scholarly journals Comparisons of urine protein-to-creatinine ratios and their dynamic change patterns during labor at term between normal pregnant women and women with pregnancy induced hypertension

2021 ◽  
Author(s):  
Po-Hui Wang ◽  
PeiYin Yang ◽  
Yi Lun Tsai ◽  
Yu-Jun Chang
Keyword(s):  
Pregnant Women ◽  
Clinical Data ◽  
Dynamic Change ◽  
Pregnancy Induced Hypertension ◽  
Continuous Variables ◽  
Active Recovery ◽  
Urine Protein ◽  
Tertiary Referral Hospital ◽  
Early Postpartum ◽  
Induced Hypertension

Objective to compare the urine protein-to-creatinine ratios (uPCRs) during labor at term between normal and women with pregnancy-induced hypertension (PIH), and to evaluate the patterns of change in uPCRs. Design observational study Setting Tertiary referral hospital in Taiwan Population normal pregnant or women only with PIH at term were enrolled Methods and Main outcome measures uPCRs in four phases (latent, active, recovery and early postpartum) and related clinical data at delivery were collected. Multivariate analysis with a linear regression model were performed to analyze continuous variables after adjusting for clinical data between two groups. Results 68 normal and 24 pregnant women with PIH were included. There were no differences in the uPCR or the proportion cases of uPCRs ≥ 300 mg/g between normal and PIH group in the latent, active, recovery or early postpartum phases. There was a statistically significant tendency for the proportion of uPCRs ≥ 300 mg/g to increase from the latent to the early postpartum phase in both groups. The proportion of uPCRs ≥ 300 mg/g significantly increased from the active to the recovery phase and then declined from the recovery to the early postpartum phase in normal pregnant women.Thus no differences in uPCRs cases change between any two phases in women with PIH, except the duration above stated. Conclusion. This is the first study to demonstrate that uPCRs data are not different between normal pregnant and PIH groups during the course of labor, but it did show different dynamic change patterns throughout the labor phases.

Serum Uric Acid Level as a Predictive Biomarker of Gestational Hypertension Severity; A Prospective Observational Case-Control Study

2020 ◽  
Vol 15 (3) ◽  
pp. 227-239 ◽  
Author(s):  
Hader I. Sakr ◽  
Akef A. Khowailed ◽  
Reham S. Al-Fakharany ◽  
Dina S. Abdel-Fattah ◽  
Ahmed A. Taha
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Case Control Study ◽  
Serum Urate ◽  
Interleukin 1Β ◽  
Pregnancy Induced Hypertension ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Induced Hypertension ◽  
Control Study

Background: Pre-eclampsia poses a significant potential risk of hypertensive disorders during pregnancy, a leading cause of maternal deaths. Hyperuricemia is associated with adverse effects on endothelial function, normal cellular metabolism, and platelet aggregation and adhesion. This study was designed to compare serum urate levels in normotensive pregnant women to those with pregnancy-induced hypertension, and to evaluate its value as a potential predictive marker of hypertension severity during pregnancy. Methods: A prospective, observational, case-control study conducted on 100 pregnant women in their third trimester. Pregnant women were classified into two groups (n=50) according to arterial blood pressure measurements: group I had normal blood pressure, and group II had a blood pressure of ≥ 140/90, which was further subdivided according to hypertension severity into IIa (pregnancy- induced hypertension, IIb (mild pre-eclampsia), and IIc (severe pre-eclampsia). Blood samples were obtained on admission. Serum urate, high sensitive C-reactive protein, and interleukin-1β levels, and lipid profile were compared among the groups. Results: A significant increase in the mean values of serum urate, C-reactive protein, and interleukin- 1β levels was detected in gestational hypertensives. In addition, there was a positive correlation between serum urate levels and C-reactive protein and interleukin-1β, as well as between serum urate levels and hypertension severity. Conclusion: Hyperuricemia and increased C-reactive protein and interleukin-1β serum levels correlate with the severity of pregnancy-induced hypertension, and these biomarkers may play a role in the pathogenesis of pre-eclampsia. Serum urate measurement is sensitive, reliable markers that correlate well with the severity of hypertension in pregnant females with pre-eclampsia.

