scholarly journals Pediatric Powered Mobility Training: Powered Wheelchair Versus Simulator-Based Practice

2021 ◽  
Author(s):  
Naomi Gefen ◽  
Philippe S. Archambault ◽  
Amihai Rigbi ◽  
Patrice L. Weiss
Keyword(s):  
Children And Adolescents ◽  
User Experience ◽  
Physical Disabilities ◽  
Group Versus ◽  
Control Group ◽  
Training Methods ◽  
Powered Wheelchair ◽  
Significant Difference ◽  
Effective Training ◽  
Mobility Training

Abstract Background: Many children with physical disabilities lack independent mobility. Powered wheelchair mobility can be a viable option, but users must be proficient drivers to ensure safety. To become a proficient driver, children need opportunities to practice. As is often the case, powered wheelchairs are scarce and direct therapy hours dedicated to powered mobility are often limited. Alternative options are needed to enable safe, unsupervised practice. Simulator-based learning has been shown to be an effective training method for powered mobility and other skill-based tasks for adults. The goal of this study was to compare two training methods of powered mobility, powered wheelchair practice (control group) versus simulator-based (experimental group) practice to determine whether simulation is a feasible and effective method for children and adolescents. The hypothesis was that children practicing on either modality at home supervised by a caregiver would similarly improve their powered mobility skills. Method: Participants included 36 children and adolescents (23 males, 13 females) with cerebral palsy and neuromuscular diseases, aged 6-18 years (mean age: 10 y, 7 mo, SD: 3y, 7 mo). Data were collected and compared at baseline and after 12 weeks of home based practice of powered mobility via a powered wheelchair or a simulator. Thirty participants completed the study and were included in the analysis Powered mobility ability was determined by the Powered Mobility Program (PMP), the Israeli Ministry of Health’s Powered Mobility Proficiency Test (PM-PT) and the Assessment of Learning Powered Mobility use (ALP). Participants (21/30) were interviewed after study completion by an independent researcher concerning the child’s and parent’s experiences regarding practice time and user experience (e.g., satisfaction with training program, views of its importance). Results: Both the powered wheelchair and simulator-based practice groups achieved significant improvement following the practice period as assessed by the PMP and PM-PT assessments, with no significant difference between them. A significant improvement was found in the ALP assessment outcomes for the powered wheelchair group only. All participants practiced for the required amount of time and both groups reported a similar user experience. Conclusions: The results demonstrate that simulator-based practice is an effective training option for powered mobility for children aged 6-18 years old with physical disabilities. Simulator-based practice can provide a safe environment to practice driving skills that could endanger the child (e.g., out of doors). This is the first study, to our knowledge, that compares two different wheelchair training methods. Trial Registration: The study protocol for this clinical trial was registered at ClinicalTrials.gov under the ID NCT04531488 and the title “ Simulator Based Powered Mobility Training of Children With Special Needs ”(Protocol ID: 004-17, URL: https://rb.gy/dfeslr).

scholarly journals Evaluation of depression and self-esteem in children with monosymptomatic nocturnal enuresis: A controlled trial

2014 ◽  
Vol 86 (3) ◽  
pp. 212 ◽  
Author(s):  
Orhan Koca ◽  
Mehmet Akyüz ◽  
Bilal Karaman ◽  
Zeynep Yesim Özcan ◽  
Metin Öztürk ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Nocturnal Enuresis ◽  
Depression Scale ◽  
Self Esteem ◽  
Control Group ◽  
Case Group ◽  
Healthy Children ◽  
Significant Difference ◽  
Monosymptomatic Nocturnal Enuresis ◽  
Age Range

Objectives: Nocturnal enuresis (NE) is very common and is one of the most common causes for patients to be admitted to urology, pediatrics, child psychiatry and child surgery departments. We aimed to investigate the effect on depression and self-esteem of this disorder that can cause problems on person's social development and human relations. Material and methods: 90 patients who were admitted to our clinic with complaints of nocturnal enuresis were enrolled. Investigations to rule out organic causes were performed in this group of patients. Out of them 38 children and adolescents (age range 8-18 years) with primary monosymptomatic nocturnal enuresis (PMNE) agreed to participate in the study In the same period 46 healthy children and adolescents with a similar age range without bed wetting complaint were included in the study as a control group. The age of the family, educational and socioeconomic level were questioned and Piers-Harris Children's Self-Concept Scale (PHCSCS) and Children's Depression Inventory (CDI) forms were filled out. Results: Mean age of the cases (18 females or 47.4% and 20 males or 52.6%) was 10.76 ± 3.82 years whereas mean age of controls (26 females or 56.5% and 20 males or 43.5%) was 10.89 ± 3.11 years. Depression scale was significantly higher (p = 0.001) in the case group than in the control group (10.42 ± 4.31 vs 7.09 ± 4.35). In both groups there was no statistically significant difference by age and sex in terms of depression scale (p > 0.05). Conclusion: NE is widely seen as in the community and is a source of stresses either for children and for their families. When patients were admitted to physicians for treatment, a multidisciplinary approach should be offered and the necessary psychological support should be provided jointly by child psychiatrists and psychologists.

