Value of intravenous contrast enhancement in the CT evaluation of intraspinal tumors

Dual-energy contrast-enhanced spectral mammography (CESM) is a new promising method for visualizing pathological changes in breast, which combines digital mammography and a functional assessment of vascularization using intravenous contrast ehnancement. According to accumulated experience CESM is well tolerated by patients and is similar to magnetic resonance imaging with dynamic contrast enhancement (MRI with DCE), but at the same time, CESM is more affordable and can be performed in patients with contraindications for MRI. However, few studies have been conducted to evaluate the role of CESM. In the world literature, interpretation of contrast images is based only on the degree of accumulation of the contrast agent, but we propose a more detailed assessment of the structure of the hypervascular lesions by highlighting the contrast enhancement patterns. Objective: to determine the diagnostic effectiveness of CESM using the contrast enhancement patterns in malignant and benign lesions. Materials and methods. 239 women with suspicious for breast cancer lesions were examined from August 2018 to December 2019. The mean age of the women was 51 years. 322 lesions were revealed, 149 (46.3%) were malignant, 173 (53.7%) were benign. All lesions were histologically confirmed. As a result of the analysis of our data, 9 types of contrast enhancement patterns were distinguished: reticulate, granular, annular, diffuse-spherical, lacunar, cloud-like, heterogeneous-annular, point, cotton-like. Results. Using an additional diagnostic feature - contrast enhancement patterns in lesions, increased the sensitivity of CESM from 91.3% to 98.0% (p=0.26), specificity from 80.3% to 93, 6% (p=0.013), accuracy from 85.4 to 95.7% (p=0.004) in comparison with using of only one feature of contrast enhancement intensity in the differential diagnosis of malignant and benign lesions. Conclusion: thus, this approach of interpreting subtraction images allows to increase the efficiency of CESM in diagnosis of breast cancer.

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THE SIGNIFICANCE OF CONTRAST ENHANCEMENT IN THE CT EVALUATION OF INTRAVENTRICULAR HEMORRHAGE

Journal of Computer Assisted Tomography ◽

10.1097/00004728-197809000-00114 ◽

1978 ◽

Vol 2 (4) ◽

pp. 520

Author(s):

F. Y. Tsai ◽

J. E. Huprich ◽

H. D. Segall ◽

J. S. Teal

Keyword(s):

Contrast Enhancement ◽

Intraventricular Hemorrhage ◽

Ct Evaluation

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FURTHER EXPERIENCE WITH CONTRAST ENHANCEMENT IN CT EVALUATION OF HEAD TRAUMA

Journal of Computer Assisted Tomography ◽

10.1097/00004728-197809000-00119 ◽

1978 ◽

Vol 2 (4) ◽

pp. 521

Author(s):

F. Y. Tsai ◽

J. E. Huprich ◽

H. D. Segall ◽

J. S. Teal

Keyword(s):

Contrast Enhancement ◽

Head Trauma ◽

Ct Evaluation

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Impact of Intravenous Contrast Enhancement Phase on Target Definition for Hepatocellular Carcinoma (HCC) and Intrahepatic Cholangiocarcinoma (IHC): Observations From Patients Enrolled on a Prospective Phase 2 Trial

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2014.05.1204 ◽

2014 ◽

Vol 90 (1) ◽

pp. S373-S374

Author(s):

J.R. Niska ◽

J.A. Wolfgang ◽

P.F. Hahn ◽

J.Y. Wo ◽

A.X. Zhu ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Contrast Enhancement ◽

Intrahepatic Cholangiocarcinoma ◽

Phase 2 ◽

Intravenous Contrast ◽

Phase 2 Trial ◽

Target Definition ◽

Prospective Phase

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The Role of Perfusion Computed Tomography as a Predictor of Pancreatic Necrosis in Acute Pancreatitis

Radiology - Practice ◽

10.52560/2713-0118-2021-4-11-21 ◽

2021 ◽

pp. 11-21

Author(s):

N. V. Klimova ◽

V. V. Darvin ◽

I. V. Bazhukhina ◽

A. A. Gaus

Keyword(s):

Computed Tomography ◽

Acute Pancreatitis ◽

Contrast Enhancement ◽

Pancreatic Necrosis ◽

Pancreatic Tissue ◽

Intravenous Contrast ◽

Surgical Department ◽

Perfusion Computed Tomography ◽

Initial Symptoms ◽

Surgical Tactics

The presented article analyzes the data obtained as a result of the applied imaging methods of the study of 38 patients admitted to the surgical department of the Surgut Regional Clinical Hospital with suspicion of acute pancreatitis. The main criterion for inclusion in the study was the period from the onset of the initial symptoms of the disease, which did not exceed three days. In the hospital, all patients underwent perfusion computed tomography (PCT) in the first 3 days and subsequently, in accordance with national recommendations, multislice computed tomography (MSCT) with bolus intravenous contrast enhancement for 3–5 days. In 31,5 % of cases (12 out of 38 patients), a violation of the perfusion characteristics of the pancreatic parenchyma corresponding to ischemic tissue damage was diagnosed. MSCT with bolus intravenous contrast enhancement confirmed the presence of a formed zone of necrosis of the pancreatic tissue in 21 % of patients. In 10,5 % of cases, progression of ischemic damage to the pancreatic tissue was not revealed by MSCT, which was confirmed by further observation of this group of patients. Based on the study, conclusions were drawn about the ability of perfusion CT to serve as an effective predictor of pancreatic necrosis, which makes it possible to choose the optimal surgical tactics at the early stages of treatment of such patients.

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Difficulties of multidisciplinary diagnostics of indeterminate colitis

Experimental and Clinical Gastroenterology ◽

10.31146/1682-8658-ecg-187-3-207-213 ◽

2021 ◽

pp. 207-213

Author(s):

S. E. Dubrova ◽

S. M. Lunina ◽

P. A. Korosteleva

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Contrast Enhancement ◽

Clinical Case ◽

Diagnostic Methods ◽

Indeterminate Colitis ◽

Resonance Imaging ◽

Intravenous Contrast ◽

Dynamic Observation ◽

Retrograde Filling

Aim of the study: Using the example of a clinical case, to show the importance of dynamic observation by means of various diagnostic methods of intestinal imaging, in combination with a pathomorphological confirmation method for setting the correct clinical diagnosis. Materials and methods: The studies were performed on multislice computed tomographs Brilliance CT and ICT (Philips Medical Systems) and magnetic resonance imaging machines (GE), with intravenous contrast enhancement. We used special methods of contrasting the lumen of the intestine with gradual and retrograde filling it with water. The surgical material fixed in 10% neutral formuline for 10-24 hours. Tissue fragments were processed in a Leica TP1020 histoprocessor (Leica BioSystems, Germany) according to a standard protocol, after which it was embedded in paraffin blocks. Histological sections with a thickness of 3-5 μm were made by a Leica RM2245 microtome (Leica BioSystems, Germany). The prepared histological preparations were stained with hematoxylin and eosin in a Leica Autosteiner XL histostiner (Leica BioSystems, Germany). Results: From 2013 to 2020 patient K. underwent 4 colonoscopies, 5 esophagogastroduodenoscopies, 1 Х-ray examination with small bowel series, 3 MRI studies and 5 CT studies, including those with intravenous contrast enhancement, with a total radiation exposure of 187 mSv. The diagnosis was revised from ulcerative colitis, Crohn’s disease to NC. The final diagnosis was made by the pathologist’s analysis of materials. Conclusion: The clinical case presented by us clearly demonstrates the importance of dynamic observation by computed and magnetic resonance imaging, in combination with a pathomorphological confirmation method.

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