1887-P: The GLP-1 Receptor Agonist Liraglutide Improves Hepatic Inflammation and Fibrosis in a Mouse Model of NASH

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1887-P
Author(s):  
SOPHIE A. MONTANDON ◽  
EMMANUEL SOMM ◽  
CLAUDIO DE VITO ◽  
FRANÇOIS R. JORNAYVAZ
Keyword(s):  
Mouse Model ◽  
Receptor Agonist ◽  
Hepatic Inflammation

Ferulic acid through mitigation of NMDA receptor pathway exerts anxiolytic-like effect in mouse model of maternal separation stress

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Zahra Lorigooini ◽  
Ali Nouri ◽  
Faezeh mottaghinia ◽  
Shima Balali-Dehkordi ◽  
Elham Bijad ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Mouse Model ◽  
Ferulic Acid ◽  
Nmda Receptors ◽  
Effective Dose ◽  
Life Stress ◽  
Receptor Agonist ◽  
Maternal Separation ◽  
Early Life Stress ◽  
Central Zone

AbstractBackgroundExperiencing early-life stress plays an important role in the pathophysiology of anxiety disorders. Ferulic acid is a phenolic compound found in some plants which has several pharmacological properties. N-methyl-D-aspartate (NMDA) receptors are involved in the pathophysiology of mood disorders. In this study we aimed to assess the anxiolytic-like effect of ferulic acid in a mouse model of maternal separation (MS) stress by focusing on the possible involvement of NMDA receptors.MethodsMice were treated with ferulic acid (5 and 40 mg/kg) alone and in combination with NMDA receptor agonist/antagonist. Valid behavioral tests were performed, including open field test (OFT) and elevated plus maze test (EPM), while quantitative real time polymerase chain reaction (qRT-PCR) was used to evaluate gene expression of NMDA subunits (GluN2A and GluN2B) in the hippocampus.ResultsFindings showed that treatment of MS mice with ferulic acid increased the time spent in the central zone of the OFT and increased both open arm time and the percent of open arm entries in the EPM. Ferulic acid reduced the expression of NMDA receptor subunit genes. We showed that administration of NMDA receptor agonist (NMDA) and antagonist (ketamine) exerted anxiogenic and anxiolytic-like effects, correspondingly. Results showed that co-administration of a sub-effective dose of ferulic acid plus ketamine potentiated the anxiolytic-like effect of ferulic acid. Furthermore, co-administration of an effective dose of ferulic acid plus NMDA receptor agonist (NMDA) attenuated the anxiolytic-like effect of ferulic acid.ConclusionsIn deduction, our findings showed that NMDA, partially at least, is involved in the anxiolytic-like effect of ferulic acid in the OFT and EPM tests.

Visfatin exacerbates hepatic inflammation and fibrosis in a methionine‐choline‐deficient diet mouse model

2021 ◽  
Author(s):  
Yu Jung Heo ◽  
Sung‐E Choi ◽  
Nami Lee ◽  
Ja Young Jeon ◽  
Seung Jin Han ◽  
...  
Keyword(s):  
Mouse Model ◽  
Hepatic Inflammation ◽  
Deficient Diet

Author response for "Peripheral versus central mechanisms of the cannabinoid type 2 receptor agonist AM1710 in a mouse model of neuropathic pain"

2020 ◽  
Author(s):  
Jenny L. Wilkerson ◽  
Lauren B. Alberti ◽  
Audra A. Kerwin ◽  
Catherine A. Ledent ◽  
Ganesh A. Thakur ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Mouse Model ◽  
Receptor Agonist ◽  
Author Response

scholarly journals G-Protein-Coupled Estrogen Receptor Agonist Suppresses Airway Inflammation in a Mouse Model of Asthma through IL-10

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0123210 ◽  
Author(s):  
Masamichi Itoga ◽  
Yasunori Konno ◽  
Yuki Moritoki ◽  
Yukiko Saito ◽  
Wataru Ito ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Mouse Model ◽  
Airway Inflammation ◽  
G Protein ◽  
Receptor Agonist ◽  
G Protein Coupled

scholarly journals The selective vitamin D receptor agonist, elocalcitol, reduces endometriosis development in a mouse model by inhibiting peritoneal inflammation

2012 ◽  
Vol 27 (7) ◽  
pp. 2010-2019 ◽  
Author(s):  
M. Mariani ◽  
P. Vigano ◽  
D. Gentilini ◽  
B. Camisa ◽  
E. Caporizzo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Mouse Model ◽  
Vitamin D Receptor ◽  
Receptor Agonist ◽  
Peritoneal Inflammation
Sign in / Sign up

Export Citation Format

Share Document