Substance P and Calcitonin Gene-related Peptide Expression at the Extensor Carpi Radialis Brevis Muscle Origin: Implications for the Etiology of Tennis Elbow

2000 ◽  
Vol 82 (12) ◽  
pp. 10
Author(s):  
Björn-Ove Ljung ◽  
Sture Forsgren ◽  
Jan Fridén
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Soo-Hong Han ◽  
Hyung Kyung Kim ◽  
Yoon Jang ◽  
Hyeon Hae Lee ◽  
Jeongbae Rhie ◽  
...  

Abstract Background In this study, we investigated whether substance P (SP) or calcitonin gene-related peptide (CGRP) expression is associated with tendon degeneration in patients with lateral epicondylitis. Methods Twenty-nine patients who underwent surgical treatment for lateral epicondylitis were enrolled in the final analyses. Extensor carpi radialis brevis tendon origins were harvested for histological analysis. Results SP and CGRP immunostaining were negative in healthy tendons but positive in degenerative tendons; moreover, their immunoreactivity increased with degeneration severity. Univariate analysis indicated that variables such as the preoperative visual analog scale (VAS) score or SP or CGRP expression levels were significantly associated with the Movin score. However, multivariate analysis revealed that only higher SP and/or CGRP signals were associated with higher Movin scores. Elevations in SP or CGRP expression were also linked with significantly severe preoperative VAS scores. Conclusion We demonstrated that tendon degeneration severity is associated with increased SP and CGRP expression in the biopsy samples of lateral epicondylitis.


2010 ◽  
Vol 36 (12) ◽  
pp. 1938-1942 ◽  
Author(s):  
Javier Caviedes-Bucheli ◽  
Maria Mercedes Azuero-Holguin ◽  
Luisa Gutierrez-Sanchez ◽  
Ferelba Higuerey-Bermudez ◽  
Veronica Pereira-Nava ◽  
...  

2012 ◽  
Vol 46 (5) ◽  
pp. 419-426 ◽  
Author(s):  
J. Caviedes-Bucheli ◽  
J. O. Moreno ◽  
C. P. Carreño ◽  
R. Delgado ◽  
D. J. Garcia ◽  
...  

1999 ◽  
Vol 842 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Josef Troger ◽  
Christian Humpel ◽  
Bernhard Kremser ◽  
Martina Kralinger ◽  
Barbara Teuchner ◽  
...  

Hypertension ◽  
1995 ◽  
Vol 26 (6) ◽  
pp. 1177-1180 ◽  
Author(s):  
Scott C. Supowit ◽  
Huawei Zhao ◽  
Donna H. Wang ◽  
Donald J. DiPette

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