scholarly journals Standarisasi Observer OSCE dengan Rubrik dan Multivideo

2012 ◽  
Vol 1 (3) ◽  
pp. 183
Author(s):  
Ide Pustaka Setiawan ◽  
Noviarina Kurniawati ◽  
Rr. Siti Rokhmah Projosasmito
Keyword(s):  
Treatment Group ◽  
Data Collection ◽  
General Practitioners ◽  
Video Recording ◽  
Control Group ◽  
Training Methods ◽  
Validity And Reliability ◽  
Factors Influencing ◽  
Significant Difference ◽  
Data Collection Session

Background: One of the factors influencing the validity and reliability of the assessment is the standardization of the observers in assessing students’ performance. A recent study by Setiawan (2011) found that there is differences in the standard of assessment used by general practitioners and specialized doctors in assessing students in OSCE.7 These differences are considered to be harmful for the students, therefore needs to be improved. Several training methods are developed to overcome the problem. This study aims to assess whether rubric and multi video can be used as a means of standardization of OSCE observers.Method: This was an experimental action research. The instruments used in this study were checklist, rubric, and video recording of students doing OSCE (n=5), which further be called multi-video. The subjects of the study were the OSCE observers in station Integrated Patient Management (IPM) who were divided into control and treatment group. The subjects assessed students’ performance from the multi-video in two data collection sessions. In the first session, both control and treatment group used checklist for assessing the multi-video. Furthermore in the second session, the control group did as the first data collection session, while the treatment group used checklist and rubric for assessing the multivideo. The result of which compared and tested using independent sample t-test.Results: As many as 33 observers, which consists of 23 general practitioners (GP) and 10 specialized doctors (SP), participated in the first data collection session. In the second data collection session, 28 observers consist of 20 GPs and 8 SPs participated. The result of the first data collection session, which used only checklist as an instrument, showed a significant difference in the standard of assessment used by the GPS and SPs (p<0.05), whereas the second data collection session, which used rubric as an additional instrument for the treatment group, showed no significant difference between GPs and SPs in the standard of assessment (p>0.05).Conclusion: Rubrics and multi video can be used as a means of standardization of OSCE observer in assessing students’ performance. 

scholarly journals Role and effects of zinc supplementation in HIV-infected patients with immunovirological discordance: A randomized, double blind, case control study

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0244823
Author(s):  
Macarena Silva ◽  
Carmen G. Montes ◽  
Andrea Canals ◽  
Maria J. Mackenna ◽  
Marcelo Wolff
Keyword(s):  
Zinc Supplementation ◽  
Group Versus ◽  
Cd4 Count ◽  
Control Group ◽  
Immune Recovery ◽  
Plasma Zinc ◽  
Absolute Increase ◽  
Number Of Patients ◽  
Significant Difference ◽  
Zinc Levels

