scholarly journals Persistent cough and asthma-like symptoms post COVID-19 hospitalization in children

2021 ◽  
Author(s):  
hossein esmaeilzadeh ◽  
Anahita Sanaei Dashti ◽  
Negar Mortazavi ◽  
Fatemian Fatemian ◽  
Mohebat Vali
Keyword(s):  
Risk Factors ◽  
Allergic Rhinitis ◽  
Medical History ◽  
Laboratory Data ◽  
Previous History ◽  
Hospitalized Children ◽  
Past Medical History ◽  
Persistent Cough ◽  
History Of

Abstract Backgrounds: Respiratory viruses are the main triggers of asthma. Coronavirus is shown to contribute to infections of the respiratory tract that can lead to prolong cough and asthma. Objectives: Present study aimed to determine the risk of developing Persistent cough and asthma-like symptoms in hospitalized children due to COVID-19. Methods: This prospective study was carried out in a tertiary referral center. During the COVID-19 pandemic, 69 hospitalized pediatric patients admitted with COVID-19 were observed from February2020 to January 2021. Clinical and laboratory data were recorded, and after discharge, patients were followed and visited for cough and asthma evaluation in one, 2 and 6 months later. Patients with asthma-like diagnosis in follow up define as asthma-like group and patients without any sign of asthma categorized as the non-asthma group. Asthma-like co-morbids and risk factors were evaluated and compared between two groups. Results: Most of the COVID-19 hospitalized patients (N=42) (58.5%) were not affected by asthma-like symptoms in follow-up. 60.9% of the COVID-19 patients were male. The asthma-like group cases had a significantly familial history of asthma (63.0%), past medical history of asthma (33.3%), and Allergic rhinitis (85.2%). Rates of signs and symptoms during hospitalization were significantly higher in patients with COVID-19 and past medical history of asthma. Conclusions: We found an asthma-like prevalence of 41.5% in the cohort of COVID-19 hospitalized children. Family history of asthma and previous history of asthma and allergic rhinitis are risk factors for asthma-like after COVID-19 hospitalization. COVID-19 presentations are more severe in the asthma-like group.

Essential Thrombocythemia: Analysis of Risk Factors for Thrombotic Events in a Series of 306 Patients.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 4937-4937
Author(s):  
Franca Radaelli ◽  
Stefania Bramanti ◽  
Mariangela Colombi ◽  
Alessandra Iurlo ◽  
Alberto Zanella
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Essential Thrombocythemia ◽  
Thrombotic Event ◽  
Previous History ◽  
Significant Difference ◽  
Platelet Number ◽  
History Of

Abstract Essential thrombocythemia (ET) is a chronic myeloproliferative disorder characterized by peripheral thrombocytosis and abnormal proliferation of megakariocytes in the bone marrow. Even thought thrombosis is frequently associated to ET, the risk factors of this clinical complication are still controversial. The aim of this retrospective, single institution study was to investigate clinical and laboratory characteristics associated with the occurrence of thrombotic events, with the purpose of identifying subgroups of patients who could benefit from antiaggregant and/or cytostatic treatment. 306 consecutive ET patients (109 men and 197 females, median age 58 yr) diagnosed between January 1979 and December 2002 were included in the study. At the time of analysis, 196 patients were still alive with a median follow up of 96 months. The following variables were investigated for the association with thrombotic complications: age, platelet count, previous history of thrombotic events, time from diagnosis, treatment with antiaggregant/cytostatic drugs, and cardiovascular risk factors such as arterial hypertension, obesity, hypercolesterolemia, diabetes, cigarette smoking. At the time of last follow up, 46 patients (15%) experienced at least one thrombotic event. The occurrence of thrombotic events was observed in 26/64 (40.6%) patients with previous history of thrombosis and in 20/242 (8.3%) patients with no previous history of thrombosis (p<0.0001 Fisher’s exact test, odd ratio 7.6). A significant difference between the two groups of patients was also confirmed when Kaplan Meier estimates of thrombosis-free survival were compared by log-rank test (p<0.0001). By logistic regression, platelet number at diagnosis did not associate with occurrence of thrombosis in the whole patient population. When patients without previous history of thrombosis were stratified according to the number of cardiovascular risk factors (none vs one vs more than one), a significant correlation with occurrence of thrombotic events was observed (Mantel-Haenszel Chi-square 5.47, p<0.05). This study confirms that history of thrombosis is strongly related with risk of further thrombotic events in patients with ET, whereas platelet number at diagnosis does not seem to represent a prognostic factor. In patients with no previous history of thrombosis, the presence of other cardiovascular risk factors has to be taken into account when establishing the therapeutic approach.

