scholarly journals Use of the Acrylonitrile Haemoglobin Adduct N‑(2‑cyanoethyl)valine as a Biomarker Of Compliance in Smokers Switching to Tobacco Heating Products

2021 ◽  
Author(s):  
Oscar M. Camacho ◽  
Michael McEwan ◽  
Nathan Gale ◽  
Nikola Pluym ◽  
Max Scherer ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Half Life ◽  
Observational Studies ◽  
Blood Levels ◽  
Operating Characteristics ◽  
Optimal Thresholds ◽  
Characteristics Analysis ◽  
Smoking Group ◽  
New Generation ◽  
Haemoglobin Adduct

Objective: To investigate the use of blood levels of N-(2 cyanoethyl)valine (CEVal), a haemoglobin adduct of acrylonitrile, to assess lack of compliance with smoking cessation. Methods: We report CEVal concentrations and percentiles over time for 2 cessation groups, compliance was established using NNAL concentrations. CEVal half-life was estimated. Optimal thresholds were calculated based on receiver operating characteristics analysis. Results: At 180 days, among 67 participants in the continued smoking group and 159 assigned to smoking cessation or sole THP use. CEVal half-life was estimated to be approximately 30 days and the optimal thresholds were for NNAL at 40 pg/mL and CEVal at 35 pmol/g globin (81% sensitivity and specificity). Conclusions: A new generation of biomarkers of compliance is required, specific to the new generation of nicotine products. Methodological validation and standardisation could allow robust assessment of effects across clinical and observational studies while promoting comparability between studies. CEVal could play an important role as biomarker of compliance for smoking cessation and switching studies.

Delay in Caffeine Elimination in Breast-Fed Infants

PEDIATRICS ◽  
1987 ◽  
Vol 79 (2) ◽  
pp. 264-268
Author(s):  
Jean-Claude Le Guennec ◽  
Bernard Billon
Keyword(s):  
Half Life ◽  
Blood Levels ◽  
Daily Consumption ◽  
Trough Blood ◽  
Caffeine Citrate ◽  
Nursing Mothers ◽  
Postconceptional Age ◽  
Breast Milk Jaundice ◽  
Caffeine Metabolism ◽  
Breast Fed

Because of a persistently elevated caffeine half-life observed in a breast-fed infant during caffeine maintenance therapy, we conducted this prospective iongitudinal study in two groups of infants (five exclusively breast-fed and 12 formula-fed). After 46 weeks' postconceptional age, all five breast-fed infants had a marked delay in caffeine elimination, compared with one infant in the formula-fed group. Four breast-fed infants had measurements of significantly longer caffeine half-lives compared with 12 formula-fed infants (76 ± 13 hours v 21 ± 28 hours and 54 ± 9 hours v 16 ± 13 hours at 47 to 50 weeks and 51 to 54 weeks postconceptional age, respwxricwly), as well as significantly higher trough blood levels (three- to five-fold) after 46 weeks' postconceptional age. The fifth breast-fed infant accumulated caffeine secondary to a steep increase in caffeine half-life from 102 hours at 44 weeks to 372 hours at 51 weeks. The elevated blood caffeine levels in breast-fed infants was not related to higher daily dosage of caffeine citrate (4.4 mg/kg compared with 8.3 mg/kg in the formula-fed group at 56 weeks' postconceptional age). Daily consumption of caffeine was low or nonexistent in four nursing mothers, and transfer of caffeine to the infant was considered to be trivial. The findings from this study suggest, as does breast milk jaundice due to inhibition of glycuronyl transferase, that some components of human milk (free fatty acid, lipase activity, or other factors) inhibit or repress the postnatal normal maturation process of caffeine metabolism by hepatic cytochrome P-450.

