scholarly journals BIOCHEMICAL STUDIES OF HIPPOCAMPAL GENE EXPRESSION OF BRAIN-DERIVED NEUROTROPIC FACTOR AND TOLL-LIKE RECEPTOR-4 IN DIABETIC RATS EXPOSED TO CHRONIC STRESS: EFFECTS OF ANTIDEPRESSANT DRUGS

2018 ◽  
Vol 11 (1) ◽  
pp. 271
Author(s):  
Sawsan Aboul-fotouh ◽  
Doaa Mohamed Hassan ◽  
Mohamed Zaki Eldeen Habib ◽  
Ahmed Ibrahim Amin ◽  
Samar K. Kassim ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Antidepressant Drugs ◽  
Chronic Administration ◽  
Diabetic Rats ◽  
Toll Like Receptor ◽  
Bdnf Expression ◽  
Toll Like Receptor 4 ◽  
Inflammatory State ◽  
Neurotropic Factor ◽  
Factor Α

  Objective: Depression and diabetes are closely associated in a reciprocal manner, leading to significant morbidity and mortality with an evidence of a pro-inflammatory state underlying pathophysiology of both diseases. Unfortunately, little information is available about the effects of antidepressant drugs on hippocampal brain-derived neurotrophic factor (BDNF) and toll-like receptor-4 (TLR-4) expression in diabetes.Methods: We investigated the effect of chronic administration of fluoxetine (FLU) and imipramine (IMIP) on behavioral, metabolic, and inflammatory abnormalities in diabetic and non-diabetic rats exposed to chronic restraint stress (CRS).Results: Both diabetes and CRS induced depressive-like behavior which was more prominent in diabetic/depressed rats; this was reversed by chronic treatment with FLU and IMIP. Diabetic and non-diabetic rats exposed to CRS showed a significant increase in hippocampal expression of TLR-4 and pro-inflammatory cytokines alongside a decrease in BDNF expression. FLU and IMIP ameliorated these inflammatory abnormalities.Conclusion: Diabetes mellitus (DM) and chronic stress induced a depressive-like behavior associated with an increase in hippocampal expression of TLR-4, tumor necrosis factor-α, and interleukin-1ß with a significant correlation to decreased BDNF expression. FLU and IMIP showed comparable effects regards the improvement of depressive and inflammatory abnormalities associated with DM.

scholarly journals BIOCHEMICAL STUDIES OF HIPPOCAMPAL GENE EXPRESSION OF BRAIN-DERIVED NEUROTROPIC FACTOR AND TOLL-LIKE RECEPTOR-4 IN DIABETIC RATS EXPOSED TO CHRONIC STRESS: EFFECTS OF ANTIDEPRESSANT DRUGS

2018 ◽  
Vol 11 (1) ◽  
pp. 271
Author(s):  
Sawsan Aboul-fotouh ◽  
Doaa Mohamed Hassan ◽  
Mohamed Zaki Eldeen Habib ◽  
Ahmed Ibrahim Amin ◽  
Samar K. Kassim ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Antidepressant Drugs ◽  
Chronic Administration ◽  
Diabetic Rats ◽  
Toll Like Receptor ◽  
Bdnf Expression ◽  
Toll Like Receptor 4 ◽  
Inflammatory State ◽  
Neurotropic Factor ◽  
Factor Α

  Objective: Depression and diabetes are closely associated in a reciprocal manner, leading to significant morbidity and mortality with an evidence of a pro-inflammatory state underlying pathophysiology of both diseases. Unfortunately, little information is available about the effects of antidepressant drugs on hippocampal brain-derived neurotrophic factor (BDNF) and toll-like receptor-4 (TLR-4) expression in diabetes.Methods: We investigated the effect of chronic administration of fluoxetine (FLU) and imipramine (IMIP) on behavioral, metabolic, and inflammatory abnormalities in diabetic and non-diabetic rats exposed to chronic restraint stress (CRS).Results: Both diabetes and CRS induced depressive-like behavior which was more prominent in diabetic/depressed rats; this was reversed by chronic treatment with FLU and IMIP. Diabetic and non-diabetic rats exposed to CRS showed a significant increase in hippocampal expression of TLR-4 and pro-inflammatory cytokines alongside a decrease in BDNF expression. FLU and IMIP ameliorated these inflammatory abnormalities.Conclusion: Diabetes mellitus (DM) and chronic stress induced a depressive-like behavior associated with an increase in hippocampal expression of TLR-4, tumor necrosis factor-α, and interleukin-1ß with a significant correlation to decreased BDNF expression. FLU and IMIP showed comparable effects regards the improvement of depressive and inflammatory abnormalities associated with DM.

