scholarly journals Splenosis: fetters of the unknown or step through existing precautions (part II)

2021 ◽  
Vol 25 (1) ◽  
pp. 80-93
Author(s):  
N. B. Gubergrits ◽  
A. D. Zubov ◽  
K. N. Borodiy ◽  
T. L. Mozhyna
Keyword(s):  
Chronic Pancreatitis ◽  
Clinical Case ◽  
Clinical Manifestations ◽  
Dynamic Monitoring ◽  
Review Of The Literature ◽  
Imaging Studies ◽  
Close Attention ◽  
Post Traumatic

Aim: to present a review of the literature on post-traumatic splenosis of different localization, as well as to complete the presentation of a rare clinical case of multiple post-traumatic intra-abdominal splenosis in combination with type 2 macroamylasemia, chronic pancreatitis in a 27-year-old woman.Main results. The literature data of the pathogenesis and classification of splenosis are considered. Close attention is paid to the clinical manifestations of post-traumatic splenosis: the results of imaging studies in intrathoracic, disseminated abdominal, intrahepatic and intrapancreatic forms of splenosis are presented.The end of the description of a rare clinical case of progressive multiple post-traumatic intra-abdominal splenosis in combination with type 2 macroamylasemia and chronic pancreatitis is presented. The process of diagnostic search, differential diagnosis is described, the controversial points to the patient’s management, the possibility and expediency of pregnancy are considered.Conclusion. The exclusivity of this clinical case requires further dynamic monitoring, especially in the possible pregnancy. 

The prevalence of subclinical hypercorticism among the patients presenting with type 2 diabetes mellitus and alimentary obesity

2014 ◽  
Vol 60 (1) ◽  
pp. 9-17
Author(s):  
A V Dreval ◽  
I V Komerdus ◽  
A V Murzina ◽  
O A Nechaeva ◽  
R S Tishenina ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Adrenal Glands ◽  
Clinical Manifestations ◽  
Cortisol Secretion ◽  
Pathological Changes ◽  
Imaging Studies ◽  
Alimentary Obesity

Subclinical hypercorticism is characterized by increased cortisol secretion in the absence of the specific clinical manifestations of the disease. The prevalence of subclinical hypercorticism has been estimated at 8 cases per 10,000 population even though the frequency of subclinical hypercorticism may be higher among certain groups of the patients. We observed 111 patients presenting with type 2 diabetes mellitus and 40 ones with alimentary obesity. As a result, subclinical hypercorticism was diagnosed in 4 (10%) patients with obesity and in 12 (12%) ones with diabetes mellitus. In two of these cases, the diagnosis was later changed to clinically manifested hypercorticism. The imaging studies revealed pathological changes in pituitary and adrenal glands in six of the 16 patients presenting with subclinical hypercorticism. An algorithm for the examination of the patients with type 2 diabetes mellitus and alimentary obesity for the purpose of diagnostics of subclinical hypercorticism is proposed.

scholarly journals Rare dermatological diseases: Devergie disease

2020 ◽  
Vol 22 (7) ◽  
pp. 54-56
Author(s):  
Kristina T. Plieva ◽  
◽  
Elena V. Denisova ◽  
Maksim A. Bobrov ◽  
Dzerassa R. Mildzikhova ◽  
...  
Keyword(s):  
Key Words ◽  
Rare Disease ◽  
Histological Examination ◽  
Clinical Case ◽  
Correct Diagnosis ◽  
Clinical Manifestations ◽  
Dermatological Diseases ◽  
Pityriasis Rubra Pilaris

Devergie disease, or pityriasis rubra pilaris, is a poorly studied and rare disease, which prevalence is estimated at about 1 in 400 thousand. The article provides relevant data on the classification of Devergie disease, features of the course and clinical manifestations of each of the 6 types of the disease, as well as the ap-proximate occurrence of these types. Erythroderma can occur in Devergie disease, but data on the incidence of this manifestation vary significantly. The article presents a clinical case of type 1 Devergie disease. This case is of particular interest, since the disease began not according to the classical scheme, i.e., with appearance of an erythematous spot, but with extensive areas of erythroderma. This case is intended to draw attention to the fact that dermatological diseases do not always develop in a typical way, and the correct diagnosis often requires a histological examination. Key words: pityriasis rubra pilaris, Devergie disease, erythroderma, clinical case. For citation: Plieva K.T., Denisova E.V., Bobrov M.A. et al. Rare dermatological diseases: Devergie disease. Consilium Medicum. 2020; 22 (7): 54–56. DOI: 10.26442/20751753.2020.7.200187

scholarly journals Regression of Liquorodynamic Disorders and Ventriculoperitoneal Shunt Overdrain Syndrome Clinic in a Patient After Severe Brain Injury with Posttraumatic Hydrocephalus and a Giant Cranial Bones Defect After Cranioplasty: Case Report