Introduction It has been estimated that between 15% and 18% of patients who start antiretroviral therapy (ART) do not achieve a successful immune recovery despite complete virological suppression. In the literature this phenomenom is known as poor immune recovery or immunovirological discordance (IVD). Zinc has an immunomodulatory role associated with T lymphocytes and its supplementation could enhance immune recovery. Objective To determine if zinc supplementation on IVD patients prevents immune failure after 12 months of supplementation. Secondary objectives were to determine serum zinc levels in HIV patients with and without IVD and the frequency of hypozincemia in discordant patients. Method We reviewed the historical record of patients under care at Arriarán Foundation. Following inclusion criteria were defined: 1) age ≥ 18 years, 2) standard ART (three effective drugs) for at least 18 months, 3) virologically suppressed for 12 months, 3) persistence of CD4 count ≤200 cells/mm3 and/or increase ≤ 80 cells/mm3 after one year of viral undetectability. A control group was assigned paired 1:1 by sex, age (± 2 years) that did achieved an increase of CD4> 350 cells/ mm3. In both groups plasma zinc levels were determined. In a later phase, patients with IVD were randomized to receive zinc (15 mg daily) versus placebo. Patients were followed for 12 months with CD4 count, viral load and zinc levels determinations every 4–6 months. Results A total of 80 patients, 40 patients with IVD criteria and 40 controls were included. 92.5% were men, and age average was 47.5 years. The median baseline CD4 was 189 cells/mm3 (71–258) in the cases vs. 552.5 cells/ mm3 (317–400) in the control group with a median increase at the end of the study of 39 cell/mm3 and 19 cell/mm3 respectively. There was no difference in baseline plasma zinc levels between both groups (81.7 + 18.1 in cases versus 86.2 + 11.0 in controls). In the 40 patients with IVD, the median absolute increase in CD4 after annual zinc supplementation was 31.5 cells/mm3 in the treated group versus 50 cells/mm3 in the placebo group, this difference being statistically not significant (p = 0.382). Conclusions Patients with IVD have plasma zinc levels similar to those who achieve adequate immune recovery. Zinc supplementation in IVD patients showed a statistically non-significant difference in in CD4 levels between cases and controls. The results warrant a comparative study with a larger number of patients.

P0080INTERLEUKIN-17A GENE POLYMORPHISM (RS2275913G>A) IN SLE PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Nehal Atef elshabrawy ◽  
Hussein Sheashaa ◽  
Adel L Abdelsalam ◽  
Ahmed Mohammed Abd El Wahab
Keyword(s):  
Lupus Nephritis ◽  
Gene Polymorphism ◽  
Inflammatory Diseases ◽  
Statistical Significance ◽  
Group Versus ◽  
University Hospital ◽  
Control Group ◽  
Cross Sectional ◽  
Dsdna Antibody ◽  
Significant Difference

Abstract Background and Aims There are six IL-17-family ligands [IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (IL-25) and IL-17F]. Interleukin-17A (IL-17A) also commonly called IL-17, is produced by the T helper17 (Th17) subset of CD4+ T cells.Interleukin-17 and other Th17 cytokines are linked to the pathogenesis of diverse autoimmune and inflammatory diseases. IL-17A is detected in synovial fluids and synovium from RA patients and induces proinflammatory cytokine production from synoviocytes, also expression of IL-17A was higher in SLE patients and its level positively correlated with the severity of lupus nephritis, because of its contribution to increasing anti-double-stranded DNA (dsDNA) antibody production in SLE. The aim of the present study is to determine the IL-17A gene polymorphism (rs2275913 G&gt;A) frequency in patients with SLE and lupus nephritis, and to determine the association of this polymorphism with the disease activity. Method This cross-sectional, observational, case control study was carried out on 50 females patients, with their age ranged from 15 to 50 years (mean 25.67±9.29 years) with SLE attending Mansoura University Hospital .A control group of 50 healthy females of matched age were also included. The patient group was subdivided into patients with and those without lupus Nephritis (35 and 15 patients, respectively). Lupus nephritis was confirmed by renal biopsy. All patients were subjected to a thorough clinical evaluation and routine laboratory tests. SLEDAI score was calculated for all patients to determine the degree of lupus activity. DNA extraction was performed for all patients as well as controls, One SNPs of IL-17A (rs2275913G&gt;A) was genotyped utilizing PCR- RFLP technique. Results The frequency of rs2275913 A allele was significantly higher in SLE patients than the control group (34.0% vs. 21.0%, respectively; p=0.04, OR =1.9, 95%CI =1.03-3.65). While G allele was significantly higher in control group, (P=0.04)). Moreover, AA genotype was significantly higher in the SLE patients than in the control group (8.0% vs. 0.0%, respectively; p=0.036) and associated with higher SLEDAI, ANA, and anti-dsDNA antibodies titer, (P=0.03, P=.039, P=0.047 respectively).on the other hand there was no significant difference in GG and GA genotypes in the SLE patients versus the control group. The frequency of both genotype GA and AA was higher in the SLE patients than the controls (60% vs. 42%, respectivley; OR=2.07, CI-95%=0.9-5.59); although the difference was not statistically significant (P= 0.07).Although A allele was numerically higher in lupus nephritis group versus non nephritis group(37.0% vs 27.0%, respectively), the Analysis of the frequency of IL-17A rs2275913 alleles and genotypes showed no statistical differences between the two groups. Moreover there was no statistical significance between different genotypes in cases of nephritis regard lupus nephritis class (P=0.9) and no statistical significance between different genotypes (GG-GA-AA) regarding activity indices (AI) or chronicity indices (CI) in lupus nephritis group (P=0.18, P=0.56 respectively). Conclusion We suggest that there was a significant association between IL-17A rs2275913 G&gt;A polymorphism and SLE, as A allele and AA genotype were increased in SLE patients, lupus nephritis especially those with high activity

scholarly journals Effects of Early Warning Score (EWS) Tutorial Simulation on Nurses' Knowledge and Clinical Performance

