scholarly journals Monitoring of metabolic syndrome and its main criterions rate in children

2014 ◽  
Vol 18 (3 (71)) ◽  
Author(s):  
N. M. Hromnatska
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Arterial Hypertension ◽  
Carbohydrate Metabolism ◽  
Abdominal Obesity ◽  
Metabolic Disorders ◽  
Total Population ◽  
High Density Lipoproteins ◽  
High Concentration

Objective. To study the rate of metabolic syndrome and its main criterions in children.Material and methods. Among 1520 children of total population 90 children with metabolic syndrome aged from 9 to 18 years were selected. Diagnosing of metabolic syndrome was provided according to International Diabetic Federation recommendations (2007).Results. It was established that the rate of metabolic syndrome in children of Lviv was 5,9%. The most spread and therefore primary criterion of metabolic syndrome in children was abdominal obesity, which was diagnosed both in overweight (36,6%) and in generalized obesity (63,4) (p=0,039) and was identified in all children with metabolic syndrome (100,0%). Insulin resistance as a sign of carbohydrate metabolism changes was identified in fewer children (41,8%), which means the primacy of abdominal obesity in relation to insulin resistance in metabolic syndrome criterions formation. Hyperglycemia and hypoalphacholesterolemia were almost of the same frequency, which suggests the likelihood of metabolic syndrome development both toward carbohydrate metabolism changes with hyperinsulinemia and hyperglycemia and to lipid metabolism with lowered cholesterol level in high density lipoproteins as well as to hypertriglyceridemia. The latter had the lowest diagnostic level (18,8%).Summary. The rate of metabolic syndrome and its main criterions in Lviv children did not differ from the universal rate. The most informative and spread metabolic syndrome criterions in descending order were: abdominal obesity → arterial hypertension→ hyperinsulinemia → insulin resistance →hyperglycemia→low concentrarion of high-densitycholesterol→high concentration of triglycerides in blood. It is rational to monitor metabolic syndrome in Ukraine, whichreflects a real spread of metabolic disorders in order to prevent and correction them.

scholarly journals EFFECT OF DYSLIPIDAEMIA AND INSULIN RESISTANCE ON THE COURSE OF ALOPECIA AREATA ASSOCIATED WITH METABOLIC SYNDROME

2021 ◽  
pp. 18-22
Author(s):  
I.I. Horda ◽  
◽  
S.V. Vozianova ◽  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Carbohydrate Metabolism ◽  
Metabolic Disorders ◽  
Blood Lipids ◽  
Severe Form ◽  
High Density Lipoproteins ◽  
Homa Index ◽  
Mild Form ◽  
The Relationship

Alopecia areata (AA) is a tissue-specific disease of the hair follicles, manifested by foci of alopecia on a scalp and other areas of skin. The objective of our study was to evaluate the values of blood lipids and carbohydrate metabolism in patients with АА associated with metabolic syndrome (MS) to determine the relationship between disease severity and metabolic disorders. Materials and methods. Clinical and anamnestic characteristics and laboratory values of lipid spectrum and carbohydrate metabolism were analysed in 50 patients with AA associated with MS. Results. As a result of the study, the following regularities have been established: values of blood lipids (cholesterol, triglycerides, high-density lipoproteins) and carbohydrate metabolism (blood glucose, glycosylated haemoglobin, HOMA index) statistically significantly deteriorate with increasing number of the MS components (p <0.05); in patients with mild AA there is a statistically significantly (p <0.05) smaller number of MS components compared with patients with moderate to severe forms (φemp=2,645 < φcr=1,64); HOMA index increases statistically significantly with increasing severity of the disease: by 14.14% in patients with moderate form compared with patients with mild form, and in the presence of severe form by 28.31% compared with patients with moderate and by 46.46% compared with patients with mild forms of AA (p <0.05); the rate of triglycerides in the blood increases statistically significantly depending on the severity of AA: by 36.17% in patients with moderate form and by 41.78% in patients with severe form compared with mild form of AA (p <0.05); the content of high-density lipoproteins in the blood decreases statistically significantly depending on the severity of AA: by 2.12% in patients with moderate form compared with mild form and by 9.53% in patients with severe form compared with moderate form (p <0.05); no relationship has been found between the severity of MS, given the number of its components, and the stage of AA: active and chronic. Conclusions. As a result of the study, the relationship between the severity of AA and the severity of metabolic disorders in the presence of MS in patients has been established. An important area is the study of correction of dyslipidaemia and insulin resistance in a comprehensive therapy of AA associated with MS.

