Cellulose Nanofibrils-based Hydrogels for Biomedical Applications: Progresses and Challenges

2020 ◽  
Vol 27 (28) ◽  
pp. 4622-4646 ◽  
Author(s):  
Huayu Liu ◽  
Kun Liu ◽  
Xiao Han ◽  
Hongxiang Xie ◽  
Chuanling Si ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Metal Ion ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Cellulose Nanofibrils ◽  
Wound Dressings ◽  
Preparation Methods ◽  
Tissue Scaffold ◽  
Surface Areas ◽  
Mechanical Methods

Background: Cellulose Nanofibrils (CNFs) are natural nanomaterials with nanometer dimensions. Compared with ordinary cellulose, CNFs own good mechanical properties, large specific surface areas, high Young's modulus, strong hydrophilicity and other distinguishing characteristics, which make them widely used in many fields. This review aims to introduce the preparation of CNFs-based hydrogels and their recent biomedical application advances. Methods: By searching the recent literatures, we have summarized the preparation methods of CNFs, including mechanical methods and chemical mechanical methods, and also introduced the fabrication methods of CNFs-based hydrogels, including CNFs cross-linked with metal ion and with polymers. In addition, we have summarized the biomedical applications of CNFs-based hydrogels, including scaffold materials and wound dressings. Results: CNFs-based hydrogels are new types of materials that are non-toxic and display a certain mechanical strength. In the tissue scaffold application, they can provide a micro-environment for the damaged tissue to repair and regenerate it. In wound dressing applications, it can fit the wound surface and protect the wound from the external environment, thereby effectively promoting the healing of skin tissue. Conclusion: By summarizing the preparation and application of CNFs-based hydrogels, we have analyzed and forecasted their development trends. At present, the research of CNFs-based hydrogels is still in the laboratory stage. It needs further exploration to be applied in practice. The development of medical hydrogels with high mechanical properties and biocompatibility still poses significant challenges.

scholarly journals Smart hydrogels based on itaconic acid for biomedical application

2009 ◽  
Vol 63 (6) ◽  
pp. 603-610
Author(s):  
Simonida Tomic ◽  
Maja Micic ◽  
Bojana Krezovic ◽  
Sava Dobic ◽  
Edin Suljovrujic ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Itaconic Acid ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
In Vitro Study ◽  
Mechanical Analysis ◽  
Wound Dressings ◽  
Temperature Sensitive ◽  
Stimuli Responsive

pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.

A Review of Water-Resistant Cellulose-Based Materials in Pharmaceutical and Biomedical Application

2021 ◽  
Vol 28 ◽  
Author(s):  
Bei He ◽  
Xinxin Liu ◽  
Shi Qi ◽  
Run Zheng ◽  
Minmin Chang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Biomedical Application ◽  
Drug Loading ◽  
Cellulose Fibers ◽  
Dip Coating ◽  
Wound Dressings ◽  
Attractive Alternative ◽  
Natural Polymers ◽  
Insoluble Drugs ◽  
Good Biocompatibility