scholarly journals Insidious-Onset Indurated Plaques on the Shins

2021 ◽  
Vol 8 (2) ◽  
pp. 185-189
Author(s):  
Rishi Agrawal ◽  
Daniel Knabel ◽  
Anthony P. Fernandez
Keyword(s):  
Medical History ◽  
Punch Biopsy ◽  
Graves Disease ◽  
Past Medical History ◽  
Graves Ophthalmopathy ◽  
Insidious Onset ◽  
History Of ◽  
Peau D’Orange ◽  
Pretibial Myxedema

A 64-year old male presented with a several-year history of an insidious-onset tender, itchy and xerotic rash on his lower legs. Past medical history was significant for Graves’ disease and Graves’ ophthalmopathy. The examination revealed peau d’orange-appearing plaques on his shins clinically consistent with pretibial myxedema. A punch biopsy showed separation of collagen bundles with extensive dermal mucin deposition, confirming the diagnosis of pretibial myxedema. After initially failing treatment with a topical clobetasol 0.05% ointment, the patient switched to regular pentoxifylline and triamcinolone 0.1% ointment under occlusion. He remains under follow-up.

scholarly journals Prediction of severe pre-eclampsia in low-risk women

2021 ◽  
Vol 6 (2) ◽  
pp. 51-58
Author(s):  
N. I. Frolova ◽  
T. E. Belokrinitskaya ◽  
K. A. Kolmakova
Keyword(s):  
Risk Factors ◽  
Medical History ◽  
Respiratory Infections ◽  
Kidney Diseases ◽  
First Trimester ◽  
Genotype Distribution ◽  
Past Medical History ◽  
Singleton Pregnancy ◽  
Uncomplicated Pregnancy ◽  
History Of

Aim. To find the predictors of severe pre-eclampsia in women without any established risk factors.Materials and Methods. We consecutively recruited 200 pregnant women (100 with severe pre-eclampsia and 100 with uncomplicated pregnancy and successful delivery). Criteria of inclusion were age from 18 to 35 years, absence of significant comorbid conditions (cardiovascular diseases, autoimmune diseases, metabolic disorders, and kidney diseases), absence of family history and past medical history of pre-eclampsia and thromboembolism, singleton pregnancy, and body mass index in the first trimester < 35 kg/m2 . We assessed allele and genotype distribution across several gene polymorphisms (ADD1-1378G>T, AGT704T>C, AGT-521C>T, AGTR1-1166A>C, AGTR2-1675G>A, NO3-894G>C, and NO3-786T>C) potentially associated with severe pre-eclampsia.Results. We found that the combination of AGTR2-1675АA and eNOS3-786СC polymorphisms (p = 0.04), bacteriuria (p < 0.001), acute respiratory infections (p = 0.011) and acute vulvovaginitis in second and third trimesters (p = 0.013), smoking (p < 0.001), and past medical history of abortions (p = 0.017) were risk factors of severe pre-eclampsia.Conclusions. Predictors of severe pre-eclampsia revealed in this study can be used in the development of personalised prognostication during pregnancy in patients without conventional risk factors of pre-eclampsia. 

scholarly journals 955Risk of drowning: the Japan Collaborative Cohort (JACC) Study

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Takashi Kimura ◽  
Satoyo Ikehara ◽  
Akiko Tamakoshi
Keyword(s):  
Risk Factors ◽  
Medical History ◽  
Heavy Drinking ◽  
The Elderly ◽  
Drinking Habits ◽  
Hazard Ratios ◽  
History Of ◽  
Current Drinker ◽  
Self Administered Questionnaire

