B12 and decreases the level of serum homocysteine significantly in vegetarian with vitamin B12 deficiency.

scholarly journals Dietary Intake and Status of Vitamin B12 in Slovenian Population

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 334
Author(s):  
Živa Lavriša ◽  
Hristo Hristov ◽  
Maša Hribar ◽  
Katja Žmitek ◽  
Anita Kušar ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Age Groups ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
High Serum ◽  
Health Concern ◽  
Dietary Vitamin ◽  
Serum Homocysteine ◽  
Daily Vitamin ◽  
B12 Deficiency

Vitamin B12 deficiency poses a health concern, especially in vulnerable populations. Dietary vitamin B12 intake was obtained by two 24 h dietary recalls and food propensity questionnaires in a representative Slovenian cross-sectional food consumption survey, SI.Menu (n = 1248 subjects; 10–74 years). For a subgroup of 280 participants, data on serum vitamin B12 were available through the Nutrihealth study. The estimated usual population-weighted mean daily vitamin B12 intakes were 6.2 µg (adults), 5.4. µg (adolescents), and 5.0 µg (elderly). Lower intakes were observed in females. Inadequate daily vitamin B12 intake (<4 µg) was detected in 37.3% of adolescents, 31.7% of adults, and 58.3% elderlies. The significant predictors for inadequate daily vitamin B12 intake were physical activity score in all age groups, sex in adolescents and adults, financial status and smoking in elderly, and employment in adults. Meat (products), followed by milk (products), made the highest vitamin B12 contribution in all age groups. In adolescents, another important vitamin B12 contributor was cereals. The mean population-weighted serum vitamin B12 levels were 322.1 pmol/L (adults) and 287.3 pmol/L (elderly). Low serum vitamin B12 concentration (<148 nmol/L) and high serum homocysteine (>15 µmol/L) were used as criteria for vitamin B12 deficiency. The highest deficiency prevalence was found in elderlies (7.0%), particularly in males (7.9%). Factors associated with high serum homocysteine were also investigated. In conclusion, although vitamin B12 status was generally not critical, additional attention should be focused particularly to the elderly.

Cognitive impairment and vitamin B12: a review

2012 ◽  
Vol 24 (4) ◽  
pp. 541-556 ◽  
Author(s):  
Eileen Moore ◽  
Alastair Mander ◽  
David Ames ◽  
Ross Carne ◽  
Kerrie Sanders ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Vitamin B12 ◽  
Neurodegenerative Disease ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
Small Subset ◽  
High Dose ◽  
Serum Homocysteine ◽  
B12 Deficiency ◽  
Potential Impact

ABSTRACTBackground: This review examines the associations between low vitamin B12 levels, neurodegenerative disease, and cognitive impairment. The potential impact of comorbidities and medications associated with vitamin B12 derangements were also investigated. In addition, we reviewed the evidence as to whether vitamin B12 therapy is efficacious for cognitive impairment and dementia.Methods: A systematic literature search identified 43 studies investigating the association of vitamin B12 and cognitive impairment or dementia. Seventeen studies reported on the efficacy of vitamin B12 therapy for these conditions.Results: Vitamin B12 levels in the subclinical low-normal range (<250 ρmol/L) are associated with Alzheimer's disease, vascular dementia, and Parkinson's disease. Vegetarianism and metformin use contribute to depressed vitamin B12 levels and may independently increase the risk for cognitive impairment. Vitamin B12 deficiency (<150 ρmol/L) is associated with cognitive impairment. Vitamin B12 supplements administered orally or parenterally at high dose (1 mg daily) were effective in correcting biochemical deficiency, but improved cognition only in patients with pre-existing vitamin B12 deficiency (serum vitamin B12 levels <150 ρmol/L or serum homocysteine levels >19.9 μmol/L).Conclusion: Low serum vitamin B12 levels are associated with neurodegenerative disease and cognitive impairment. There is a small subset of dementias that are reversible with vitamin B12 therapy and this treatment is inexpensive and safe. Vitamin B12 therapy does not improve cognition in patients without pre-existing deficiency. There is a need for large, well-resourced clinical trials to close the gaps in our current understanding of the nature of the associations of vitamin B12 insufficiency and neurodegenerative disease.

scholarly journals Assessment of risk factors, central foveal thickness, visual acuity outcome and therapeutic approach in retinal vein occlusion patients of different age groups: a retrospective record based study