ADMINISTRATION OF DRUG HAZARDOUS ADMINISTRATION OF MALE MEDICINE STUDENTS IN THAI BINH UNIVERSITY OF MEDICINE AND PHARMACY IN 2020

2021 ◽  
Vol 62 (5) ◽  
Author(s):  
Phan Thu Nga ◽  
Nguyen Thi Ai ◽  
Nguyen Ha My ◽  
Bui Thi Huyen Dieu ◽  
Pham Tuan Dat
Keyword(s):  
Smoking Cessation ◽  
Male Students ◽  
Cross Sectional ◽  
Epidemiological Research ◽  
Smoking Group ◽  
One Year

The study was designed according to descriptive epidemiological research through an analytical cross-sectional investigation. Directly interviewing 434 male students of joint medicine at Thai BinhUniversity of Medicine and Pharmacy in 2020. Results Research shows: Up to 69.0% of subjects who are smoking have smoking time more than 5 years; 40.8% of those who had smoked in the pastwere in the group who smoked less than one year. In the currently smoking group, up to 82.8% of the subjects had tried to quit and started smoking again. 85.3% of subjects chose to try to quit smokingwithout assistance, accounting for the highest percentage of the smoking cessation methods chosen by the subjects in the study.

Abstract WP5: Outcomes Are Not Different Between Patients With Intermediate and High Dwi-aspects After Stent-retriever Thrombectomy

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Woong Yoon ◽  
Seul Kee Kim ◽  
Tae Wook Heo ◽  
Byung Hyun Baek ◽  
Jaechan Park
Keyword(s):  
Functional Outcome ◽  
Time Window ◽  
Multivariate Logistic Regression Analysis ◽  
Area Under The Curve ◽  
Stent Retriever ◽  
Operating Characteristics ◽  
Anterior Circulation ◽  
Good Outcome ◽  
Characteristics Analysis ◽  
The Impact

Introduction: Few studies have investigated the association between pretreatment DWI-ASPECTS and functional outcome after stent-retriever thrombectomy in patients with acute anterior circulation stroke. Hypothesis: Patients with acute stroke and DWI-ASPECTS <7 might have a similar chance of a good outcome compared to those with a higher DWI-ASPECTS, if they are treated with a stent-retriever thrombectomy in a short time window. However, this hypothesis has not been tested. Thus, this study aimed to investigate the impact of DWI-ASPECTS on functional outcome in patients with acute anterior circulation stroke who received a stent-retriever thrombectomy. Methods: We retrospectively analyzed the clinical and DWI data from 171 patients with acute anterior circulation stroke who were treated with stent-retriever thrombectomy within 6 hours of symptom onset. The DWI-ASPECTS was assessed by two readers. A good outcome was defined as a modified Rankin Scale score of 0-2 at 3 months. Results: The median DWI-ASPECTS was 7 (interquartile range, 6-8). Receiver operating characteristics analysis revealed an ASPECTS ≥ 7 was the optimal cut-off to predict a good outcome at 3 months (area under the curve=0.57; sensitivity, 75.3%; specificity, 34.4%). The rates of good outcome, symptomatic hemorrhage, and mortality were not different between high DWI-ASPECTS (scores of 7-10) and intermediate (scores of 4-6) groups. In patients with an intermediate DWI-ASPECTS, good outcome was achieved in 46.5% (20/43) of patients with successful revascularization (modified TICI 2b or 3), whereas no patients without successful revascularization had a good outcome ( P =0.016). In multivariate logistic regression analysis, independent predictors of good outcome were age and successful revascularization. Conclusions: Our study suggested that treatment outcomes were not different between patients with a high DWI-ASPECTS and those with an intermediate DWI-ASPECTS who underwent stent-retriever thrombectomy for acute anterior circulation stroke. Thus, patients with an intermediate DWI-ASPECTS otherwise eligible for endovascular therapy should not be excluded for stent-retriever thrombectomy or stroke trials.

The Association between Serum Sodium Levels and Febrile Seizures Recurrence: Is the Degree of Hyponatremia a Risk Factor?

2021 ◽  
Author(s):  
Esma Keleş Alp ◽  
Ahmet Midhat Elmacı
Keyword(s):  
Serum Sodium ◽  
Medical Records ◽  
Febrile Seizure ◽  
Serum Sodium Level ◽  
Febrile Seizures ◽  
Lower Sensitivity ◽  
Operating Characteristics ◽  
Serum Electrolyte ◽  
Optimal Cutoff ◽  
Characteristics Analysis

