A Review of Water-Resistant Cellulose-Based Materials in Pharmaceutical and Biomedical Application

2021 ◽  
Vol 28 ◽  
Author(s):  
Bei He ◽  
Xinxin Liu ◽  
Shi Qi ◽  
Run Zheng ◽  
Minmin Chang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Biomedical Application ◽  
Drug Loading ◽  
Cellulose Fibers ◽  
Dip Coating ◽  
Wound Dressings ◽  
Attractive Alternative ◽  
Natural Polymers ◽  
Insoluble Drugs ◽  
Good Biocompatibility

Background: Cellulose, huge reserves of natural polymers, have been widely applied in pharmaceutical and biomedicine fields due to its good biocompatibility, biodegradability, non-toxicity and excellent mechanical properties. At present, water-resistant metal-based and petroleum-based materials applied in medical field exists obvious problems of poor biocompatibility and high cost. Therefore, water-resistant cellulose-based materials with good biocompatibility and low price will become an attractive alternative. This review aims to summarize the preparation of water-resistant cellulose-based materials and their potential application in pharmaceutical and biomedical in recent years. Methods: Common hydrophobic treatments of cellulose fibers or paper were overviewed. The preparation, properties and applications of water-resistant cellulose-based materials in the pharmaceutical and biomedical fields were summarized. Results: Common hydrophobic treatments of cellulose fibers or paper were divided into chemical modification (graft polymerization, crosslinking, solution casting or dip-coating), physico-chemical surface modifications (plasma treatments, surface patterning, electrostatic spraying and electrowetting) and physical processing (electrostatic spinning, SAS process and 3D EHD printing). These hydrophobically processed cellulose fibers or paper could be prepared into various water-resistant cellulose-based materials and applied in pharmaceutical excipients, drug-loaded amphiphilic micelles, drug-loaded composite fibers, hydrophobic biocomposite film/coatings and paper-based detectors. They presented excellent water resistance and biocompatibility, low cytotoxicity and high drug loading ability, and stable drug release rate, etc., which could be used for water-insoluble drugs carriers, wound dressings, and medical testing equipment. Conclusion: Currently, water-resistant cellulose-based materials were mainly applied in water-insoluble drugs delivery carriers, wound dressing and medical diagnosis and presented great application prospects. However, the contradiction between hydrophobicity and mechanical properties of these reported water-resistant cellulose-based materials limited their wider application in biomedicine such as tissue engineering. In the future, attention will be focused on the higher hydrophobicity of water-resistant cellulose-based materials with excellent mechanical properties. In addition, clinical medical research of water-resistant cellulose-based materials should be strengthened.

Cellulose Nanofibrils-based Hydrogels for Biomedical Applications: Progresses and Challenges

2020 ◽  
Vol 27 (28) ◽  
pp. 4622-4646 ◽  
Author(s):  
Huayu Liu ◽  
Kun Liu ◽  
Xiao Han ◽  
Hongxiang Xie ◽  
Chuanling Si ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Metal Ion ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Cellulose Nanofibrils ◽  
Wound Dressings ◽  
Preparation Methods ◽  
Tissue Scaffold ◽  
Surface Areas ◽  
Mechanical Methods

Background: Cellulose Nanofibrils (CNFs) are natural nanomaterials with nanometer dimensions. Compared with ordinary cellulose, CNFs own good mechanical properties, large specific surface areas, high Young's modulus, strong hydrophilicity and other distinguishing characteristics, which make them widely used in many fields. This review aims to introduce the preparation of CNFs-based hydrogels and their recent biomedical application advances. Methods: By searching the recent literatures, we have summarized the preparation methods of CNFs, including mechanical methods and chemical mechanical methods, and also introduced the fabrication methods of CNFs-based hydrogels, including CNFs cross-linked with metal ion and with polymers. In addition, we have summarized the biomedical applications of CNFs-based hydrogels, including scaffold materials and wound dressings. Results: CNFs-based hydrogels are new types of materials that are non-toxic and display a certain mechanical strength. In the tissue scaffold application, they can provide a micro-environment for the damaged tissue to repair and regenerate it. In wound dressing applications, it can fit the wound surface and protect the wound from the external environment, thereby effectively promoting the healing of skin tissue. Conclusion: By summarizing the preparation and application of CNFs-based hydrogels, we have analyzed and forecasted their development trends. At present, the research of CNFs-based hydrogels is still in the laboratory stage. It needs further exploration to be applied in practice. The development of medical hydrogels with high mechanical properties and biocompatibility still poses significant challenges.