scholarly journals The prevalence of pediatric metabolic syndrome—a critical look on the discrepancies between definitions and its clinical importance

2020 ◽  
Vol 45 (1) ◽  
pp. 12-24
Author(s):  
Carolin Reisinger ◽  
Benedicta N. Nkeh-Chungag ◽  
Per Morten Fredriksen ◽  
Nandu Goswami
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
International Diabetes Federation ◽  
Clinical Importance ◽  
High Density Lipoproteins ◽  
Future Research ◽  
The Metabolic Syndrome ◽  
Definition Of

Abstract Introduction The Metabolic Syndrome (MetS) describes the clustering of cardio-metabolic risk factors—including abdominal obesity, insulin resistance, elevated blood pressure, high levels of triglycerides, and low levels of high-density lipoproteins—that increase the risk for developing cardiovascular diseases and type 2 diabetes mellitus. However, a generally accepted definition of MetS in pediatric patients is still lacking. Objectives The aim was to summarize current prevalence data of childhood MetS as well as to discuss the continuing disagreement between different pediatric definitions and the clinical importance of such diagnosis. Methodology A systematic literature search on the prevalence of pediatric MetS was conducted. Articles that were published during the past 5 years (2014–2019), using at least one of four predetermined classifications (International Diabetes Federation, Cook et al., Ford et al., and de Ferranti et al.), were included. Results The search resulted in 1167 articles, of which 31 publications met all inclusion criteria. Discussion The prevalence of MetS ranged between 0.3 and 26.4%, whereby the rising number of children and adolescents with MetS partly depended on the definition used. The IDF definition generally provided the lowest prevalences (0.3–9.5%), whereas the classification of de Ferranti et al. yielded the highest (4.0–26.4%). In order to develop a more valid definition, further research on long-term consequences of childhood risk factors such as abdominal obesity, insulin resistance, hypertension, and dyslipidemia is needed. There is also a temptation to suggest one valid, globally accepted definition of metabolic syndrome for pediatric populations but we believe that it is more appropriate to suggest definitions of MetS that are specific to males vs. females, as well as being specific to race/ethnicity or geographic region. Finally, while this notion of definitions of MetS specific to certain subgroups is important, it still needs to be tested in future research.

scholarly journals Evaluation of the hemostatic state, carbohydrate and lipid metabolism in young women with abdominal obesity and hypertension

2015 ◽  
Vol 12 (4) ◽  
pp. 29-33
Author(s):  
Veronika Andreevna Sumerkina ◽  
Vasiliy Sergeevich Chulkov ◽  
Vladislav Sergeevich Chulkov ◽  
Elena Stanislavovna Golovneva ◽  
Larisa Fedorovna Telesheva ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Arterial Hypertension ◽  
Total Cholesterol ◽  
Blood Coagulation ◽  
Abdominal Obesity ◽  
Young Women ◽  
The Metabolic Syndrome ◽  
Carbohydrate And Lipid Metabolism ◽  
The Individual