2019 ◽  
Vol 9 (2) ◽  
pp. 231-241
Author(s):  
Roshy Damayanti ◽  
Yanny Trisyani ◽  
Aan Nuraeni
Keyword(s):  
Early Warning ◽  
Clinical Performance ◽  
Intervention Group ◽  
Early Warning Score ◽  
Control Group ◽  
Training Methods ◽  
Chi Square ◽  
Significant Difference ◽  
And Control ◽  
Nurses Knowledge

Background: The Early Warning Score (EWS) system has been recommended for early identification tool of deterioration. However, its implementation has not been optimal; one of which is due to the low level of knowledge and understanding of EWS among nurses.Purpose: This study aimed to determine the effects of EWS tutorial simulation on nurses’ knowledge and clinical performance.Methods: This study employed a pretest posttest quasi-experimental design with a control group. Purposive sampling was used to recruit the samples of 42 respondents each in the intervention group and control group. The data were collected using the questionnaires to measure the knowledge and clinical performance, and analyzed using Chi square, Wilcoxon and Mann-Whitney tests.Results: The results showed that there were differences in the pre-test and post-test of knowledge and clinical performance in the intervention group and control group (p<0.001). There was also a significant difference in clinical performance between the intervention group and the control group (p<0.001). However, no significant difference in knowledge was found between.Conclusions: Tutorial simulation of EWS had an effect on increasing nurses’ clinical performance. Although there was no significant difference in knowledge between the intervention group and the control group, but the intervention group showed a better value than the control group. EWS tutorial simulation can be used as one of the training methods to increase nurses' knowledge and clinical performance in EWS.

scholarly journals Herbal Medicines and Ovarian Hyperstimulation Syndrome: A Retrospective Cohort Study

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Athar Rasekhjahromi ◽  
Masoumeh Hosseinpoor ◽  
Farzaneh Alipour ◽  
Mehrnoosh Maalhagh ◽  
Saeed Sobhanian
Keyword(s):  
Cohort Study ◽  
Side Effects ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Polycystic Ovary ◽  
Herbal Medicines ◽  
Group Versus ◽  
Control Group ◽  
Case Group ◽  
Significant Difference

Background. The aim of this study was to assess the association between herbal medication and OHSS.Methods. This retrospective cohort study was conducted with 101 polycystic ovary syndrome patients. 66 patients took conventional pharmacological medications and 35 took herbal medications. Data were analyzed by statistical test including Fisher’s Exact and binominal logistic regression.P<0.05was considered significant.Results. Of the 101 females, 53 were married and 48 were single. There was no significant association between the groups in marriage. No significant association was found in mean age between the two groups (23.9 ± 5.8 years in the control group versus 26.3 ± 6.7 years in the case group). There was a significant difference between the two groups .After adding the dependent (OHSS prevalence) and independent (marriage and group) variables into the model, the Hosmer-Lemeshow test showed suitability. Variances analyzed with this model ranged between 29.4% and 40.7%.Conclusion. The indiscriminate use of herbs is correlated with OHSS. Because patients increasingly consume herbs, they should be aware of potential side effects. However, appropriate dosages of herbs could be obtained for use instead of conventional treatments, which often have side effects.

scholarly journals PENGARUH PELATIHAN LADDER DRILL DENGAN METODE ASCENDING DAN DESCENDING TERDADAP PENINGKATAN KECEPATAN DAN KELINCAHAN

2021 ◽  
Vol 7 (1) ◽  
pp. 1-8
Author(s):  
Muhammad Dzul Fikri ◽  
Oce Wiriawan ◽  
Achmad Widodo
Keyword(s):  
Control Group ◽  
Training Methods ◽  
Control Group Design ◽  
Group Design ◽  
Speed Test ◽  
Scheffe Test ◽  
Significant Difference ◽  
Run Test ◽  
Post Hoc ◽  
Shuttle Run