AbstractFebrile seizures are common disorders in childhood. We evaluated the serum electrolyte levels and the associated factors in children with single and recurrent febrile seizures in 24 hours period of hospitalization. The medical records of children who were clinically diagnosed with febrile seizures and hospitalized were retrospectively revealed and analyzed. Data were collected for children aged 1 to 6 years including demographic parameters and serum electrolyte levels. A total of 244 children were enrolled in the study in which 209 were diagnosed with single febrile seizures and 35 of them with recurrent febrile seizures. Serum sodium levels were significantly lower in children with recurrent febrile seizure (138.5 ± 2.38 and 134.2 ± 3.55, p < 0.001). Correlation analysis revealed that mild hyponatremia is associated with recurrence of febrile seizure within 24 hours. However, receiver-operating characteristics analysis for hyponatremia showed lower sensitivity (50.3%) and specificity (43.1%) values for optimal cutoff value of 133.5 mmol/L of serum sodium level. Our study suggested that serum sodium levels were significantly lower in children with recurrent febrile seizures. However, because of its lower sensitivity and specificity values, mild hyponatremia cannot be used as an indicator for febrile seizure recurrence.

scholarly journals IL-4 Level in Rifampicin-Sensitive and Rifampicin-Resistant Lung Tuberculosis Patients

2020 ◽  
Vol 27 (1) ◽  
Author(s):  
Joko Susanto ◽  
Jusak Nugraha ◽  
Soedarsono Soedarsono
Keyword(s):  
Pulmonary Tuberculosis ◽  
Operating Characteristics ◽  
Mycobacterium Tuberculosis Infection ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Lung Tuberculosis ◽  
Characteristics Analysis ◽  
Resistant Group ◽  
The Difference ◽  
Sensitive Group

Tuberculosis remains a global health burden. Mycobacterium tuberculosis infection causes humoral and cellularresponses. Macrophages of patients with pulmonary tuberculosis evolve M1 polarization that blocks infection orimmunosuppressive M2, promoting tissue repair mediated by IL-4, IL-10, and IL-13. Previous research showed a decrease ofIL-4R and IL-10 expression in lung macrophages of anti-TB drug resistance. A molecular test can detectrifampicin- resistance. There has been no study, which showed the difference in serum IL-4 levels in rifampicin-sensitive andrifampicin-resistant tuberculosis patients. This study aimed to determine the difference between circulating IL-4 levels inrifampicin-sensitive and rifampicin-resistant pulmonary tuberculosis patients. This cross-sectional observational studyconsecutively recruited subjects based on positive molecular and acid-fast bacilli microscopic examination from MDR-TBClinic of the Dr. Soetomo Hospital between December 2018 to March 2019. Subjects were classified into arifampicin-sensitive and rifampicin-resistant group. On ELISA measurement, IL-4 data were analyzed with SPSS version 17.Mann-Whitney U test and ROC analysis tests were performed, and p < 0.05 was significant for α=0.05 (95% CI). There wassignificant difference between rifampicin-sensitive group (420±281 pg/mL) and rifampicin-resistant group(253±279 pg/mL) (p=0.014). Receiver operating characteristics analysis showed AUC 0.70, the sensitivity of 81.5%, thespecificity of 63.6%, and the cut-off value of 235.6 pg/mL. There was a significantly higher level of circulating IL-4 in therifampicin-sensitive group than the rifampicin-resistant group. IL-4 level in healthy subjects should be measured as thenormal value in the population. Immunology and metabolic parameters should be performed to increase samplehomogeneity. Further study was also needed to understand the IL-4 role in rifampicin resistance of lung tuberculosispatients in the Indonesia population.

scholarly journals Vision-Based Finger Tapping Detection Without Fingertip Observation

2021 ◽  
Vol 33 (3) ◽  
pp. 484-493
Author(s):  
Shotaro Narita ◽  
◽  
Shingo Kagami ◽  
Koichi Hashimoto
Keyword(s):  
High Speed ◽  
Feature Vector ◽  
False Positive Rate ◽  
Finger Tapping ◽  
Surface Patch ◽  
Operating Characteristics ◽  
Machine Learning Approach ◽  
History Information ◽  
Characteristics Analysis ◽  
Positive Rate

A machine learning approach is investigated in this study to detect a finger tapping on a handheld surface, where the movement of the surface is observed visually; however, the tapping finger is not directly visible. A feature vector extracted from consecutive frames captured by a high-speed camera that observes a surface patch is input to a convolutional neural network to provide a prediction label indicating whether the surface is tapped within the sequence of consecutive frames (“tap”), the surface is still (“still”), or the surface is moved by hand (“move”). Receiver operating characteristics analysis on a binary discrimination of “tap” from the other two labels shows that true positive rates exceeding 97% are achieved when the false positive rate is fixed at 3%, although the generalization performance against different tapped objects or different ways of tapping is not satisfactory. An informal test where a heuristic post-processing filter is introduced suggests that the use of temporal history information should be considered for further improvements.

