scholarly journals Evaluating Equity and Coverage in Mass Drug Administration for Soil-Transmitted Helminth Infections among School-Age Children in the Hard-to-Reach Setting of Southern Ethiopia

2021 ◽  
Vol Volume 12 ◽  
pp. 325-333
Author(s):  
Mekuria Asnakew Asfaw ◽  
Chernet Hailu ◽  
Tariku J Beyene
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
School Age Children ◽  
Southern Ethiopia ◽  
School Age ◽  
Helminth Infections

scholarly journals Soil-Transmitted Helminth Reinfection and Associated Risk Factors among School-Age Children in Chencha District, Southern Ethiopia: A Cross-Sectional Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Zerihun Zerdo ◽  
Tsegaye Yohanes ◽  
Befikadu Tariku
Keyword(s):  
Risk Factors ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Predictor Variable ◽  
Cross Sectional Study ◽  
School Age Children ◽  
School Age ◽  
Sectional Study ◽  
Cross Sectional ◽  
Associated Risk Factors

Mass drug administration (MDA) to the most risky population including school-age children (SAC) is the central strategy to control soil-transmitted helminth (STH) infection. The present study was aimed at estimating the prevalence of STHs reinfection three months posttreatment and associated risk factors among SAC in Chencha district. A cross-sectional study design was employed from April 20 to May 5, 2015, to enroll 408 SAC. Structured questionnaire and Kato-Katz thick smear technique were used to interview parents or guardians and quantify the number of eggs per gram of stool. Pearson chi-square and logistic regression were used to assess the association between predictor variable and STH reinfection. The prevalence of STHs within three months of mass chemotherapy among SAC was 36.8% which is 93.4% of the prevalence (39.4%) before treatment. The estimated prevalence of reinfection (95%CI) forAscaris lumbricoides,Trichuris trichiura, and hookworms was 23.8% (21.1–28.2), 16.2% (12.7–20.1), and 1.0% (0.3–2.5), respectively. Children of merchant fathers were more likely to be reinfected by STHs in Chencha district. In conclusion, there is rapid reinfection after mass chemotherapy among SAC in Chencha district. Further studies should be carried out to generate cost efficient methods that can supplement mass drug administration to accelerate the control of STHs.

scholarly journals A Systematic Review and Metanalyis of Soil Transmitted Helminths Infections Among Preschool and School-age Children in Ethiopia: Evaluation of Neglected Tropica Diseases (NTDS) Elimination Program by 2020

2020 ◽  
Author(s):  
Legese Chelkeba ◽  
Tsegaye Melaku ◽  
Daniel Emana ◽  
Worku Jimma
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
Intestinal Parasites ◽  
School Age Children ◽  
School Age ◽  
Amhara Region ◽  
Soil Transmitted Helminths ◽  
Tigray Region ◽  
Predominant Species ◽  
Risk Zones

Abstract Background: Comprehensive nationwide on prevalence, geographic distribution of different species and time trends of soil-transmitted helminths (STHs) are lacking. Therefore, the aim of this study was to provide a summary and location of the available data on STHs infection among preschool and school-age children in Ethiopia. Methods: The search were carried out in Medline via PubMed, Scopus, Science Direct, Web of Science and Google Scholar on data published between 1995 to Fabruary 2020 for studies describing rate of STHs infection among preschool and school-age in Ethiopian. We followed Patient, intervention, Comparsion and Outcome (PICO) approach to identify the studies. Endnote citation manager software version X9 for Windows was utilized to collect and organize search outcomes (into relevant and irrelevant studies) and for removal duplicate articles . We conducted meta-regression to understand the trends and the source of heterogeneity and pooled the prevalence using ‘metaprop’ command using STATA software version 14.Results: A total of 29,311 of the 61,690 children examined during the period under review were infected with one or more species of intestinal parasites yielding an overall prevalence of 48 % (95%CI: 43-53%). The overall pooled estimate of STHs was 33% (95% CI: 28-38%). The prevalence was 44% (95%CI : 31% - 58%) in SNNPR, 34%((95%CI : 28% - 41%) in Amhara region, 31% (95%CI : 19% - 43%) in Oromia region and 10% (95%CI : 7% - 12%) in Tigray region. Soil-transmitted helminths infection rate has been decreasing from 44% (95% CI:30-57%) pre-Mass Drug Administration (MDA) era (1997-2012) to 30% (95% CI:25-34%) post-MDA (2013-2020), although statistically not significant (p = 0.45). A. lumbricoides was the predominant species with a prevalence of 17%. Conclusion: Southern Nations Nationalities and Peoples Region , Amhara and Oromia regions carry the highest burden and are categorized to Moderate Risk Zones (MRZ) and therefore, requiring mass drug administration (MDA) once annually with Albendazole or Mebendazole. Prevalence of SHTs decreased after MDA compared to before MDA, but the decline was not statistically significant. A. lumbricoides was the predominant species of STHs among preschool and school-age children in Ethiopia.