scholarly journals Sintesis Hidrogel Pektin – Gelatin dengan Penambahan Ekstrak Kulit Buah Naga Sebagai Kandidat Pembalut Luka Bakar

2020 ◽  
Vol 4 (1) ◽  
pp. 53
Author(s):  
Fadhil Muhammad Tarmidzi ◽  
Inggit Kresna Maharsih ◽  
Tina Raihatul Jannah ◽  
Cici Sari Wahyuni
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Citric Acid ◽  
Wound Dressing ◽  
Wound Care ◽  
Crosslinking Agent ◽  
Wound Dressings ◽  
Esterification Reaction ◽  
Natural Polymers ◽  
Fruit Peel

Teknik pembalutan luka saat ini menerapkan metode perawatan luka modern dengan cara mempertahankan isolasi lingkungan luka dalam keadaan tertutup dan lembab. Ada beberapa jenis pembalut luka yang telah dikembangkan, salah satunya hidrogel. Hidrogel merupakan pembalut luka berbentuk lembaran yang memiliki kemampuan menyerap cairan luka dan memiliki stabilitas yang baik pada pH asam sehingga dapat digunakan untuk pengobatan luka bakar. Dalam penelitian ini, hidrogel dibuat menggunakan polimer alami seperti pektin dan gelatin. Kedua bahan tersebut dikombinasikan menggunakan metode ikatan silang dengan penambahan asam sitrat sebagai agen pengikat silang. Penambahan asam sitrat memberikan pengaruh terhadap karakteristik material hidrogel yang dihasilkan, sehingga diperlukan jumlah yang tepat agar didapatkan hidrogel dengan properti material yang baik. Hidrogel juga ditambahkan zat aktif berupa flavonoid pada ekstrak kulit buah naga agar dapat digunakan sebagai pembalut luka untuk menyembuhkan luka bakar. Dari hasil penelitian, hidrogel dengan konsentrasi asam sitrat 4% (Hidrogel CA 4%) menghasilkan nilai swelling, tensile strength, dan elongation tertinggi sebesar 890%, 0,05 Mpa, dan 200%. Hasil properti mekanik dari Hidrogel CA 4% ini dibuktikan dengan uji FTIR yang telah dilakukan, yaitu munculnya gugus karbonil C=O sebagai hasil reaksi esterifikasi yang terjadi antara polimer dengan asam sitrat di daerah serapan 1733,9 cm-1.Wound dressing technique currently applies modern wound care methods by maintaining the environmental isolation of the wound in a closed and moist state. There are several types of wound dressing that have been developed, one of them is hydrogel. Hydrogel is sheet-shaped wound dressings which have the ability to absorb exudate and have good stability acidic pH that can be used for the treatment of burns. In this study, hydrogel were made using natural polymers such as pectin and gelatin. The two polymers were combined using crosslinking method with the addition of citric acid as a crosslinking agent. The addition of citric acid has affect on the characteristics of the hydrogel material produced, therefore the right amount is needed to obtain a hydrogel with good mechanical properties. Hydrogel also added by an active substance in the form of flavonoids from dragon fruit peel extract that can be used as a wound dressing to cure burns. This study resulting hydrogel with a concentration of 4% citric acid (Hydrogel CA 4%) produced highest value of swelling, tensile strength, and elongation are 890%, 0.05 Mpa, and 200%, repectively. The mechanical properties of Hydrogel CA 4% was proved by FTIR test that had been carried out, namely the presence of C=O carbonyl group as a result of the esterification reaction that occurred between the polymers and citric acid in the absorption area of 1733.9 cm-1.

scholarly journals Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2286 ◽  
Author(s):  
Sibusiso Alven ◽  
Xhamla Nqoro ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Wound Healing ◽  
Transmission Rate ◽  
Biological Activities ◽  
Drug Loading ◽  
Healing Process ◽  
Antioxidant Properties ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Microbial Invasion ◽  
Good Biocompatibility

Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

scholarly journals Design, characterization and in vitro evaluation of thin films enriched by tannic acid complexed by Fe(III) ions

2020 ◽  
Vol 9 (4) ◽  
pp. 249-257
Author(s):  
B. Kaczmarek ◽  
O. Mazur ◽  
O. Miłek ◽  
M. Michalska-Sionkowska ◽  
A. Das ◽  
...  
Keyword(s):  
Tannic Acid ◽  
Biomedical Application ◽  
Blood Compatibility ◽  
Medical Application ◽  
Wound Dressings ◽  
Acid Mixture ◽  
Natural Polymers ◽  
Carbohydrate Polymers ◽  
Potential Applications

