The scattered puzzle effect: implantation disorders in chronic endometritis

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (6) ◽  
pp. 93-100
Author(s):  
Victor E. Radzinsky ◽  
Mekan R. Orazov ◽  
Liliia R. Toktar ◽  
Liudmila M. Mihaleva ◽  
Pavel A. Semenov ◽  
...  
Keyword(s):  
Uterine Cavity ◽  
Special Role ◽  
Inadequate Response ◽  
Chronic Endometritis ◽  
Vitro Fertilization ◽  
Endometrial Cells ◽  
Adverse Pregnancy ◽  
Relationship Of

Chronic endometritis (CE) is defined as a state of inflammation localized in the endometrium, accompanied by edema, dissociated maturation of epithelial cells and fibroblasts, increased stromal density and the presence of plasma cell infiltrate in it. The connection between chronic inflammation in the endometrium and infertility deserves special attention. Inadequate response of immunocompetent endometrial cells, including impaired synthesis of proinflammatory cytokines, dysreceptiveness, disorders of proliferation and differentiation processes are the main links in the formation of infertility in patients with CE. Despite the fact that the presence of a normocenosis of the uterine cavity today is not in doubt this is a physiological norm, persistent bacterial infection of the endometrium is still called the main etiopathogenetic factor of CE and, therefore, the main point of application of therapeutic agents. Nevertheless, a number of works have emphasized the special role of not bacterial, but viral etiology of endometritis, especially in the context of infertility developing against this background. It seems that the role of viral endometrial infection in adverse pregnancy outcomes and in vitro fertilization programs is underestimated. Further research is needed to clarify the relationship of viral infection as a trigger of implantation failure in infertile women with CE.

scholarly journals The role of chronic endometritis in development of infertility in terms of etiological factors

2021 ◽  
pp. 22-27
Author(s):  
Ihor I. Chermak ◽  
Volodymyr I. Chermak ◽  
Mariia A. Matvian ◽  
Mansi Singh
Keyword(s):  
In Vitro Fertilization ◽  
Preterm Labor ◽  
Recurrent Miscarriage ◽  
Uterine Cavity ◽  
Implantation Failure ◽  
Chronic Endometritis ◽  
Vitro Fertilization ◽  
Persistent Inflammation

Chronic endometritis (CE) is a persistent inflammation of the inner lining of the uterine cavity caused by bacteria such as Enterococcus, Streptococcus, Staphylococcus, Enterobacteriaceae. A majority of CE produces no signs or sometimes mild symptoms, and the prevalence rate of CE is 10-15%. Several studies have shown that it is a condition frequently associated with repeated unexplained implantation failure at in vitro fertilization, recurrent miscarriage, as well as preterm labor. In this study, we reviewed how chronic endometritis plays an important role in the development of infertility. Also, we discuss the importance of hysteroscopic procedures in the diagnosis of chronic endometritis.

Influence of chronic endometritis on women`s reproductive health: current view

2020 ◽  
pp. 57-63
Author(s):  
T.G. Romanenko ◽  
◽  
A.D. Haiduk ◽  
N.V. Yesyp ◽  
◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Uterine Cavity ◽  
Diagnostic Techniques ◽  
Diagnostic Methods ◽  
Diagnostic Process ◽  
Current View ◽  
Antibiotic Administration ◽  
Chronic Endometritis ◽  
Vitro Fertilization

Chronic inflammatory process in endometrium is an obvious factor of infertility and recurrent pregnancy loss. But uncertainty of its etiology in most of the clinical cases results in complications of diagnostic process of the disease despite the broad spectrum of diagnostic techniques. Shift of the focus from specific infectious agents towards opportunistic pathogens also leads to several complications in interpretation of bacteriological examination results. Moreover, the role of viruses as ethiological factor of chronic endometritis is still not well established. At the same time the capability of invasive diagnostic techniques is always discussed by the clinicians because of additional risks from intervention into uterine cavity. From this point of view treatment of chronic endometritis (CE) and pregravid preparation of women involved in in vitro fertilization algorithm with such pathology requires comprehensive analysis. Routine antibiotic administration, principles of choice of these medications and effectiveness of other therapeutical approaches, for example, physiotherapy techniques, are still controversial. This article highlights modern ideas about chronic endometritis: ethiological factors of the disorder, coincidence with infertility and reproductive failure, diagnostic methods, treatment and pregravid preparation of women with the disease and ways of optimization of patient management for preserving their reproductive potential. Key words: chronic endometritis, infertility, in vitro fertilization, antibiotic therapy.

scholarly journals CO-CULTIVATION OF EMBRYOS WITH HUMAN ENDOMETRIUM: OPTIMIZATION OF IN VITRO FERTILIZATION

2012 ◽  
Vol 61 (4) ◽  
pp. 16-22 ◽  
Author(s):  
Eduard Karpovich Ailamazyan ◽  
Anna Olegovna Durnova ◽  
Viktoriya Olegovna Polyakova ◽  
Mariya Nikolaevna Sudalina ◽  
Igor Moiseevich Kvetnoy
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Development ◽  
Current Knowledge ◽  
Human Endometrium ◽  
Human Embryos ◽  
Vitro Fertilization ◽  
Endometrial Cells ◽  
Methodological Aspects