scholarly journals Identification and Validation of an 6-Metabolism-Related Gene Signature and Its Correlation With Immune Checkpoint in Hepatocellular Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
He Ren ◽  
Wanjing Li ◽  
Xin Liu ◽  
Shuliang Li ◽  
Hao Guo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Checkpoint ◽  
Immune Cell ◽  
Enrichment Analysis ◽  
Gene Signature ◽  
Clinicopathological Characteristics ◽  
Gene Set Enrichment Analysis ◽  
Operating Characteristics ◽  
Kaplan Meier ◽  
Characteristics Analysis

Hepatocellular carcinoma (HCC) is a common malignant tumor with relatively high malignancy and rapid disease progression. Metabolism-related genes (MRGs) are involved in the pathogenesis of HCC. This study explored potential key MRGs and their effect on T-cell immune function in the tumor immune microenvironment to provide new insight for the treatment of HCC. Of 456 differentially expressed MRGs identified from TCGA database, 21 were screened by MCODE and cytoHubba algorithms. From the key module, GAD1, SPP1, WFS1, GOT2, EHHADH, and APOA1 were selected for validation. The six MRGs were closely correlated with survival outcomes and clinicopathological characteristics in HCC. Receiver operating characteristics analysis and Kaplan-Meier plots showed that these genes had good prognostic value for HCC. Gene set enrichment analysis of the six MRGs indicated that they were associated with HCC development. TIMER and GEPIA databases revealed that WFS1 was significantly positively correlated and EHHADH was negatively correlated with tumor immune cell infiltration and immune checkpoint expression. Finally, quantificational real-time polymerase chain reaction (qRT-PCR) confirmed the expression of WFS1 and EHHADH mRNA in our own patients’ cohort samples and four HCC cell lines. Collectively, the present study identified six potential MRG biomarkers associated with the prognosis and tumor immune infiltration of HCC, thus providing new insight into the pathogenesis and treatment of HCC.

scholarly journals Daily Players’ Satisfaction with Pitching Performance Could Predict Shoulder and Elbow Injuries in High-school Baseball Pitchers: A Prospective Time-to-event Study

2021 ◽  
Author(s):  
Hitoshi Shitara ◽  
Tsuyoshi Tajika ◽  
Takuro Kuboi ◽  
Tsuyoshi Ichinose ◽  
Tsuyoshi Sasaki ◽  
...  
Keyword(s):  
High School ◽  
Event Study ◽  
Operating Characteristics ◽  
Time To Event ◽  
Elbow Injury ◽  
Shoulder Range Of Motion ◽  
Elbow Injuries ◽  
Characteristics Analysis ◽  
Baseball Pitchers ◽  
The Relationship

Abstract The relationship between baseball pitchers’ satisfaction with their own performance and the incidence of shoulder and elbow injuries is unclear. We analyzed the relationship between daily satisfaction scores before injury and incidence of shoulder/elbow injury in high-school baseball pitchers in this prospective, time-to-event study. We collected baseline data on baseball experience, height, weight, elbow and shoulder range of motion, and shoulder muscle strength. The 108 enrolled participants aged 15-17 years were divided into satisfied (88) and unsatisfied (22) groups based on the Receiver operating characteristics analysis results that revealed the cutoff value to be 4 points. The incidence of injury was 10.2% and 50.0% in the satisfied and unsatisfied groups, respectively. We observed that high-school baseball pitchers with a low satisfaction significantly increased the risk of shoulder and elbow injuries: these players had a 7.3-times greater risk of injuries and a 1.9-times earlier occurrence of injuries than pitchers who are satisfied with their performance. High-school baseball pitchers who had low satisfaction with their pitching performance had higher risk of shoulder and elbow injuries and lower time to injury than satisfied pitchers. Daily evaluation of players’ self-satisfaction could predict shoulder and elbow injuries in high-school baseball pitchers.