AbstractMaterials based on carbohydrate polymers may be used for biomedical application. However, materials based on natural polymers have weak physicochemical properties. Thereby, there is a challenge to improve their properties without initiation of toxicity. The alternative method compared to toxic chemical agents’ addition is the use of metal complexation method. In this study, chitosan/tannic acid mixtures modified by Fe(III) complexation are proposed and tested for potential applications as wound dressings. Thereby, surface properties, blood compatibility as well as platelet adhesion was tested. In addition, the periodontal ligament stromal cells compatibility studies were carried out. The results showed that the iron(III) addition to chitosan/tannic acid mixture improves properties due to a decrease in the surface free energy and exhibited a reduction in the hemolysis rate (below 5%). Moreover, cells cultured on the surface of films with Fe(III) showed higher metabolic activity. The current findings allow for the medical application of the proposed materials as wound dressings.

Synthesis and Characterisation of New Superelastic and Low Elastic Modulus Ti-Nb-X Alloys for Biomedical Application

2011 ◽  
Vol 409 ◽  
pp. 170-174
Author(s):  
A. Ramarolahy ◽  
Philippe Castany ◽  
Thierry Gloriant ◽  
Frédéric Prima ◽  
P. Laheurte ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Elastic Modulus ◽  
Yield Strength ◽  
Shape Memory ◽  
Biomedical Application ◽  
The Other ◽  
Alloying Element ◽  
Low Elastic Modulus ◽  
Superelastic Behavior ◽  
Good Biocompatibility

Ti-Nb based alloys are well known to their good mechanical properties, shape memory effect, superelasticity, as well as good biocompatibility. The Ti-24Nb (at%) binary alloy presents a shape memory behavior and low elastic modulus. Our study is focused on the improvement of their mechanical properties by adding a third alloying element (oxygen, nitrogen or silicon). Addition of 0.5 at% of N or O modifies drastically the mechanical behavior of Ti-24Nb alloy that exhibits superelastic behavior instead of shape memory one. On the other hand, addition of 0.5 at% of Si increased yield strength of the Ti-24Nb shape memory alloy.

scholarly journals Analysis of the Degradation Process of Alginate-Based Hydrogels in Artificial Urine for Use as a Bioresorbable Material in the Treatment of Urethral Injuries

Processes ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 304 ◽  
Author(s):  
Jagoda Kurowiak ◽  
Agnieszka Kaczmarek-Pawelska ◽  
Agnieszka G. Mackiewicz ◽  
Romuald Bedzinski
Keyword(s):  
Mechanical Properties ◽  
Sodium Alginate ◽  
Low Cost ◽  
Brown Seaweed ◽  
Barium Chloride ◽  
Degradation Process ◽  
Dip Coating ◽  
Natural Polymers ◽  
Artificial Urine ◽  
Crosslinking Agents

Hydrogels from natural polymers such as sodium alginate have great potential in regenerative medicine because of their biocompatibility, biodegradability, mechanical properties, bioresorption ability, and relatively low cost. Sodium alginate, a polysaccharide derived from brown seaweed, is the most widely investigated and used biomaterial in biomedical applications. Alginate dressings are also useful as a delivery platform in order to provide a controlled release of therapeutic substances (e.g., pain-relieving, antibacterial, and anti-inflammatory agents). In our work, we aimed to analyze process of degradation of alginate hydrogels. We also describe an original hybrid crosslinking process by using not one, as usual, but a mixture of two crosslinking agents (calcium chloride and barium chloride). We proved that different crosslinking agents allow producing hydrogels with a spectrum of mechanical properties, similar to the urethra tissue. Hydrogels were formed using a dip-coating technique, and then examined by mechanical testing, FTIR (Fourier-Transform Infrared Spectroscopy), and resorption on artificial urine. Obtained hydrogels have a different degradation rate in artificial urine, and they can be used as a material for healing of urethra injuries, especially urethra strictures, which significantly affect the quality of life of patients.

scholarly journals Smart hydrogels based on itaconic acid for biomedical application

2009 ◽  
Vol 63 (6) ◽  
pp. 603-610
Author(s):  
Simonida Tomic ◽  
Maja Micic ◽  
Bojana Krezovic ◽  
Sava Dobic ◽  
Edin Suljovrujic ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Itaconic Acid ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
In Vitro Study ◽  
Mechanical Analysis ◽  
Wound Dressings ◽  
Temperature Sensitive ◽  
Stimuli Responsive

pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.