Background: Cellulose, huge reserves of natural polymers, have been widely applied in pharmaceutical and biomedicine fields due to its good biocompatibility, biodegradability, non-toxicity and excellent mechanical properties. At present, water-resistant metal-based and petroleum-based materials applied in medical field exists obvious problems of poor biocompatibility and high cost. Therefore, water-resistant cellulose-based materials with good biocompatibility and low price will become an attractive alternative. This review aims to summarize the preparation of water-resistant cellulose-based materials and their potential application in pharmaceutical and biomedical in recent years. Methods: Common hydrophobic treatments of cellulose fibers or paper were overviewed. The preparation, properties and applications of water-resistant cellulose-based materials in the pharmaceutical and biomedical fields were summarized. Results: Common hydrophobic treatments of cellulose fibers or paper were divided into chemical modification (graft polymerization, crosslinking, solution casting or dip-coating), physico-chemical surface modifications (plasma treatments, surface patterning, electrostatic spraying and electrowetting) and physical processing (electrostatic spinning, SAS process and 3D EHD printing). These hydrophobically processed cellulose fibers or paper could be prepared into various water-resistant cellulose-based materials and applied in pharmaceutical excipients, drug-loaded amphiphilic micelles, drug-loaded composite fibers, hydrophobic biocomposite film/coatings and paper-based detectors. They presented excellent water resistance and biocompatibility, low cytotoxicity and high drug loading ability, and stable drug release rate, etc., which could be used for water-insoluble drugs carriers, wound dressings, and medical testing equipment. Conclusion: Currently, water-resistant cellulose-based materials were mainly applied in water-insoluble drugs delivery carriers, wound dressing and medical diagnosis and presented great application prospects. However, the contradiction between hydrophobicity and mechanical properties of these reported water-resistant cellulose-based materials limited their wider application in biomedicine such as tissue engineering. In the future, attention will be focused on the higher hydrophobicity of water-resistant cellulose-based materials with excellent mechanical properties. In addition, clinical medical research of water-resistant cellulose-based materials should be strengthened.

Mechanical Property and Microstructure of Ti-Ta-Ag Alloy for Biomedical Applications

2012 ◽  
Vol 520 ◽  
pp. 254-259 ◽  
Author(s):  
Ming Wen ◽  
Cui E Wen ◽  
Peter D. Hodgson ◽  
Yun Cang Li
Keyword(s):  
Mechanical Properties ◽  
Mechanical Property ◽  
Elastic Modulus ◽  
Spark Plasma Sintering ◽  
Biomedical Applications ◽  
High Hardness ◽  
Vacuum Sintering ◽  
Preparation Methods ◽  
Plasma Sintering ◽  
Spark Plasma

Ti and some of its alloys (e.g. Ti–6Al–4V alloy) have become the metals of choice for the endosseous parts of presently available dental implants. In the present study, Ti-Ta-Ag alloys with a different Ag content were prepared using vacuum sintering (VS) and spark plasma sintering (SPS) process. The microstructure and mechanical properties of the Ti-Ta-Ag alloys were investigated. The results show that dense Ti-Ta-Ag alloys prepared using the SPS process exhibit high hardness and a suitable elastic modulus for implant materials for load-bearing applications. The effect of preparation methods on the microstructure of Ti-Ta-Ag alloys is discussed.

Structure, Microstructure, and Selected Mechanical Properties of Ti-Zr-Mo Alloys for Biomedical Applications

2014 ◽  
Vol 922 ◽  
pp. 75-80 ◽  
Author(s):  
Diego Rafael Nespeque Correa ◽  
Pedro Akira Bazaglia Kuroda ◽  
Carlos Roberto Grandini
Keyword(s):  
Mechanical Properties ◽  
Young’S Modulus ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Young's Modulus ◽  
Microstructural Analysis ◽  
Melting Furnace ◽  
High Hardness ◽  
Mechanical Analysis ◽  
Β Phase

New titanium alloys for biomedical applications have been developed primarily with the addition of Nb, Ta, Mo, and Zr, because those elements stabilize the β phase and they don’t cause cytotoxicity in the organism. The objective of this paper is to analyze the effect of molybdenum on the structure, microstructure, and selected mechanical properties of Ti-15Zr-xMo (x = 5, 10, 15, and 20 wt%) alloys. The samples were produced in an arc-melting furnace with inert argon atmosphere, and they were hot-rolled and homogenized. The samples were characterized using chemical, structural, and microstructural analysis. The mechanical analysis was made using Vickers microhardness and Young’s modulus measurements. The compositions of the alloys were sensitive to the molybdenum concentration, indicating the presence of α’+α”+β phases in the Ti-15Zr-5Mo alloy, α”+β in the Ti-15Zr-10Mo alloy, and β phase in the Ti-15Zr-15Mo and Ti-15Zr-20Mo alloys. The mechanical properties showed favorable values for biomedical application in the alloys presenting high hardness and low Young’s modulus compared with CP-Ti.