Layer-specific strain analysis: investigation of regional deformations in a rat model of acute versus chronic myocardial infarction

2012 ◽  
Vol 303 (5) ◽  
pp. H549-H558 ◽  
Author(s):  
Noa Bachner-Hinenzon ◽  
Offir Ertracht ◽  
Assaf Malka ◽  
Marina Leitman ◽  
Zvi Vered ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Wall Thickness ◽  
Strain Analysis ◽  
Scar Tissue ◽  
The Other ◽  
Tissue Formation ◽  
Operating Characteristics ◽  
Specific Strain ◽  
Characteristics Analysis ◽  
Extent Of Damage

Myocardial infarction (MI) injury extends from the endocardium toward the epicardium. This phenomenon should be taken into consideration in the detection of MI. To study the extent of damage at different stages of MI, we hypothesized that measurement of layer-specific strain will allow better delineation of the MI extent than total wall thickness strain at acute stages but not at chronic stages, when fibrosis and remodeling have already occurred. After baseline echocardiography scans had been obtained, 24 rats underwent occlusion of the left anterior descending coronary artery for 30 min followed by reperfusion. Thirteen rats were rescanned at 24 h post-MI and eleven rats at 2 wk post-MI. Next, rats were euthanized, and histological analysis for MI size was performed. Echocardiographic scans were postprocessed by a layer-specific speckle tracking program to measure the peak circumferential strain (SCpeak) at the endocardium, midlayer, and epicardium as well as total wall thickness SCpeak. Linear regression for MI size versus SCpeak showed that the slope was steeper for the endocardium compared with the other layers ( P < 0.001), meaning that the endocardium was more sensitive to MI size than the other layers. Moreover, receiver operating characteristics analysis yielded better sensitivity and specificity in the detection of MI using endocardial SCpeak instead of total wall thickness SCpeak at 24 h post-MI ( P < 0.05) but not 2 wk later. In conclusion, at acute stages of MI, before collagen deposition, scar tissue formation, and remodeling have occurred, damage may be nontransmural, and thus the use of endocardial SCpeak is advantageous over total wall thickness SCpeak.

Suicide risk with selective serotonin reuptake inhibitors and other new-generation antidepressants in adults: a systematic review and meta-analysis of observational studies

2021 ◽  
pp. jech-2020-214611
Author(s):  
Michael P Hengartner ◽  
Simone Amendola ◽  
Jakob A Kaminski ◽  
Simone Kindler ◽  
Tom Bschor ◽  
...  
Keyword(s):  
Systematic Review ◽  
Suicide Attempt ◽  
Publication Bias ◽  
Serotonin Reuptake ◽  
Observational Studies ◽  
Suicide Risk ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Treatment Indications ◽  
Trim And Fill ◽  
New Generation

BackgroundThere is ongoing controversy whether antidepressant use alters suicide risk in adults with depression and other treatment indications.MethodsSystematic review of observational studies, searching MEDLINE, PsycINFO, Web of Science, PsycARTICLES and SCOPUS for case–control and cohort studies. We included studies on depression and various indications unspecified (including off-label use) reporting risk of suicide and/or suicide attempt for adult patients using selective serotonin reuptake inhibitors (SSRI) and other new-generation antidepressants relative to non-users. Effects were meta-analytically aggregated with random-effects models, reporting relative risk (RR) estimates with 95% CIs. Publication bias was assessed via funnel-plot asymmetry and trim-and-fill method. Financial conflict of interest (fCOI) was defined present when lead authors’ professorship was industry-sponsored, they received industry-payments, or when the study was industry-sponsored.ResultsWe included 27 studies, 19 on depression and 8 on various indications unspecified (n=1.45 million subjects). SSRI were not definitely related to suicide risk (suicide and suicide attempt combined) in depression (RR=1.03, 0.70–1.51) and all indications (RR=1.19, 0.88–1.60). Any new-generation antidepressant was associated with higher suicide risk in depression (RR=1.29, 1.06–1.57) and all indications (RR=1.45, 1.23–1.70). Studies with fCOI reported significantly lower risk estimates than studies without fCOI. Funnel-plots were asymmetrical and imputation of missing studies with trim-and-fill method produced considerably higher risk estimates.ConclusionsExposure to new-generation antidepressants is associated with higher suicide risk in adult routine-care patients with depression and other treatment indications. Publication bias and fCOI likely contribute to systematic underestimation of risk in the published literature.RegistrationOpen Science Framework, https://osf.io/eaqwn/

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