In vitro characterization of novel multidrug-eluting soy protein wound dressings

2020 ◽  
pp. 088532822097517
Author(s):  
Lior Matsliah ◽  
Daniella Goder ◽  
Shir Giladi ◽  
Meital Zilberman
Keyword(s):  
Mechanical Properties ◽  
Water Vapor ◽  
Soy Protein ◽  
Wound Dressings ◽  
Hemostatic Agent ◽  
Animal Origin ◽  
Swelling Kinetics ◽  
Natural Polymers ◽  
Analgesic Drug ◽  
Antibiotic Drug

Polymers derived from natural sources are of interest in the scientific and medical communities, especially soy protein which exhibits low immunogenicity and good mechanical properties, and supports cell proliferation. Soy protein is cost-effective compared to other natural polymers and is attractive also due to its non-animal origin and relatively long storage stability. In the current study, hybrid film structures were developed and studied as a novel wound dressing platform with controlled release of three bioactive agents. The dense top layer is designed to provide mechanical support, control the water vapor permeability and to elute the antibiotic drug cloxacillin and the analgesic drug bupivacaine to the wound site. The porous sub-layer is designed to absorb the wound exudates and release the hemostatic agent tranexamic acid for bleeding control. The results show that the formulation parameters, i.e. crosslinker and plasticizer concentrations, affected the mechanical properties of the wound dressings as well as relevant physical properties (water vapor transmission rate and swelling kinetics), but had almost no effect on the drug-release profiles. While the antibiotic drug and the analgesic drug were released within several hours, the hemostatic agent was released within several minutes, according to the well designed hybrid structure. In conclusion, our novel soy protein hybrid wound dressings are biocompatible, can deliver various drugs simultaneously in a controlled fashion for each drug individually, and can be adjusted to suit various types of wounds by altering their properties through formulation effects.

Plasma-Sprayed Wollastonite Coatings for Biomedical Application

2005 ◽  
Vol 486-487 ◽  
pp. 201-204 ◽  
Author(s):  
Wei Chang Xue ◽  
Xuan Yong Liu ◽  
Xue Bin Zheng ◽  
Chuan Xian Ding
Keyword(s):  
Mechanical Properties ◽  
Body Fluid ◽  
Biomedical Application ◽  
Fibrous Tissue ◽  
New Bone Formation ◽  
Living Bone ◽  
Good Biocompatibility ◽  
Plasma Sprayed

A new bioceramic coating based on wollastonite was prepared by plasma spraying. The coatings exhibited good mechanical properties. The bond strength of the coating on substrate was about 40 MPa, which is higher than that of HA coatings used in orthopedics and dentistry. The bioactivity of wollastonite coatings was evaluated in vitro and in vivo. After immersed in simulated body fluid, a bone-like apatite layer was formed on the surface of wollastonite coatings. Osteoblast could survive and proliferate on the surface of coatings. After implanted in dog’s cortical bone, histological observation demonstrated that bone tissue could extend and grow along the surface of wollastonite coatings. The coating bonded directly to bone without any fibrous tissue, indicating good biocompatibility and bone conductivity. The wollastonite coatings also showed good bone inductivity property, inducing new-bone formation on their surface after implanted in marrow. The results obtained indicated that the plasma-sprayed wollastonite coatings possessed good mechanical properties and excellent bioactivity in vitro and in vivo. It appears that a wollastonite coating may be suitable for the repair and replacement of living bone, especially for load-bearing situations.

NIKROTHAL TE

Alloy Digest ◽  
2013 ◽  
Vol 62 (10) ◽  
Keyword(s):  
Mechanical Properties ◽  
Physical Properties ◽  
Tensile Properties ◽  
Turn Of The Century ◽  
Heating Element ◽  
Attractive Alternative ◽  
Electric Resistance ◽  
Household Appliances ◽  
Nickel Chromium ◽  
Heating Technology

Abstract NIKROTHAL TE is a member of the Nikrothal family of alloys, which are one of two main types of electric-resistance alloys. Nickel-chromium (80Ni-20Cr, for example), developed around the turn of the century, was used as heating-element material in industrial furnaces and electric household appliances. Nikrothal alloys offer advantages in heating-element applications requiring very good mechanical properties in the hot state. This alloy is an attractive alternative to Nikrothal Alloys 40, 60, 70, and 80 (see Alloy Digest Ni-529, September 1997). This datasheet provides information on composition, physical properties, hardness, and tensile properties. It also includes information on forming. Filing Code: Ni-710. Producer or source: Sandvik Heating Technology.

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