Engineering of nanometer-sized cross-linked hydrogels for biomedical applications

2010 ◽  
Vol 88 (3) ◽  
pp. 173-184 ◽  
Author(s):  
Jung Kwon Oh
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Water Content ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
High Water ◽  
Delivery Systems ◽  
High Water Content ◽  
Surface Areas

Microgels/nanogels (micro/nanogels) are promising drug-delivery systems (DDS) because of their unique properties, including tunable chemical and physical structures, good mechanical properties, high water content, and biocompatibility. They also feature sizes tunable to tens of nanometers, large surface areas, and interior networks. These properties demonstrate the great potential of micro/nanogels for drug delivery, tissue engineering, and bionanotechnology. This mini-review describes the current approaches for the preparation and engineering of effective micro/nanogels for drug-delivery applications. It emphasizes issues of degradability and bioconjugation, as well as loading/encapsulation and release of therapeutics from customer-designed micro/nanogels.

scholarly journals Technology Overview and Current Biomedical Application of Polymeric Nanoparticles

2018 ◽  
Vol 8 (6) ◽  
pp. 285-295
Author(s):  
Gurpreet Singh ◽  
Abdul Faruk ◽  
Preet Mohinder Singh Bedi
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Polymeric Nanoparticles ◽  
Preparation Methods ◽  
Polymeric Nanoparticle ◽  
Potential Applications ◽  
Dialysis Method ◽  
Novel Drug ◽  
Current Potential

Polymeric nanoparticle are of great importance in the treatment of various diseases, due to the flexibility in the  modification of their structures. Recent advances in the field of nanotechnology facilitate the engineering of multifunctional polymeric nanoparticles. All the scientific efforts of the pharmaceuticals companies are mainly focusing on two basic aspects, one is to discover new molecules of potential therapeutic interest and second is to develop of a new drug delivery system. In the last few decades,  research and development (R&D) scientists has directed their efforts toward formulating novel drug delivery systems that includes sustained and controlled release, modified release and targeted drug release dosage forms. Application of nanoscience and nanotechnology has opened several new possibilities in development of formulation This review compiles the different preparation methods of polymeric nanoparticles and then briefly explained their current potential applications. Keywords: Polymeric nanoparticles, PLGA, Biomedical applications, Biodegradable, Dialysis method

scholarly journals Optimized Synthesis of Biodegradable Elastomer PEGylated Poly(glycerol sebacate) and Their Biomedical Application

Polymers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 965 ◽  
Author(s):  
Yanxiang Wang ◽  
Haiwa Wu ◽  
Zihao Wang ◽  
Jingjing Zhang ◽  
Jing Zhu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Mechanical Strength ◽  
Biomedical Applications ◽  
Bone Repair ◽  
Biomedical Application ◽  
Vascular Reconstruction ◽  
Curing Process ◽  
Thermal Curing ◽  
Potential Applications ◽  
Degradation Behaviors

Poly(glycerol sebacate) (PGS), a biodegradable elastomer, has been extensively explored in biomedical applications for its favorable mechanical properties and biocompatibility. Efforts have been made to fabricate multifunctional PGS copolymer in recent years, in particular PGS-co-PEG (poly(glycerol sebacate)-co-polyethylene glycol) polymers. However, rare research has been systematically conducted on the effect of reactant ratios on physicochemical properties and biocompatibility of PGS copolymer till now. In this study, a serial of PEGylated PGS (PEGS) with PEG content from 20% to 40% and carboxyl to hydroxyl from 0.67 to 2 were synthesized by thermal curing process. The effects of various PEGS on the mechanical strength and biological activity were further compared and optimized. The results showed that the PEGS elastomers around 20PEGS-1.0C/H and 40PEGS-1.5C/H exhibited the desirable hydrophilicity, degradation behaviors, mechanical properties and cell viability. Subsequently, the potential applications of the 20PEGS-1.0C/H and 40PEGS-1.5C/H in bone repair scaffold and vascular reconstruction were investigated and the results showed that 20PEGS-1.0C/H and 40PEGS-1.5C/H could significantly improve the mechanical strength for the calcium phosphate scaffolds and exhibited preferable molding capability for fabrication of the vascular substitute. These results confirmed that the optimized PEGS elastomers should be promising multifunctional substrates in biomedical applications.

