Heterogeneous Catalytic Hydrogenations as an Environmentally Benign Tool for Organic Synthesis

2011 ◽  
Vol 8 (2) ◽  
pp. 187-207 ◽  
Author(s):  
Aditya Kulkarni ◽  
Bela Torok
Keyword(s):  
Organic Synthesis ◽  
Environmentally Benign ◽  
Heterogeneous Catalytic

Metal and Non-Metal Catalysts in the Synthesis of Five-Membered S-Heterocycles

2019 ◽  
Vol 16 (2) ◽  
pp. 258-275 ◽  
Author(s):  
Navjeet Kaur
Keyword(s):  
Organic Synthesis ◽  
Biological Activities ◽  
Reaction Times ◽  
Research Field ◽  
Environmentally Benign ◽  
Metal Catalyst ◽  
Efficient Synthesis ◽  
Heterocyclic Molecules ◽  
The Past ◽  
Harsh Conditions

Background:A wide variety of biological activities are exhibited by N, O and S containing heterocycles and recently, many reports appeared for the synthesis of these heterocycles. The synthesis of heterocycles with the help of metal and non-metal catalyst has become a highly rewarding and important method in organic synthesis. This review article concentrated on the synthesis of S-heterocylces in the presence of metal and non-metal catalyst. The synthesis of five-membered S-heterocycles is described here.Objective:There is a need for the development of rapid, efficient and versatile strategy for the synthesis of heterocyclic rings. Metal, non-metal and organocatalysis involving methods have gained prominence because traditional conditions have disadvantages such as long reaction times, harsh conditions and limited substrate scope.Conclusion:The metal-, non-metal-, and organocatalyst assisted organic synthesis is a highly dynamic research field. For ßthe chemoselective and efficient synthesis of heterocyclic molecules, this protocol has emerged as a powerful route. Various methodologies in the past few years have been pointed out to pursue more sustainable, efficient and environmentally benign procedures and products. Among these processes, the development of new protocols (catalysis), which avoided the use of toxic reagents, are the focus of intense research.

scholarly journals Iron-Catalyzed C(sp2)–C(sp3) Cross-Coupling of Aryl Chlorobenzoates with Alkyl Grignard Reagents

Molecules ◽  
2020 ◽  
Vol 25 (1) ◽  
pp. 230 ◽  
Author(s):  
Elwira Bisz ◽  
Michal Szostak
Keyword(s):  
Organic Synthesis ◽  
Nucleophilic Addition ◽  
Functional Group ◽  
High Selectivity ◽  
Cross Coupling ◽  
Environmentally Benign ◽  
Grignard Reagents ◽  
High Importance ◽  
Iron Salts ◽  
The Cross

Aryl benzoates are compounds of high importance in organic synthesis. Herein, we report the iron-catalyzed C(sp2)–C(sp3) Kumada cross-coupling of aryl chlorobenzoates with alkyl Grignard reagents. The method is characterized by the use of environmentally benign and sustainable iron salts for cross-coupling in the catalytic system, employing benign urea ligands in the place of reprotoxic NMP (NMP = N-methyl-2-pyrrolidone). It is notable that high selectivity for the cross-coupling is achieved in the presence of hydrolytically-labile and prone to nucleophilic addition phenolic ester C(acyl)–O bonds. The reaction provides access to alkyl-functionalized aryl benzoates. The examination of various O-coordinating ligands demonstrates the high activity of urea ligands in promoting the cross-coupling versus nucleophilic addition to the ester C(acyl)–O bond. The method showcases the functional group tolerance of iron-catalyzed Kumada cross-couplings.

Anodic Oxidation as an Enabling Tool for the Synthesis of Natural Products

Synthesis ◽  
2020 ◽  
Vol 52 (19) ◽  
pp. 2781-2794
Author(s):  
Till Opatz ◽  
Leander Geske ◽  
Eisuke Sato
Keyword(s):  
Organic Synthesis ◽  
Large Scale ◽  
Bond Formation ◽  
Short Review ◽  
Natural Product Synthesis ◽  
Environmentally Benign ◽  
Full Potential ◽  
Future Prospects ◽  
Reaction Conditions ◽  
Chemical Oxidants

Electrochemistry provides a valuable toolbox for organic synthesis and offers an appealing, environmentally benign alternative to the use of stoichiometric quantities of chemical oxidants or reductants. Its potential to control current efficiency along with providing alternative reaction conditions in a classical sense makes electrochemistry a suitable method for large-scale industrial transformations as well as for laboratory applications in the synthesis of complex molecular architectures. Even though research in this field has intensified over the recent decades, many synthetic chemists still hesitate to add electroorganic reactions to their standard repertoire, and hence, the full potential of preparative organic electrochemistry has not yet been unleashed. This short review highlights the versatility of anodic transformations by summarizing their application in natural product synthesis.1 Introduction2 Shono-Type Oxidation3 C–N/N–N Bond Formation4 Aryl–Alkene/Aryl–Aryl Coupling5 Cycloadditions Triggered by Oxidation of Electron-Rich Arenes6 Spirocycles7 Miscellaneous Transformations8 Future Prospects

scholarly journals Sodium Hypochlorite Pentahydrate Crystals (NaOCl·5H2O): A Convenient and Environmentally Benign Oxidant for Organic Synthesis

2017 ◽  
Vol 21 (12) ◽  
pp. 1925-1937 ◽  
Author(s):  
Masayuki Kirihara ◽  
Tomohide Okada ◽  
Yukihiro Sugiyama ◽  
Miyako Akiyoshi ◽  
Takehiro Matsunaga ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Sodium Hypochlorite ◽  
Environmentally Benign

Biomimetic flavin-catalysed reactions for organic synthesis

2015 ◽  
Vol 13 (28) ◽  
pp. 7599-7613 ◽  
Author(s):  
H. Iida ◽  
Y. Imada ◽  
S.-I. Murahashi
Keyword(s):  
Hydrogen Peroxide ◽  
Catalytic Oxidation ◽  
Molecular Oxygen ◽  
Organic Synthesis ◽  
Environmentally Benign ◽  
Wide Scope ◽  
Biomimetic Catalysts ◽  
Mild Conditions ◽  
Related Compounds

Using simple riboflavin related compounds as biomimetic catalysts, catalytic oxidation of various substrates with hydrogen peroxide or molecular oxygen can be performed selectively under mild conditions. The principle of these reactions is fundamental and will provide a wide scope for environmentally benign future practical methods.

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