Abstract Background In Japan, the unintentional drowning mortality rate among the elderly is exceptionally high. However, the risk factors for drowning in Japan are not fully understood. This study aims to explore the risk factors of drowning in Japan. Methods This study used data from the Japan Collaborative Cohort Study, a prospective cohort aged 40–79 years initiated 1988-1990. A total of 86,298 individuals (35,984 men and 50,314 women) completed a self-administered questionnaire and were mainly followed up by the end of 2009. We calculated hazard ratios (HRs) and 95% confidence intervals (95%CIs) for drowning according to age, body mass index, drinking habits, medical history, marital status, and years of education. Results A total of 194 drownings occurred during a median follow-up period of 18.9 years. The multivariable HRs (95%CIs) of drowning were 0.21 (0.10–0.45) for aged &lt;50 years, 0.37 (0.21-0.65) for 50–59 years compared with 60–69 years, 3.08 (1.39–6.85) for bereaved compared with married, 3.39 (1.19-9.66) for with medical history of stroke compared without, and 3.18 (1.39–7.30) for current drinker with ≥69.0g ethanol/day compared with never drinker in men, 0.20 (0.09-0.43) for aged &lt;50 years and 3.39 (1.19-9.66) for 50-59 years in women. Conclusions Younger people were found to have a lower risk of drowning. For men, bereavement, history of stroke, and current heavy drinking were found to have higher risk of drowning. Key messages In Japan, bereavement, a history of stroke, and heavy drinking among men found to have higher risk of drowning

Prevalence and risk factors of exit-site infection in incident peritoneal dialysis patients

2020 ◽  
Vol 40 (2) ◽  
pp. 164-170
Author(s):  
Jianxiong Lin ◽  
Hongjian Ye ◽  
Jianying Li ◽  
Yagui Qiu ◽  
Haishan Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Peritoneal Dialysis ◽  
Mechanical Stress ◽  
Laboratory Data ◽  
Site Infection ◽  
Exit Site ◽  
Exit Site Infection ◽  
Increased Risk ◽  
History Of

Background: Exit-site infection (ESI) is a common complication in peritoneal dialysis (PD) patients. Clearly understanding the risk factors may be useful for the prevention of ESI. This study was to explore the prevalence and risk factors of ESI in incident PD patients. Methods: We evaluated ESI in incident PD patients who had catheter insertion in our center between 1 January 2009 and 31 December 2013, with follow-up for 1 year. We collected data on demographics, clinical features, and nursing care methods of the exit site (ES). Results: We recruited 1133 incident PD patients (687 male (60.6%); mean age 47.0 ± 15.1 years), and 245 (21.6%) had diabetes. Median follow-up was 12.0 months. One hundred and thirty-one patients had 139 episodes of ESI with a rate of 92.8 patient-months per episode (0.13 episodes per year). Coagulase-negative staphylococcus was the main pathogen, accounting for 33.8% of the ESIs. Gram-positive rods, Staphylococcus aureus, Pseudomonas, fungi, and other organisms accounted for 23.0%, 15.8%, 1.4%, 1.4%, and 2.9%, respectively. No bacterial growth was found in 15.1%. There were no differences in demographic and laboratory data (age, gender, primary kidney disease, hemoglobin, white blood cell, serum albumin, blood urea nitrogen, serum creatinine, and C-reactive protein) between the ESI and non-ESI groups. Poor competency of ES care, poor catheter immobilization, history of catheter-pulling injury, and mechanical stress on the ES were significantly associated with increased risk of ESI. Conclusions: The prevalence of ESI was 0.13 episodes per year. Poor competency of ES care, catheter mobilization, history of catheter-pulling injury, and mechanical stress by waist belt or the protective bag of PD on ES were risk factors for ESI.

scholarly journals Factors Associated With Hospitalization in Children and Adolescents With SARS-CoV-2 Infection

