Is Antibiotic Prophylaxis Necessary before Dental Implant Procedures in Patients with Orthopaedic Prostheses? A Systematic Review

As the population ages, more and more patients with orthopaedic prostheses (OPs) require dental implant treatment. Surveys of dentists and orthopaedic surgeons show that prophylactic antibiotics (PAs) are routinely prescribed with a very high frequency in patients with OPs who are about to undergo dental procedures. The present study aims to determine the need to prescribe prophylactic antibiotic therapy in patients with OPs treated with dental implants to promote their responsible use and reduce the risk of antimicrobial resistance. An electronic search of the MEDLINE database (via PubMed), Web of Science, LILACS, Google Scholar, and OpenGrey was carried out. The criteria used were those described by the PRISMA® Statement. No study investigated the need to prescribe PAs in patients with OPs, so four studies were included on the risk of infections of OPs after dental treatments with varying degrees of invasiveness. There is no evidence to suggest a relationship between dental implant surgeries and an increased risk of OP infection; therefore, PAs in these patients are not justified. However, the recommended doses of PAs in dental implant procedures in healthy patients are the same as those recommended to avoid infections of OPs.

Design of a Fully Integrated VHF CP-PLL Frequency Synthesizer with an All-Digital Defect-Oriented Built-In Self-Test.

This paper presents the design of an on-chip charge pump phase-locked loop (CP-PLL) with a fully digital defect oriented built-in self-test (BIST) for very-high frequency (VHF) applications. The frequency synthesizer has a 40 to 100 MHz tuning range and uses a ring voltage-controlled oscillator for frequency synthesis. The PLL exhibits a phase noise of -132 dBc/Hz at 1 MHz and consumes 1.8 mW on a 3 V supply. The BIST implementation uses fewer external input or output, is capable of efficient fault diagnosis, and is compact, posing a low area overhead. The integrated circuit design was realized in the AMI 0.6µ complementary metal oxide-semiconductor process.

Dynamical behavior of cardiac conduction system under external disturbances: simulation based on microcontroller technology

The heart rhythm is one of the most interesting aspects of the dynamic behavior of biological systems. Understanding heart rhythms is essential in the dynamic analysis of the heart. Each type of dynamic behaviour can describe normal or pathological physiology. The heart is made up of nodes ranging from SA node (natural pacemaker) to Purkinje fibers. The electric current originates in the sinus node and travels through the heart until it reaches the Purkinje fibers, causing after its passage through each of the nodes a heartbeat thus constituting the electrocardiogram (ECG). Since the origin of the electric current is the sinus node, in this article we study numerically and experimentally by microcontroller the influence of the sinus node on the propagation of electric current through the heart. A study of the sinus node in its autonomous state shows us that in their coupled state, the nodes of the heart qualitatively reproduce the time series of the action potential of this latter, which leads to the recording of the ECG. A study when the sinus node is subjected to periodic pulsed excitation E 1(t) = kP(t), assumed to come from blood pressure, with P(t) the blood pressure, shows that for some selected frequencies, it is found that the nodes of the heart and the ECG exhibit responses having the same shape and the same frequencies as those of the pulsatile blood pressure. This suggests the possibility of using such a conversion and excitation mechanism to replicate the functioning of cardiac conduction system. The chaotic analysis of the sinus node subjected to a sinusoidal type disturbance (E 0sin(ωt)) is also presented, it shows that in its chaotic state, the nodes of the heart, as well as the ECG, provide very high frequency signals. This requires the control of the sinus node (natural pacemaker) in such a situation

Large Scale System for Social Media Data Warehousing

Social media data become an integral part in the business data and should be integrated into the decisional process for better decision making based on information which reflects better the true situation of business in any field. However, social media data are unstructured and generated in very high frequency which exceeds the capacity of the data warehouse. In this work, we propose to extend the data warehousing process with a staging area which heart is a large scale system implementing an information extraction process using Storm and Hadoop frameworks to better manage their volume and frequency. Concerning structured information extraction, mainly events, we combine a set of techniques from NLP, linguistic rules and machine learning to succeed the task. Finally, we propose the adequate data warehouse conceptual model for events modeling and integration with enterprise data warehouse using an intermediate table called Bridge table. For application and experiments, we focus on drug abuse events extraction from Twitter data and their modeling into the Event Data Warehouse.