Abstrak Penelitian ini dilatarbelakangi oleh penurunan prestasi atlet futsal SMA Antartika Sidoarjo. Penelitian ini bertujuan mengkaji pengaruh latihan Ladder Drill dengan metode latihan ascending dan metode latihan descending terhadap peningkatan kecepatan dan kelincahan pada siswa ekstrakurikuler futsal SMA Antartika Sidoarjo. Jenis penelitian dalam penelitian ini adalah kuantitatif dengan metode quasi-experiment. Desain yang digunakan dalam penelitian adalah Pretest-Posttest Control Group Design yang dilaksanakan dalam 24 kali pertemuan dalam 8 minggu. Instrumen tes kecepatan menggunakan lari 40 meter, sedangkan instrumen kelincahan menggunakan shuttle run test. Analisis data yang digunakan untuk mengolah hasil penelitian menggunakan uji-t, MANOVA, dan Post Hoc dengan uji Scheffe. Hasil penelitian menunjukkan peningkatan kecepatan dan kelincahan yang signifikan dari metode ascending dan descending. Sedangkan analisis post hoc uji Scheffe tidak terdapat perbedaan yang signifikan antara kelompok ascending dan kelompok descending terhadap kecepatan dan kelincahan. Hasil penelitian ini menyimpulkan bahwa kedua metode ascending dan descending, dapat meningkatkan kecepatan dan kelincahan sama baiknya terhadap atlet futsal SMA Antartika Sidoarjo. Abstract This research was motivated by a decrease in the achievement of futsal athletes at SMA Antartika Sidoarjo. This study aims to examine the effect of ladder drill training with ascending training methods and descending training methods on increasing speed and agility in futsal extracurricular students at SMA Antartika Sidoarjo. The type of research in this research is quantitative with a quasi-experimental method. The design used in the study was the Pretest-Posttest Control Group Design which was carried out in 24 meetings in 8 weeks. The speed test instrument uses 40 meters running, while the agility instrument uses the shuttle run test. Analysis of the data used to process the research results using the t-test, MANOVA, and Post Hoc with the Scheffe test. The results showed a significant increase in speed and agility from the ascending and descending methods. While the post hoc analysis of the Scheffe test, there was no significant difference between the ascending and descending groups in terms of speed and agility. The results of this study concluded that both ascending and descending methods can improve speed and agility as well as futsal athletes at SMA Antartika Sidoarjo.

Idiopathic coccygodynia as a ‘mask’ of lesions caused by overload in sports associated with the art of movement

2021 ◽  
Vol 16 (3) ◽  
pp. 110-114
Author(s):  
O.S. Vasilyev ◽  
◽  
S.P. Levushkin ◽  
E.E. Achkasov ◽  
O.A. Sultanova ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Indirect Evidence ◽  
Physical Rehabilitation ◽  
Pain Severity ◽  
Control Group ◽  
Rhythmic Gymnastics ◽  
Number Of Patients ◽  
Significant Difference ◽  
Muscle Hypertonia ◽  
Experimental Group

In this study, we analyzed specific manifestations of idiopathic coccygodynia in children and adolescents involved in rhythmic gymnastics and choreography. The experimental group consisted of 34 individuals aged 10 to 14 years with complaints of discomfort and/or pain in the pelvis, sacrum, coccyx, and hip joints, increasing during professional movements and who had no history of injuries. The control group comprised 12 healthy adolescents from the same teams. We evaluated local muscle hypertonia, pain severity (using a visual analog scale) in all study participants. In addition to that, they have undergone sports and choreographic testing and isokinetic examination (using the multiarticular complex ‘Biodex System 4 Pro’). Individuals in the experimental group had a 2-week rehabilitation course that included modification of training; intramuscular injections of 2.0 mL of 0.1% lidocaine solution into the area of muscle hypertonia; application of ointment (2.2 mL); manual therapy; special exercises to relax spasmed muscles). We identified significant difference in pain severity when performing basic choreographic elements between the two groups in the beginning of the study. We also observed a significant decrease in pain in the experimental group after the rehabilitation course. We obtained an indirect proof of the hypothesis that local muscle hypertonia is the leading cause of discomfort and pain. The results of isometric examination suggest that the number of patients with a bilateral difference (according to two of the three parameters studied) significantly differed between participants in the experimental group after a course of physical rehabilitation and controls. This fact can serve as an indirect evidence that hypertonia affects functional activation of muscles, and a 2-week course of physical rehabilitation is not sufficient. The introduction of the concept of ‘sports coccygodynia’ will allow orthopedic traumatologists and sports medicine doctors to focus on several therapeutic and diagnostic measures and to avoid unnecessary instrumental examination, which will significantly increase the effectiveness of patient rehabilitation. Key words: children and adolescents, muscle hypertonia, coccygodynia, lesions caused by overload, choreography, rhythmic gymnastics

scholarly journals Evaluation of Corneal Endothelium in Children and Adolescents with Type 1 Diabetes Mellitus

