Wonderful Natural Drugs with Surprising Nutritional Values, Rheum Species, Gifts of the Nature

2022 ◽  
Vol 19 ◽  
Author(s):  
Mohamad Hesam Shahrajabian ◽  
Wenli Sun ◽  
Qi Cheng
Keyword(s):  
Medicinal Plants ◽  
Biological Effects ◽  
Nutrition Therapy ◽  
Antibacterial Activities ◽  
Anticancer Activities ◽  
Important Health ◽  
Botanical Description ◽  
Phytochemical Compounds ◽  
Natural Drugs ◽  
Key Terms

Abstract: Nutrition therapy on the basis of traditional medicinal plants and herbs is common in many Asian countries, especially Iran and China. Rheum species, especially rhubarbs, belong to plant medicines recognized in 2500 BC. An online search of the literature was carried out at Pubmed/Medline, Scopus, and Google scholar, covering all years until April 2021. The following key terms were used, usually in combinations: Rheum species, rhubarb, natural products, pharmaceutical benefits, anthraquinones and anthranone. After performing the literature search, the bibliographies of all articles were checked for cross-references that were not found in the search databases. Articles were selected if they reported any biological effects, ethnomedicinal uses, phytochemical compounds and botanical description of Rheum species. The most important components of rhubarb are anthraquinones, anthranone, stilbenes, tannins and butyrophenones. Anthraquinones consist of rhein, emodin, aloe-emodin and chrysophanl, and anthranone includes sennosides and rheinosides. The most important health benefits of rhubarb are antioxidant and anticancer activities, antimicrobial activity, wound healing action, hepatoprotective and anti-diabetic effects, and nephroprotective effect, as well as anti-inflammatory, analgesic and antibacterial activities. Integration of both traditional pharmaceutical science and modern medicines may promote sustainability, lead to organic life and promote the cultivation of medicinal plants.

scholarly journals Chemical Characterisation and Biological Effects of Essential Oils of Four Gabonese Medicinal Plants

2021 ◽  
pp. 52-60
Author(s):  
Elvis Jolinom Mbot ◽  
Cédric Sima Obiang ◽  
Maximilienne Ascenssion Nyegue ◽  
Bill Raphaël Bikanga ◽  
Huguette Agnaniet ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Chemical Composition ◽  
Medicinal Plants ◽  
Essential Oils ◽  
Biological Effects ◽  
Antibacterial Activities ◽  
Chemical Compositions ◽  
Aromatic Plants ◽  
Bacterial Strains

Aims: The objective of this work is to determine the chemical composition and in vitro evaluation of the antibacterial activities of essential oils of four species of aromatic plants of Gabonese origin obtained by hydrodistillation. Methods: All the samples were examined by chromatographic analyzes and by GC / MS coupling. Antimicrobial activity was assessed by diffusion and microdilution methods. Results: The most common compounds found in essential oils were terpene hydrocarbons and oxygenates. The major constituents are β-phellandrene (56.3%), β-pinene (11%) and myrcene (10.4%). The three bacterial strains used are sensitive to essential oils. However, some essential oils stood out with greater spectra of action compared to others, such as Maranthes gabunensis and Mammea africana which showed activity against all strains. The inhibition parameters (MIC and CMB) are between 0.78 and 25 mg / mL. Some oils have shown bacteriostatic and / or bactericidal activity on the targeted strains. Conclusion: The essential oils studied present a diversity of chemical compositions and good antibacterial activities.

scholarly journals The Wonderful Activities of the Genus Mentha: Not Only Antioxidant Properties

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1118
Author(s):  
Majid Tafrihi ◽  
Muhammad Imran ◽  
Tabussam Tufail ◽  
Tanweer Aslam Gondal ◽  
Gianluca Caruso ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Essential Oils ◽  
Antioxidant Properties ◽  
Antibacterial Activities ◽  
Anticancer Activities ◽  
Invasion And Migration ◽  
Cycle Arrest ◽  
Migration Potential ◽  
Considerable Impact ◽  
And Migration

Medicinal plants and their derived compounds have drawn the attention of researchers due to their considerable impact on human health. Among medicinal plants, mint (Mentha species) exhibits multiple health beneficial properties, such as prevention from cancer development and anti-obesity, antimicrobial, anti-inflammatory, anti-diabetic, and cardioprotective effects, as a result of its antioxidant potential, combined with low toxicity and high efficacy. Mentha species are widely used in savory dishes, food, beverages, and confectionary products. Phytochemicals derived from mint also showed anticancer activity against different types of human cancers such as cervix, lung, breast and many others. Mint essential oils show a great cytotoxicity potential, by modulating MAPK and PI3k/Akt pathways; they also induce apoptosis, suppress invasion and migration potential of cancer cells lines along with cell cycle arrest, upregulation of Bax and p53 genes, modulation of TNF, IL-6, IFN-γ, IL-8, and induction of senescence phenotype. Essential oils from mint have also been found to exert antibacterial activities against Bacillus subtilis, Streptococcus aureus, Pseudomonas aeruginosa, and many others. The current review highlights the antimicrobial role of mint-derived compounds and essential oils with a special emphasis on anticancer activities, clinical data and adverse effects displayed by such versatile plants.