2020 ◽  
Vol 7 (5) ◽  
pp. 1732
Author(s):  
Neepa R. Gohil ◽  
Vijay Mahadeo Shinde ◽  
Kaumudi K. Shinde
Keyword(s):  
Risk Factors ◽  
Visual Acuity ◽  
Retinal Vein Occlusion ◽  
Therapeutic Approach ◽  
Age Groups ◽  
Age Group ◽  
Foveal Thickness ◽  
Central Foveal Thickness ◽  
Vein Occlusion ◽  
Serum Homocysteine

Background: This study was conducted to investigate associated systemic diseases, other risk factors, visual prognosis, treatment approach and central foveal thickness in retinal vein occlusion patients of different age groups.Methods: This single centre, retrospective record based hospital study included patients with retinal vein occlusion presenting to ophthalmic department. All the records of 30 patients were reviewed and data was abstracted and analysed. Initial and final clinical parameters e.g. visual acuity, central foveal thickness, age-group distribution, risk factors, therapeutic approach were analysed.Results: Out of 30 patients, 19 patients were of age-group >50 years and 11 were <50 years. In present study, most common type of retinal vein occlusion (RVO) was ST- BRVO in both the groups. Most common association of RVO in group >50 years was hypertension (84%), and <50 years was hypertension (27.3%), raised lipid level (TG, cholesterol) (27%) and raised serum homocysteine. Patients with uncontrolled DM and hypertension (in our study, 2 patients) required multiple injections even after 4 months of follow-up. Age-group <50 years had better visual acuity and central foveal thickness at initial and final presentation. Raised serum homocysteine level associated with RVO in age-group <50 years (27.3%) versus age-group >50 years (5%).Conclusions: Patients with good control of systemic disorders with RVO shows significantly improved (p value<0.05) visual acuity and central foveal thickness, in both the age-groups. Patients of age group >50 years were more associated with systemic disorder e.g., hypertension and DM. Patients of age group <50 years were more associated with medical condition e.g. hyperlipidemia, raised serum homocysteine. In present study, single patient in age-group <50 years was associated only with sudden and severe dehydration. 

Vitamin B12 levels in patients with retinal vein occlusion and their relation with clinical outcome: a retrospective study

2022 ◽  
Author(s):  
Francesco Paciullo ◽  
Paola Santina Menduno ◽  
Davide Tucci ◽  
Anna Caricato ◽  
Carlo Cagini ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Clinical Outcome ◽  
Vitamin B12 ◽  
Retinal Vein Occlusion ◽  
Vein Occlusion

scholarly journals ANEMIA AND VITAMIN B12 DEFICIENCY IN ELDERLY.

2018 ◽  
Vol 11 (1) ◽  
pp. 402
Author(s):  
Zaozianlungliu Gonmei ◽  
Supriya Dwivedi ◽  
Gurudayal Singh Toteja ◽  
Karuna Singh ◽  
Naval Kishore Vikram ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Elderly Population ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Serum Homocysteine ◽  
B12 Deficiency ◽  
Prevalence Of Anemia

 Objective: The present study was carried out to assess the prevalence of anemia, vitamin B12 deficiency and hyperhomocysteinemia among elderly in slums of West Delhi.Methods: A cross-sectional study was carried out among 234 elderly aged 60 and above in slums of West Delhi. 5 ml blood was collected from 116 elderly and was analyzed for hemoglobin, Vitamin B12 and homocysteine. Anemia was defined as hemoglobin <130 g/L and <120 g/l for male and female, respectively, Vitamin B12 deficiency as serum Vitamin B12 <203 pg/ml and hyperhomocysteinemia as serum homocysteine >15 μmol/l.Results: The overall prevalence of anemia, Vitamin B12 deficiency, and hyperhomocysteinemia among elderly was 57.76%, 36.36%, and 57.57%, respectively. Among anemic elderly, 33.33% and 64.15% had Vitamin B12 deficiency and hyperhomocysteinemia, respectively.Conclusion: More than half of the elderly population was anemic, while one-third was having Vitamin B12 deficiency.

Lipid profile and serum folate, vitamin B12 and homocysteine levels in patients with retinal vein occlusion

2021 ◽  
Author(s):  
José Javier Napal Lecumberri ◽  
Paula González Bores ◽  
Alicia Cuesta Marín ◽  
Francisco Alejandro Caballero Avendaño ◽  
Jose Manuel Olmos Martínez ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Lipid Profile ◽  
Retinal Vein Occlusion ◽  
Serum Folate ◽  
Vein Occlusion
Sign in / Sign up

Export Citation Format

Share Document