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Beata Urban ◽  
Dorota Raczyńska ◽  
Alina Bakunowicz-Łazarczyk ◽  
Krystyna Raczyńska ◽  
Małgorzata Krętowska
Keyword(s):  
Diabetes Mellitus ◽  
Children And Adolescents ◽  
Corneal Endothelium ◽  
Corneal Thickness ◽  
Group Versus ◽  
Control Group ◽  
Diabetic Patients ◽  
Duration Of Diabetes ◽  
The Mean

Purpose. To evaluate the systemic and local factors that contribute to the damage of endothelial cells in diabetic patients and to compare the endothelial structure of the cornea in diabetic and nondiabetic patients.Materials and Methods. The endothelial cell density (ECD) and central corneal thickness (CCT) were investigated in 123 eyes of type 1 diabetic patients and in 124 eyes of nondiabetic patients. The mean diabetic patients age was 15.34 ± 3.06 years versus 14.58 ± 2.01 years in the control group. The mean duration of diabetes was 8.02 ± 3.9 years. The corneal endothelium was imaged by the Topcon SP-2000P.Results. The mean ECD in diabetic eyes was 2435.55 ± 443.43 cells/mm2and was significantly lower than in control group (2970.75 ± 270.1 cells/mm2). The mean CCT was 0.55 ± 0.03 mm in diabetic group versus 0.53 ± 0.033 mm in control group. ECD and CCT significantly correlated only with duration of diabetes. There was no correlation between ECD and CCT and patient age, sex, HbA1C level, and plasma creatinine level.Conclusions. ECD is decreased and CCT is increased in children and adolescents with diabetes mellitus. Duration of diabetes is the factor that affects ECD and CCT.

scholarly journals Preventive Effect of Bifidobacterium Supplementation on Neonatal Cholestasis in Preterm Neonates with Very Low Birth Weight

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Gaohong Wu ◽  
Xiaoqian Chen ◽  
Ningxun Cui ◽  
Yunxia He ◽  
Jiaying Fan ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Infants ◽  
Very Low Birth Weight ◽  
Group Versus ◽  
Preterm Neonates ◽  
Control Group ◽  
Neonatal Cholestasis ◽  
Biochemical Tests ◽  
Significant Difference

Background. Cholestasis is a common but serious clinical condition in preterm neonates. The current management for preterm neonatal cholestasis has limitations. The aim of this study was to determine effects of Bifidobacterium supplementation on the prevention and alleviation of cholestasis in preterm infants with very low birth weight. Methods. Preterm neonates with very low birth weight were enrolled in the Children’s Hospital of Soochow University between December 2012 and December 2017. The patients were randomly assigned into Bifidobacterium and control groups, and effects of Bifidobacterium supplementation on the outcomes were compared between the two groups. Results. There was no significant difference in the baseline characteristics in the two groups. Notably, the proportion of cases with neonatal cholestasis was significantly lower, with fewer neonatal cholestasis-associated complications in the Bifidobacterium group compared with the control group (6% versus 22%, P<0.01). Furthermore, the Bifidobacterium group exhibited less severe cholestasis and better improvement of the liver function than the control group as evidenced by the biochemical tests (P<0.05). Finally, comparison of the other outcomes revealed that significant shorter duration of hospitalization (14.45±2.13 versus 16.12±2.22 days, P<0.01), fewer days to reach the full enteral feeding (9.2±2.11 versus 12±5.67 days, P<0.01), shorter duration of meconium passage (5.0±3.6 versus 6.6±3.38 days, P<0.05), lower proportion of cases on fasting and duration of fasting (0.8% versus 5.6%, P<0.05 and 3.0±1.6 versus 5.6±2.38 days, P<0.01, respectively), and shorter duration of weight gain to normal (4.77±2.49 versus 6.87±2.71 days, P<0.01) in the Bifidobacterium group versus the control group. Conclusions. Bifidobacterium supplementation has significantly preventive and other beneficial effects on the management of cholestasis in preterm infants with very low birth weight. Its long-term safety and effectiveness will need further investigation. This trial is registered with the Chinese Clinical Trial Registry (Registration No. ChiCTR1900022296).

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