Incidence of Pregnancy Induced Hypertensive Women and its Associated Factors

2021 ◽  
Vol 15 (12) ◽  
pp. 3307-3309
Author(s):  
Samia Saifullah ◽  
Maryam Shoaib ◽  
Muhammad Sohail Tareen ◽  
Nosheen Sikander Baloch
Keyword(s):  
Blood Pressure ◽  
Family History ◽  
Pregnant Women ◽  
Cross Sectional Study ◽  
Mean Value ◽  
Renal Diseases ◽  
Pregnancy Induced Hypertension ◽  
Cross Sectional ◽  
Induced Hypertension ◽  
Keywords Pregnancy

Background: Pregnancy induced hypertension is a fetal disease resulting into morbidity and mortality of female as well as its neonate. Objective: To find the incidence of pregnancy induced hypertension in Pakistani women. Study Design: Cross sectional study Place and Duration of the Study: Department of Obstetrics & Gynaecology, Sandeman Provincial Hospital, Quetta from 1st March 2019 to 31st March 2021. Methodology: Seven hundred and twenty eight females were identified with pregnancy induced hypertension from all the pregnant women attending the outdoor were enrolled. Each female was checked for their protein urea as well as systolic and diastolic blood pressure according to standard operating protocol. Socio-demographic, clinical and family history were documented. Results: Among all pregnant women, 150 were identified as pregnancy induced hypertensive with a 20.6% incidence of pregnancy induced hypertension. The mean value systolic blood pressure value was 144.3±5.2 and of diastolic as 83.1±5.2 in pregnancy induced hypertension women. Conclusion: Family history, obesity and renal diseases are the main factors associated with pregnancy induced hypertension with an incidence of 20.6% among pregnant women. Keywords: Pregnancy induced hypertension, Body mass index, Pregnant women, Hypertension

scholarly journals Comparison of the Antioxidant Nutrient Profile among Normal Pregnant Women and Women having Pregnancy Induced Hypertension

2021 ◽  
Vol 10 (4) ◽  
pp. 246-251
Author(s):  
Kausar Aamir ◽  
Arfa Azhar ◽  
Fatima Abid ◽  
Shamaila Khalid ◽  
Fiza Ali Khan
Keyword(s):  
Vitamin E ◽  
Pregnant Women ◽  
Cell Damage ◽  
Alpha Tocopherol ◽  
Control Group ◽  
P Value ◽  
Pregnancy Induced Hypertension ◽  
Nutrient Profile ◽  
Induced Hypertension ◽  
Mild Hypertensive

Background: Preeclampsia is a multifactorial disorder comprising many organs. Oxidative stress (OS) has been intensely linked to its occurrence. Vitamin E, a lipophilic chain breaking antioxidant has been proved to suppress the OS. Present study was designed to investigate antioxidant nutrient profile in patients with different grades of pregnancy induced hypertension (PIH) and to compare them with normal pregnant controls. Methods: The study group comprised 110 patients divided in three groups as Group A (n=40) Normotensive patients, Group B (n=40) Mild hypertensive, Group C (n=30) Severe hypertensive. Vitamin A, B-Carotene, serum alpha tocopherol (vitamin E) and vitamin C levels were analysed. Results: Serum alpha tocopherol (vitamin E) was significantly low in severe and mild cases (0.32±0.00 mg/dl, 0.74±0.03 mg/dl respectively), when compared with normal pregnant women levels (0.78±0.040). All other nutrients were also found to be in reduced quantity for Group C when compared to control group (P value <0.001). Conclusion: It was therefore concluded that in patients with risk of preeclampsia (PE) adequate antioxidant nutrients may have a role in cessation of free radical-mediated cell disturbances, and thereby protecting against endothelial cell damage, which is the key factor in PE development.

