scholarly journals Soy-enriched bread, a pilot study to determine its beneficial effects in menopause

2021 ◽  
Author(s):  
Daniela Giustarini ◽  
Comasia Ricci ◽  
Ilaria Ceccarelli ◽  
Stefano Pieretti ◽  
Paolo Andre ◽  
...  
Keyword(s):  
Experimental Tests ◽  
The Body ◽  
Many Body ◽  
Beneficial Effects ◽  
Regular Consumption ◽  
Aging Women ◽  
Before And After ◽  
Quality Of Life Index ◽  
Antioxidant Parameters ◽  
History Of

Menopause is the last step in the reproductive history of a woman. The ovaries stop producing hormones and the body reacts by lowering its functions, including the neuronal one. Phytoestrogens are plant products with estrogen-like activity able to affect many body functions. The aim of the present experiment was to study the effects of 30 days of regular consumption of a soy-enriched bread containing a known amount of phytoestrogens (genistein and daidzein). Women at climacteric, within 5 years or more than 5 years of menopause, were asked to include in their diet 200 g/day of a bread containing 40 mg of phytoestrogens. The effect on common menopausal symptoms and neurophysiological, hormonal and antioxidant parameters were determined before and after 30 days through questionnaires and experimental tests. Phytoestrogens were measured in the urine. In all groups, there was a significant increase of phytoestrogens in the urine and a decrease of the classical symptoms of menopause as well as a significant improvement in attentional performance tests, the quality of life index and pain intensity. Phytoestrogens present in the soy-enriched bread, are an important supplement in aging women due to their ability to induce estrogen-like effects without the potential side effects of estrogens.

scholarly journals THE VALUE OF PENICILLIN IN THE TREATMENT OF AGRANULOCYTOSIS CAUSED BY THIOURACIL

Blood ◽  
1946 ◽  
Vol 1 (1) ◽  
pp. 53-66 ◽  
Author(s):  
MARY CATHERINE TYSON ◽  
PETER VOGEL ◽  
NATHAN ROSENTHAL
Keyword(s):  
Bone Marrow ◽  
Antibacterial Agents ◽  
Bone Marrow Cells ◽  
The Body ◽  
Bacterial Invasion ◽  
Beneficial Effects ◽  
Penicillin Therapy ◽  
History Of ◽  
Per Se ◽  
Hemopoietic System

Abstract Thiouracil has been found to be an effective drug in the treatment of hyperthyroidism. Agranulocytosis following its use occurred in nine cases, four of which terminated fatally. In five others a complete and rapid recovery took place following penicillin therapy. The latter drug is believed to be ideal for all cases of agranulocytosis, and especially those in which chemotherapy has been used and may have been responsible for the condition. Thus far we have not seen any report of any untoward effect on the hemopoietic system from the use of penicillin. The use of antibacterial agents for the treatment of agranulocytosis was suggested by Dameshek and Wolfson21 in 1942. It was believed by these authors that patients with agranulocytosis died not of the leukopenia per se but of the sepsis which developed secondarily to the lack of granulocytes. Two very severe cases of aminopyrine agranulocytosis treated with sulfathiazole made complete recoveries. For the treatment of sulfonamide agranulocytosis, it was suggested that a preparation differing from that which had already been used be given. With the discovery of penicillin, and its complete lack of possible deleterious effect on the bone marrow, its use was suggested by Dameshek17 (1944). A report on the beneficial effects of this medication in a case of sulfonamide agranulocytosis was later reported by Dameshek and Knowlton18 and similar cases by Sprague and Ferguson19 and by Meredith and Fink.20 Since sulfonamides may cause further toxic effect on the bone marrow, we feel that their use should be avoided in the treatment of agranulocytosis, especially where a history of previous use is obtained. We do not agree with others21, 22 who continue the use of sulfonamides in the treatment of leukopenia or agranulocytosis where these very drugs may have been responsible for the condition. It would seem better judgment to use penicillin, which by combating the bacterial invasion of the body and the consequent toxemia enables the patient to survive until the bone marrow cells regenerate.

