scholarly journals Thrombocyte indices in dogs infected with Ehrlichia canis and Anaplasma phagocytophilum

2014 ◽  
pp. 4277-4288 ◽  
Author(s):  
Funda Özata ◽  
Kerem Ural
Keyword(s):  
Anaplasma Phagocytophilum ◽  
Significant Positive Correlation ◽  
Point Of Care ◽  
Control Group ◽  
Healthy Controls ◽  
Positive Correlation ◽  
Vector Borne Diseases ◽  
Elisa Kit ◽  
Group I ◽  
Vector Borne

ABSTRACTObjectives. In the present study alterations in trombocyte numbers and trombocyte indices were investigated in 51 dogs naturally infected with E. canis and/or A. phagocytophilum. Achieved results were compared to those of 20 healty dogs comprising control group. Materials and methods. Naturally occuring vector borne diseases were diagnosed by use of a canine point-of-care ELISA kit (Snap 4Dx, Idexx). Dogs were enrolled into 3 groups as follows; II. group involved A. phagocytophilum infected dogs (n=10), III. group (n=13) E. canis+ A. phagocytophilum co-infected, and IV. group (n=28) E. canis infected dogs. Healthy controls (n=20) were enrolled in group I. Results. Mean PLT counts were significantly decreased in II., III. and IV. groups (159.6±63.5, 142.3±44.3, 148.7±33.5, respectively) in comparison to control group (370.4±28.6) (p≤0.01). Mean PCT values in groups II., III. and IV. (0.1530±0.590, 0.1531±0.0441, 0.1450±0.314, respectively) were significantly decreased in contrast to control group (0.3695±0.0283) (p≤0.01). Between PLT and PCT values, statistically significant positive correlation (p≤0.01) (r=0.988, 0.990 and 0.981, respectively) was evident among groups II., III. and IV. Conclusions. Infected dogs showed significant alterations (p≤0.01) among mean PLT and PCT values and a positive correlation was evident between those 2 parameters (p≤0.01), whereas alterations on mean MPV and PDWc were not statistically significant. Finally it was suggested that according to the aforimentioned results, PLT and PCT values may be used as valuable parameters for diagnosis and probably for monitorization and prognosis in infected dogs with Ehrlichiosis and/or Anaplasmosis

Increased plasma kynurenine and its relationship to neopterin and tryptophan in Tourette's syndrome

1996 ◽  
Vol 26 (4) ◽  
pp. 857-862 ◽  
Author(s):  
H. Rickards ◽  
S. M. Dursun ◽  
G. Farrar ◽  
T. Betts ◽  
J. A. Corbett ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Negative Correlation ◽  
Plasma Levels ◽  
Significant Positive Correlation ◽  
Significant Negative Correlation ◽  
Healthy Controls ◽  
Positive Correlation ◽  
Control Value ◽  
Cellular Immune ◽  
Patient Value

SynopsisFasting plasma levels of tryptophan, kynurenine and the pteridines, neopterin and tetrahydrobiopterin were measured in seven patients with Gilles de la Tourette syndrome (GTS) and 10 healthy controls. Plasma kynurenine was significantly elevated in the GTS patients. The lowest patient value was higher than the highest control value. Values for tryptophan, neopterin and tetrahydrobiopterin were similar in TS patients and controls. However, in TS patients only, there was a significant negative correlation between tryptophan and neopterin and a significant positive correlation between kynurenine and neopterin when controlling for tryptophan. This finding indicates that activation of cellular immune processes is a possible explanation for the rise in plasma kynurenine.

scholarly journals Levels of some trace metals and related enzymes in workers at storage-battery factories in Iraq

2000 ◽  
Vol 6 (1) ◽  
pp. 76-82 ◽  
Author(s):  
J. K. Mehdi ◽  
F. J. M. Al Imarah ◽  
A. A. Al Suhail
Keyword(s):  
Trace Metals ◽  
Private Sector ◽  
Significant Positive Correlation ◽  
Storage Battery ◽  
Positive Correlation ◽  
Group Iii ◽  
Group I ◽  
Lead And Zinc ◽  
Lead Levels ◽  
Aminolevulinate Dehydratase

