scholarly journals Contribution of Reactive Oxygen and Nitrogen Species to Particulate-Induced Lung Injury

1998 ◽  
Vol 106 ◽  
pp. 1157 ◽  
Author(s):  
Sha Zhu ◽  
Machelle Manuel ◽  
Shogo Tanaka ◽  
Nonghoon Choe ◽  
Elliott Kagan ◽  
...  
Keyword(s):  
Lung Injury ◽  
Reactive Oxygen ◽  
Nitrogen Species

scholarly journals Contribution of reactive oxygen and nitrogen species to particulate-induced lung injury.

1998 ◽  
Vol 106 (suppl 5) ◽  
pp. 1157-1163 ◽  
Author(s):  
S Zhu ◽  
M Manuel ◽  
S Tanaka ◽  
N Choe ◽  
E Kagan ◽  
...  
Keyword(s):  
Lung Injury ◽  
Reactive Oxygen ◽  
Nitrogen Species

scholarly journals Enhanced Lung Injury and Delayed Clearance of Pneumocystis carinii in Surfactant Protein A-Deficient Mice: Attenuation of Cytokine Responses and Reactive Oxygen-Nitrogen Species

2004 ◽  
Vol 72 (10) ◽  
pp. 6002-6011 ◽  
Author(s):  
Elena N. Atochina ◽  
James M. Beck ◽  
Angela M. Preston ◽  
Angela Haczku ◽  
Yaniv Tomer ◽  
...  
Keyword(s):  
Lung Injury ◽  
Pneumocystis Carinii ◽  
Protein A ◽  
Reactive Oxygen ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Interleukin 4 ◽  
Nitrogen Species ◽  
Cell Counts ◽  
Deficient Mice

ABSTRACT Surfactant protein A (SP-A), a member of the collectin family, selectively binds to Pneumocystis carinii and mediates interactions between pathogen and host alveolar macrophages in vitro. To test the hypothesis that mice lacking SP-A have delayed clearance of Pneumocystis organisms and enhanced lung injury, wild-type C57BL/6 (WT) and SP-A-deficient mice (SP-A−/−) with or without selective CD4+-T-cell depletion were intratracheally inoculated with Pneumocystis organisms. Four weeks later, CD4-depleted SP-A-deficient mice had developed a more severe Pneumocystis infection than CD4-depleted WT (P. carinii pneumonia [PCP] scores of 3 versus 2, respectively). Whereas all non-CD4-depleted WT mice were free of PCP, intact SP-A−/− mice also had evidence of increased organism burden. Pneumocystis infection in SP-A-deficient mice was associated histologically with enhanced peribronchial and/or perivascular cellularity (score of 4 versus 2, SP-A−/− versus C57BL/6 mice, respectively) and a corresponding increase in bronchoalveolar lavage (BAL) cell counts. Increases in SP-D content, gamma interferon, interleukin-4, interleukin-5, and tumor necrosis factor alpha in BAL fluid occurred but were attenuated in PCP-infected SP-A−/− mice compared to WT mice. There were increases in total BAL NO levels in both infected groups, but nitrite levels were higher in SP-A−/− mice, indicating a reduction in production of higher oxides of nitrogen that was also reflected in lower levels of 3-nitrotyrosine staining in the SP-A−/− group. We conclude that despite increases in inflammatory cells, SP-A-deficient mice infected with P. carinii exhibit an enhanced susceptibility to the organism and attenuated production of proinflammatory cytokines and reactive oxygen-nitrogen species. These data support the concept that SP-A is a local effector molecule in the lung host defense against P. carinii in vivo.

Reactive oxygen and nitrogen species induce cell apoptosis via a mitochondria‐dependent pathway in hyperoxia lung injury

2018 ◽  
Vol 120 (4) ◽  
pp. 4837-4850 ◽  
Author(s):  
Dongmei Zou ◽  
Jing Li ◽  
Qianqian Fan ◽  
Xuemei Zheng ◽  
Jian Deng ◽  
...  
Keyword(s):  
Lung Injury ◽  
Cell Apoptosis ◽  
Reactive Oxygen ◽  
Nitrogen Species ◽  
Induce Cell Apoptosis ◽  
Dependent Pathway

Evaluation of plant stress due to plasma-generated reactive oxygen and nitrogen species using electrolyte leakage

2020 ◽  
Vol 60 (1) ◽  
pp. 010504
Author(s):  
Keisuke Takashima ◽  
Ahmad Shahir bin Ahmad Nor ◽  
Sugihiro Ando ◽  
Hideki Takahashi ◽  
Toshiro Kaneko
Keyword(s):  
Electrolyte Leakage ◽  
Plant Stress ◽  
Reactive Oxygen ◽  
Nitrogen Species

Anti-toxicant Properties of Saffron and Relevance to Protection from Toxins and Drugs

2020 ◽  
Vol 16 (3) ◽  
pp. 265-283
Author(s):  
Kyriaki Hatziagapiou ◽  
George I. Lambrou
Keyword(s):  
Redox Reactions ◽  
Case Reports ◽  
Meta Analysis ◽  
Reactive Oxygen ◽  
Crocus Sativus ◽  
Protective Effects ◽  
Nitrogen Species ◽  
Eligibility Criteria ◽  
Crocus Sativus L

Background: Reactive oxygen species and reactive nitrogen species, which are collectively called reactive oxygen nitrogen species, are inevitable by-products of cellular metabolic redox reactions, such as oxidative phosphorylation in the mitochondrial respiratory chain, phagocytosis, reactions of biotransformation of exogenous and endogenous substrata in endoplasmic reticulum, eicosanoid synthesis, and redox reactions in the presence of metal with variable valence. Among medicinal plants there is a growing interest in Crocus sativus L. It is a perennial, stemless herb, belonging to Iridaceae family, cultivated in various countries such as Greece, Italy, Spain, Israel, Morocco, Turkey, Iran, India, China, Egypt and Mexico. Objective: The present study aims to address the anti-toxicant role of Crocus sativus L. in the cases of toxin and drug toxification. Materials and Methods: An electronic literature search was conducted by the two authors from 1993 to August 2017. Original articles and systematic reviews (with or without meta-analysis), as well as case reports were selected. Titles and abstracts of papers were screened by a third reviewer to determine whether they met the eligibility criteria, and full texts of the selected articles were retrieved. Results: The authors focused on literature concerning the role of Crocus Sativus L. as an anti-toxicant agent. Literature review showed that Saffron is a potent anti-toxicant agent with a plethora of applications ranging from anti-oxidant properties, to chemotherapy protective effects. Conclusion: Literature findings represented in current review herald promising results for using Crocus Sativus L. and/or its active constituents as anti-toxicant, chemotherapy-induced protection and toxin protection.

scholarly journals Antioxidants of Natural Products

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 612
Author(s):  
Mee Ree Kim
Keyword(s):  
Oxidative Stress ◽  
Health Promotion ◽  
Natural Products ◽  
Disease Prevention ◽  
Biological Systems ◽  
Reactive Oxygen ◽  
Nitrogen Species ◽  
Beneficial Effects

Antioxidant ingredients are known to contribute to the beneficial effects of natural products in health promotion as well as disease prevention by reducing oxidative stress, caused by reactive oxygen or nitrogen species, in biological systems [...]

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