scholarly journals PREVALENCE THRESHOLDS THAT SHOULD BE APPLIED IN SCHISTOSOMIASIS MASS DRUG ADMINISTRATION PRGROGRAMMES: SYSTEMATIC REVIEW AND META-ANALYSIS

2021 ◽  
Author(s):  
Anthony Danso-Appiah ◽  
Amadou Djirmay Garba ◽  
Nathan C Lo ◽  
Massimiliano Orso ◽  
Kwadwo Owusu Akuffo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Sensitivity Analyses ◽  
School Age Children ◽  
School Age ◽  
Intensity Of Infection ◽  
Global Prevalence

Background WHO-recommended prevalence thresholds for deciding schistosomiasis mass drug administration (MDA) are based on anecdotal evidence and unclear. Objectives This systematic review and meta-analysis commissioned by the WHO, as part of its new schistosomiasis evidence-based guideline development, was to generate a single and global prevalence threshold that should be applied in MDA programmes. Methods We searched several databases from 1979 to 31st March 2021 without language restriction. Two reviewers selected studies, extracted data and assessed the risk of bias using relevant risk of bias tools and resolved disagreements through discussion. The review followed the PRISMA guidelines. Data were analysed and presented as prevalence reduction (PR) and relative risk (RR) for dichotomous outcomes or mean difference for continuous outcomes with their 95% confidence intervals (CIs). Meta-regression of observations on prevalence rates and intensity of infection of MDA programmes and sensitivity analyses to assess the robustness of the results to the risk of bias components were performed. Evidence on benefits, harms, values, preferences, compliance, acceptability, equity and feasibility were also assessed. The overall level of evidence was graded using GRADE. Results Out of 1,232 studies retrieved, 38 studies met our inclusion criteria and 34 studies were included in the meta-analysis. No direct relation was observed between prevalence and intensity of infection. Praziquantel reduced prevalence of S. haematobium in school age children (SAC) at 12 months (RR 0.38, 95% CI 0.28 to 0.52; 8 studies, n=37,868); at 24 months (RR 0.30; 95% CI 0.30 to 0.52; 7 studies; n=37107); at 36 months (RR 0.39, 95% CI 0.21 to 0.71; 5 studies, n=28,146). There was no significant reduction in prevalence at 48 months (2 studies, n=10,954). For S. mansoni, there were reductions in prevalence at 12 months (RR 0.56, 95% CI 0.46 to 0.69; 14 studies, n=86,073); 24 months (RR 0.46; 95% CI 0.32 to 0.66; 14 studies; n=83,721);36 months (RR 0.44, 95% CI 0.33 to 0.58; 7 studies, n=70,933) and at 48 months (RR 0.25, 95% CI 0.11 to 0.59; 5 studies; n=27,483). Further analyses were performed from a series of created prevalence thresholds of 5%, 10%, 15%, 20%, 30% and ≥40% which showed differences in effect of MDA when each of the thresholds was applied. For annual MDA of school age children (SAC), school-based treatment (SBT) appears to perform better than community-wide treatment (CWT) in terms of prevalence reduction. For the different schistosome species, the model suggests, using the same prevalence threshold, it will take shorter time to reach elimination for S. haematobium than S. mansoni; annual MDA using SBT approach for S. haematobium will require about 10 years to achieve elimination whereas it will take over 10 years to around 15 years to achieve elimination for S. mansoni. Conclusion The evidence presented in this systematic review suggests that 10% prevalence should be used as the global prevalence threshold for implementing MDA in endemic countries.

scholarly journals Schistosomiasis in School Age Children in Sierra Leone After 6 Years of Mass Drug Administration With Praziquantel