Aim of this study was to determine the characteristics of the laboratory parameters of hemostasis, carbohydrate and lipid metabolism in women with metabolic syndrome, isolated abdominal obesity or with hypertension.Materials and methods. The study included 71 women aged 30 – 44 years and was conducted at laboratory study of hemostasis system, carbohydrate and lipid metabolism.Results. In women with abdominal obesity and arterial hypertension we found an increased levels of glucose, total cholesterol, LDL-C and triglycerides and a decrease in a concentration of HDL-C compared to healthy women. The study of hemostasis revealed prothrombotic changes in the form of activation of coagulation hemostasis and fibrinolysis system activity.Conclusions. The disorders of carbohydrate and lipid metabolism are very prevalent in young women with abdominal obesity and hypertension with every second woman meeting the criteria for the metabolic syndrome. The most pronounced signs of activation of blood coagulation markes was seen in women with abdominal obesity and hypertension. In women with the individual components of the metabolic syndrome there were no significant changes in carbohydrate and lipid metabolism, although we saw an early signs of activation of hemocoagulation.

scholarly journals Role of immunological disorders, endothelial dysfunction and hemostatic disorders in the genesis of arterial hypertension in the metabolic syndrome

2020 ◽  
Vol 22 (2) ◽  
pp. 221-230
Author(s):  
E. I. Polozova ◽  
E. V. Puzanova ◽  
A. A. Seskina
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Immune Cells ◽  
Metabolic Disorders ◽  
Vascular Wall ◽  
Immunological Disorders ◽  
Hemostatic Disorders

Mortality from diseases of the circulatory system is a challenge for the modern health care. Arterial hypertension (AH) mostly contributes to development of cardiovascular complications. It often proceeds against the background of metabolic disorders. Pathogenesis of hypertension is currently being considered a multifactorial disease. Pathogenesis of hypertension certainly has distinct features in presence of metabolic disorders,. Therefore, it is relevant to summarize current literature on the role of immunological disorders, endothelial dysfunction and hemostatic disorders in AH genesis during metabolic syndrome (MS). Most authors agree with existence of several mechanisms that determine relationships between AH and insulin resistance. Development of hypertension in MS patients with is a consequence of immunometabolic processes. Abdominal obesity is an important component of MS. It is associated with chronic inflammation of visceral adipose tissue, its excessive infiltration by immune cells, and increased production of adipokines and cytokines (TNFα, IL-6) with hypertension. AH is associated with a significant increase in T cells, that mediate endothelial dysfunction (ED) and provide a link between hypertension and subsequent atherosclerosis. T lymphocytes trigger a cascade of reactions. IL-17 is the end product of these events It is involved not only in increasing blood pressure, but also contributes to the development of vascular wall stiffness in АН patients. Thus, the relationship between several types of immune cells leads to inflammatory reactions, including those of vascular wall, initiating endothelial dysfunction. Chronic non-specific inflammation in MS, supported by the cytokine system, is a triggering mechanism for ED progression. Excessive production of endothelin-1 and inhibition of nitric oxide production are the classic markers of ED. Immune damage leads to imbalance in the production of vasoconstrictor and vasodilating substances, proliferative and antiproliferative factors in endothelium. It was shown that ED is an integral aspect of the insulin resistance syndrome in pathogenesis of arterial hypertension associated with metabolic disorders, and contributes to its worsening, increased vascular reactivity and further AH development. According to modern studies, it has been shown that excessive synthesis of pro-inflammatory cytokines introduces disturbances in the system of vascular hemostasis. When studying the effects of metabolic disorders upon hemostatic system, we may conclude that activation of fibrinolytic and plasma chains occurs in the same way for both men and women, with small gender characteristics of individual components. The rheological properties of the blood are also changed with developing MS. Systematization of the available literature data on the issue under study can serve as a basis for determining prognostic criteria of hypertension progression and risk of thrombotic complications.

scholarly journals Circulating ANGPTL8 Is Associated with the Presence of Metabolic Syndrome and Insulin Resistance in Polycystic Ovary Syndrome Young Women

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Danlan Pu ◽  
Ling Li ◽  
Jingxia Yin ◽  
Rui Liu ◽  
Gangyi Yang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Metabolic Disorders ◽  
Polycystic Ovary ◽  
Serum Marker ◽  
Healthy Controls ◽  
Ovary Syndrome

