scholarly journals THERMODYNAMIC UNCERTAINTY RELATION AS A FUNDAMENTAL ASPECT OF QUANTUM THERMODYNAMICS

2018 ◽  
pp. 17-29
Author(s):  
Anton А. Artamonov ◽  
Еvgeny Plotnikov
Keyword(s):  
Transport Properties ◽  
Uncertainty Relation ◽  
Critical Role ◽  
Silicon Crystal ◽  
Experimental Studies ◽  
Fundamental Aspect ◽  
Quantum Computers ◽  
State Control ◽  
Quantum Thermodynamics ◽  
The Moment

The paper addresses physics of thermodynamic fluctuations in temperature and energy. These fluctuations are interrelated and, hence, can affect various micro- and macro systems. It is shown that the thermodynamic uncertainty relation must be taken into account in the physics of superconductivity, in quantum computations and other branches of science, where temperature and energy fluctuations play a critical role. One of the most important applications of quantum thermodynamics is quantum computers. It is assumed that in the near future the state structures will create a specific quantum cryptocurrency obtained using quantum computing. The quantum cryptocurrency exhibits two main features: the maximum reliability (quantum protection against hacking threats) and the possibility of state control (at the moment, only large scientific state centers have quantum computers). The paper reviews the studies aimed to theoretically prove the validity of the thermodynamic uncertainty relation. This relation connects fluctuations in temperature and energy of a system. Other similar relations are considered, including the relationship between fluctuations in pressure and volume, in entropy and temperature, and others. The main purpose of the paper is to validate the thermodynamic analogue of the uncertainty relation that interconnects temperature and energy fluctuations. Experimental data was obtained on the basis of the study of the transport properties of semiconductor devices – transistors. In the experiment, the transport properties of a pair of semiconductor transistors placed on a single silicon crystal were studied. In this system, one transistor was used to determine temperature fluctuations, and the other one was employed to estimate energy fluctuations. The key role of the thermodynamic uncertainty relation in modern thermodynamics has been clarified. The performed experimental studies confirm the validity of the thermodynamic uncertainty relation.

Computational and experimental studies of the strength of full-scale samples of pipes with defects "metal loss" and "dent with groove"

2020 ◽  
Vol 10 (3) ◽  
pp. 226-233
Author(s):  
Dmitry A. Neganov ◽  
◽  
Victor M. Varshitsky ◽  
Andrey A. Belkin ◽  
◽  
...  
Keyword(s):  
Internal Pressure ◽  
Experimental Studies ◽  
Full Scale ◽  
The Other ◽  
Metal Loss ◽  
Calculation Methods ◽  
Reliable Operation ◽  
Sufficient Stability ◽  
Comparative Results ◽  
The Moment

The article contains the comparative results of the experimental and calculated research of the strength of a pipeline with such defects as “metal loss” and “dent with groove”. Two coils with diameter of 820 mm and the thickness of 9 mm of 19G steel were used for full-scale pipe sample production. One of the coils was intentionally damaged by machining, which resulted in “metal loss” defect, the other one was dented (by press machine) and got groove mark (by chisel). The testing of pipe samples was performed by applying static internal pressure to the moment of collapse. The calculation of deterioration pressure was carried out with the use of national and foreign methodical approaches. The calculated values of collapsing pressure for the pipe with loss of metal mainly coincided with the calculation experiment results based on Russian method and ASME B31G. In case of pipe with dent and groove the calculated value of collapsing pressure demonstrated greater coincidence with Russian method and to a lesser extent with API 579/ASME FFS-1. In whole, all calculation methods demonstrate sufficient stability of results, which provides reliable operation of pipelines with defects.

The capacity of short term memory from an evolutionary perspective

2019 ◽  
Author(s):  
Majid Manoochehri
Keyword(s):  
Short Term Memory ◽  
Memory Span ◽  
Critical Role ◽  
Experimental Studies ◽  
Cognitive System ◽  
Evolutionary Approach ◽  
Evolutionary Perspective ◽  
Short Term ◽  
Term Memory

Memory span in humans has been intensely studied for more than a century. In spite of the critical role of memory span in our cognitive system, which intensifies the importance of fundamental determinants of its evolution, few studies have investigated it by taking an evolutionary approach. Overall, we know hardly anything about the evolution of memory components. In the present study, I briefly review the experimental studies of memory span in humans and non-human animals and shortly discuss some of the relevant evolutionary hypotheses.