scholarly journals Exercise Induced Adipokine Changes and the Metabolic Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Saeid Golbidi ◽  
Ismail Laher
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
The Body ◽  
Beneficial Effects ◽  
The Metabolic Syndrome ◽  
Before And After ◽  
Inflammatory State ◽  
Exercise Induced

The lack of adequate physical activity and obesity created a worldwide pandemic. Obesity is characterized by the deposition of adipose tissue in various parts of the body; it is now evident that adipose tissue also acts as an endocrine organ capable of secreting many cytokines that are though to be involved in the pathophysiology of obesity, insulin resistance, and metabolic syndrome. Adipokines, or adipose tissue-derived proteins, play a pivotal role in this scenario. Increased secretion of proinflammatory adipokines leads to a chronic inflammatory state that is accompanied by insulin resistance and glucose intolerance. Lifestyle change in terms of increased physical activity and exercise is the best nonpharmacological treatment for obesity since these can reduce insulin resistance, counteract the inflammatory state, and improve the lipid profile. There is growing evidence that exercise exerts its beneficial effects partly through alterations in the adipokine profile; that is, exercise increases secretion of anti-inflammatory adipokines and reduces proinflammatory cytokines. In this paper we briefly describe the pathophysiologic role of four important adipokines (adiponectin, leptin, TNF-α, and IL-6) in the metabolic syndrome and review some of the clinical trials that monitored these adipokines as a clinical outcome before and after exercise.

scholarly journals Effects of acute caffeine, theanine and tyrosine supplementation on mental and physical performance in athletes

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Javier Zaragoza ◽  
Grant Tinsley ◽  
Stacie Urbina ◽  
Katelyn Villa ◽  
Emily Santos ◽  
...  
Keyword(s):  
Physical Performance ◽  
Linear Models ◽  
Dynamic Testing ◽  
Collegiate Athletes ◽  
Performance Testing ◽  
The Body ◽  
Double Blind ◽  
Movement Accuracy ◽  
Beneficial Effects ◽  
Before And After

Abstract Background A limited amount of research has demonstrated beneficial effects of caffeine and theanine supplementation for enhancement of mental performance. The purpose of this investigation was to determine whether the acute ingestion of a supplement containing caffeine, theanine and tyrosine improves mental and physical performance in athletes. Methods Twenty current or former male collegiate athletes (age: 20.5 ± 1.4 y; height: 1.82 ± 0.08 m; weight: 83.9 ± 12.6 kg; body fat: 13.8 ± 5.6%) completed this randomized, double-blind, placebo-controlled crossover trial. After familiarization, each participant completed two identical testing sessions with provision of a proprietary dietary supplement (SUP) containing caffeine theanine and tyrosine or a placebo (PL). Within each testing session, participants completed assessments of mental and physical performance before and after provision of SUP or PL, as well as after two rounds of exercise. Assessments were performed using a performance testing device (Makoto Arena) that evaluated multiple aspects of mental and physical performance in response to auditory and visual stimuli. Testing was performed both with the body in a static position and during dynamic movement. General linear models were used to evaluate the effects of SUP and PL on performance. Results Changes in movement accuracy during performance assessment were greater following SUP ingestion as compared to PL for both static and dynamic testing (SUP: + 0.4 to 7.5%; PL: − 1.4 to 1.4% on average; p < 0.05). For dynamic testing, the change in number of targets hit was higher and the change in average hit time was lower with SUP as compared to PL (p < 0.05). However, there were no differences between conditions for the changes in number of targets hit or average hit time during static testing. There were no differences in changes of subjective variables during either condition, and performance measures during the two rounds of exercise did not differ between conditions (p > 0.05). Discussion The present results indicate that a combination of a low-dose of caffeine with theanine and tyrosine may improve athletes’ movement accuracy surrounding bouts of exhaustive exercise without altering subjective variables. Based on this finding, supplementation with caffeine, theanine and tyrosine could potentially hold ergogenic value for athletes in sports requiring rapid and accurate movements. Trial registration NCT03019523. Registered 24 January 2017.

scholarly journals Brief Training in Mindfulness Meditation Reduces Symptoms in Patients with a Chronic or Recurrent Lifetime History of Depression: A Randomized Controlled Study