2019 ◽  
Vol 7 ◽  
Author(s):  
Yakuba M. Bah ◽  
Jusufu Paye ◽  
Mohamed S. Bah ◽  
Abdulai Conteh ◽  
Sam Saffa ◽  
...  
Keyword(s):  
Sierra Leone ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
School Age Children ◽  
School Age

scholarly journals The promise and pitfalls of mass drug administration to control intestinal helminth infections

2012 ◽  
Vol 25 (5) ◽  
pp. 584-589 ◽  
Author(s):  
Debbie Humphries ◽  
Sara Nguyen ◽  
Daniel Boakye ◽  
Michael Wilson ◽  
Michael Cappello
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
Intestinal Helminth ◽  
Helminth Infections

scholarly journals Helminth infections and micronutrients in school-age children: a systematic review and meta-analysis

2014 ◽  
Vol 99 (6) ◽  
pp. 1499-1509 ◽  
Author(s):  
Brechje de Gier ◽  
Maiza Campos Ponce ◽  
Margot van de Bor ◽  
Colleen M Doak ◽  
Katja Polman
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
School Age Children ◽  
School Age ◽  
Helminth Infections

scholarly journals Prevalence and factors associated with stunting and thinness among school-age children in Arba Minch Health and Demographic Surveillance Site, Southern Ethiopia

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0206659 ◽  
Author(s):  
Eshetu Zerihun Tariku ◽  
Getaneh Alemu Abebe ◽  
Zeleke Aschalew Melketsedik ◽  
Befikadu Tariku Gutema
Keyword(s):  
School Age Children ◽  
Southern Ethiopia ◽  
School Age ◽  
Demographic Surveillance Site ◽  
Factors Associated ◽  
Surveillance Site

scholarly journals Prevalence of scabies and its associated factors among school age children in Arba Minch zuria district, Southern Ethiopia, 2018

2020 ◽  
Author(s):  
Abayneh Tunje ◽  
Chuchu Churko ◽  
Desta Haftu ◽  
Amsalu Alagaw ◽  
Eyayou Girma
Keyword(s):  
Bacterial Infection ◽  
Skin Disease ◽  
General Health ◽  
Associated Factors ◽  
School Age Children ◽  
Southern Ethiopia ◽  
School Age ◽  
The World ◽  
History Of ◽  
Considerable Impact

AbstractBackgroundScabies, a common human skin disease with a prevalence range of 0.2% to 71.4% in the world. It can have considerable impact on general health leading to illness and death not only through direct effect of its infestation and as a result of secondary bacterial infection. The aim of this study was to assess the prevalence of scabies and its associated factors among school age children in Arba Minch zuria district, Gamo zone, Southern Ethiopia.MethodsA community based cross sectional study was carried out in 845 school age children from February 20 to March 30, 2018. Multi-stage sampling technique was used to select study populations. Logistic regression an analysis was used to identify factors associated with scabies. Findings were presented using 95% CI of Crude Odds Ratios (COR) and Adjusted Odds Ratios (AOR. To declare statistical significance, p-value less than 0.05 was used.ResultA total of 825 children participated in the study with response rate of 97.6%. The overall prevalence of scabies was 16.4% [95% CI: 13.9%, 18.9%]. overcrowding index, family history of itching in the past two weeks, wealth index, knowledge of scabies, climatic zone, frequency of washing body, frequency of washing clothes, finger nails cutting practice, history of skin contact with scabies patient, washing hair more than once weekly, and sharing of clothes were significantly associated scabies disease.ConclusionIn conclusion, the prevalence of scabies in Arba Minch lies at 16.4% in the global scabies range 0.2% to 71.4%. The prevalence was highest in highlands followed by midland and then lowland. This represents a significant scabies burden which we recommend warrants health service intervention.Authors summaryScabies, a common human skin disease with a prevalence range of 0.2% to 71.4% in the world. It can have considerable impact on general health leading to illness and death not only through direct effect of its infestation and as a result of secondary bacterial infection. Conducting a research on this neglected tropical disease would contribute in designing a policies and strategies on prevention and control measures in the study area. Therefore, the aim of this study was to assess the prevalence of scabies and its associated factors among school age children in Arba Minch zuria district, Gamo zone, Southern Ethiopia.

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