Levels of some trace metals [copper, iron, lead and zinc], aminolevulinate dehydratase [ALAD], caeruloplasmin and haemoglobin were measured in the blood of 37 male workers from private-sector storage-battery factories. The men were divided into three groups depending on their jobs: 11 chargers [group I], 8 repair workers [group II]and 18 casting workers [group III]; 60 men were selected as controls. Mean levels were 14.63, 36.35, 58.00 and 71.70 mg/100 mL for lead, 192.54, 133.90, 96.75 and 45.37 U/mL for ALAD, and 14.02, 12.72, 12.20 and 11.40 g/100 mL for haemoglobin for control and groups I, II and III respectively. Significant negative correlations were found between lead and both ALAD and haemoglobin. The only significant positive correlation was between lead levels and duration of exposure

Anti carbamylated protein antibodies as a diagnostic marker in patients with rheumatoid arthritis and its association with disease activity

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Magda Medhat Awad El debsy ◽  
Mervat Mohammed Abdul Hakim ◽  
Henaz Farouk Khaled ◽  
Hala Mohamed Abd El Sabour Sabbah
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Plasma Levels ◽  
Significant Positive Correlation ◽  
Diagnostic Marker ◽  
Complete Blood Count ◽  
Control Group ◽  
Positive Correlation ◽  
Larsen Score ◽  
Function Tests

Abstract Background Despite the diagnostic contribution of anti-citrullinated protein( anti-CCP) antibody and rheumatoid factor (RF), approximately one-third of patients with rheumatoid arthritis (RA) remain seronegative .Anti-carbamylated protein (Anti-Carp) antibodies have been attracting increasing attention as a new diagnostic marker of RA. Objective evaluate levels of anti-carp antibodies in RA patients in order to detect its role as a diagnostic marker and its possible association with disease activity and severity. Methods This study included thirty adult patients with clinical evidence of rheumatoid arthritis and thirty healthy matched age and sex as controls. All underwent history taking, clinical examination, assessment of disease activity with modified Disease Activity28 (DAS28), Laboratory investigations including Complete blood count (CBC), erythrocytes sedimentation rate (ESR), C-Reactive Protein (CRP), Liver function tests, Kidney function tests, Serum uric acid, RF, anti CCP Ab, anti-Carp Ab and radiographic Assessment with Larsen score. Results Plasma levels of anti-Carp Ab were significantly higher in patients than control group (p > 0,001) with sensitivity of 73.33% and specificity of 100%.it showed significant positive correlation with CRP (r = 0.37 )(p < 0.05) as a marker of activity of RA and also there was significant positive correlation with RF and ACPA (r = 0.45)(r = 0.48) (p < 0.05) respectively as a diagnostic marker for RA. Plasma levels of anti-Carp Ab were higher in patients with more joints damage and erosions as assessed by Larsen radiological score as there was a highly significant correlation between Larsen score and serum Anti-Carp(r = 0.61)(p < 0.001).. Conclusion serum Anti–Carp antibody level was higher in RA patients which serve as a diagnostic marker for RA, also its significant correlation with CRP and Larsen score may serve as a marker for disease progression and severity.

Association of Vitamin D Status with Semen Parameters and Male Reproductive Hormones in Egyptian Infertile Men

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Doaa Abou-Taleb AE ◽  
◽  
Mahran AM ◽  
Mahmoud MA ◽  
Gaber MA ◽  
...  
Keyword(s):  
Vitamin D ◽  
Significant Positive Correlation ◽  
Reproductive Hormones ◽  
Male Reproduction ◽  
Semen Parameters ◽  
Unknown Etiology ◽  
Control Group ◽  
Positive Correlation ◽  
Infertile Men

Background: Although vitamin D receptor (VDR) is expressed in human sperm, little is known about the role of vitamin D (Vit. D) in male reproduction. Our objective was to assess Vit. D levels both in serum and seminal fluid and to establish the relation between serum and seminal Vit. D levels, semen parameters, male sex hormones and serum calcium level in Egyptian infertile men. Patients and Methods: We conducted a prospective case control study including 30 healthy fertile males as a control group and 60 male patients with infertility of unknown etiology. Semen samples were collected and semen parameters were evaluated. Also, seminal Vit. D level was measured. Blood samples were taken as serum levels of Vit. D, calcium, testosterone, Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) were estimated. Results: There was significant decrease of both serum and seminal Vit. D level in groups of male infertility compared to control group. A significant positive correlation was found between serum and seminal Vit. D levels in different study groups. Also, significant positive correlation between serum Vit. D level and non-progressive sperm motility. Conclusion: Our results support the role of Vit. D in semen parameters and male fertility status.