Effects of Amygdalin on TLR4/NF-αB Signaling Pathway-Mediated Proliferation and Apoptosis of Gastric Cancer Cells

2021 ◽  
Vol 20 (1) ◽  
pp. 153-158
Author(s):  
Abulajiang Abudoukelimu ◽  
Xinhui Yang ◽  
Lei Ge ◽  
Xiangyue Zeng ◽  
Yin Shu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
B Cell Lymphoma ◽  
Toll Like Receptor ◽  
Gastric Cancer Cells ◽  
Toll Like Receptor 4 ◽  
Proliferation And Apoptosis ◽  
High Incidence Rate ◽  
Factor Α

Gastric cancer is a highly malignant tumor of the digestive tract with high incidence rate and mortality. In the present study, we have shown decreased cell proliferation, increased apoptosis, and expression of proinflammatory cytokines (Interleukin-6, Interleukin-1β, and Tumor necrosis factor-α) in gastric cancer cells MGC-803 by amygdalin. Also, amygdalin treatment significantly reduced expression of the mRNA and protein for B-cell lymphoma 2 protein, CyclinD1, toll-like receptor 4, and REL-associated protein involved in NF-κB heterodimer formation in MGC-803 cells. In summary, amygdalin inhibits the proliferation of gastric cancer cells MGC-803 and promotes cell apoptosis by regulating the toll-like receptor 4/ nuclear factor-kappa B signaling pathway.

Blockade of Toll-Like Receptor 4 Attenuates Erectile Dysfunction in Diabetic Rats

2018 ◽  
Vol 15 (9) ◽  
pp. 1235-1245 ◽  
Author(s):  
Kenia Pedrosa Nunes ◽  
Amanda Almeida de Oliveira ◽  
Theodora Szasz ◽  
Vinicia Campana Biancardi ◽  
R. Clinton Webb
Keyword(s):  
Erectile Dysfunction ◽  
Diabetic Rats ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

scholarly journals Hypertension and Erectile Dysfunction: Breaking Down the Challenges

2020 ◽  
Author(s):  
Amanda Almeida de Oliveira ◽  
Kenia Pedrosa Nunes
Keyword(s):  
Erectile Dysfunction ◽  
Innate Immune System ◽  
Innate Immune ◽  
Low Grade ◽  
Oxygen Species ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Corpora Cavernosa ◽  
Inflammatory State ◽  
Antioxidant Mechanisms

Abstract A diagnostic of hypertension increases the risk of erectile dysfunction (ED); likewise, ED can be an early sign of hypertension. In both cases, there is evidence that endothelial dysfunction is a common link between the 2 conditions. During hypertension, the sustained and widespread release of procontractile factors (e.g., angiotensin II, endothelin 1, and aldosterone) impairs the balance between vasoconstrictors and vasodilators and, in turn, detrimentally impacts vascular and erectile structures. This prohypertensive state associates with an enhancement in the generation of reactive oxygen species, which is not compensated by internal antioxidant mechanisms. Recently, the innate immune system, mainly via Toll-like receptor 4, has also been shown to actively contribute to the pathophysiology of hypertension and ED not only by inducing oxidative stress but also by sustaining a low-grade inflammatory state. Furthermore, some drugs used to treat hypertension can cause ED and, consequently, reduce compliance with the prescribed pharmacotherapy. To break down these challenges, in this review, we focus on discussing the well-established as well as the emerging mechanisms linking hypertension and ED with an emphasis on the signaling network of the vasculature and corpora cavernosa, the vascular-like structure of the penis.

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