Assessment of Prevalence of Hypertension in pregnant women with its Complications: A Cross Sectional Study

2021 ◽  
pp. 3805-3808
Author(s):  
Hemalatha S. ◽  
S. M. Shaheedha ◽  
Ramakrishna Borra
Keyword(s):  
Pregnant Women ◽  
Cross Sectional Study ◽  
World Health ◽  
Chronic Hypertension ◽  
Pregnancy Induced Hypertension ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Gynecology And Obstetrics ◽  
Induced Hypertension ◽  
History Of

Introduction: World Health Organization has reported that pregnancy induced hypertension is one of the main causes for mortality and morbidity in maternal and fetal deaths. About 60% of deaths accounted of eclampsia. Aims and Objectives: To diagnose for hypertension in pregnant women. To evaluate the knowledge of pregnancy induced hypertension among the pregnant women. To investigate the complications reported in Pregnancy induced hypertension (PIH) women, during and after labor. Study area and period: The present study was conducted in Chittoor government hospital, Chittoor, during the period of Jan 2016 and Dec 2017. The information and materials required for the study have been collected from the gynecology and obstetrics departments of the respective hospital. Results: During the study period of Jan 2016 and Dec 2017, about 2234 number of pregnant women have visited the obstetrics and gynecology department. All the 2234 pregnant women were tested for blood pressure. Among which 198 women were found to have hypertension, which may be of early onset PIH or chronic hypertension (HTN). Different variables of the study population like period of gestation [<20 weeks, ≥20 weeks], previous cesarean section if present, previous preterm delivery if present, hypertension in previous pregnancy, history of paternal hypertension, history of abortions if have been, history of any still births, family history of PIH have been noted and reported in table 2. More than 8% of women were found to been falling in <20 weeks of gestational age (GA). Conclusion: The study included 2234 pregnant women, in which 198 women were diagnosed with hypertension. Thus, prior investigation and identification hypertension in pregnant women helps in better management of PIH and to overcome the complications that are reported due to PIH during and after labor. Better knowledge and treatment is required for managing hypertension in maternal women in gynecology and obstetrics department for maternal and fetal care.

Pregnancy syphilis epidemic trends, clinical features, APOs risk factors, pregnancy-induced hypertension epidemics and related factors, in Northeast China Jilin Maternity Hospital 2013-2017

2019 ◽  
Author(s):  
Fangfang Hu ◽  
Huixin Yang ◽  
Lixin Sun ◽  
Jingjing Luo ◽  
Siwen Zhang ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Maternity Hospital ◽  
Age Group ◽  
Pregnancy Induced Hypertension ◽  
Child Transmission ◽  
Related Factors ◽  
Induced Hypertension ◽  
Maternal Syphilis ◽  
Mother To Child ◽  
In Pregnancy

Abstract Background. It is of great public health significance to monitor the global meiosis mother-to-child transmission plan proposed by WHO and monitor the prevalence of maternal syphilis and the factors affecting mother-to-child transmission. Methods. We collected 271 medical records of prenatally diagnosed (from 87286 pregnant women) of syphilis among pregnant women a maternity hospital in Jilin Province China from 2013 to 2017. The chi-square test and Logistic multiple regression analysis were used to describe the clinical characteristics of pregnant women with syphilis and the related factors of adverse pregnancy outcome. Results. The average prevalence of maternal syphilis is 0.31% (95%[CI]: 0.27%-0.35%). The mean age of 271 pregnant women with syphilis is 27.62±5.4 years old. The maternal syphilis prevalence of absence of paid occupation is 73.8%; rural population accounts for 43.6%. Maternal women with a history of abortion accounted for 43.1%, of which 53.1% had abortion ≥2; The average rate of treatment in pregnancy is 25.5% (95%[CI]: 25.4%-25.6%). The prevalence rate of APOs are 43.9% (95%[CI]: 38.1%-49.9%), declined in five years (P<0.05). APOs was significantly higher in women at 30–34 age group than that in 0-24 age group (OR= 2.916, 95%CI: 1.298-6.549) and higher in Un-treatment in pregnancy than that in receive treatment (OR=2.469, 95%CI:1.225-4.975). PROM occurrence (OR=2.702, 95%CI:1.219-5.988); CRP elevation (≥10 mg/L) and RPR high titer (≥1:8) are related to the occurrence of APOs. Abortion, prematurity and low birth weight are associated with no treatment during pregnancy (P<0.05). Comparison of 42 cases of pregnancy-induced hypertension and non-pregnancy-induced hypertension, Dysmenorrhea (OR= 3.654, 95%CI:1.812-7.369) and elevated urine protein (OR= 2.259, 95%CI:1.161-4.394) are the influencing factors of maternal syphilis complicated with pregnancy-induced hypertension. Conclusions. The prevalence of maternal syphilis in northern China is lower than that of 10 years ago, but the decline is still lower than that in the economically developed regions of the south. The rate of non-treatment of syphilis during pregnancy is high, and should be alert to the rebound of maternal syphilis.