2017 ◽  
Author(s):  
Emilia Winnebeck ◽  
Maria Fissler ◽  
Matti Gärtner ◽  
Paul Chadwick ◽  
Thorsten Barnhofer
Keyword(s):  
Mindfulness Meditation ◽  
Controlled Study ◽  
Stress Buffering ◽  
Beneficial Effects ◽  
Lifetime History ◽  
Brief Training ◽  
Treatment Of Depression ◽  
Before And After ◽  
History Of ◽  
To Receive

Background: Training in mindfulness has been introduced to the treatment of depression as a means of relapse prevention. However, from a stress-buffering perspective, mindfulness techniques would be expected to unfold their beneficial effects particularly in those who are currently suffering from symptoms. This study investigated whether a brief and targeted mindfulness-based intervention can reduce symptoms in acutely depressed patients.Methods: Seventy-four patients with a chronic or recurrent lifetime history were randomly allocated to receive either a brief mindfulness-based intervention (MBI) encompassing three individual sessions and regular home practice or a control condition that combined psycho-educational components and regular rest periods using the same format as the MBI. Self-reported severity of symptoms, mindfulness in every day life, ruminative tendencies and cognitive reactivity were assessed before and after intervention.Results: Patients in the MBI condition showed pronounced and significantly stronger reductions in symptoms than those in the control condition. In the MBI group only, patients showed significant increases in mindfulness, and significant reductions in ruminative tendencies and cognitive reactivity.Conclusions: Findings are in line with a stress-buffering account of mindfulness and suggest that brief targeted mindfulness interventions can help to reduce symptoms in acutely depressed patients with chronic or recurrent lifetime history.

scholarly journals Effects of green tea and chamomile tea on plaque pH, salivary pH, Streptococcus mutans count

2017 ◽  
Vol 5 (04) ◽  
pp. 01-03
Author(s):  
M.A. Adil Ahmed ◽  
B. Pavani ◽  
Tasneem L. Tanzila ◽  
Gabby Dharshana S. Thanga ◽  
B. Thejaswini ◽  
...  
Keyword(s):  
Streptococcus Mutans ◽  
Green Tea ◽  
Test Results ◽  
Beneficial Effects ◽  
Regular Consumption ◽  
Plaque Ph ◽  
Significant Difference ◽  
Before And After ◽  
Interesting Alternative

Aim: Green tea is healthy beverage and is a part of our day to day life. Similarly, chamomile tea is known for its aspirin like properties. Beneficial effects of these tea includes protection against dental caries, periodontal disease and tooth loss and found that can a decrease in streptococcus mutans count as well as increase in pH. Hence the present study was to compare the pH of saliva and plaque, before and after the intake of green tea and to evaluate the role of green tea and chamomile tea on growth of s.mutans in culture using saliva. Material and Methods: Salivary samples were collected from 30 healthy individuals aged 20-30 years with certain criteria. The pH of saliva was determined by collecting samples before, immediately after and 15 min, 30 min after drinking tea using pH meter. Similarly the microbial colonies were also counted. The Data obtained were analyzed using Wilcoxon’s, Friedman's and Mann Whitney test. Results: There was statistically no significant difference between salivary streptococcus mutans count before and after (p 0.001) intake of green tea and chamomile tea. Conclusion: The result of the present study has proved that consumption of green tea and chamomile tea inhibit salivary Streptococcus mutans count and cause reduction of pH in saliva. So, it is advisable to encourage the regular consumption of this widely available, tasty and inexpensive beverage as an interesting alternative to other drinks.

scholarly journals BENEFICIAL EFFECTS OF TREATMENT WITH TOCILIZUMAB IN MODERATE TO CRITICALLY ILL COVID-19 PATIENTS

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
MA Rana ◽  
MS Hashmi ◽  
R Pervaiz ◽  
A Qayyum ◽  
MMU Saif ◽  
...  
Keyword(s):  
Critically Ill ◽  
Serum Ferritin ◽  
The Body ◽  
Rank Test ◽  
P Value ◽  
Beneficial Effects ◽  
Before And After ◽  
Interleukin 6 Receptor ◽  
Clinical Benefits ◽  
Signed Rank Test