Background. ANGPTL8 has been reported to be a regulator of lipid metabolism, and it is associated with insulin resistance (IR) and metabolic syndrome (MetS). We investigated whether ANGPTL8 plays a role in MetS. Methods. ANGPTL8 and adiponectin concentrations were measured in PCOS patients with or without MetS and in their corresponding healthy controls. The association of circulating ANGPTL8 with adiponectin and other parameters was also examined. Results. Circulating ANGPTL8 concentrations were higher in PCOS women with MetS than in those without MetS and in the controls (P<0.01). ANGPTL8 was positively correlated with age, BMI, FAT%, WHR, SBP, TG, FBG, HbA1c, Fins, and HOMA-IR (all P<0.01) in the study populations and negatively associated with adiponectin and M-values (P<0.001). In addition, ANGPTL8 was positively correlated with PRL, LH, TEST, and FAI and negatively correlated with SHBG (all P<0.01). ROC curve analyses showed that the AUCMetS was 0.87 (P<0.001), with a sensitivity of 92.4% and specificity of 75.4%, and the AUCIR was 0.82 (P<0.01), with a sensitivity of 76.4% and specificity of 75.6%. Conclusion. ANGPTL8 levels progressively decrease from PCOS patients with MetS to those without MetS and may be a serum marker associated with the degree of metabolic disorders.

scholarly journals ASSOCIATIONS OF IRS-1 POLYMORPHISM WITH VARIOUS COMPONENTS OF THE METABOLIC SYNDROME IN HYPERTENSIVE PATIENTS

2019 ◽  
Vol 72 (8) ◽  
pp. 1494-1498
Author(s):  
Maryna Kochuieva ◽  
Valentyna Psarova ◽  
Larysa Ruban ◽  
Nataliia Kyrychenko ◽  
Olena Alypova ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Glucose Tolerance ◽  
Arterial Hypertension ◽  
Abdominal Obesity ◽  
Healthy Individuals ◽  
Hypertensive Patients ◽  
The Metabolic Syndrome

Introduction: The metabolic syndrome is one of the most discussed cross-disciplinary problems of modern medicine. Now there are various definitions and criteria of diagnostics of metabolic syndrome. The abdominal obesity is considered the main component of the metabolic syndrome, as a reflection of visceral obesity which degree is offered to be estimated on an indirect indicator – a waist circumference. Alongside with abdominal obesity, a number of classifications distinguish insulin resistance (IR) as a diagnostic criterion of metabolic syndrome. It is proved that IR is one of the pathophysiological mechanisms influencing the development and the course of arterial hypertension (AH), type 2 DM and obesity. There are two components in the development of IR: genetic (hereditary) and acquired. In spite of the fact that IR has the accurate genetic predisposition, exact genetic disorders of its appearance have not been identified yet, thus demonstrating its polygenic nature. The aim: To establish possible associations of the insulin receptor substrate-1 (IRS-1) gene polymorphism with the severity of the metabolic syndrome components in patients with arterial hypertension (AH). Materials and methods: 187 patients with AH aged 45-55 years and 30 healthy individuals. Methods: anthropometry, reactive hyperemia, color Doppler mapping, biochemical blood analysis, HOMA-insulin resistance (IR), glucose tolerance test, enzyme immunoassay, molecular genetic method. Results: Among hypertensive patients, 103 had abdominal obesity, 43 - type 2 diabetes, 131 - increased blood triglycerides, 19 - decreased high density lipoproteins, 59 -prediabetes (33 - fasting hyperglycemia and 26 - impaired glucose tolerance), 126 had IR. At the same time, hypertensive patients had the following distribution of IRS-1 genotypes: Gly/Gly - 47.9%, Gly/Arg - 42.2% and Arg/Arg - 10.7%, whereas in healthy individuals the distribution of genotypes was significantly different: Gly/Gly - 86.8% (p<0.01), Gly/ Arg - 9.9% (p<0.01) and Arg/Arg - 3.3% (p<0.05). Hypertensive patients with Arg/Arg and Gly/Arg genotypes had significantly higher HOMA-IR (p<0.01), glucose, insulin and triglycerides levels (p<0.05), than in Gly/Gly genotype. At the same time, body mass index, waist circumference, blood pressure, adiponectin, HDL, interleukin-6, C-reactive protein, degree of endothelium-dependent vasodilation, as well as the frequency of occurrence of impaired glucose tolerance did not significantly differ in IRS-1 genotypes. Conclusions: in hypertensive patients, the genetic polymorphism of IRS-1 gene is associated with such components of the metabolic syndrome as hypertriglyceridemia and fasting hyperglycemia; it is not associated with proinflammatory state, endothelial dysfunction, dysglycemia, an increase in waist circumference and decrease in HDL.

