Severe Loss of Visceral Fat and Skeletal Muscle After Chemotherapy Predict Poor Prognosis in Metastatic Gastric Cancer Patients Without Gastrectomy

2019 ◽  
Author(s):  
Wanjing Feng ◽  
Mingzhu Huang ◽  
Xiaoying Zhao ◽  
Siyuan Chen ◽  
Chenchen Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Skeletal Muscle ◽  
Cancer Patients ◽  
Visceral Fat ◽  
Poor Prognosis ◽  
Metastatic Gastric Cancer ◽  
Severe Loss ◽  
Gastric Cancer Patients

scholarly journals Severe loss of visceral fat and skeletal muscle after chemotherapy predicts poor prognosis in metastatic gastric cancer patients without gastrectomy

2020 ◽  
Vol 11 (11) ◽  
pp. 3310-3317 ◽  
Author(s):  
Wanjing Feng ◽  
Mingzhu Huang ◽  
Xiaoying Zhao ◽  
Siyuan Chen ◽  
Chenchen Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Skeletal Muscle ◽  
Cancer Patients ◽  
Visceral Fat ◽  
Poor Prognosis ◽  
Metastatic Gastric Cancer ◽  
Severe Loss ◽  
Gastric Cancer Patients

scholarly journals Clinicopathological Characteristics and Prognosis of cT1N0M1 Gastric Cancer: A Population-Based Study

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Jianbo Han ◽  
Junhao Tu ◽  
Chaoyang Tang ◽  
Xiang Ma ◽  
Chi Huang
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Metastatic Gastric Cancer ◽  
Clinicopathological Characteristics ◽  
The Other ◽  
Rank Test ◽  
Cancer Specific Survival ◽  
Log Rank Test ◽  
Gastric Cancer Patients

Background. Distant metastasis of early gastric cancer is a rare subgroup and poorly understood. The present study is aimed at summarizing the clinicopathological characteristics, prognosis, and management of clinical T1N0M1 (cT1N0M1) gastric cancer. Method. Between 2004 and 2015, patients diagnosed with cT1N0M1 gastric cancer were retrospectively analyzed using the Surveillance, Epidemiology, and End Results (SEER) database. Results. A total of 1093 cT1N0M1 gastric cancer patients were identified. 49 patients (4.5%) received cancer-directed surgery, and 113 patients (10.4%) were managed with radiotherapy. Compared with the other stage IV diseases, a relatively high proportion of black population (19.9% vs. 15.8%), patients older than 60 years (63.1% vs. 57.8%), and adenocarcinoma (59.5% vs. 55.9%) were observed in the cT1N0M1 gastric cancer subgroup. Besides that, patients with cT1N0M1 had the characteristics of less poor differentiated or undifferentiated (54.3% vs. 61.7%). Patients with cT1N0M1 had worse cancer-specific survival (CSS) and overall survival (OS) as compared to the other metastatic gastric cancer patients (CSS: p=0.002, OS: p=0.001 for log-rank test). Intriguingly, patients with cT1N0M1 had poor prognosis as compared to patients with cT1N+M1 (CSS: p=0.015, OS: p=0.007 for log-rank test). The 3-year and 5-year CSS for patients with cT1N0M1 were 5.7% and 4.0%, respectively. The addition of surgery resulted in improved CSS (p<0.001 for log-rank test) while radiotherapy was not associated with CSS (p=0.756 for log-rank test) in patients with cT1N0M1. A multivariate Cox analysis showed that surgery (HR=0.378, 95% CI: 0.255-0.562) and patients younger than 60 (HR=0.745, 95% CI: 0.647-0.858) years were independent protective factors for these subgroup patients. Conclusion. Patients with cT1N0M1 gastric cancer had distinctive clinicopathological characteristics and presented poor prognosis. Knowledge of these differences contributes to guiding clinical evaluation for metastatic gastric cancer patients. More aggressive therapeutic strategy should be highlighted for this subgroup.

scholarly journals P21-Activated Kinase 4 Overexpression in Metastatic Gastric Cancer Patients

2011 ◽  
Vol 4 (6) ◽  
pp. 345-349 ◽  
Author(s):  
Hee Kyung Ahn ◽  
Jiryeon Jang ◽  
Jeeyun Lee ◽  
Hoon Park Se ◽  
Joon Oh Park ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Metastatic Gastric Cancer ◽  
P21 Activated Kinase ◽  
Gastric Cancer Patients

scholarly journals Low FAT4 expression is associated with a poor prognosis in gastric cancer patients

Oncotarget ◽  
2017 ◽  
Vol 9 (4) ◽  
pp. 5137-5154 ◽  
Author(s):  
Xiaoting Jiang ◽  
Zhengchuang Liu ◽  
Yingjie Xia ◽  
Jungang Luo ◽  
Ji Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Gastric Cancer Patients

scholarly journals HOXB7 overexpression promotes cell proliferation and correlates with poor prognosis in gastric cancer patients by inducing expression of both AKT and MARKs

Oncotarget ◽  
2016 ◽  
Vol 8 (1) ◽  
pp. 1247-1261 ◽  
Author(s):  
Xujun He ◽  
Zhengchuang Liu ◽  
Yingjie Xia ◽  
Ji Xu ◽  
Guocai Lv ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Gastric Cancer Patients

scholarly journals LAPTM4B-35, a Cancer-Related Gene, Is Associated with Poor Prognosis in TNM Stages I-III Gastric Cancer Patients

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0121559 ◽  
Author(s):  
Xiaojing Cheng ◽  
Zhixue Zheng ◽  
Zhaode Bu ◽  
Xiaojiang Wu ◽  
Lianhai Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Related Gene ◽  
Cancer Related Gene ◽  
Gastric Cancer Patients

scholarly journals Simple combinations of 5-FU pathway genes predict the outcome of metastatic gastric cancer patients treated by S-1

2006 ◽  
Vol 119 (8) ◽  
pp. 1927-1933 ◽  
Author(s):  
Wataru Ichikawa ◽  
Takehiro Takahashi ◽  
Kenichi Suto ◽  
Yoshinori Shirota ◽  
Zenro Nihei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Metastatic Gastric Cancer ◽  
Gastric Cancer Patients

Patient-reported symptoms in metastatic gastric cancer patients in the last 6 months of life

2020 ◽  
Vol 29 (1) ◽  
pp. 515-524 ◽  
Author(s):  
Lev D. Bubis ◽  
Victoria Delibasic ◽  
Laura E. Davis ◽  
Yunni Jeong ◽  
Kelvin Chan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Metastatic Gastric Cancer ◽  
Patient Reported ◽  
Gastric Cancer Patients
Sign in / Sign up

Export Citation Format

Share Document