Differential gene expression of SMAD family members and S1PR1 in circulating CD4+ T cells in multiple sclerosis

2017 ◽  
Author(s):  
Jose Manuel Garcia Dominguez
Keyword(s):  
Gene Expression ◽  
Multiple Sclerosis ◽  
T Cells ◽  
Differential Gene Expression ◽  
Cd4 T Cells ◽  
Family Members ◽  
Differential Gene

Differential Gene Expression in CD4+ T Cells from Atopic Dermatitis Patients is Due to Selective Expression in the Skin Homing T Cells

Dermatitis ◽  
2008 ◽  
Vol 19 (4) ◽  
pp. 218-238
Author(s):  
Dirk Jan Hijnen ◽  
Evert H. Nijhuis ◽  
Leo Koenderman ◽  
Carla A. F. M. Bruijnzeel-Koomen ◽  
Marjolein S. de Bruin-Weller ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cells ◽  
Atopic Dermatitis ◽  
Differential Gene Expression ◽  
Cd4 T Cells ◽  
Selective Expression ◽  
Skin Homing ◽  
Differential Gene

scholarly journals Nef-induced differential gene expression in primary CD4+ T cells following infection with HIV-1 isolates

Virus Genes ◽  
2019 ◽  
Vol 55 (4) ◽  
pp. 541-544
Author(s):  
Robert L. Furler ◽  
Ayub Ali ◽  
Otto O. Yang ◽  
Douglas F. Nixon
Keyword(s):  
Gene Expression ◽  
T Cells ◽  
Differential Gene Expression ◽  
Cd4 T Cells ◽  
Differential Gene ◽  
Hiv 1

Differential gene expression in peripheral blood CD4+ T-Cells of patients with atopic dermatitis

2005 ◽  
Vol 115 (2) ◽  
pp. S102
Author(s):  
D. Hijnen ◽  
E. Knol ◽  
I. Kok ◽  
M. Groot Koerkamp ◽  
C. Bruijnzeel-Koomen ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cells ◽  
Atopic Dermatitis ◽  
Differential Gene Expression ◽  
Peripheral Blood ◽  
Cd4 T Cells ◽  
Differential Gene

scholarly journals No differential gene expression for CD4+ T cells of MS patients and healthy controls

2019 ◽  
Vol 5 (2) ◽  
pp. 205521731985690 ◽  
Author(s):  
Ina S Brorson ◽  
Anna Eriksson ◽  
Ingvild S Leikfoss ◽  
Elisabeth G Celius ◽  
Pål Berg-Hansen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Multiple Sclerosis ◽  
T Cells ◽  
Differential Gene Expression ◽  
Genetic Variants ◽  
Healthy Controls ◽  
Expression Studies ◽  
Differential Gene ◽  
Gene Expression Studies ◽  
Multiple Sclerosis Patients

Background Multiple sclerosis-associated genetic variants indicate that the adaptive immune system plays an important role in the risk of developing multiple sclerosis. It is currently not well understood how these multiple sclerosis-associated genetic variants contribute to multiple sclerosis risk. CD4+ T cells are suggested to be involved in multiple sclerosis disease processes. Objective We aim to identify CD4+ T cell differential gene expression between multiple sclerosis patients and healthy controls in order to understand better the role of these cells in multiple sclerosis. Methods We applied RNA sequencing on CD4+ T cells from multiple sclerosis patients and healthy controls. Results We did not identify significantly differentially expressed genes in CD4+ T cells from multiple sclerosis patients. Furthermore, pathway analyses did not identify enrichment for specific pathways in multiple sclerosis. When we investigated genes near multiple sclerosis-associated genetic variants, we did not observe significant enrichment of differentially expressed genes. Conclusion We conclude that CD4+ T cells from multiple sclerosis patients do not show significant differential gene expression. Therefore, gene expression studies of all circulating CD4+ T cells may not result in viable biomarkers. Gene expression studies of more specific subsets of CD4+ T cells remain justified to understand better which CD4+ T cell subsets contribute to multiple sclerosis pathology.

Differential Gene Expression Identifies Novel Markers of Myelin-Specific Murine Memory CD4+ T Cells

2007 ◽  
Vol 123 ◽  
pp. S149
Author(s):  
Wassim Elyaman ◽  
Pia Kivisakk ◽  
Jaime Imitola ◽  
Samia Khoury ◽  
Mohamed Sayegh
Keyword(s):  
Gene Expression ◽  
T Cells ◽  
Differential Gene Expression ◽  
Cd4 T Cells ◽  
Differential Gene ◽  
Memory Cd4 T Cells

scholarly journals Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8+ T-cell response

Blood ◽  
2006 ◽  
Vol 108 (10) ◽  
pp. 3363-3370 ◽  
Author(s):  
Monchou Fann ◽  
Jason M. Godlove ◽  
Marta Catalfamo ◽  
William H. Wood ◽  
Francis J. Chrest ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cells ◽  
T Cell ◽  
Differential Gene Expression ◽  
Cd8 T Cells ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Memory Cd8 T Cells ◽  
Differential Gene ◽  
H3k9 Acetylation

Abstract To understand the molecular basis for the rapid and robust memory T-cell responses, we examined gene expression and chromatin modification by histone H3 lysine 9 (H3K9) acetylation in resting and activated human naive and memory CD8+ T cells. We found that, although overall gene expression patterns were similar, a number of genes are differentially expressed in either memory or naive cells in their resting and activated states. To further elucidate the basis for differential gene expression, we assessed the role of histone H3K9 acetylation in differential gene expression. Strikingly, higher H3K9 acetylation levels were detected in resting memory cells, prior to their activation, for those genes that were differentially expressed following activation, indicating that hyperacetylation of histone H3K9 may play a role in selective and rapid gene expression of memory CD8+ T cells. Consistent with this model, we showed that inducing high levels of H3K9 acetylation resulted in an increased expression in naive cells of those genes that are normally expressed differentially in memory cells. Together, these findings suggest that differential gene expression mediated at least in part by histone H3K9 hyperacetylation may be responsible for the rapid and robust memory CD8+ T-cell response.

scholarly journals Global Characterization of Differential Gene Expression Profiles in Mouse Vγ1+ and Vγ4+ γδ T Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e112964 ◽  
Author(s):  
Peng Dong ◽  
Siya Zhang ◽  
Menghua Cai ◽  
Ning Kang ◽  
Yu Hu ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cells ◽  
Differential Gene Expression ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Γδ T Cells ◽  
Differential Gene
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