scholarly journals Emerging roles of C1Q tumor necrosis factor-related proteins in metabolic diseases

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Manjunath Ramanjaneya ◽  
Jayakumar Jerobin ◽  
Ilham Bettahi ◽  
Kodappully Sivaraman Siveen ◽  
Abdul-Badi Abou-Samra
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Metabolic Disorders ◽  
Pharmacological Intervention ◽  
Alcoholic Fatty Liver ◽  
The Metabolic Syndrome ◽  
Related Proteins ◽  
Necrosis Factor

AbstractObesity and insulin resistance are key elements of the metabolic syndrome, which includes type 2 diabetes (T2D), dyslipidemia, systemic inflammation, hypertension, elevated risk for cardiovascular diseases, non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS). C1Q Tumor necrosis factor-related proteins (CTRPs) have recently emerged as important regulators of metabolism as a core component in the interrelationship between insulin resistance, adiposity and inflammation. To date 15 CTRP members have been identified and most of the CTRPs are dysregulated in obesity, T2D, coronary artery disease and NAFLD. Pharmacological intervention and lifestyle modification alter expression of CTRPs in circulation and in metabolically active tissues. CTRPs enhance metabolism mainly through activation of AMPK/AKT dependent pathways and possess insulin sensitizing properties. Thus dysregulated expression of CTRPs in metabolic disorders could contribute to the pathogenesis of the disease. For these reasons CTRPs appear to be promising targets for early detection, prevention and treatment of metabolic disorders. This review article aims at exploring the role of CTRPs in metabolic syndrome.

Effect of Abdominal Obesity on Insulin Resistance and the Components of the Metabolic Syndrome: Evidence Supporting Obesity as the Central Feature

2003 ◽  
Vol 13 (5) ◽  
pp. 699-705 ◽  
Author(s):  
Çavlan Türkoglu ◽  
Belgin Süsleyici Duman ◽  
Demet Günay ◽  
Penbe Çagatay ◽  
Remzi Özcan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Central Feature ◽  
The Metabolic Syndrome

Abstract P088: Obesity, Hypertension and Insulin Resistance in a Primary Pediatric Setting in Southern Italy

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Giampaolo De Filippo ◽  
Domenico Rendina ◽  
Domenico Viggiano ◽  
Antonio Fasolino ◽  
Paola Sabatini ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Children And Adolescents ◽  
Diagnostic Criteria ◽  
Southern Italy ◽  
Serum Insulin ◽  
High Density Lipoproteins ◽  
Obese Children ◽  
Campania Region