Introduction: COVID-19 virus initiates an inflammatory response in the body involving many cytokines. Interluukin-6 (IL-6) is one of them, elevated levels of which found to be directly related to morbidity and mortality of infected patients. The aim of the current study was to evaluate the clinical benefits of Tocilizumab, a monoclonal antibody against interleukin-6 receptor, as a therapeutic agent for the treatment of Coronavirus disease 2019. Methods: The current retrospective study was conducted at Bahria Town International hospital from rom May 1st to 5th July 2020. Total of one twenty (n=120) moderate to severely ill patients (94 males and 26 females), infected with SARS-CoV-2 virus, were included to assess the effect of TOCILIZUMAB in improvement of PF ratio and other biochemical variables of prognostic importance, including CRP, serum ferritin levels, D-dimers and LDH. These parameters were compared before and after the ten days of treatment with tocilizumab. Demographic, laboratory and clinical finding were recorded for the feather analyses.  Statistical analysis was performed by using software SPSS version 21.0. The Wilcoxon signed‐rank test used to compare parameters whenever appropriate. A P‐value of less than .05 was considered statistically significant. Results: The results of our study showed statistically significant improvement in PF ratio and decrease in CRP levels. Other parameters such as D-Dimer, Serum ferritin levels and LDH showed no change before and after treatment with tocilizumab. Conclusion: In summary, TOCILIZUMAB improved the PF and CRP ratio in COVID-19 patients, but other markers did not improve in response to TOCILIZUMAB in critically ill COVID-19 patients.

scholarly journals The Quality of life of patients with morbid obesity before and after gastric banding and gastric bypass

2014 ◽  
Vol 11 (2) ◽  
pp. 13-16
Author(s):  
V Egiev ◽  
J Majorova ◽  
M Leont’yeva ◽  
A Meleshko
Keyword(s):  
Quality Of Life ◽  
Morbid Obesity ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Gastric Banding ◽  
The Body ◽  
Control Group ◽  
Before And After ◽  
Quality Of Life Index

In order to estimate the quality of life in bariatric surgery patients usually two scales are used: GIQLI (gastrointestinal Quality of life index) and BAROS (Bariatric analysis and reporting outcome system). In our work we used the original estimation of the quality of life, based on the questionnaire GIQLI. This questionnaire consists of two parts: universal and specific. For the estimation of the level of morbid obesity two main scores are utilized: overweight and the Body Mass Index (BMI). We estimated the quality of life of patients with morbid obesity before the operation (25 patients), after gastric banding (25 patients) and gastric bypass (25 patients). For the control group we show the answers for the same questionnaire of 26 volunteers without any chronic diseases, including morbid obesity. Gastric bypass was performed in patients with BMI more than 40 kg/m2, gastric banding was performed in patients with BMI less than 40 kg/m2. The median periods of supervising the patients after gastric bypass and gastric banding were 3±1,9 years and 4,3±1,7 years for each. After the surgery the percentage of reduction of the overweight was significantly higher in the patients after the gastric bypass. It means that the weight loss is more effective after gastric bypass than gastric banding. The index of the quality of life of the patients with the morbid obesity was much lower than in the control group (р0,05). After the surgical treatment all the scores increased in the group of the patients being operated on, than in the group of the patients with obesity before the operations (р0,05). While comparatively estimating the two operations we got practically the same results after gastric bypass and gastric banding. For gastric banding a very important index of the improvement of the quality of life is the level of the weight loss, but after the gastric bypass there were no such outcome.

A Primer on Walrasian Theories of Economic Behavior

1989 ◽  
Vol 11 (1) ◽  
pp. 1-24 ◽  
Author(s):  
Donald A. Walker
Keyword(s):  
Economic Analysis ◽  
General Equilibrium ◽  
Economic Behavior ◽  
The Body ◽  
Equilibrium Theory ◽  
The Other ◽  
General Equilibrium Theory ◽  
Before And After ◽  
History Of ◽  
Two Phases

The story of the body of economic analysis that were initiated by Léon Walras can be divided into developments before and after 1930. During the period before 1930 there were two phases to the story. The first was the seminal achievement of Walras. The second was the refinements and extensions made by the generation of Walrasian theorists that followed him. During the period after 1930 the story is also divided into two phases. One is the work that has been done on the type of Walrasian model in which there are no disequilibrium transactions. The other is the beginning of work on the behavior of general equilibrium systems in which disequilibrium transactions and production occur. These phases will be sketched very briefly with the objective of giving a beginner's introduction to some major aspects of the history of general equilibrium theory.