2020 ◽  
Vol 2 (3) ◽  
pp. 263-272
Author(s):  
Alexey N. Vorobyev ◽  
Inessa G. Shchelkunova ◽  
Dmitrii V. Levin ◽  
Oleg B. Lukyanec ◽  
Alexandr A. Shaybak ◽  
...  
Keyword(s):  
Brain Injury ◽  
Clinical Case ◽  
Clinical Manifestations ◽  
Brain Structures ◽  
Cranial Vault ◽  
Shunt System ◽  
Cranial Defect ◽  
Post Traumatic ◽  
Relationship Of

Introduction. The frequency of post-traumatic hydrocephalus is 3.9%. The incidence of post-traumatic defects of the skull is 10.46 per 100,000 per year. Overdrain syndrome occurs in 1012% of cases in patients with long-term ventricular shunting. The presence of a cranial defect causes a violation of blood flow and cerebrospinal fluid dynamics in the area of the defect, a displacement of brain structures under the influence of gravity and atmospheric pressure, which can cause a deterioration in the patients condition and a significant slowdown in recovery after a severe head injury. Both craniotomy syndrome and excessive shunting can impede the verticalization and rehabilitation of patients with post-traumatic hydrocephalus and post-traumatic defects of the bones of the cranial vault. Description of the clinical case. Clinical case demonstrates an example of a differential approach and an algorithm for deciding on surgical treatment in a patient with post-traumatic hydrocephalus and cranial bones defect in case of deterioration during attempts at verticalization in a complex of rehabilitation measures. Conclusion. The clinical manifestations of trephine skull syndrome and syndrome of shunt overdrain in the patient after severe traumatic brain injury combines post-traumatic hydrocephalus, may be similar. And not always, as demonstrated in this clinical case, narrowed ventricles and the relationship of deterioration to verticalization should be interpreted as a syndrome of excessive drainage of the shunt system. The plastic surgery of the defect of the bones of the cranial vault performed in this case made it possible to improve the patients condition and regress symptoms.

scholarly journals SYNDROME OF THE FIRST GILL ARCH IN A NEWBORN CHILD (CLINICAL CASE)

2020 ◽  
Vol 20 (4) ◽  
pp. 237-240
Author(s):  
M. Yе. Fesenko ◽  
O. A. Scherban ◽  
M. M. Fastovets ◽  
O.O. Kalyuzhka ◽  
Yu. I. Chernyavska
Keyword(s):  
At Risk ◽  
Clinical Case ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Facial Asymmetry ◽  
Final Diagnosis ◽  
Gill Arch ◽  
Dynamic Monitoring ◽  
Large Variability ◽  
Neuropsychological Development

The article describes a clinical case of “First Gill Arch Syndrome" in a newborn girl, the peculiarities of the syndrome, its diagnosis. The characteristics of this disease is that the mother of the child was at risk group due to smoking, anaemia during the pregnancy and medical abortions in the past obstetric history. The aetiology of "First Gill Arch Syndrome" is insufficiently studied, but, according to latest concepts, this condition results from the mutations in the TCOF1 gene. The aetiology of the disease also does not exclude the role of adverse obstetric and gynaecological anamnesis and diseases of the mother, previous medical abortions and teratogenic factors. Difficulties in diagnosis are due to the large variability of clinical manifestations and course of the disease. The final diagnosis of the child was based on specific clinical signs of the disease: facial asymmetry, unilateral facial paralysis (lesions of the facial nerve on the right), the presence of blind fistula of the left cheek and skin suspension of the left auricle. We can conclude about the necessity to elaborate preventive measures to reduce the occurrence of this disease: timely ultrasound examination of pregnant women, who are at risk and mandatory dynamic monitoring of a child with this disease to assess physical and neuropsychological development.

