scholarly journals Evaluation of MU2net as an Online Secondary Dose Check for MR Guided Radiation Therapy with the Elekta Unity MR Linac

2021 ◽  
Author(s):  
John Baines ◽  
Ariadne Shoobridge
Keyword(s):  
Dose Calculation ◽  
Measured Data ◽  
Reference Points ◽  
Planning System ◽  
Treatment Planning System ◽  
Computational Accuracy ◽  
Adaptive Workflow ◽  
Step And Shoot ◽  
Secondary Dose ◽  
Gantry Angle

Abstract During the adaptive workflow associated with MRgRT, a secondary dose calculation is required and MU2net (DOSIsoft, France) is one commercial option. The suitability of MU2net to be used in conjunction with the online Monaco treatment planning system of the Elekta Unity (Elekta AB, Stockholm, Sweden), is evaluated in this work. Monaco and MU2net point doses are compared for various fields on and off axis and at different SSDs. To investigate the comparative effects of attenuation due to the cryostat, couch and posterior coil, measured, MU2net and Monaco dose outputs at the isocentre, as a function of gantry angle, were compared. Point doses for the beams of nine step and shoot IMRT (SSIMRT) test plans (courtesy Elekta) were calculated with Monaco v5.4 and compared to corresponding doses computed with MU2net. In addition, Monaco v5.4 and MU2net point doses were compared for 1552 beams treated on the Unity at our facility. For the on-axis fields investigated the agreement between MU2net and measured data is acceptable. MU2net and Monaco point doses for the Elekta SSIMRT test plans were within ± 5.0 % and ± 6.4 % for beams delivered from gantry zero and at planned beam angles, respectively. For the 1552 beams delivered approximately 80.0 % of MU2net and Monaco point doses agree within ± 5.0 %, therefore it is recommended to correlate MU2net Dose Reference Points (DRPs )with pre and post treatment dosimetry verification. Computational accuracy of MU2net could be enhanced with improved modelling of attenuation due to the couch, cryostat and posterior MR imaging coil.

scholarly journals Monte Carlo-Based Dose Calculation in Postprostatectomy Image-Guided Intensity Modulated Radiotherapy: A Pilot Study

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Ashley Rankine ◽  
Kirsty Turnbull ◽  
Stuart Greenham ◽  
Thomas P. Shakespeare ◽  
Justin Westhuyzen ◽  
...  
Keyword(s):  
Pilot Study ◽  
Volumetric Modulated Arc Therapy ◽  
Intensity Modulated Radiotherapy ◽  
Dose Calculation ◽  
Target Volume ◽  
Planning System ◽  
Treatment Planning System ◽  
Intensity Modulated ◽  
Arc Therapy ◽  
Step And Shoot

Step-and-shoot (S&S) intensity-modulated radiotherapy (IMRT) using the XiO treatment planning system (TPS) has been routinely used for patients receiving postprostatectomy radiotherapy (PPRT). After installing the Monaco, a pilot study was undertaken with five patients to compare XiO with Monaco (V2.03) TPS for PPRT with respect to plan quality for S&S as well as volumetric-modulated arc therapy (VMAT). Monaco S&S showed higher mean clinical target volume (CTV) coverage (99.85%) than both XiO S&S (97.98%, P = 0.04) and Monaco VMAT (99.44, P = 0.02). Rectal V60Gy volumes were lower for Monaco S&S compared to XiO (46.36% versus 58.06%, P = 0.001) and Monaco VMAT (46.36% versus 54.66%, P = 0.02). Rectal V60Gy volume was lowest for Monaco S&S and superior to XiO (mean 19.89% versus 31.25%, P = 0.02). Rectal V60Gy volumes were lower for Monaco VMAT compared to XiO (21.09% versus 31.25%, P = 0.02). Other organ-at-risk (OAR) parameters were comparable between TPSs. Compared to XiO S&S, Monaco S&S plans had fewer segments (78.6 versus 116.8 segments, P = 0.02), lower total monitor units (MU) (677.6 MU versus 770.7 MU, P = 0.01), and shorter beam-on times (5.7 min versus 7.6 min, P = 0.03). This pilot study suggests that Monaco S&S improves CTV coverage, OAR doses, and planning and treatment times for PPRT.

scholarly journals Evaluation of a treatment planning system developed for clinical boron neutron capture therapy and validation against an independent Monte Carlo dose calculation system

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Naonori Hu ◽  
Hiroki Tanaka ◽  
Ryo Kakino ◽  
Syuushi Yoshikawa ◽  
Mamoru Miyao ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Treatment Planning ◽  
Neutron Capture ◽  
Gamma Ray ◽  
Dose Calculation ◽  
Planning System ◽  
Treatment Planning System ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Monte Carlo Dose Calculation

AbstractBoron neutron capture therapy (BNCT) for the treatment of unresectable, locally advanced, and recurrent carcinoma of the head and neck cancer has been approved by the Japanese government for reimbursement under the national health insurance as of June 2020. A new treatment planning system for clinical BNCT has been developed by Sumitomo Heavy Industries, Ltd. (Sumitomo), NeuCure® Dose Engine. To safely implement this system for clinical use, the simulated neutron flux and gamma ray dose rate inside a water phantom was compared against experimental measurements. Furthermore, to validate and verify the new planning system, the dose distribution inside an anthropomorphic head phantom was compared against a BNCT treatment planning system SERA and an in-house developed Monte Carlo dose calculation program. The simulated results closely matched the experimental results, within 5% for the thermal neutron flux and 10% for the gamma ray dose rate. The dose distribution inside the head phantom closely matched with SERA and the in-house developed dose calculation program, within 3% for the tumour and a difference of 0.3 Gyw for the brain.

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