scholarly journals Aluminium Phosphide Poisoning - A Rare Case of Survival

2021 ◽  
Vol 8 (24) ◽  
pp. 2124-2126
Author(s):  
Chandrashekhar K ◽  
Seetaram N.K ◽  
Gayatri B.H ◽  
Ishwar S. Hasabi ◽  
Suryakanth N. Betageri

Aluminium phosphide (ALP) is a widely available pesticide. It is highly toxic when ingested, and can lead to refractory hypotension, acute respiratory distress syndrome (ARDS) and fatal arrhythmias.1 Management of aluminium phosphide toxicity is mainly supportive due to the fact that there is no specific antidote, so mortality with aluminium phosphide poisoning is very high, ranging from 37 % to 100 %.

2008 ◽  
Vol 114 (6) ◽  
pp. 403-412 ◽  
Author(s):  
Rafal Fudala ◽  
Agnieszka Krupa ◽  
Dorota Stankowska ◽  
Timothy C. Allen ◽  
Anna K. Kurdowska

ALI/ARDS (acute lung injury/acute respiratory distress syndrome) is a severe inflammatory lung disease associated with very high mortality. Importantly, no effective therapy has been developed to date for ALI/ARDS. Neutrophils have been implicated in the pathogenesis of ALI/ARDS, and IL-8 (interleukin-8) has been identified as the main chemotactic factor for neutrophils in lung fluids of patients with ALI/ARDS. Significantly, studies from our laboratory have revealed the presence of anti-IL-8 autoantibody:IL-8 immune complexes in lung fluids from patients with ALI/ARDS. Autoantibodies to several cytokines, including IL-8, have been found in human plasma and other tissues. The function of anticytokine autoantibodies is far from clear; however, in some instances, it has been suggested that such autoantibodies may contribute to the pathogenesis of variety of human diseases. In addition, many of these autoantibodies can form immune complexes with target cytokines. Furthermore, immune complexes consisting of anti-IL-8 autoantibodies and IL-8 are very stable due to the high affinity of autoantibodies against IL-8. These complexes are present in various human tissues, including the lung, as they have been detected in lung fluids from patients with ALI/ARDS. In this review, the significance of the latter findings are explored, and the possible involvement of anti-IL-8 autoantibody:IL-8 immune complexes in pathogenesis of ALI/ARDS is discussed.


2014 ◽  
Vol 21 (2) ◽  
pp. e31-e34 ◽  
Author(s):  
Ankit J. Kansagra ◽  
Eric Yang ◽  
Sudheer Nambiar ◽  
Pratik S. Patel ◽  
Monroe S. Karetzky

2013 ◽  
Vol 57 (6) ◽  
pp. 625
Author(s):  
Dheeraj Kapoor ◽  
Nitika Goel ◽  
Manpreet Singh ◽  
Jasveer Singh

2021 ◽  
Vol 10 (3) ◽  
pp. 209
Author(s):  
FahmiYousef Khan ◽  
ElmukhtarM Habas ◽  
RazaAli Akbar ◽  
TheebOsama Sulaiman

Sign in / Sign up

Export Citation Format

Share Document