Medicinal Plants: Antibacterial Effects and Chemical Composition of Essential Oil of Foeniculum vulgare

2017 ◽  
Vol 8 (01) ◽  
Author(s):  
Azadeh Foroughi ◽  
Pouya Pournaghi ◽  
Fariba Najafi ◽  
Akram Zangeneh ◽  
Mohammad Mahdi Zangeneh ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Medicinal Plants ◽  
Essential Oil ◽  
Antibacterial Properties ◽  
Screen Test ◽  
Antibacterial Activities ◽  
Gas Chromatography Mass Spectrometry ◽  
Resistant Bacteria ◽  
Antibacterial Effects ◽  
Foeniculum Vulgare

Medicinal plants are considered modern resources for producing agents that could act as alternatives to antibiotics in demeanor of antibiotic-resistant bacteria. The aim of the study was to evaluate the chemical composition and antibacterial activities of essential oil of Foeniculum vulgare (FV) against Pseudomonas aeruginosa and Bacillus subtilis. Gas chromatography mass spectrometry was done to specify chemical composion. As a screen test to detect antibacterial properties of the essential oil, agar disk and agar well diffusion methods were employed. Macrobroth tube test was performed to determinate MIC. The results indicated that the most substance found in FV essential oil was Trans-anethole (47.41 %), also the essential oil of FV with 0.007 g/ml concentration has prevented P. aeruginosa and with 0.002 g/ml concentration has prevented B. subtilis from the growth. Thus, the research represents the antibacterial effects of the medical herb on test P. aeruginosa and B. subtilis. We believe that the article provide support to the antibacterial properties of the essential oil. The results indicate the fact that the essential oil from the plant can be useful as medicinal or preservatives composition.

Rheumatoid Arthritis: History, Stages, Epidemiology, Pathogenesis, Diagnosis and Treatment

2017 ◽  
Vol 9 (02) ◽  
Author(s):  
Abeer Fauzi Al-Rubaye ◽  
Mohanad Jawad Kadhim ◽  
Imad Hadi Hameed
Keyword(s):  
Rheumatoid Arthritis ◽  
Medicinal Plants ◽  
Systemic Disease ◽  
Modern Medicine ◽  
Whole Body ◽  
Internal Organs ◽  
Synthetic Drugs ◽  
Relieve Pain ◽  
Medicinal Treatment ◽  
Natural Drugs

The pharmacological mechanisms of the medicinal plants traditionally used for RA in Persian medicine are discussed in the current review. Further investigations are mandatory to focus on bioefficacy of these phytochemicals for finding novel natural drugs. Rheumatoid arthritis is chronic, progressive, disabling autoimmune disease characterized by systemic inflammation of joints, damaging cartilage and bone around the joints. It is a systemic disease which means that it can affect the whole body and internal organs such as lungs, heart and eyes. Although numbers of synthetic drugs are being used as standard treatment for rheumatoid arthritis but they have adverse effect that can compromise the therapeutic treatment. Unfortunately, there is still no effective known medicinal treatment that cures rheumatoid arthritis as the modern medicine can only treat the symptoms of this disease that means to relieve pain and inflammation of joints. It is possible to use the herbs and plants in various forms in order to relieve the pain and inflammation in the joints. There are so many medicinal plants that have shown anti rheumatoid arthritis properties. So the plants and plant product with significant advantages are used for the treatment of rheumatoid arthritis. The present review is focused on the medicinal plants having anti rheumatoid arthritis activity

scholarly journals Medicinal Plants, Phytochemicals, and Herbs to Combat Viral Pathogens Including SARS-CoV-2

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1775
Author(s):  
Arumugam Vijaya Anand ◽  
Balasubramanian Balamuralikrishnan ◽  
Mohandass Kaviya ◽  
Kathirvel Bharathi ◽  
Aluru Parithathvi ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Entry ◽  
Antiviral Agents ◽  
Special Focus ◽  
Direct Inhibition ◽  
Viral Pathogens ◽  
Important Health ◽  
Antiviral Activities ◽  
Important Health Issue