Beneficial effects of GLP-1 on endothelial function in humans: dampening by glyburide but not by glimepiride

2007 ◽  
Vol 293 (5) ◽  
pp. E1289-E1295 ◽  
Author(s):  
Ananda Basu ◽  
Nisha Charkoudian ◽  
William Schrage ◽  
Robert A. Rizza ◽  
Rita Basu ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Venous Occlusion ◽  
Family History Of Diabetes ◽  
Beneficial Effects ◽  
Before And After ◽  
History Of ◽  
Per Se ◽  
Glucagon Like Peptide 1 ◽  
Induced Changes

Sulfonylureas (SU) with glucagon-like peptide-1 (GLP-1)-based therapy are an emerging therapeutic combination for type 2 diabetes. Prior human studies have hinted at endothelial effects of GLP-1 and SU. To study the endothelial effects of GLP-1 per se and to evaluate the modulatory effects, if any, of SU agents on GLP-1-induced changes in endothelial function, healthy, nondiabetic, normotensive, nonsmokers, age 18–50 yr with no family history of diabetes, were studied. Subjects were randomized to either placebo ( n = 10), 10 mg of glyburide ( n = 11), or 4 mg of glimepiride ( n = 8) orally. Euglycemic somatostatin pancreatic clamp with replacement basal insulin, glucagon, and growth hormone was performed for 240 min. Forearm blood flow (FBF) was measured by venous occlusion plethysmography with graded brachial artery infusions of acetylcholine (Ach) and nitroprusside (NTP) before and after intravenous infusion of GLP-1. GLP-1 (preinfusion 3.4 ± 0.2, postinfusion 25.5 ± 2.8 pM) enhanced ( P < 0.03) Ach-mediated vasodilatation (Δ+6.5 ± 1.1 vs. Δ+9.1 ± 1.2 ml·100 ml−1·min−1, change from baseline FBF) in those on placebo. However, in contrast, glyburide abolished GLP-1-induced Ach-mediated vasodilatation (Δ+11.7 ± 2.0 vs. Δ+11.7 ± 2.5 ml·100 ml−1·min−1). On the other hand, glimepiride did not alter the ability of GLP-1 to enhance Ach-mediated vasodilatation (Δ+7.9 ± 0.5 vs. Δ+10.2 ± 1.3 ml·100 ml−1·min−1, P < 0.04). Neither GLP-1 nor SU altered NTP-induced vasodilatation. These data demonstrate that GLP-1 per se has direct beneficial effects on endothelium-dependent vasodilatation in humans that are differentially modulated by SU.

Parathyroid gland before and after cisplatin treatment

1987 ◽  
Vol 45 ◽  
pp. 860-861
Author(s):  
S.K. Aggarwal ◽  
J.M. Fadool
Keyword(s):  
Parathyroid Gland ◽  
Wistar Rats ◽  
Antitumor Agent ◽  
The Body ◽  
Cross Linking ◽  
Limiting Factor ◽  
Hormonal Changes ◽  
Primary Mechanism ◽  
Before And After ◽  
Dna Strands

Cisplatin (CDDP) a potent antitumor agent suffers from severe toxic side effects with nephrotoxicity being the major dose-limiting factor, The primary mechanism of its action has been proposed to be through its cross-linking DNA strands. It has also been shown to inactivate various transport enzymes and induce hypocalcemia and hypomagnesemia that may be the underlying cause for some of its toxicities. The present is an effort to study its influence on the parathyroid gland for any hormonal changes that control calcium levels in the body.Male Swiss Wistar rats (Crl: (WI) BR) weighing 200-300 g and of 60 days in age were injected (ip) with cisplatin (7mg/kg in normal saline). The controls received saline injections only. The animals were injected (iv) with calcium (0.5 ml of 10% calcium gluconate/day) and were killed by decapitation on day 1 through 5. Trunk blood was collected in heparinized tubes.

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