2021 ◽  
pp. 000992282110598
Author(s):  
Jerry Y. Chao ◽  
Ariel Sugarman ◽  
Atsumi Kimura ◽  
Steven Flamer ◽  
Tina T. Jing ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Medical History ◽  
Bimodal Distribution ◽  
Hospitalized Children ◽  
Past Medical History ◽  
Lower Socioeconomic Status ◽  
Obesity And Diabetes ◽  
Lower Socioeconomic ◽  
History Of ◽  
Univariate Statistics

In this retrospective study of 319 children with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we assessed whether age, asthma, obesity, diabetes, and socioeconomic status were associated with hospitalization for coronavirus disease 2019 (COVID-19). Demographic and clinical characteristics were assessed using univariate statistics, excluding incidental or unrelated positives. There was a bimodal distribution of age among hospitalized children. Obesity ( P < .001) and a past medical history of diabetes ( P = .001) were significantly more prevalent in hospitalized children, including cases of new-onset diabetes and diabetic ketoacidosis. Neither a past medical history of asthma nor lower socioeconomic status was associated with hospitalization. Although limited to a single center, the findings in this study may have important clinical implications. Targeted, proactive health outreach to children with obesity and diabetes, with prioritization of preventative efforts such as vaccination, may be important in preventing worse SARS-CoV-2 infection in this vulnerable group.

scholarly journals Hypogonadism in Children with a Previous History of Cancer: Endocrine Management and Follow-Up

2019 ◽  
Vol 91 (2) ◽  
pp. 93-103 ◽  
Author(s):  
Hanneke M. van Santen ◽  
Marry M. van den Heuvel-Eibrink ◽  
Marianne D. van de Wetering ◽  
W. Hamish Wallace
Keyword(s):  
Risk Factors ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Previous History ◽  
Childhood Cancer Survivors ◽  
History Of ◽  
Primary Gonadal Failure ◽  
History Of Cancer ◽  
Gonadal Failure

Hypogonadism after treatment for childhood cancer is a recognized complication and its cause may be subdivided into primary gonadal failure and central hypogonadism. Here, we provide an overview of the risk factors for the development of hypogonadism, assessment and potential interventions and give a summary of the current recommendations for management and follow-up of hypogonadism in childhood cancer survivors.

Abstract T MP94: Venous Thromboembolism Complications In Patients With Intracerebral Hemorrhage

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Jennifer Osborne ◽  
Fernando Testai ◽  
Padmini Sekar ◽  
Charles J Moomaw ◽  
Michael L James ◽  
...  
Keyword(s):  
Risk Factor ◽  
Venous Thromboembolism ◽  
Intracerebral Hemorrhage ◽  
Medical History ◽  
Univariate Analysis ◽  
Previous History ◽  
Prior History ◽  
Past Medical History ◽  
Vein Thrombosis ◽  
History Of

Introduction: Intracerebral hemorrhage (ICH) is often more severe than ischemic stroke. Venous thromboembolism (VTE), such as deep vein thrombosis (DVT) and pulmonary embolism (PE) can extend length of stay and impede recovery. For ICH patients, there is the added challenge of timing and dosage of anticoagulation used to prevent VTEs. We sought to describe the rate of VTE and factors associated with it among ICH cases in a multi-ethnic population. Methods: ERICH is a multi-center, prospective case-control study of ICH among white, black, and Hispanic patients. Data were collected by hospital chart review and personal interview. CT Images were collected and analyzed by a neuroimaging core. Past medical history and acute clinical data were examined for association with VTE during the hospital stay. Results: Between 8/1/10 and 12/31/13, 2276 cases of ICH were enrolled. CT data are available for 2038 patients. Of these, 63 had VTE complications: 41-DVT, 16-PE, and 6 - both DVT and PE. In univariate analysis, Blacks, previous history of DVT, low GCS at presentation, increased ICH volume, presence of intraventricular hemorrhage (IVH),and need for intubation. In comparison, patients at higher risk for PE were those with past medical history of PE and required intubation (Table). In addition, patients with DVT and PE had higher modified Rankin Scale at both hospital discharge and 3 months. In multivariate analysis, only previous VTE, the need for intubation and the presence of IVH were associated with DVT or PE. Conclusion: We confirmed within a large and ethnically diverse ICH patient population that clinically diagnosed VTE events are relatively rare at 3%. The strongest risk factor for development of DVT/PE was a prior history of DVT/PE. But the most prevalent risk factor was a need for intubation. Further study is needed to understand the efficacy of VTE preventative strategies among ICH patients.