Background: Obesity is the main risk factor for essential hypertension (EH) in childhood. The O.Si.Me. study (Obesity and Metabolic Syndrome in children and adolescents) evaluated the prevalence of metabolic syndrome (MetS) and its constitutive traits in a sample of obese children and adolescents living in Campania, southern Italy. Patients and methods: Four hundred and fifteen children and adolescents consecutively referred to the National Health Service participating Outpatient Clinics for minor health problems and found to have a Body Mass Index (BMI) Z-score > 2.0 were enrolled in the study. The entire sample was screened for MetS, which was defined as the presence of at least 2 of the following alterations in addition to obesity: fasting hyperglycemia, low levels of high-density lipoproteins cholesterol, hypertriglyceridemia, and EH. The present analysis evaluated the clinical characteristics of the O.Si.Me subgroup of EH participants (systolic and/or diastolic BP ≥ 95 th percentile for age, gender and height) as compared with normotensive participants. Results: The prevalence of EH in the O.Si.Me population was 23.6 % (98/415, 48M and 50F.) and two-thirds of the EH participants met the MetS diagnostic criteria. The EH participants featured serum insulin and HOMA-IR levels significantly higher compared with normotensive ones (11.6±0.6 vs. 9.5±0.4 μIU/ml, p = 0.014; 2.6±0.1 vs. 2.2±0.1, p = 0.028 for insulin and HOMA-IR, respectively). These differences were common to boys and girls and remained significant after correction for age, pubertal stage, body weight, length, BMI, gestational age at birth, duration of breastfeeding and anthropometric parental parameters. Accordingly, children and adolescents with EH had a a relative risk of being insulin resistant (defined as a HOMA-IR ≥2.5) significantly greater compared to those without. Moreover, they exhibited higher serum creatinine levels (53.8±7.1 vs. 35.4±6.8 μmol/l, p=0.025) accounting for gender and body weight. Conclusions: More than a quarter of obese children and adolescents meet the diagnostic criteria for EH in the Campania region in southern Italy. These obese boys and girls have an increased prevalence of insulin resistance and apparently an initial reduction in renal function compared with obese children and adolescents with normal BP.

Abstract P033: Relationship Between Adiponectin Level and Metabolic Syndrome after Weight Loss in Patients with Abdominal Obesity

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Aelita Berezina ◽  
Olga Belyaeva ◽  
Olga Berkovich ◽  
Elena Baranova ◽  
Tatyina Karonova
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Abdominal Obesity ◽  
Metabolic Disorders ◽  
Intervention Program ◽  
Adiponectin Level ◽  
The Metabolic Syndrome ◽  
Outpatient Intervention ◽  
Before And After ◽  
The Relationship

Objective: to investigate the relationship between adiponectin level and metabolic syndrome (MS) after weight loss in patients with abdominal obesity (AO). Method: A 3-year randomized lifestyle intervention trial performed in 153 patients with AO, age 43,2±0,8 yrs, BMI 32,1±1,9 kg/m 2 . 74 patients keep hypocaloric diet (gr.1), 79 patients keep diet and performed aerobic exercise (gr.2). Adiponectin concentration, body mass (BM), waist circumference (WC), body fat (BF), BMI, the levels of BP, glucose, insulin, HOMA-IR, TC, HDL-C, LDL-C, TG, CRP were measured before and after a 3-years outpatient intervention program. Results. 100% patients with AO had some metabolic disorders and 38% had MS before the treatment. The adiponectin levels and others parameters didn’t differ between the groups before intervention (p>0,05). In 3 years 53 (71,6%) and 58 (73,4%) patients from 1 and 2 groups reduced weight. The rate of improving BM, BMI, BF, WC, HDL-C, TG and insulin was grater in patients gr.2 (p<0,05). The favorable dynamics of MS (MS didn’t appeared at the end of study or didn’t registered in patients who had it before) didn’t differ between the groups 1 and 2 (81,1% and 91,4%, p>0,05). The increasing of adiponectin level occurred more often in patients gr.2, than gr.1 (93,1% and 58,5%, p=0,001, respectively). Adiponectin level increased only in patients gr.2 (18,0±1,1mcg/ml and 23,8±1,3 mcg/ml, p= [[Unable to Display Character: &#1088;]]=0,0001), didn’t changed in gr.1 (p>0,05). It was established that in patients with combination of weight loss and increasing of adiponectin level favorable dynamics of MS occurred more often than in patients who lost weight without increasing of adiponectin level (91,7% and 69,2%, p=0,0001). In patients with favorable dynamics of MS increasing of adiponectin level had met more often, than in patients with unfavorable dynamics of MS (MS continued or appeared) (88,6% and 11,4%, p=0,0001). Increasing of adiponectin level associated with positive dynamics of the MS - OR=9,1 (4,0-20,6). Conclusion. Combination of weight loss and increasing of adiponectin level associated with favorable dynamics of the metabolic syndrome.

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