scholarly journals Echocardiographic Assessment of Aortic Pulse Wave Velocity as a New Diagnostic Parameter for Left Ventricular Diastolic Dysfunction

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M A S Ammar ◽  
A M Elshazly ◽  
M F Ismail ◽  
H G M Helmy
Keyword(s):  
Prognostic Value ◽  
Significant Positive Correlation ◽  
Pulse Wave ◽  
Aortic Pulse Wave Velocity ◽  
Left Ventricular ◽  
Control Group ◽  
Case Group ◽  
Diagnostic Parameter ◽  
Positive Correlation ◽  
Echocardiographic Assessment

Abstract Background The association between increased arterial stiffness and Left ventricular (LV) diastolic dysfunction (DD) has been well characterized, suggesting a close interaction between the arterial system and the left ventricle. Aortic pulse-wave velocity (PWV) is a measure of aortic stiffness, and it has an established prognostic role in cardiovascular diseases and in the general population. Aim Evaluation of aortic PWV assessed by echocardiography as a new diagnostic parameter for LV DD by correlation with current echocardiographic LV DD indices, and also evaluation of aortic PWV prognostic value in patients with DD by correlation with Brain natriuretic peptide (BNP). Methods This study was conducted at Ain-Shams and Helwan University hospitals from December 2017 to December 2018. It included 100 subjects aged from 55 to 60 years; they were divided into two groups, 1st group (case group): 80 patients with asymptomatic LV DD with preserved ejection fraction ≥50%, 2nd group (control group): 20 patients with normal diastolic function. All patients were subjected to full history and thorough physical examination. BNP, ECG and full echocardiography with assessment of aortic PWV were done. Results A total of 100 patients were enrolled, 38 (47.5%) males in case group vs. 9 (45%) in control group. Hypertension, diabetes and dyslipidemia were significantly higher in case vs. control (P-values: <0.001, 0.005, 0.002 respectively). Aortic PWV has significant positive correlation with both age and body mass index (r = 0.422, r = 0.847 respectively with P < 0.001 for both). Aortic PWV has significant positive correlation with E/e’ (r = 0.957, P < 0.001), tricuspid regurge velocity (r = 0.941, P < 0.001), and left atrial volume index (r = 0.947, P < 0.001), but it has significant negative correlation with septal e’ (r=-0.970, P < 0.001) and lateral e’ (r=-0.932, P < 0.001). Aortic PWV has significant positive correlation with plasma BNP level (r = 0.958, P < 0.001). Aortic PWV was significantly higher in case vs. control group with mean values (15.5±1.32 vs. 10.11±0.78 m/s respectively; P < 0.001). The area under the ROC curve for aortic PWV to detect DD was 0.86 (95% CI, 0.76–0.98; P < 0.001) and the optimal cutoff point of 12.5 m/s produced 92.3% sensitivity and 75.0% specificity (the positive and negative predictive values were 93.5 and 72.7%, respectively with an accuracy of 89.0%). Conclusion Echocardiographic assessment of aortic PWV appears not only to be a highly sensitive, reliable, easy, rapid and practical parameter for LV DD detection but also has a promising prognostic value in patients with LV DD.

Molecular evidence of vector-borne pathogens coinfecting dogs from Poland

2011 ◽  
Vol 59 (2) ◽  
pp. 215-223 ◽  
Author(s):  
Anna Rymaszewska ◽  
Małgorzata Adamska
Keyword(s):  
Anaplasma Phagocytophilum ◽  
Molecular Evidence ◽  
Chain Reactions ◽  
Group Iii ◽  
Polymerase Chain Reactions ◽  
Group I ◽  
Vector Borne ◽  
Polymerase Chain ◽  
Pathogenic Agents