scholarly journals Risk Factors for Hospital-Acquired Venous Thromboembolism in Children: Findings from the Children's Hospital-Acquired Thrombosis (CHAT) Registry

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 142-142
Author(s):  
Brian R. Branchford ◽  
Julie Jaffray ◽  
Stacy E. Croteau ◽  
Michael Silvey ◽  
Nihal Bakeer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Medical History ◽  
Research Funding ◽  
Venous Catheter ◽  
Past Medical History ◽  
Central Venous ◽  
History Of ◽  
Hospital Acquired ◽  
Active Cancer ◽  
Or History

Abstract Introduction Pediatric hospital-acquired venous thromboembolism (HA-VTE) rates are increasing along with associated mortality, short- and long-term morbidity, and healthcare costs. National process improvement efforts are underway to decrease HA-VTE in children, but risk-stratified prevention strategies will be safest and most effective if informed by robust risk factor data. The objective of this work was to identify risk factors for HA-VTE in children via a multicenter study Methods The Children's Hospital-Acquired Thrombosis (CHAT) Registry is a multi-institutional pediatric HA-VTE registry that we created to generate a risk-prediction model for future use in clinical trials of thromboprophylaxis. Designed as a retrospective case-control study, CHAT Registry data has been entered by 7 U.S. pediatric institutions for subjects admitted between January 1, 2012 and December 31, 2016. Cases (aged 0-21 years) that developed HA-VTE during the admission were matched by institution and admission year with 1:1 frequency to randomly sampled non-HA-VTE controls. Univariate analyses tested associations between risk factors and the development of HA-VTE. Analyses utilized weighted logistic regression, in which controls were weighted by the inverse sampling probability in order to recreate the population from which the controls were sampled. Year of admission and hospital sites were included in the assessment of each predictor to control for effects of time and treating hospital. Results 825 HA-VTE cases and 841 controls from participating hospitals comprise the analytical cohort (total 1,666 hospital admissions). HA-VTE cases showed a male predominance (58%). The majority, 73%, were related to central venous catheters (CVCs). HA-VTE most commonly occurred in the lower extremity (32%) followed by upper extremity (16%), thorax/neck (16%), cerebral sinovenous (5%), abdomen (5%), lung (3%), cardiac (2%), and other (22%). VTE were asymptomatic or identified incidentally in 21% of cases. Subjects were most commonly located in an intensive care unit (ICU) (58%) when diagnosed with a VTE, followed by general medical ward (23%), hematology/oncology unit (13%), surgical unit (3%), emergency department (1%), and other (1%). Significant association with HA-VTE incidence (Table 1) was found with infancy compared to other age groups, prior hospitalization within 1 month (Odds Ratio [OR] 3.6, 95% Confidence Interval [CI] 2.7-4.8) compared to no recent prior admission, admission to ICU (cardiac/pediatric ICU OR 10.1, 95% CI 6.0-17.1 and NICU OR 9.0, 95% CI 5.2-15.7) or hematology/oncology units (OR 2.7, 95% CI 1.6-6.0) compared to admission to general pediatric ward, complete immobility acutely (OR 32.3, 95% CI 13.2-79.2 ) compared to no loss of mobility from baseline, chronic bed-bound/wheelchair-bound immobility (OR 2.2, 95% CI 1.4-3.6), and a past medical history of protein-losing state (OR 34.6, 95% CI 4.1-290.9), inflammatory/autoimmune disease (OR 31.8, 95% CI 3.9-262.1), congenital heart disease (OR 28.5, 95% CI 12.7-64.2), central venous catheter placed on the day of admission (OR 22.0, 95% CI 14.2-34.1) or prior to admission (OR 5.2, 95% CI 3.4-7.9) thrombophilia/VTE (OR 9.7, 95% CI 2.6-35.5), TPN dependence (OR 8.0, 95% CI 1.6-39.3), or history of cancer (OR 1.5, 95% CI 1.0-2.4) compared to the absence of past medical history. Additionally, active cancer conferred an overall odds ratio of 2.0, with the recurrent/metastatic subtype conferring an OR of 3.4 compared to other active cancer subtypes. Conclusions The multi-institution CHAT Registry contains a larger dataset of pediatric HA-VTE cases and controls than any similar collection published to date. Key demographic and clinical factors associated with HA-VTE include infant age, male sex, ICU admission, central venous catheter, decreased mobility, cancer, use of certain medications, or certain past medical history (protein-losing state, congenital heart disease, inflammatory/autoimmune condition, thrombophilia or history of VTE, and TPN dependence). Further analysis is being performed on these and other risk factors to develop a pediatric-specific HA-VTE risk-prediction model for future validation in an even larger multi-institutional cohort. This validated risk model will then be used to identify children at high risk of HA-VTE to guide preventative strategies to decrease the incidence in the pediatric population. Disclosures Jaffray: CSL Behring: Consultancy, Research Funding; Octapharma: Consultancy; Bayer: Consultancy. Croteau:Tremeau Pharmaceuticals: Consultancy; Baxalta/Shire: Consultancy, Research Funding; Biomarin: Consultancy; Bioveritiv: Consultancy; Catalyst Biosciences: Consultancy; CSL-Behring: Consultancy; Genetech: Consultancy, Research Funding; Novo Nordisk: Consultancy; Octapharma: Consultancy, Honoraria, Research Funding; Pfizer: Research Funding; Spark Therapeutics: Research Funding; Bayer: Consultancy. Silvey:Bayer: Honoraria; Pfizer: Honoraria; CSL Behring: Honoraria; Octapharma: Honoraria. Young:Bioverativ: Consultancy, Honoraria; Bayer: Consultancy; CSL Behring: Consultancy, Honoraria; Genentech/Roche: Consultancy, Honoraria; Kedrion: Consultancy; Novo Nordisk: Consultancy, Honoraria; Shire: Consultancy, Honoraria. Mahajerin:Genentech Inc.: Consultancy.

