Correction: Towards a Modular Architecture for Intelligent Aerial Manipulator Systems

2018 ◽  
Author(s):  
Jishu K. Medhi ◽  
Catharine L. McGhan
Keyword(s):  
Modular Architecture ◽  
Aerial Manipulator

Protein Interaction Domains and Post-Translational Modifications: Structural Features and Drug Discovery Applications

2020 ◽  
Vol 27 (37) ◽  
pp. 6306-6355 ◽  
Author(s):  
Marian Vincenzi ◽  
Flavia Anna Mercurio ◽  
Marilisa Leone
Keyword(s):  
Drug Discovery ◽  
Protein Interaction ◽  
Protein Interactions ◽  
Structural Information ◽  
Protein Complexes ◽  
Structural Features ◽  
Protein Protein Interactions ◽  
Modular Architecture ◽  
Post Translational Modifications ◽  
Interaction Domains

Background:: Many pathways regarding healthy cells and/or linked to diseases onset and progression depend on large assemblies including multi-protein complexes. Protein-protein interactions may occur through a vast array of modules known as protein interaction domains (PIDs). Objective:: This review concerns with PIDs recognizing post-translationally modified peptide sequences and intends to provide the scientific community with state of art knowledge on their 3D structures, binding topologies and potential applications in the drug discovery field. Method:: Several databases, such as the Pfam (Protein family), the SMART (Simple Modular Architecture Research Tool) and the PDB (Protein Data Bank), were searched to look for different domain families and gain structural information on protein complexes in which particular PIDs are involved. Recent literature on PIDs and related drug discovery campaigns was retrieved through Pubmed and analyzed. Results and Conclusion:: PIDs are rather versatile as concerning their binding preferences. Many of them recognize specifically only determined amino acid stretches with post-translational modifications, a few others are able to interact with several post-translationally modified sequences or with unmodified ones. Many PIDs can be linked to different diseases including cancer. The tremendous amount of available structural data led to the structure-based design of several molecules targeting protein-protein interactions mediated by PIDs, including peptides, peptidomimetics and small compounds. More studies are needed to fully role out, among different families, PIDs that can be considered reliable therapeutic targets, however, attacking PIDs rather than catalytic domains of a particular protein may represent a route to obtain selective inhibitors.

A Switchable Unmanned Aerial Manipulator System for Window-Cleaning Robot Installation

2021 ◽  
pp. 1-1
Author(s):  
Yinshuai Sun ◽  
Zhongliang Jing ◽  
Peng Dong ◽  
Jianzhe Huang ◽  
Wujun Chen ◽  
...  
Keyword(s):  
Cleaning Robot ◽  
Aerial Manipulator

scholarly journals The INUS Platform: A Modular Solution for Object Detection and Tracking from UAVs and Terrestrial Surveillance Assets

Computation ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 12
Author(s):  
Evangelos Maltezos ◽  
Athanasios Douklias ◽  
Aris Dadoukis ◽  
Fay Misichroni ◽  
Lazaros Karagiannidis ◽  
...  
Keyword(s):  
Decision Making ◽  
Object Detection ◽  
Situational Awareness ◽  
Machine Learning Techniques ◽  
Measurement Instruments ◽  
Time Data ◽  
Modular Architecture ◽  
Seamless Integration ◽  
Object Detection And Tracking ◽  
Detection And Tracking

Situational awareness is a critical aspect of the decision-making process in emergency response and civil protection and requires the availability of up-to-date information on the current situation. In this context, the related research should not only encompass developing innovative single solutions for (real-time) data collection, but also on the aspect of transforming data into information so that the latter can be considered as a basis for action and decision making. Unmanned systems (UxV) as data acquisition platforms and autonomous or semi-autonomous measurement instruments have become attractive for many applications in emergency operations. This paper proposes a multipurpose situational awareness platform by exploiting advanced on-board processing capabilities and efficient computer vision, image processing, and machine learning techniques. The main pillars of the proposed platform are: (1) a modular architecture that exploits unmanned aerial vehicle (UAV) and terrestrial assets; (2) deployment of on-board data capturing and processing; (3) provision of geolocalized object detection and tracking events; and (4) a user-friendly operational interface for standalone deployment and seamless integration with external systems. Experimental results are provided using RGB and thermal video datasets and applying novel object detection and tracking algorithms. The results show the utility and the potential of the proposed platform, and future directions for extension and optimization are presented.

Sign in / Sign up

Export Citation Format

Share Document