Ticks of the genusIxodesare vectors for many pathogens, includingBorrelia burgdorferisensu lato,Anaplasma phagocytophilumandRickettsiaspp., and may also serve as vectors forBartonellaspp. However, the role of ticks inBartonellatransmission requires additional studies. The aim of this study was to investigate whether coinfection with two or more vector-borne pathogens can occur in the following three groups of dogs: I — dogs with suspected borreliosis (N = 92), II — dogs considered healthy (N = 100), and III — dogs with diagnosed babesiosis (N = 50). Polymerase chain reactions were performed to detect DNA ofAnaplasma phagocytophilum, Rickettsiaspp. andBartonellaspp. in the blood of dogs. In dogs of Group I, the DNA of bothA. phagocytophilumandBartonellasp. was detected (14% and 1%, respectively). In eight dogs, coinfection was indicated:A. phagocytophilumorBartonellasp. withB. burgdorferis.l. (the presence of antibodies against and/or DNAB. burgdorferis.l.). In the case of five dogs positive forA. phagocytophilumDNA, no coinfection withB. burgdorferis.l. was shown. In Group II, the DNA ofA. phagocytophilumwas detected in four dogs. In Group III, no pathogenic agents possibly transmitted by ticks were confirmed. No DNA ofR. helveticawas detected in any of the groups studied.

scholarly journals EFFECT OF COMMUNITY PARTICIPATION ON KNOWLEDGE OF SELECTED VECTOR BORNE DISEASES AMONG THE SELF HELP GROUPS

2014 ◽  
Vol 04 (03) ◽  
pp. 015-018
Author(s):  
Neethu Maria Babu ◽  
Shashidara Y N. ◽  
Keyword(s):  
Community Participation ◽  
The Self ◽  
Control Group ◽  
Research Approach ◽  
Vector Borne Diseases ◽  
Self Help ◽  
Post Test ◽  
Vector Borne ◽  
Self Help Groups ◽  
Health Teaching

AbstractThe study is conducted to assess the effect of community participation on knowledge of selected vector borne diseases among the self help groups. The sample include eight self help groups having 10 members each, with 40 in the experimental and control group each. Research approach was quantitative-evaluative approach and design used was quasi experimental pre test post test control group design. The study was carried out in two phases. In the first phase, the health teaching by the researcher was given to selected members of self help groups with a duration of 45 minutes and in the phase 2, these trained members gave health teaching to the other members of the self help groups. A leaflet was given to the control group. The post test knowledge was assessed over a period of 7 to 9 days after the intervention in both the phases. The community participation has found to be effective with a p value of.001. The study concluded that the community participation was effective in terms of knowledge gain.

Study of Non-alcoholic fatty liver disease among chronic kidney disease patients by Controlled attenuation parameter

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohamed Mahrous Salem ◽  
Sahar Mahmoud Shawky ◽  
Maha Abd Elmoneim Behairy ◽  
Ahmed Fouad Helmy
Keyword(s):  
Risk Factors ◽  
Fatty Liver Disease ◽  
Significant Positive Correlation ◽  
Liver Steatosis ◽  
Control Group ◽  
Controlled Attenuation Parameter ◽  
Alcoholic Fatty Liver ◽  
Positive Correlation ◽  
Ckd Stage ◽  
Alcoholic Fatty Liver Disease

Abstract Background/Aim Preliminary data suggest an association between chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD). The aim of this study was evaluate the frequency of NAFLD and its associated risk factors among nondiabetic CKD patients not on dialysis. METHODS A total of 40 subjects were enrolled in the study. Group A (30) Pre dialysis non-diabetic CKD patiens and Group B (10) normal subjects matched for age and sex as a control group. Liver stiffness measurement was used to detect liver fibrosis and CAP (controlled attenuation parameter) was used to detect and quantify liver steatosis (Fibroscan®). NAFLD was defined by CAP values ≥238 dB/m. RESULTS Results of the current study showed that CKD stage III was present in 17 patients (56.7%) and CKD stage IV in 9 patients (30%) and CKD stage V in in 4 patients (13.3%). The total frequency of presence of steatosis (CAP values ≥238 dB/m) whatever degree was significantly higher in CKD group than control; More than (53%) of CKD patients have NAFLD, and (30%) of control group have NAFLD. The severity of liver steatosis was negatively correlated with GFR, Hb and HDL, and positively correlated with Creatinine, BUN, CRP, Cholesterol, TG, LDL, SGPT, SGOT, FBG and HBA1C. There was significant relation between steatosis and CKD etiology. (82.3%) of Patients with hypertension have Steatosis, (33.3%) of Patients with reflux nephropathy have steatosis, (16.7%) of Patients had other causes have steatosis, while patients had renal stones have no steatosis. There was significant positive correlation between fibrosis degree and age of CKD patients and also significant positive correlation between steatosis and fibrosis among CKD patients. The study showed significant positive correlation between SGPT and fibrosis degree. The results suggest a high prevalence of NAFLD in non-diabetic CKD patients. The severity of liver steatosis is negatively correlated with kidney function; there was significant correlation between CKD stage and other risk factors of hepatic steatosis

scholarly journals Plasma Catestatin Levels and Advanced Glycation End Products in Patients on Hemodialysis

