scholarly journals Glyceraldehyde 3-phosphate dehydrogenase converts methylmercury to its sulfur adduct with lowered toxicity through sulfane sulfur atoms on Cys247

2022 ◽  
Vol 9 (1) ◽  
pp. 1-5
Author(s):  
Yumi Abiko ◽  
Eiko Yoshida ◽  
Yoshito Kumagai
Keyword(s):  
Sulfane Sulfur

scholarly journals The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species

2021 ◽  
pp. 107916
Author(s):  
Brandán Pedre ◽  
Uladzimir Barayeu ◽  
Daria Ezeriņa ◽  
Tobias P. Dick
Keyword(s):  
Mechanism Of Action ◽  
Sulfur Species ◽  
Sulfane Sulfur

scholarly journals The conversion of H2S to sulfane sulfur

2012 ◽  
Vol 13 (12) ◽  
pp. 803-803 ◽  
Author(s):  
John I. Toohey
Keyword(s):  
Sulfane Sulfur

scholarly journals Menadione effect on l-cysteine desulfuration in U373 cells.

2007 ◽  
Vol 54 (2) ◽  
pp. 407-411 ◽  
Author(s):  
Maria Wróbel ◽  
Halina Jurkowska
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Control Culture ◽  
Oxygen Species ◽  
Active Centers ◽  
Glutathione Synthesis ◽  
Sulfane Sulfur ◽  
Mercaptopyruvate Sulfurtransferase ◽  
Sulfur Level ◽  
U373 Cells

The non-cytotoxic concentration (20 microM) of menadione (2-methyl-1,4-naphthoquinone), after 1 h of incubation, leads to loss of the activity of rhodanese by 33%, 3-mercaptopyruvate sulfurtransferase by 20%, as well as the level of sulfane sulfur by about 23% and glutathione by 12%, in the culture of U373 cells, in comparison with the control culture. Reactive oxygen species generated by menadione oxidize sulfhydryl groups in active centers of the investigated enzymes, inhibiting them and saving cysteine for glutathione synthesis. A decreased sulfane sulfur level can be correlated with an oxidative stress.

scholarly journals Sodium trisulfide, a sulfane sulfur donor, stimulates bovine aortic endothelial cell proliferation in culture

2021 ◽  
Vol 46 (7) ◽  
pp. 341-344
Author(s):  
Musubu Takahashi ◽  
Ruri Iwai ◽  
Ryoko Takasawa ◽  
Tsuyoshi Nakano ◽  
Tomoya Fujie ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Endothelial Cell Proliferation ◽  
Bovine Aortic Endothelial Cell ◽  
Sulfane Sulfur ◽  
Aortic Endothelial Cell ◽  
Sulfur Donor ◽  
Aortic Endothelial

scholarly journals OxyR senses sulfane sulfur and activates the genes for its removal in Escherichia coli

Redox Biology ◽  
2019 ◽  
Vol 26 ◽  
pp. 101293 ◽  
Author(s):  
Ningke Hou ◽  
Zhenzhen Yan ◽  
Kaili Fan ◽  
Huanjie Li ◽  
Rui Zhao ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Sulfane Sulfur

scholarly journals Effect of S-Allyl –L-Cysteine on MCF-7 Cell Line 3-Mercaptopyruvate Sulfurtransferase/Sulfane Sulfur System, Viability and Apoptosis

2020 ◽  
Vol 21 (3) ◽  
pp. 1090 ◽  
Author(s):  
Patrycja Bronowicka-Adamska ◽  
Anna Bentke ◽  
Małgorzata Lasota ◽  
Maria Wróbel
Keyword(s):  
Cell Viability ◽  
Cell Line ◽  
Breast Adenocarcinoma ◽  
Sulfane Sulfur ◽  
Mercaptopyruvate Sulfurtransferase ◽  
Late Apoptosis ◽  
Sulfur Level ◽  
H2s Production ◽  
Level Reduction ◽  
Mcf 7

The S-Allyl-L-cysteine (SAC) component of aged garlic extract (AGE) is proven to have anticancer, antihepatotoxic, neuroprotective and neurotrophic properties. γ-Cystathionase (CTH), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (MPST) are involved in H2S/sulfane sulfur endogenous formation from L-cysteine. The aim of the study was to determine the effect of SAC on MCF-7 cells survival and apoptosis, which is a widely known approach to reduce the number of cancer cells. An additional goal of this paper was to investigate the effect of SAC on the activity and expression of enzymes involved in H2S production. The experiments were carried out in the human breast adenocarcinoma cell line MCF-7. Changes in the cell viability were determined by MTT assay. Cell survival was determined by flow cytometry (FC). Changes in enzymes expression were analyzed using Western blot. After 24 h and 48 h incubation with 2245 µM SAC, induction of late apoptosis was observed. A decrease in cell viability was observed with increasing SAC concentration and incubation time. SAC had no significant cytotoxic effect on the MCF-7 cells upon all analyzed concentrations. CTH, MPST and CBS expression were confirmed in non-treated MCF-7 cells. Significant decrease in MPST activity at 2245 µM SAC after 24 h and 48 h incubation vs. 1000 µM SAC was associated with decrease in sulfane sulfur levels. The presented results show promising SAC effects regarding the deterioration of the MCF-7 cells’ condition in reducing their viability through the downregulation of MPST expression and sulfate sulfur level reduction.

Sulfane Sulfur in Toxicology: A Novel Defense System Against Electrophilic Stress

2019 ◽  
Vol 170 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Yasuhiro Shinkai ◽  
Yoshito Kumagai
Keyword(s):  
Defense System ◽  
Sulfane Sulfur ◽  
Electrophilic Stress

Hydrogen Sulfide Increases Endothelial Permeability by Bound Sulfane Sulfur

2014 ◽  
Vol 76 ◽  
pp. S56
Author(s):  
Shuai Yuan ◽  
Arif Yurdagul ◽  
Sibile Pardue ◽  
A. Wayne Orr ◽  
Christopher G. Kevil
Keyword(s):  
Hydrogen Sulfide ◽  
Endothelial Permeability ◽  
Sulfane Sulfur

scholarly journals Lipoic Acid as a Possible Pharmacological Source of Hydrogen Sulfide/Sulfane Sulfur

Molecules ◽  
2017 ◽  
Vol 22 (3) ◽  
pp. 388 ◽  
Author(s):  
Anna Bilska-Wilkosz ◽  
Małgorzata Iciek ◽  
Danuta Kowalczyk-Pachel ◽  
Magdalena Górny ◽  
Maria Sokołowska-Jeżewicz ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Lipoic Acid ◽  
Sulfane Sulfur
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