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome corona virus-2 (SARS-CoV-2), is the most important health issue, internationally. With no specific and effective antiviral therapy for COVID-19, new or repurposed antiviral are urgently needed. Phytochemicals pose a ray of hope for human health during this pandemic, and a great deal of research is concentrated on it. Phytochemicals have been used as antiviral agents against several viruses since they could inhibit several viruses via different mechanisms of direct inhibition either at the viral entry point or the replication stages and via immunomodulation potentials. Recent evidence also suggests that some plants and its components have shown promising antiviral properties against SARS-CoV-2. This review summarizes certain phytochemical agents along with their mode of actions and potential antiviral activities against important viral pathogens. A special focus has been given on medicinal plants and their extracts as well as herbs which have shown promising results to combat SARS-CoV-2 infection and can be useful in treating patients with COVID-19 as alternatives for treatment under phytotherapy approaches during this devastating pandemic situation.

scholarly journals Apoptosis Induced by Tanshinone IIA and Cryptotanshinone Is Mediated by Distinct JAK/STAT3/5 and SHP1/2 Signaling in Chronic Myeloid Leukemia K562 Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Ji Hoon Jung ◽  
Tae-Rin Kwon ◽  
Soo-Jin Jeong ◽  
Eun-Ok Kim ◽  
Eun Jung Sohn ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Biological Effects ◽  
K562 Cells ◽  
Tanshinone Iia ◽  
Anticancer Activities ◽  
Caspase 9 ◽  
Anticancer Effects ◽  
Induced Apoptosis ◽  
Better Than

Though tanshinone IIA and cryptotanshinone possess a variety of biological effects such as anti-inflammatory, antioxidative, antimetabolic, and anticancer effects, the precise molecular targets or pathways responsible for anticancer activities of tanshinone IIA and cryptotanshinone in chronic myeloid leukemia (CML) still remain unclear. In the present study, we investigated the effect of tanshinone IIA and cryptotanshinone on the Janus activated kinase (JAK)/signal transducer and activator of transcription (STAT) signaling during apoptotic process. We found that both tanshinone IIA and cryptotanshinone induced apoptosis by activation of caspase-9/3 and Sub-G1 accumulation in K562 cells. However, they have the distinct JAK/STAT pathway, in which tanshinone IIA inhibits JAK2/STAT5 signaling, whereas cryptotanshinone targets the JAK2/STAT3. In addition, tanshinone IIA enhanced the expression of both SHP-1 and -2, while cryptotanshinone regulated the expression of only SHP-1. Both tanshinone IIA and cryptotanshinone attenuated the expression of bcl-xL, survivin, and cyclin D1. Furthermore, tanshinone IIA augmented synergy with imatinib, a CML chemotherapeutic drug, better than cryptotanshinone in K562 cells. Overall, our findings suggest that the anticancer activity of tanshinone IIA and cryptotanshinone is mediated by the distinct the JAK/STAT3/5 and SHP1/2 signaling, and tanshinone IIA has the potential for combination therapy with imatinib in K562 CML cells.

scholarly journals Bioactive Compounds, Antioxidant Activity, and Biological Effects of European Cranberry (Vaccinium oxycoccos)

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 24 ◽  
Author(s):  
Tunde Jurikova ◽  
Sona Skrovankova ◽  
Jiri Mlcek ◽  
Stefan Balla ◽  
Lukas Snopek
Keyword(s):  
Antioxidant Activity ◽  
Biological Effects ◽  
Folk Medicine ◽  
Meat Products ◽  
Biologically Active ◽  
Anticancer Activities ◽  
Fruit Species ◽  
American Cranberry ◽  
Antibacterial And Antifungal ◽  
Active Substances

Lesser known fruits or underutilized fruit species are recently of great research interest due to the presence of phytochemicals that manifest many biological effects. European cranberry, Vaccinium oxycoccos fruit, as an important representative of this group, is a valuable source of antioxidants and other biologically active substances, similar to American cranberry (V. macrocarpon) which is well known and studied. European cranberry fruit is rich especially in polyphenolic compounds anthocyanins (12.4–207.3 mg/100 g fw), proanthocyanins (1.5–5.3 mg/100 g fw), and flavonols, especially quercetin (0.52–15.4 mg/100 g fw), which mostly contribute to the antioxidant activity of the fruit. Small cranberry is also important due to its various biological effects such as urinary tract protection (proanthocyanidins), antibacterial and antifungal properties (quercetin, proanthocyanidins, anthocyanins), cardioprotective (proanthocyanidins) and anticancer activities (proanthocyanidins), and utilization in food (juice drinks, jams, jellies, sauces, additive to meat products) and pharmacological industries, and in folk medicine.

