PRIMARY LYMPHOMAS OF THE FEMALE GENITAL TRACT

Abstract Introduction Malignant mesonephric tumors are uncommon in the female genital tract, and they are usually located where embryonic remnants of Wolffian ducts are detected, such as the uterine cervix. The information about these tumors, their treatment protocol, and prognosis are scarce. Case report A 60-year-old woman with postmenopausal vaginal bleeding was initially diagnosed with endometrial carcinoma. After suspicion co-testing, the patient underwent a loop electrosurgical excision of the cervix and was eventually diagnosed with mesonephric adenocarcinoma. She was subjected to a radical hysterectomy, which revealed International Federation of Gynecology and Obstetrics (FIGO) IB1 stage, and adjuvant radiotherapy. The follow-up showed no evidence of recurrence after 60 months. Conclusion We present the case of a woman with cervical mesonephric adenocarcinoma. When compared with the literature, this case had the longest clinical follow-up without evidence of recurrence, which reinforces the concept that these tumors are associated with a favorable prognosis if managed according to the guidelines defined for the treatment of patients with cervical adenocarcinomas. Though a rare entity, it should be kept in mind as a differential diagnosis for other cervical cancers.

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Vaginal, Cervical and Uterine pH in Women with Normal and Abnormal Vaginal Microbiota

Pathogens ◽

10.3390/pathogens10020090 ◽

2021 ◽

Vol 10 (2) ◽

pp. 90

Author(s):

Malene Risager Lykke ◽

Naja Becher ◽

Thor Haahr ◽

Ebbe Boedtkjer ◽

Jørgen Skov Jensen ◽

...

Keyword(s):

Pregnant Women ◽

Genital Tract ◽

Quantitative Polymerase Chain Reaction ◽

Female Genital Tract ◽

Uterine Cavity ◽

Vaginal Microbiota ◽

Reproductive Age ◽

Ph Gradient ◽

Increased Risk ◽

Female Genital

Introduction: Healthy women of reproductive age have a vaginal pH around 4.5, whereas little is known about pH in the upper genital tract. A shift in the vaginal microbiota may result in an elevated pH in the upper genital tract. This might contribute to decreased fertility and increased risk of preterm birth. Therefore, we aimed to measure pH in different compartments of the female genital tract in both nonpregnant and pregnant women, stratifying into a normal and abnormal vaginal microbiota. Material and methods: In this descriptive study, we included 6 nonpregnant, 12 early-pregnant, and 8 term-pregnant women. A pH gradient was recorded with a flexible pH probe. An abnormal vaginal microbiota was diagnosed by a quantitative polymerase chain reaction technique for Atopobium vaginae; Sneathia sanguinegens; Leptotrichia amnionii; bacterial vaginosis-associated bacterium 1, 2, 3, and TM7; and Prevotella spp. among others. Results: In all participants we found the pH gradient in the lower reproductive canal to be most acidic in the lower vagina and most alkaline in the upper uterine cavity. Women with an abnormal vaginal microbiota had an increased pH in the lower vagina compared to the other groups. Conclusions: There is a pronounced pH gradient within the female genital tract. This gradient is not disrupted in women with an abnormal vaginal microbiota.

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Malacoplakia of the Uterine Cervix: A Case Report

Pathogens ◽

10.3390/pathogens10030343 ◽

2021 ◽

Vol 10 (3) ◽

pp. 343

Author(s):

Adela Saco ◽

Natalia Rakislova ◽

Lorena Marimon ◽

Aureli Torne ◽

Berta Diaz-Feijoo ◽

...

Keyword(s):

Uterine Cervix ◽

Genital Tract ◽

Vaginal Bleeding ◽

Female Genital Tract ◽

Granulomatous Inflammation ◽

Resonance Imaging ◽

Chain Reaction ◽

Polymerase Chain ◽

Cervical Tumors ◽

Female Genital

Malacoplakia is an uncommon chronic granulomatous inflammation that rarely affects the female genital tract. A case of a 78-year-old woman with malacoplakia involving the uterine cervix and the vagina is described. The patient complained of vaginal bleeding. Clinically, a 13-mm mass was detected in the cervix, which was confirmed by ultrasound scan and magnetic resonance imaging. Histological examination showed a dense histiocytic infiltrate with abundant Michaelis–Gutmann bodies involving the uterine cervix and the upper vagina. The presence of Escherichia coli was confirmed in the lesion by immunohistochemistry and polymerase chain reaction. Only 12 cases of cervical malacoplakia have been reported to date. This condition should be included in the differential diagnosis of cervical tumors.

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