Formation of Carbon-Oxygen Bond Mediated by Hypervalent Iodine Reagents Under Metal-free Conditions

2020 ◽  
Vol 17 ◽  
Author(s):  
Ayesha Jalil ◽  
Yaxin O Yang ◽  
Zhendong Chen ◽  
Rongxuan Jia ◽  
Tianhao Bi ◽  
...  
Keyword(s):  
Natural Products ◽  
Bond Formation ◽  
Building Blocks ◽  
Review Article ◽  
Hypervalent Iodine ◽  
Metal Free ◽  
Bioactive Natural Products ◽  
The Past ◽  
Oxygen Bond ◽  
Privileged Scaffolds

: Hypervalent iodine reagents are a class of non-metallic oxidants have been widely used in the construction of several sorts of bond formations. This surging interest in hypervalent iodine reagents is essentially due to their very useful oxidizing properties, combined with their benign environmental character and commercial availability from the past few decades ago. Furthermore, these hypervalent iodine reagents have been used in the construction of many significant building blocks and privileged scaffolds of bioactive natural products. The purpose of writing this review article is to explore all the transformations in which carbon-oxygen bond formation occurred by using hypervalent iodine reagents under metal-free conditions

Hypervalent Iodine-Mediated Synthesis of Spiroheterocycles via Oxidative Cyclization

2019 ◽  
Vol 23 (1) ◽  
pp. 14-37 ◽  
Author(s):  
Linlin Xing ◽  
Yong Zhang ◽  
Yunfei Du
Keyword(s):  
Natural Products ◽  
Building Blocks ◽  
Review Article ◽  
Oxidative Cyclization ◽  
Hypervalent Iodine ◽  
Metal Free ◽  
Bioactive Natural Products ◽  
Privileged Scaffolds

Hypervalent iodine reagents have been widely used in the construction of many important building blocks and privileged scaffolds of bioactive natural products. This review article aims to briefly discuss strategies that have used hypervalent iodine reagents as oxidants to synthesize spiroheterocyclic compounds and to stimulate further study for novel syntheses of spiroheterocyclic core structures using hypervalent iodine reagents under metal-free conditions.

Formation of Carbon-Nitrogen Bond Mediated by Hypervalent Iodine Re-agents Under Metal-free Conditions

2020 ◽  
Vol 24 ◽  
Author(s):  
Yaxin O Yang ◽  
Xi Wang ◽  
Jiaxi Xiao ◽  
Yadong Li ◽  
Fengxia Sun ◽  
...  
Keyword(s):  
Building Blocks ◽  
Review Article ◽  
Hypervalent Iodine ◽  
Coupling Reactions ◽  
Organic Transformations ◽  
Metal Free ◽  
Bond Forming ◽  
The Past ◽  
Oxidative Coupling Reactions ◽  
Nitrogen Bond

: In the past several decades, hypervalent iodine chemistry has witnessed prosperous development as hypervalent iodine reagents have been widely used in various organic transformations. Specifically, hypervalent iodine reagents have been vastly used in various bond-forming reactions. Among these oxidative coupling reactions, the reactions involving the formation of C-N bond have been extensively explored to construct various heterocyclic skeletons and synthesize various useful building blocks. This review article is to summarize all the transformations in which carbon-nitrogen bond formation occurred by using hypervalent iodine reagents under metal-free conditions.

Electrocatalytic Difunctionalization of Olefins as a General Approach to the Synthesis of Vicinal Diamines

Synlett ◽  
2018 ◽  
Vol 29 (03) ◽  
pp. 257-265 ◽  
Author(s):  
Song Lin ◽  
Joseph Parry ◽  
Niankai Fu
Keyword(s):  
Natural Products ◽  
Building Blocks ◽  
Therapeutic Agents ◽  
Recent Contribution ◽  
Structural Motifs ◽  
Bioactive Natural Products ◽  
Methodological Approaches ◽  
Molecular Catalysts ◽  
Vicinal Diamines

Vicinal diamines are highly prevalent structural motifs in therapeutic agents, bioactive natural products, and molecular catalysts. However, there are currently few unified methodological approaches for making these pertinent synthetic building blocks. This Synpacts article provides an overview of selected landmark developments in the area of olefin diamination. In particular, we highlight our recent contribution on the electrocatalytic diazidation of olefins as a general, selective, and sustainable method for the synthesis of vicinal diamines.1 Introduction2 Background: Intermolecular Diamination of Olefins3 Background: Intermolecular Diazidation of Olefins4 Electrocatalytic Diazidation of Olefins

scholarly journals Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 669 ◽  
Author(s):  
Anastasia Detsi ◽  
Eleni Kavetsou ◽  
Ioanna Kostopoulou ◽  
Ioanna Pitterou ◽  
Antonella Rozaria Nefeli Pontillo ◽  
...  
Keyword(s):  
Natural Products ◽  
Review Article ◽  
Modified Chitosan ◽  
The Past ◽  
Natural Extracts ◽  
Naturally Occurring ◽  
Natural Polysaccharide ◽  
Low Toxicity ◽  
Valuable Compounds ◽  
Chitosan Biopolymer

Chitosan is a cationic natural polysaccharide, which has emerged as an increasingly interesting biomaterialover the past few years. It constitutes a novel perspective in drug delivery systems and nanocarriers’ formulations due to its beneficial properties, including biocompatibility, biodegradability and low toxicity. The potentiality of chemical or enzymatic modifications of the biopolymer, as well as its complementary use with other polymers, further attract the scientific community, offering improved and combined properties in the final materials. As a result, chitosan has been extensively used as a matrix for the encapsulation of several valuable compounds. In this review article, the advantageous character of chitosan as a matrix for nanosystemsis presented, focusing on the encapsulation of natural products. A five-year literature review is attempted covering the use of chitosan and modified chitosan as matrices and coatings for the encapsulation of natural extracts, essential oils or pure naturally occurring bioactive compounds are discussed.