scholarly journals Ethno Botanical Studies of District Dera Ghazi Khan, Province Punjab, Pakistan

2020 ◽  
Author(s):  
Tahira Aziz Mughal ◽  
Hamna Yasin ◽  
Zubaida Yousaf ◽  
Ismat Naeem Naeem
Keyword(s):  
Medicinal Plants ◽  
Rural Areas ◽  
Neurological Diseases ◽  
Herbal Medicines ◽  
Climatic Conditions ◽  
Structured Interviews ◽  
Medicinal Uses ◽  
Plant Parts ◽  
Floral Diversity ◽  
Natural Drugs

Abstract Background The chief aim of this study was to enlist the Ethnobotanical uses of plants in Dera Ghazi Khan, Punjab, Pakistan. Due to unique geographical and climatic conditions, Pakistan has a great floral diversity. Plants have been used by the indigenous people for treatment of different ailments since long. They are still dependent on the plants for their domestic purposes. Moreover, plants are used as first aid to treat diverse ailments such as hepatic disorders, cardiac diseases, neurological diseases, anticancer, respiratory diseases, ENT problems, gynecological problems etc. The traditional uses of medicinal plants lead to the discovery of natural drugs. This is first quantitative ethno medicinal documentation of medicinal plants in Dera Ghazi Khan. Punjab, Pakistan. Methods This ethno botanical information was collected from about 200 informants including male and female. Sample size was determined by statistical formula. The informative data was based on semi-structured interviews, group discussions, Questionnaire and field visits. Then the data was analyzed by applying different quantitative indices such as Informant Consent Factor (ICF), Use value (UV), Relative Frequency of Citation (RFC) and the Fidelity level (FL). Results Almost 185 plants belonging to 52 families were reported. Most-frequently cited families were Astreaceae (20 species) and Solanaceae (10 species). The most dominant life form was herbs (51%). The most-used plant parts were leaves (68%), followed by whole plant (65%), Most common mode of administration is extraction (50%). Generally herbal medicines were acquired from fresh plant material. Many species were reported with their different medicinal uses as has been reported in literature. Conclusions This ethno botanical documentation revealed that the plants are still used by natives of rural areas in their day-to-day lives. This study provides basis for the conservation of local flora. Plants with high ICF, UV and FL can be further used for phytochemical and pharmacological studies. This documentation could provide baseline information which can be used to develop new plant-based commercial drugs.

scholarly journals Chemical Composition, in vitro Cytotoxic, and Antibacterial Activities of Moroccan Medicinal Plants Euphorbia resinifera and Marrubium vulgare

2020 ◽  
Vol 10 (6) ◽  
pp. 7343-7355
Keyword(s):  
Medicinal Plants ◽  
Solid Medium ◽  
Chemical Compounds ◽  
Antibacterial Activities ◽  
Antibacterial Effects ◽  
Animal Cells ◽  
Aerial Parts ◽  
Marrubium Vulgare ◽  
Major Chemical

The purpose of our study was to bring elements of knowledge on the anticancer and antibacterial effects of two plants, widely used in Moroccan traditional pharmacopeia. These plants are: Marrubium vulgare and Euphorbia resinifera. The aerial parts of each plant were extracted successively with Hexane, Dichloromethane, and finally with methanol. The MTT-based method was applied to evaluate the cytotoxicity of the cancer cells: animal cells BSR and Vero and human cell RD. We evidenced an anticancer activity of the extract of the Marrubium vulgare and the dichloromethane extract of Euphorbia resinifera against the studied cells. The antibacterial activity was evaluated for three species of Rhodococcus: Rhodococcus equi, and strains GK1, GK3, grown in a liquid medium, or this medium solidified with agar. In the last test, the method is based on substance diffusion from well throughout the solid medium. The obtained profiles showed that the growth of bacteria is strongly inhibited by the extracts of Marrubium vulgare. However, the extracts of Euphorbia resinifera had no significant effect on bacterial growth. The chemical analysis of the raw extracts of Marrubium vulgare and Euphorbia resinifera by GC-MS analysis showed the presence of several major chemical compounds, mainly: octadecane, 2,6,10,15-tetramethylheptadecane, 2,6,10-trimethyltetradecane, linoleic acid, and deisopropylatrazine. Our observations an encouraging for deepening the studies of the extracts, in order to target better the active molecules, isolate them and to determine their mechanisms of action. The suggested studies would result in the much better valorization of these two medicinal plants.

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