scholarly journals Inhibition of the platelet-derived growth factor receptor beta (PDGFRB) using gene silencing, crenolanib besylate, or imatinib mesylate hampers the malignant phenotype of mesothelioma cell lines

2017 ◽  
Vol 8 (1-2) ◽  
pp. 438-452 ◽  
Author(s):  
Ombretta Melaiu ◽  
Calogerina Catalano ◽  
Chiara De Santi ◽  
Monica Cipollini ◽  
Gisella Figlioli ◽  
...  
Keyword(s):  
Growth Factor ◽  
Gene Silencing ◽  
Imatinib Mesylate ◽  
Cell Lines ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Malignant Phenotype ◽  
Mesothelioma Cell ◽  
Receptor Beta

Imatinib mesylate for platelet-derived growth factor receptor-beta–positive Erdheim-Chester histiocytosis

Blood ◽  
2008 ◽  
Vol 111 (11) ◽  
pp. 5413-5415 ◽  
Author(s):  
Julien Haroche ◽  
Zahir Amoura ◽  
Frédéric Charlotte ◽  
Juan Salvatierra ◽  
Bertrand Wechsler ◽  
...  
Keyword(s):  
Growth Factor ◽  
Imatinib Mesylate ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Erdheim Chester ◽  
Receptor Beta

scholarly journals Computational analysis revealing that K634 and T681 mutations modulate the 3D-structure of PDGFR-β and lead to sunitinib resistance

RSC Advances ◽  
2017 ◽  
Vol 7 (60) ◽  
pp. 37612-37626 ◽  
Author(s):  
Vishal Nemaysh ◽  
Pratibha Mehta Luthra
Keyword(s):  
Endothelial Cells ◽  
Growth Factor ◽  
Blood Vessels ◽  
Computational Analysis ◽  
3D Structure ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Receptor Beta

Platelet-derived growth factor receptor-beta (PDGFR-β) is expressed by endothelial cells (ECs) of tumor-associated blood vessels and regulates primarily early hematopoiesis.

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