Role of Platelet-Activating Factor in Cardiovascular Pathophysiology

2000 ◽  
Vol 80 (4) ◽  
pp. 1669-1699 ◽  
Author(s):  
Giuseppe Montrucchio ◽  
Giuseppe Alloatti ◽  
Giovanni Camussi
Keyword(s):  
Cardiovascular System ◽  
Cell Biology ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Critical Role ◽  
Experimental Studies ◽  
Platelet Activating Factor ◽  
Biologically Active ◽  
Endothelial Cell Migration

Platelet-activating factor (PAF) is a phospholipid mediator that belongs to a family of biologically active, structurally related alkyl phosphoglycerides. PAF acts via a specific receptor that is coupled with a G protein, which activates a phosphatidylinositol-specific phospholipase C. In this review we focus on the aspects that are more relevant for the cell biology of the cardiovascular system. The in vitro studies provided evidence for a role of PAF both as intercellular and intracellular messenger involved in cell-to-cell communication. In the cardiovascular system, PAF may have a role in embryogenesis because it stimulates endothelial cell migration and angiogenesis and may affect cardiac function because it exhibits mechanical and electrophysiological actions on cardiomyocytes. Moreover, PAF may contribute to modulation of blood pressure mainly by affecting the renal vascular circulation. In pathological conditions, PAF has been involved in the hypotension and cardiac dysfunctions occurring in various cardiovascular stress situations such as cardiac anaphylaxis and hemorrhagic, traumatic, and septic shock syndromes. In addition, experimental studies indicate that PAF has a critical role in the development of myocardial ischemia-reperfusion injury. Indeed, PAF cooperates in the recruitment of leukocytes in inflamed tissue by promoting adhesion to the endothelium and extravascular transmigration of leukocytes. The finding that human heart can produce PAF, expresses PAF receptor, and is sensitive to the negative inotropic action of PAF suggests that this mediator may have a role also in human cardiovascular pathophysiology.

Causal mediation in developmental science: A primer

2021 ◽  
pp. 016502542098164
Author(s):  
Jorge Cuartas ◽  
Dana Charles McCoy
Keyword(s):  
Best Practices ◽  
Mediation Analysis ◽  
Critical Role ◽  
Experimental Studies ◽  
Developmental Theory ◽  
Potential Outcomes ◽  
Mediation Effects ◽  
Causal Mediation ◽  
Developmental Science ◽  
Potential Outcomes Framework

Mediation has played a critical role in developmental theory and research. Yet, developmentalists rarely discuss the methodological challenges of establishing causality in mediation analysis or potential strategies to improve the identification of causal mediation effects. In this article, we discuss the potential outcomes framework from statistics as a means for highlighting several fundamental challenges of establishing causality in mediation analysis, including the difficulty of meeting the key assumption of sequential ignorability, even in experimental studies. We argue that this framework—which, although commonplace in other fields, has not yet been taken up in developmental science—can inform solutions to these challenges. Based on the framework, we offer a series of recommendations for improving causal inference in mediation analysis, including an overview of best practices in both study design and analysis, as well as resources for conducting analysis. In doing so, our overall objective in this article is to support the use of rigorous methods for understanding questions of mechanism in developmental science.

CONTROL SYSTEM FOR NEEDLE INSERTION INTO THE PERIPHERAL VENOUS VESSEL

2021 ◽  
pp. 122-125
Author(s):  
Екатерина Александровна Витоженц ◽  
Александр Викторович Кобелев
Keyword(s):  
Experimental Studies ◽  
Needle Insertion ◽  
Tissue Type ◽  
Mixed System ◽  
Injection Needle ◽  
Recorded Signal ◽  
Venous Puncture ◽  
Complex Design ◽  
The Moment ◽  
Venous Vessel

Предложен новый способ контроля введения инъекционной иглы в просвет вены на основе измерений электрического импеданса с помощью смешанной системы электродов, состоящей из биполярного и тетраполярного звеньев. Исследованы альтернативные схемы расположения электродов при проведении контроля венозной пункции биоимпедансным методом - они имеют более сложную конструкцию, используют дорогостоящие специализированные коаксиальные иглы, не позволяют однозначно определить факт прокола стенки венозного сосуда, нуждаются в дополнительной фильтрации регистрируемого сигнала с целью корректной интерпретации результата. Эффективность предложенной методики проверялась в ходе экспериментальных исследований на 5 добровольцах. Результаты экспериментов позволили идентифицировать 4 стадии нахождения инъекционной иглы относительно верхней конечности: нет касания, касание кожного покрова, нахождение под кожей коже, попадание в просвет вены. Идентификация положений инъекционной иглы происходит в реальном времени без дополнительной фильтрации регистрируемого сигнала. Метод позволяет обнаружить момент прокола стенки венозного сосуда стандартной инъекционной иглой, что в дальнейшем позволит сэкономить на изготовлении специализированных многослойных игольчатых электродов и внедрить данный способ контроля за проведением венепункции в медицинскую практику. Дальнейшее развитие предложенного подхода предполагает идентификацию двойного прокола вены, дифференцирование типа ткани в процессе введения иглы и исследование возможности определения типа кровеносного сосуда A new method for controlling the penetration of an injection needle into the vein based on measurements of electrical impedance using a mixed system of electrodes consisting of bipolar and tetrapolar parts is proposed. Alternative schemes for the arrangement of electrodes for monitoring venous puncture using the bioimpedance method have been investigated - they have a more complex design, use expensive specialized coaxial needles, do not allow to unambiguously determine the fact of a puncture of the venous vessel wall, require additional filtering of the recorded signal in order to correctly interpret the result. The effectiveness of the proposed technique was tested in experimental studies on 5 volunteers. The results of the experiments made it possible to identify 4 stages of finding the injection needle relative to the upper limb: no touching, touching the skin, being under the skin of the skin, getting into the lumen of the vein. Identification of the positions of the injection needle occurs in real time without additional filtering of the recorded signal. The method allows detecting the moment of puncture of the wall of a venous vessel with a standard injection needle, which in the future will save on the manufacture of specialized multilayer needle electrodes and introduce this method of monitoring venipuncture into medical practice. Further development of the proposed approach involves the identification of a double vein puncture, differentiation of tissue type during needle insertion, and investigation of the possibility of determining the type of blood vessel