scholarly journals Pterygoid hamulus syndrome: a case report

2020 ◽  
Vol 26 (4) ◽  
pp. 42
Author(s):  
Paul Galvez ◽  
Nathan Moreau ◽  
Mathilde Fenelon ◽  
Jean-Marie Marteau ◽  
Sylvain Catros ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Surgical Treatment ◽  
Orofacial Pain ◽  
Review Of The Literature ◽  
Traumatic Origin ◽  
Post Traumatic ◽  
Mucosal Lesions ◽  
Type 2 Diabetic

Introduction: Pterygoid hamulus syndrome (PHS) is a little-known differential diagnosis of orofacial pain. It is characterized by oropharyngeal pain, secondary to inflammatory bursitis of the tensor veli muscle of post-traumatic origin, frequently fostered by an associated hypertrophy of the hamular process. Observation: A 64-year-old female patient, type 2 diabetic, consulted for constant posterior palatal pain located near to 17, lasting for 10 years. The inspection did not reveal any mucosal lesions. Right hamulus palpation increased the pain and revealed hamulus hypertrophy. A diagnosis of PHS was evoked. Comment: A review of the literature is proposed. The treatment of PHS is initially conservative, but a surgical treatment can be proposed in case of morphological anomalies. Conclusion: PHS is a little-known syndrome whose diagnosis must be mentioned by the oral surgeon faced with chronic oropharyngeal pain. The diagnosis is clinical and radiological, the treatment is medical and/or surgical.

scholarly journals Adrenal Ganglioneuroblastoma in Adults: A Case Report and Review of the Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Stefano Benedini ◽  
Giorgia Grassi ◽  
Carmen Aresta ◽  
Antonietta Tufano ◽  
Luca Fabio Carmignani ◽  
...  
Keyword(s):  
Adrenal Mass ◽  
Clinical Case ◽  
Ultrasound Examination ◽  
Flank Pain ◽  
Review Of The Literature ◽  
Imaging Studies ◽  
Left Flank ◽  
Adrenal Masses ◽  
Conclusive Diagnosis ◽  
Left Flank Pain

Incidentally discovered adrenal masses are very common given the increased number of imaging studies performed in recent years. We here report a clinical case of a 20-year-old woman who presented with left flank pain. Ultrasound examination revealed a contralateral adrenal mass, which was confirmed at computed tomography (CT) scan. Hormonal hypersecretion was excluded. Given the size (11 × 10 × 7 cm) and the uncertain nature of the mass, it was surgically removed and sent for pathological analyses. Conclusive diagnosis was ganglioneuroblastoma. Ganglioneuroblastoma is an uncommon malignant tumor, extremely rare in adults, particularly in females. This neoplasm is frequently localized in adrenal gland.

scholarly journals Symptom-based clinical profiles in the classification of post-traumatic headache

Neurology ◽  
2018 ◽  
Vol 91 (23 Supplement 1) ◽  
pp. S28.2-S28
Author(s):  
Andrew H Ahn ◽  
Sylvia M Lucas
Keyword(s):  
Unmet Need ◽  
Clinical Manifestations ◽  
Primary Headache ◽  
Current Data ◽  
Headache Disorders ◽  
Primary Headache Disorders ◽  
Specific Outcome ◽  
Post Traumatic ◽  
Definition Of

There are currently no established therapies for post-traumatic headache (PTH). One key obstacle standing in the way of meeting this unmet need is the fundamental gap in our understanding of the clinical course and functional impact of PTH. In this presentation we examine the existing schema used to characterize the clinical characteristics of PTH, including the International Classification of Headache Disorders (ICHD), and find that they leave major unresolved questions about the diagnosis, classification, and measurement of the clinical impact of PTH. Specifically, current data suggest that the ICHD classification, which is based on the extent of brain injury and the duration of condition, have limited prognostic and treatment implications. There are several challenges to the classification of PTH, as the clinical manifestations of PTH do not map well to the primary headache disorders, and the definition of the continuous and chronic daily headache require further study. Importantly, the existing classification do not provide or imply specific outcome measures for PTH, again a fundamental roadblock to testing therapeutic hypotheses for PTH. We hypothesize that a symptom-based classification is needed to begin an examination of these unresolved questions, and to establish clinically relevant endpoints for research and clinical trials for effective therapies.