A Phylogenetic Approach to the Uneven Global Distribution of the COVID-19 Pandemic

A possible role of Y chromosomal haplogroups in COVID-19 mortality is discussed without claiming causality. The mortality of COVID-19 seems unequally distributed in different populations and statistically significant regional covariation is presented between COVID-19 mortality and the haplogroup Y-R1b. Y-R1b is suggested as a possible marker for mortality in the first wave of the pandemic affecting the Western Europe. September 2020 the pandemic involved also Eastern Europe severely in a second wave, while South East Asia, with a very high frequency of Y-0, had strikingly low COVID-19 mortality rate. Eastern Europe is dominated by Y-haplogroups (i.e., Y-R1a), with close ancestry to Y-R1b. Molecular mechanisms mediated by the Y chromosome involved in COVID-19 mortality are discussed, presenting a possible role of KDM5D in androgen receptor modulation and regulation of TMPRSS2 known to enable SARS-CoV-2 binding to ACE2 and facilitating virus entrance into the cell and virus replication. Sex bias and comorbidities point at the role of variations in the Y-chromosomal phylogeny.

Ab-initio simulation of hydrogenated graphene properties

Ab-initio simulation of hydrogenated graphene properties was performed. At present, graphene is considered one of the most promising materials for the formation of new semiconductor devices with good characteristics. Graphene has been the subject of many recent investigations due to its peculiar transport, mechanical and others properties [1]. The chemical modification of graphene named as graphane has recently entered the investigation as a possible candidate to solve problems connected with the lack of a graphene bandgap. Graphane is a compound material consisting of two-dimensional graphene bonded by some atoms of hydrogen. The investigation shows that graphane has the three valley Г-М-K band structure with the Г valley, which has the smallest energy gap between the conductivity zone and the valence zone. The calculation of relative electron masses and non-parabolic coefficients in Г, М and K valleys was performed. Based on the obtained characteristics, it is possible to implement a statistical multi-particle Monte Carlo method to determine the characteristics of electron transfer in heterostructure semiconductor devices. A research on modified graphene structures is important for fundamental science and technological applications in high-speed transistor structures operating in the microwave and very high frequency ranges.

DEPRESSION AND ANXIETY AMONG PATIENTS SEEKING RHINOPLASTY

Objective: To evaluate the presence and relation of depression and anxiety among patients seeking rhinoplasty Study Design: A cross-sectional study. Place and Duration of Study: Departments of Psychiatry, department of Plastic Surgery and ENT, Combined Military Hospital Multan, from Jan 2019 to Mar 2020. Methodology: A total of 102 patients were recruited that reported to Plastic surgery and ENT unit. Patients were divided equally in two groups of 51 each. One group included patients seeking rhinoplasty while other group included those patients that reported in Plastic surgery and ENT unit for reasons other than rhinoplasty. Symptom were assessed using Beck Depressive Inventory for depression and Beck Anxiety Inventory for anxiety. Results: A total of 102 participants were included in the study, of these 51 were patients seeking rhinoplasty and 51 were controls. Significant correlation exist between anxiety and depression (p<0.00). Conclusion: There is a very high frequency of anxiety and depression among patients seeking Rhinoplasty along with significant positive correlation.

Design and Implementation of High Directivity Directional Coupler at VHF Band Using Grounding Composed of Strip Lines Technics

This paper proposes a design of high directivity directional coupler (D.C) based on grounding composed of strip lines for high power Radar transmitter at Very High Frequency (VHF), (150 – 200 MHz). The directional coupler is used to check and verify the transmitter output high power, frequency, and reflected signal from an antenna connected with the Radar transmitter. The performance requirements of directional couplers are a strong coupling to reduce the effect on the transmitted output power and high directivity to suppress the interference of the reflected signal from the antenna. So far, various architectures have been proposed to gain high directivity, and there have been many studies used to obtain a strong coupling and higher directivity. However, the conventional architecture of the directional coupler has a directivity of only about 20 dB, and there have been difficulties to achieve the higher directivity of more than 20 dB. In this paper, the proposed architecture of directional coupler based on grounding composed of strip lines is discussed and compares the test results of the proposed directional coupler with the conventional one. The high directivity directional coupler is designed using a computer-aided design Simulation program; Advance Design System (ADS 2016), using Rogers 4003 substrate. The directional coupler was fabricated on printed circuit board (PCB) technology and measured using a vector network analyzer (VNA). The results show that the proposed directional coupler has directivity between -25 to -24 dB inside the working bandwidth and is adequate for a high-power radar transmitter.