scholarly journals Estimates of Michaelis-Menten Constants for the Two Membranes of the Brain Endothelium

1984 ◽  
Vol 4 (2) ◽  
pp. 241-249 ◽  
Author(s):  
Albert Gjedde ◽  
Ove Christensen
Keyword(s):  
Steady State ◽  
Endothelial Cell ◽  
Transport Properties ◽  
Glucose Transport ◽  
Cell Membranes ◽  
Experimental Studies ◽  
Facilitated Diffusion ◽  
Capillary Endothelial Cells ◽  
The Individual ◽  
Tracer Experiments

Tracer studies on facilitated diffusion across the blood–brain barrier lead to the calculation of Michaelis-Menten constants that describe the rate of transport. However, the barrier consists of two endothelial cell membranes, and the relevance of single Michaelis-Menten constants in relation to the two cell membranes is unknown. We have formulated a model of two endothelial cell membranes and show that the measured Michaelis-Menten constants are simple functions of the properties of the individual membranes when transport across the endothelium is rapid ( P1 > 10−6 cm s−1). We also show that the Michaelis-Menten constants determined in tracer experiments describe facilitated diffusion in the steady state only if the two membranes have similar transport properties. As an application of this observation, we have examined three experimental studies that measure glucose transport in the steady state and show that the Michaelis-Menten constants for glucose transport calculated from the tracer experiments are equal to the constants calculated from the steady-state experiments. We conclude that the luminal and abluminal membranes of brain capillary endothelial cells have equal glucose transport properties.

scholarly journals Investigation of the structure of cement conglomerates

2021 ◽  
Vol 266 ◽  
pp. 03005
Author(s):  
D. N. Shabanov ◽  
E. Trambitsky ◽  
E. Borovkova
Keyword(s):  
Strain State ◽  
Residual Life ◽  
Experimental Studies ◽  
Cement Stone ◽  
Virtual Model ◽  
Structural Studies ◽  
Acoustic Sensors ◽  
Cement Pastes ◽  
The Moment ◽  
Physical And Chemical

This article describes the structural studies of a cement conglomerate, its evolution from the moment of formation to the loss of operational properties. Physical and chemical phenomena and interactions of various elements of cement stone are considered. The study of its rheology includes creating a virtual model and monitoring the formation of the structure of cement pastes by acoustic emission (AE). The results of combined experimental studies to determine the residual life of cement stone samples using AE and tensometry methods are presented. The authors created a complex for monitoring the stress-strain state of artificial conglomerates, which includes both internal and acoustic sensors.

scholarly journals The Anti-Neuroinflammatory Effect of Fuzi and Ganjiang Extraction on LPS-Induced BV2 Microglia and Its Intervention Function on Depression-Like Behavior of Cancer-Related Fatigue Model Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Songwei Yang ◽  
Yantao Yang ◽  
Cong Chen ◽  
Huiqin Wang ◽  
Qidi Ai ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Inflammatory Mediators ◽  
Critical Role ◽  
Chinese Herb ◽  
Experimental Studies ◽  
Research Results ◽  
Cancer Related Fatigue