Degradable magnesium-based alloys for biomedical applications: The role of critical alloying elements

2019 ◽  
Vol 33 (10) ◽  
pp. 1348-1372 ◽  
Author(s):  
Yang Chen ◽  
Jinhe Dou ◽  
Huijun Yu ◽  
Chuanzhong Chen
Keyword(s):  
Mechanical Properties ◽  
Corrosion Rate ◽  
Magnesium Alloys ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Healing Process ◽  
Alloying Elements ◽  
The Novel ◽  
The Status ◽  
Mechanical Properties And Corrosion

Magnesium-based alloys exhibit biodegradable, biocompatible and excellent mechanical properties which enable them to serve as ideal candidate biomedical materials. In particular, their biodegradable ability helps patients to avoid a second surgery. The corrosion rate, however, is too rapid to sustain the healing process. Alloying is an effective method to slow down the corrosion rate. However, currently magnesium alloys used as biomaterials are mostly commercial alloys without considering cytotoxicity from the perspective of biosafety. This article comprehensively reviews the status of various existing and newly developed degradable magnesium-based alloys specially designed for biomedical application. The effects of critical alloying elements, compositions, heat treatment and processing technology on the microstructure, mechanical properties and corrosion resistance of magnesium alloys are discussed in detail. This article covers Mg–Ca based, Mg–Zn based, Mg–Sr based, Mg–RE based and Mg–Cu-based alloy systems. The novel methods of fabricating Mg-based biomaterials and surface treatment on Mg based alloys for potential biomedical applications are summarized.

3D bioprinting of dual-crosslinked nanocellulose hydrogels for tissue engineering applications

2021 ◽  
Author(s):  
Marzieh Monfared ◽  
Damia Mawad ◽  
Jelena Rnjak-Kovacina ◽  
Martina Heide Stenzel
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Cellulose Nanofibrils ◽  
3D Bioprinting ◽  
Engineering Applications ◽  
The Poor

Hydrogels based on cellulose nanofibrils (CNFs) have been widely used as scaffolds for biomedical applications, however, the poor mechanical properties of CNFs hydrogels limit their use as ink for 3D...

Advances in Biomedical Application of Nanocellulose-Based Materials: A Review

2020 ◽  
Vol 28 ◽  
Author(s):  
Qi Yuan ◽  
Jing Bian ◽  
Ming-Guo Ma
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Wound Dressing ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Cellulose Nanofibers ◽  
Three Dimensional ◽  
Two Dimensional ◽  
One Dimensional ◽  
Sustainable Resources

Background: Recently, there has been increasing interest in nanomaterials processed using renewable and sustainable resources. Nanocellulose-based materials are of paramount value in the applications of biomedicine owing to their tailorable surface modification, favorable optical transparency, good hydrophilicity, excellent biocompatibility, and outstanding mechanical properties. Methods: In the review, the recent advancements of nanocellulose, including cellulose nanofibers (CNFs), cellulose nanocrystals (CNCs), and bacterial cellulose (BC), are summarized, which are promising for biomedical applications. Results: By discussing different forms (one-dimensional (1D), two-dimensional (2D), and three-dimensional (3D)), the superiority of the nanocellulose-based materials with different constructed structures will be clarified for various biomedical applications, such as biosensing, drug delivery, wound dressing, and tissue engineering. Conclusion: Furthermore, the challenges and prospects for future development of nanocellulose-based materials in biomedical applications are also discussed at the end in the review.

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