Fibroblast Activation Protein (FAP)-Targeted CAR-T Cells: Launching an Attack on Tumor Stroma

ImmunoTargets and Therapy ◽

10.2147/itt.s291767 ◽

2021 ◽

Vol Volume 10 ◽

pp. 313-323

Author(s):

Reyisa Bughda ◽

Paraskevi Dimou ◽

Reena R D'Souza ◽

Astero Klampatsa

Keyword(s):

T Cells ◽

Tumor Stroma ◽

Fibroblast Activation Protein ◽

Fibroblast Activation ◽

Car T Cells ◽

Car T

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Local delivery of CAR T cells targeting fibroblast activation protein is safe in patients with pleural mesothelioma: first report of FAPME, a phase I clinical trial

Annals of Oncology ◽

10.1016/j.annonc.2020.10.474 ◽

2021 ◽

Vol 32 (1) ◽

pp. 120-121

Author(s):

S. Hiltbrunner ◽

C. Britschgi ◽

P. Schuberth ◽

L. Bankel ◽

T.D.L. Nguyen-Kim ◽

...

Keyword(s):

Clinical Trial ◽

T Cells ◽

Phase I ◽

Local Delivery ◽

Fibroblast Activation Protein ◽

Phase I Clinical Trial ◽

Pleural Mesothelioma ◽

First Report ◽

Car T Cells ◽

Car T

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Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma

Immunological Reviews ◽

10.1111/imr.12125 ◽

2013 ◽

Vol 257 (1) ◽

pp. 83-90 ◽

Cited By ~ 131

Author(s):

Markus Chmielewski ◽

Andreas A. Hombach ◽

Hinrich Abken

Keyword(s):

T Cells ◽

Chimeric Antigen Receptor ◽

Antigen Receptor ◽

Tumor Stroma ◽

Car T Cells ◽

Car T

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Abstract 3241: Targeting the tumor stroma using CAR T-cells

10.1158/1538-7445.am2020-3241 ◽

2020 ◽

Author(s):

Sarah Ash ◽

Frances Turrell ◽

Clare Isacke ◽

Steven Lee

Keyword(s):

T Cells ◽

Tumor Stroma ◽

Car T Cells ◽

Car T

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Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity

Cancer Immunology Research ◽

10.1158/2326-6066.cir-13-0027 ◽

2013 ◽

Vol 2 (2) ◽

pp. 154-166 ◽

Cited By ~ 186

Author(s):

Liang-Chuan S. Wang ◽

Albert Lo ◽

John Scholler ◽

Jing Sun ◽

Rajrupa S. Majumdar ◽

...

Keyword(s):

T Cells ◽

Tumor Growth ◽

Chimeric Antigen Receptor ◽

Antigen Receptor ◽

Tumor Stroma ◽

Fibroblast Activation Protein ◽

Host Immunity ◽

Severe Toxicity ◽

Inhibit Tumor Growth ◽

Fibroblast Activation

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Decision letter for "CXCR2‐modified CAR‐T cells have enhanced trafficking ability that improves treatment of hepatocellular carcinoma"

10.1002/eji.201948457/v2/decision1 ◽

2020 ◽

Keyword(s):

Hepatocellular Carcinoma ◽

T Cells ◽

Car T Cells ◽

Car T

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Review for "CXCR2‐modified CAR‐T cells have enhanced trafficking ability that improves treatment of hepatocellular carcinoma"

10.1002/eji.201948457/v1/review2 ◽

2019 ◽

Keyword(s):

Hepatocellular Carcinoma ◽

T Cells ◽

Car T Cells ◽

Car T

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Autologous Active IL-7 Receptor Co-expressing GD2-specific CAR T-cells

10.32388/ohva3w ◽

2020 ◽

Author(s):

Keyword(s):

T Cells ◽

Car T Cells ◽

Car T

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13 / Evaluation of immunosuppressive surface molecules, essential for resistance to CAR T-cells

10.26226/morressier.5b3b802db1b87b000eced9d4 ◽

2018 ◽

Author(s):

Titov Aleksei

Keyword(s):

T Cells ◽

Surface Molecules ◽

Car T Cells ◽

Car T

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Cord Blood Derived CAR-T Cells in Refractory/Relapsed B Cell Malignancies

Case Medical Research ◽

10.31525/ct1-nct03881774 ◽

2019 ◽

Author(s):

Keyword(s):

T Cells ◽

Cord Blood ◽

B Cell ◽

B Cell Malignancies ◽

Car T Cells ◽

Car T

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Modified Immune Cells (Autologous CAR T Cells) in Treating Patients With Advanced, Recurrent Platinum Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Case Medical Research ◽

10.31525/ct1-nct03907527 ◽

2019 ◽

Author(s):

Keyword(s):

T Cells ◽

Fallopian Tube ◽

Immune Cells ◽

Primary Peritoneal Cancer ◽

Peritoneal Cancer ◽

Car T Cells ◽

Platinum Resistant ◽

Car T

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