scholarly journals Catalytic Conversion of Carbon Dioxide through C-N Bond Formation

Molecules ◽  
2019 ◽  
Vol 24 (1) ◽  
pp. 182 ◽  
Author(s):  
Jing-Yuan Li ◽  
Qing-Wen Song ◽  
Kan Zhang ◽  
Ping Liu
Keyword(s):  
Carbon Dioxide ◽  
Catalytic Mechanism ◽  
Bond Formation ◽  
Catalytic Efficiency ◽  
Chemical Fixation ◽  
Catalytic Systems ◽  
Formation Reaction ◽  
Metal Free ◽  
The Past ◽  
Regulatory Strategies

From the viewpoint of green chemistry and sustainable development, it is of great significance to synthesize chemicals from CO2 as C1 source through C-N bond formation. During the past several decade years, many studies on C-N bond formation reaction were involved, and many efforts have been made on the theory. Nevertheless, several great challenges such as thermodynamic limitation, low catalytic efficiency and selectivity, and high pressure etc. are still suffered. Herein, recent advances are highlighted on the development of catalytic methods for chemical fixation of CO2 to various chemicals through C-N bond formation. Meanwhile, the catalytic systems (metal and metal-free catalysis), strategies and catalytic mechanism are summarized and discussed in detail. Besides, this review also covers some novel synthetic strategies to urethanes based on amines and CO2. Finally, the regulatory strategies on functionalization of CO2 for N-methylation/N-formylation of amines with phenylsilane and heterogeneous catalysis N-methylation of amines with CO2 and H2 are emphasized.

Metal-Free Enantioselective Oxidative Arylation of Alkenes: Hypervalent-Iodine-Promoted Oxidative C−C Bond Formation

2016 ◽  
Vol 128 (51) ◽  
pp. 16029-16033 ◽  
Author(s):  
Mio Shimogaki ◽  
Morifumi Fujita ◽  
Takashi Sugimura
Keyword(s):  
Bond Formation ◽  
Hypervalent Iodine ◽  
Metal Free

scholarly journals Natural Products as Potential Lead Compounds for Drug Discovery Against SARS-CoV-2

2021 ◽  
Author(s):  
Oyere Tanyi Ebob ◽  
Smith B. Babiaka ◽  
Fidele Ntie-Kang
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Infectious Diseases ◽  
Review Article ◽  
Literature Survey ◽  
Lead Compounds ◽  
The Past ◽  
The World ◽  
Bacteria And Fungi ◽  
New Vaccines

AbstractFor the past 2 years, the coronavirus responsible for the COVID-19 infection has become a world pandemic, ruining the lives and economies of several nations in the world. This has scaled up research on the virus and the resulting infection with the goal of developing new vaccines and therapies. Natural products are known to be a rich source of lead compounds for drug discovery, including against infectious diseases caused by microbes (viruses, bacteria and fungi). In this review article, we conducted a literature survey aimed at identifying natural products with inhibitory concentrations against the coronaviruses or their target proteins, which lie below 10 µM. This led to the identification of 42 compounds belonging to the alkaloid, flavonoid, terpenoid, phenolic, xanthone and saponin classes. The cut off concentration of 10 µM was to limit the study to the most potent chemical entities, which could be developed into therapies against the viral infection to make a contribution towards limiting the spread of the disease.

Recent developments in the synthesis of azaindoles from pyridine and pyrrole building blocks

2021 ◽  
Author(s):  
Damoder Reddy Motati ◽  
Radhika Amaradhi ◽  
Thota Ganesh
Keyword(s):  
Natural Products ◽  
Building Blocks ◽  
Bioactive Natural Products ◽  
Biological Importance ◽  
Recent Developments ◽  
Synthetic Approaches

The azaindole framework is ubiquitous in bioactive natural products and pharmaceuticals. This review highlights the synthetic approaches to azaindoles with advantages and limitations, mechanistic pathways and biological importance.

Sharpless Asymmetric Epoxidation: Applications in the Synthesis of Bioactive Natural Products

2020 ◽  
Vol 17 ◽  
Author(s):  
Suélen Karine Sartori ◽  
Izabel Luzia Miranda ◽  
Marisa Alves Nogueira Diaz ◽  
Gaspar Diaz-Muñoz
Keyword(s):  
Natural Products ◽  
Building Blocks ◽  
Heterocyclic Ring ◽  
Biologically Active ◽  
Asymmetric Epoxidation ◽  
Allylic Alcohols ◽  
Titanium Tetraisopropoxide ◽  
Bioactive Natural Products ◽  
Tert Butyl Hydroperoxide ◽  
Sharpless Asymmetric Epoxidation

: This review discusses an important synthetic tool proposed by K. B. Sharpless in 1980, known as the Sharpless asymmetric epoxidation of allylic alcohols, and examines its use in the total synthesis of representative exponents of biologically active natural products. Focus is given to the synthesis of simple to highly complex secondary metabolites, including lactones, amino acids, diterpenes, and macrolides. The Sharpless approach involves the use of a catalyst, titanium tetraisopropoxide [Ti(OiPr)4], dialkyl tartrate as chiral ligand, and tert-butyl hydroperoxide (TBHP) as oxidizing agent. The method allows converting allylic alcohols to epoxides, which are chiral building blocks and versatile intermediates in the synthesis of natural products. The biological and synthetic importance of epoxides lies in the susceptibility of the threemembered heterocyclic ring to stereo- and regioselective opening by nucleophilic or acidic reagents, providing oxygen adducts.

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