The Chinese herb couple Fuzi and Ganjiang (FG) has been a classic combination of traditional Chinese medicine that is commonly used clinically in China for nearly 2000 years. Traditional Chinese medicine suggests that FG can treat various ailments, including heart failure, fatigue, gastrointestinal upset, and depression. Neuroinflammation is one of the main pathogenesis of many neurodegenerative diseases in which microglia cells play a critical role in the occurrence and development of neuroinflammation. FG has been clinically proven to have an efficient therapeutic effect on depression and other neurological disorders, but its mechanism remains unknown. Cancer-related fatigue (CRF) is a serious threat to the quality of life of cancer patients and is characterized by both physical and psychological fatigue. Recent studies have found that neuroinflammation is a key inducement leading to the occurrence and development of CRF. Traditional Chinese medicine theory believes that extreme fatigue and depressive symptoms of CRF are related to Yang deficiency, and the application of Yang tonic drugs such as Fuzi and Ganjiang can relieve CRF symptoms, but the underlying mechanisms remain unknown. In order to define whether FG can inhibit CRF depression-like behavior by suppressing neuroinflammation, we conducted a series of experimental studies in vitro and in vivo. According to the UPLC-Q-TOF/MSE results, we speculated that there were 49 compounds in the FG extraction, among which 30 compounds were derived from Fuzi and 19 compounds were derived from Ganjiang. Our research data showed that FG can effectively reduce the production of pro-inflammatory mediators IL-6, TNF-α, ROS, NO, and PGE2 and suppress the expression of iNOS and COX2, which were related to the inhibition of NF-κB/activation of Nrf2/HO-1 signaling pathways. In addition, our research results revealed that FG can improve the depression-like behavior performance of CRF model mice in the tail suspension test, open field test, elevated plus maze test, and forced swimming test, which were associated with the inhibition of the expression of inflammatory mediators iNOS and COX2 in the prefrontal cortex and hippocampus of CRF model mice. Those research results suggested that FG has a satisfactory effect on depression-like behavior of CRF, which was related to the inhibition of neuroinflammation.

scholarly journals Satellite Inertia Parameters Estimation Based on Extended Kalman Filter

2019 ◽  
Author(s):  
Abdellatif Bellar ◽  
Mohammed Arezki Si Mohammed
Keyword(s):  
Kalman Filter ◽  
Extended Kalman Filter ◽  
Critical Role ◽  
Low Earth Orbit ◽  
Parameters Estimation ◽  
Moment Of Inertia ◽  
Satellite Mission ◽  
Inertia Matrix ◽  
Inertia Parameters ◽  
The Moment

The moment of inertia parameters play a critical role in assuring the spacecraft mission throughout its lifetime. However, determination of the moment of inertia is a key challenge in operating satellites. During satellite mission, those parameters can change in orbit for many reasons such as sloshing, fuel consumption, etc. Therefore, the inertia matrix should be estimated in orbit to enhance the attitude estimation and control accuracy. This paper investigates the use of gyroscope to estimate the attitude rate and inertia matrix for low earth orbit satellite via extended Kalman filter. Simulation results show the effectiveness and advantages of the proposed algorithm in estimating these parameters without knowing the nominal inertia. The robustness of the proposed algorithm has been validated using the Monte-Carlo method. The obtained results demonstrate that the accuracy of the estimated inertia and angular velocity parameters is satisfactory for satellite with coarse accuracy mission requirements. The proposed method can be used for different types of satellites.

scholarly journals Can Hypoxic Conditioning Improve Bone Metabolism? A Systematic Review

2019 ◽  
Vol 16 (10) ◽  
pp. 1799 ◽  
Author(s):  
Marta Camacho-Cardenosa ◽  
Alba Camacho-Cardenosa ◽  
Rafael Timón ◽  
Guillermo Olcina ◽  
Pablo Tomas-Carus ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Critical Role ◽  
Hypoxia Inducible Factor ◽  
Experimental Studies ◽  
Hormonal Responses ◽  
Hypoxia Exposure ◽  
Ambient Oxygen ◽  
The Impact

Among other functions, hypoxia-inducible factor plays a critical role in bone–vascular coupling and bone formation. Studies have suggested that hypoxic conditioning could be a potential nonpharmacological strategy for treating skeletal diseases. However, there is no clear consensus regarding the bone metabolism response to hypoxia. Therefore, this review aims to examine the impact of different modes of hypoxia conditioning on bone metabolism. The PubMed and Web of Science databases were searched for experimental studies written in English that investigated the effects of modification of ambient oxygen on bone remodelling parameters of healthy organisms. Thirty-nine studies analysed the effect of sustained or cyclic hypoxia exposure on genetic and protein expression and mineralisation capacity of different cell models; three studies carried out in animal models implemented sustained or cyclic hypoxia; ten studies examined the effect of sustained, intermittent or cyclic hypoxia on bone health and hormonal responses in humans. Different modes of hypoxic conditioning may have different impacts on bone metabolism both in vivo and in vitro. Additional research is necessary to establish the optimal cyclical dose of oxygen concentration and exposure time.

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