scholarly journals Evaluating the Risk Factors and Induced Cardiotoxicity in Breast Cancer Patients

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Habib Haybar ◽  
Sasan Razmjoo ◽  
Samira Razaghi ◽  
Mitra Ranjbaran
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Heart Disease ◽  
Laboratory Data ◽  
Significant Risk ◽  
Common Side Effect ◽  
Breast Cancer Patients ◽  
Treatment Protocols ◽  
History Of

Background: Breast cancer (BC) is one of the most common cancers among women. The survival of the BC patients is based on new treatment protocols. Cardiotoxicity is the most common side effect in these patients. Methods: This was a descriptive study in which we selected our patients randomly among the BC patients and used questionnaires for data completion.66 BC patients whose disease were confirmed according to the histology and laboratory data taken to the oncology section of Ahvaz Golestan hospital between 2017 - 2018. Risk factors, history of the patients, and the function of the heart were evaluated 6 and 12 months after chemotherapy through echocardiography. Result: Six months after chemotherapy, the follow-up patients in 6 indicated five significant risk factor included Age (P < 0.03), history of heart disease (P < 0.02), blood pressure (P < 0.00), diabetes (P < 0.00), and cholesterol (P < 0.04), which confirm the dysregulation function of heart and indication of cardiotoxicity. In 12 months follow- up, the result indicated that only the history of heart disease was significantly correlated with cardiotoxicity (P < 0.01). Conclusion: Finally, the detection of risk factors in BC can introduce a prognostic factor when cardiotoxicity occurs simultaneously with the conduction of chemotherapy.

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