Craniometaphyseal dysplasia

1977 ◽  
Vol 91 (2) ◽  
pp. 159-170 ◽  
Author(s):  
F. W. Martin
Keyword(s):  
Clinical Manifestations ◽  
Review Of The Literature ◽  
Facial Paresis ◽  
Genetic Transmission ◽  
X Ray ◽  
Cranial Nerve Palsies ◽  
Craniometaphyseal Dysplasia ◽  
Loss Of Hearing ◽  
Mastoid Surgery

AbstractA case report of craniometaphyseal dysplasia is presented with a classification of this disease, supported by a review of the literature. Certain unusual features are observed—mastoid surgery and later contralateral temporary facial paresis. The patient showed no further deterioration of symptoms when last reviewed.Craniometaphyseal dysplasia is one of a number of craniotubular bony dysplasias. These dysplasias are characterized by (a) genetic transmission and (b) dysplastic or hyperostotic involvement of the cranial and tubular bones (Gorlin, et al., 1969). Craniometaphyseal dysplasia may be dominant or recessive in form, the latter being more severe in its clinical manifestations, viz. nasal obstruction and deformity and cranial nerve palsies, such as optic atrophy and loss of hearing. There may also be enlargement of the mandible and flaring of the metaphyses of long bones on X-ray examination.

scholarly journals Splenosis: fetters of the unknown or step through existing precautions (part I)

2020 ◽  
Vol 24 (4) ◽  
pp. 64-73
Author(s):  
N. B. Gubergrits ◽  
A. D. Zubov ◽  
K. N. Borodiy ◽  
T. L. Mozhyna
Keyword(s):  
Detailed Analysis ◽  
Diagnostic Process ◽  
Laboratory Studies ◽  
Imaging Studies ◽  
Palpable Mass ◽  
Anatomy And Physiology ◽  
History Of ◽  
Post Traumatic ◽  
The Right

Aim: to present a rare clinical case of multiple post-traumatic intra-abdominal splenosis in combination with type 2 macroamylasemia, chronic pancreatitis in a 27-year-old woman, clinically manifested like a palpable mass in the right iliac region.Main results. In the first part of the article, a detailed analysis of the medical history is given, the results of archival imaging studies and the data of laboratory and instrumental examination at the time of treatment are presented. The literature review presents modern definitions of splenosis, as well as brief information about the anatomy and physiology of the spleen.Conclusion. The diagnostic process requires a detailed analysis of the history of the disease, the performance of laboratory studies in combination with modern imaging studies, as well as a thorough study of the literature data.

scholarly journals Clinical case: severe course of adenoviral conjunctivitis with a hemorrhagic component complicated by a toxic-allergic reaction against a pregnancy

2018 ◽  
Vol 9 (1) ◽  
pp. 76-81
Author(s):  
V. N. Trubilin ◽  
E. G. Poluninа ◽  
D. V. Andzhelova ◽  
E. A. Kasparova ◽  
Yu. V. Evstigneeva
Keyword(s):  
Allergic Reaction ◽  
Blood Test ◽  
Clinical Case ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Clinical Feature ◽  
Adenovirus Infection ◽  
Close Attention ◽  
Complex Approach ◽  
Comprehensive Examination

One of the manifestations of adenovirus keratoconjunctivitis – extensive subconjunctival hemorrhages – is the characteristic of rather rare hemorrhagic form of conjunctivitis of severe course. Patients, especially pregnant women, with clinical manifestations of adenoviral conjunctivitis of severe course with a hemorrhagic component complicated by a toxic-allergic reaction, require close attention not only from ophthalmologists. It is necessary to conduct a comprehensive examination, including: general blood test, coagulogram, consultation of the therapist. Clinical signs of deterioration, in the early days of the disease, against the backdrop of treatment, is a clinical feature of the course of adenovirus infection, which should be informed to the patient. The use of a complex approach using the domestic non-toxic inducer of interferon formation of Poludan (polyA:polyU complex) in instillations and injections, supplemented by scraping-massage with a glass rod of the tarsal conjunctiva, facilitating the elimination of adenovirus from conjunctival follicles, quickly and effectively reversed the phenomenon of severe AVC. The appointment of corticosteroid therapy, regardless of the severity of the toxic-allergic reaction, is shown no earlier than 7 days after the manifestation of the disease.

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