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 456
Author(s):  
Mirko Luketin ◽  
Maja Mizdrak ◽  
Dijana Boric-Skaro ◽  
Dinko Martinovic ◽  
Daria Tokic ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Advanced Glycation End Products ◽  
Significant Positive Correlation ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Controls ◽  
Advanced Glycation ◽  
Positive Correlation ◽  
Glycation End Products ◽  
End Products ◽  
Stage Renal Disease

Catestatin (CST) is a pleiotropic peptide involved in cardiovascular protection with its antihypertensive and angiogenic effects. Considering that patients with end-stage renal disease (ESRD) who are undergoing hemodialysis (HD) are associated with higher cardiovascular risk, the aim of this study was to investigate plasma CST levels in HD patients, compare them to healthy controls and evaluate possible CST associations with advanced glycation end products (AGEs) and laboratory, anthropometric and clinical parameters. The study included 91 patients on HD and 70 healthy controls. Plasma CST levels were determined by an enzyme-linked immunosorbent assay in a commercially available diagnostic kit, while AGEs were determined using skin autofluorescence. Plasma CST levels were significantly higher in the HD group compared to the controls (32.85 ± 20.18 vs. 5.39 ± 1.24 ng/mL, p < 0.001) and there was a significant positive correlation between CST and AGEs (r = 0.492, p < 0.001). Furthermore, there was a significant positive correlation between plasma CST levels with both the Dialysis Malnutrition Score (r = 0.295, p = 0.004) and Malnutrition-Inflammation Score (r = 0.290, p = 0.005). These results suggest that CST could be playing a role in the complex pathophysiology of ESRD/HD and that it could affect the higher cardiovascular risk of patients on HD.

scholarly journals Young and Old Sugar Apple (Annona squamosa Linn) Leaf Extracts As an Aedes aegypti Larva Insecticide

2019 ◽  
Author(s):  
Abdul Khair ◽  
Noraida Noraida
Keyword(s):  
Aedes Aegypti ◽  
Leaf Extract ◽  
Hemorrhagic Fever ◽  
Control Group ◽  
Leaf Extracts ◽  
Control Group Design ◽  
Vector Borne Diseases ◽  
Apple Leaves ◽  
Significant Difference ◽  
Vector Borne

Vector-borne diseases are still a health problem in some tropical countries. One vector-borne disease is Dengue Hemorrhagic Fever (DHF). DHF never decreases and even tends to continue to increase, and many cause deaths in children, 90% of them attack children under 15 years. DHF cases in 2018 amounted to 65,602 cases, with 467 deaths (CFR = 0.71%). The behavior of holding water in various places such as tubs and tendons indirectly creates a breeding place for Aedes aegypti mosquitoes. The use of chemicals as insecticides can cause the death of non-target animals, environmental pollution, and the occurrence of vector resistance to insecticides. Therefore it is necessary to do other methods including the use of vegetable insecticides. Sugar apple leaves can be used to kill Aedes aegypti larvae. Sugar apple leaves will obtain throughout the year. The purpose of this study is to know the ability of young and old sugar apple leaves to kill Aedes aegypti larvae. This type of research is a posttest only control group design. The study sample was part of the Aedes aegypti larvae on the final instar III. The experiment to kill Aedes aegypti larvae use two types of sugar apple leaf extract, namely young and old sugar apple leaves with nine treatments four replications. Each treatment consisted of 25 larvae. The research results show There was no significant difference in the number of dead larvae using either extracts from young sugar apple leaves or old sugar apple leaves. LC90 of sugar apple leaf extract was between 0.05632 to 0.08324% and the effective residual age at LC90 (0.06568%) with the death of Aedes aegypti larvae was 92% over 24 hours (1 day).

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