scholarly journals Direct laboratory evidence that pregnancy-induced hypertension might be associated with increased catecholamines and decreased renalase concentrations in the umbilical cord and mother’s blood

2019 ◽  
Vol 43 (2) ◽  
pp. 77-85
Author(s):  
Yakup Baykus ◽  
Sefer Ustebay ◽  
Rulin Deniz ◽  
Kader Ugur ◽  
Şeyda Yavuzkir ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Enzyme Linked Immunosorbent Assay ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
Healthy Control ◽  
C 30 ◽  
Body Mass Indexes ◽  
Umbilical Cord Vein

Abstract Background Renalase (RNL) is a controversial enzyme as to whether it oxidizes catecholamines (CAs) (as is generally accepted) in the blood or not. CAs (dopamine [DPMN], epinephrine [EPI] and norepinephrine [NEPI]) are associated with hypertension, including pregnancy-induced hypertension, which occurs in 8–10% of all pregnancies. Therefore, the aim of the study was to compare CAs and renalase concentration in (i) normotensive controls (C), (ii) patients with preeclampsia (PE) and (iii) patients with severe preeclampsia (SPE), which is one of the well-known symptoms of hypertension. Methods This case-control study involved 90 women divided into three groups – 30 C, 30 PE and 30 SPE – whose age and body mass indexes (BMIs) were similar. A total of 270 blood samples (90 maternal samples, 90 umbilical cord artery samples and 90 umbilical cord vein samples) were obtained. CAs and RNL concentrations of the biological samples were measured by enzyme-linked immunosorbent assay (ELISA). Results Comparing the amounts of CAs, RNL and systolic blood pressure (SBP)/diastolic blood pressure (DBP) between healthy control pregnant women and pregnant women with PE and SPE (SBP/DBP was 120/80 mm Hg for C, above 140/90 mm Hg for PE and above 160/110 mm Hg for SPE), the levels of CAs were significantly increased whereas RNL was reduced. The correlation between SBP/DBP and the amount of RNL in pregnant women with PE and SPE was negative. Conclusions These novel results are evidence that hypertension seen in PE and SPE is directly related to increased levels of CAs and reduced RNL concentrations. The use of RNL preparations may be preferred in future to prevent maternal and perinatal morbidity and mortality due to pregnancy-induced hypertension.

Abnormalities of peripheral venous tone in women with pregnancy-induced hypertension

1986 ◽  
Vol 70 (2) ◽  
pp. 155-157 ◽  
Author(s):  
Karen Stainer ◽  
Rachel Morrison ◽  
C. Pickles ◽  
A. J. Cowley
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Inverse Correlation ◽  
The Other ◽  
Normal Blood ◽  
Pregnancy Induced Hypertension ◽  
Normal Blood Pressure ◽  
Venous Tone ◽  
Arterial Blood ◽  
Induced Hypertension

1. Forearm venous tone was measured in two groups of pregnant women: one group with pregnancy-induced hypertension and the other group with normal blood pressure. 2. The women with pregnancy-induced hypertension were venoconstricted in the forearm (P < 0.01) compared with the pregnant women with normal blood pressure. However, there was no difference in venous tone between the women with pregnancy-induced hypertension and nonpregnant women. 3. There was an inverse correlation between mean arterial blood pressure and forearm venous tone (r = −0.581, P < 0.001) for all the pregnant women studied. Further evaluation of peripheral venous tone may provide valuable information about the pathophysiology and treatment of women with pregnancy-induced hypertension.

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