The review is devoted to analysis of current knowledge about co-cultivation of human embryos with endometrial cells. The role of signaling molecules for regulation of implantation as well as embryo development is discussed. The special attention takes to the methodological aspects of cocultivation, which are promising for in vitro fertilization

scholarly journals CHRONIC ENDOMETRITIS AS A FACTOR OF FAILURE ATTEMPT IN ASSISTED REPRODUCTIVE TECHNOLOGIES

2019 ◽  
pp. 13-21
Author(s):  
O. V. Onysko ◽  
О. О. Korchynska ◽  
Stefania Andrashchikova ◽  
Sylvia Zhultakova ◽  
Alena Shlosserova
Keyword(s):  
Plasma Cells ◽  
Assisted Reproductive Technologies ◽  
Proteolytic Enzymes ◽  
Uterine Cavity ◽  
Reproductive Function ◽  
Reproductive Technologies ◽  
Careful Study ◽  
Chronic Endometritis ◽  
Vitro Fertilization

Increase in frequency of disorders of women's reproductive function justifies a careful study of the underlying pathological processes. In recent years, increased attention in solving fertility problems is paid to endometrial pathology when chronic endometritis plays an important role. Current worksarefeeding an in-depth study of the etiology and pathogenesis of chronic endometritis. However, results of research pose new questions with an imaginary comprehensive study of this problem. Chronic endometritis is one of the causes of infertility and may play a role in certain complications of pregnancy and childbirth (30.3 % in patients with repeated failures of in vitro fertilization, 9.3 % with recurrent miscarriages, 9.8 % in infertility). Clinically, chronic endometritis is often asymptomatic or accompanied by nonspecific symptoms such as pelvic pain, dyspareunia, abnormal uterine bleeding, and discharges. Previously, scientists considered the uterine cavity as a sterile container. But a team of Spanish scientists sought to test for the presence of intrauterine microflora, which differs from the vaginal. As a result, the study of endometrial fluid and vaginal samples from the same patients revealed different bacterial compositions. Microflora in the intrauterine fluid was classified as Lactobacillus, and women with non-lactobacillary flora of the endometrium had a significantly lower frequency of implantation. At the initial stage of endometrial inflammation is an activation of neutrophils and macrophages, increased cytokines synthesis, extracellular matrix degradation by proteolytic enzymes. Disorders of microcirculation and sclerotic processes in the area of ​​injury lead to the ischemia and tissue hypoxia, which activates the processes of sclerosis and angiogenesis. Chronization of the process increases the expression of chemokines and adhesion molecules, that is lead to migration of B-lymphocytes from the bloodstream and their differentiation into plasma cells, increases the activity of matrix metalloproteinases, changes local expression of estrogen and progesterone receptors. Lack of a pronounced specific clinical picture of chronic endometritis, its later detection causes impaired reproductive function. Untimely diagnosis and treatment of chronic endometritis has significant consequences in terms of the possibility of implantation of a fertilized egg in the programs of assisted reproductive technologies.

scholarly journals Role of thyroid dysimmunity and thyroid hormones in endometriosis

2019 ◽  
pp. 201820469
Author(s):  
Marine Peyneau ◽  
Niloufar Kavian ◽  
Sandrine Chouzenoux ◽  
Carole Nicco ◽  
Mohamed Jeljeli ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Thyroid Autoimmunity ◽  
Uterine Cavity ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Disorder ◽  
Endometrial Cells ◽  
Thyroid Metabolism ◽  
Ectopic Endometrium

Endometriosis is characterized by the presence of ectopic endometrial cells outside the uterine cavity. Thyroid autoimmunity has been associated with endometriosis. This work investigated the potential pathophysiological link between endometriosis and thyroid disorders. Transcripts and proteins involved in thyroid metabolism are dysregulated in eutopic and ectopic endometrium of endometriotic patients, leading to resistance of ectopic endometrium to triiodothyronine (T3) action and local accumulation of thyroxine (T4). Thyroid-stimulating hormone (TSH) acts as a proliferative and prooxidative hormone on all endometria of endometriosis patients and controls, whereas T3 and T4 act to specifically increase ectopic endometrial cell proliferation and reactive oxygen species (ROS) production. Mouse studies confirmed the data gained in vitro since endometriotic implants were found to be bigger when thyroid hormones increased. A retrospective analysis of endometriosis patients with or without a thyroid disorder revealed an increased chronic pelvic pain and disease score in endometriotic patients with a thyroid disorder.

scholarly journals Suplementación de vitamina D en embarazadas y en mujeres con patologías ginecológicas

2021 ◽  
Vol 81 (04) ◽  
pp. 377-389
Author(s):  
Jorly Mejía-Montilla ◽  
◽  
Eduardo Reyna-Villasmil ◽  
María Albán-Andrade ◽  
Mariela Meza-Lozada ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Mineralization ◽  
Vitamin D Supplementation ◽  
Dietary Intakes ◽  
Vitro Fertilization ◽  
Beneficial Effects ◽  
Adverse Pregnancy ◽  
Reproductive Processes

Apart from the well-known effects of vitamin D in maintaining calcium homeostasis and promoting bone mineralization, there is evidence to suggest that it modulates reproductive processes. About 70% adults have vitamin D deficiencies and there is a gap between recommended dietary intakes and deficient supply in general population. Observational studies show that vitamin D deficiency is a risk marker for reducing fertility and resulting adverse pregnancy. Evidence suggests that it could have beneficial effects on metabolic, hormonal and cellular parameters of polycystic ovarian syndrome, uterine myomatosis and endometriosis, while it seems to be associated with improvements in outcome of in vitro fertilization. The objective of this review was to evaluate the data of current literature on the role of vitamin D supplementation in pregnant women and in women with gynecological pathologies. Keywords: Vitamin D, Supplementation, Pregnancy, Endometriosis, Uterine myomatosis, Infertility.

scholarly journals The role of bacterial biofilms in the development of chronic pathological processes in the vagina and endometrium

2016 ◽  
Vol 65 (4) ◽  
pp. 65-75 ◽  
Author(s):  
Kira V. Shalepo ◽  
Tatiana G. Mihailenko ◽  
Alevtina M. Savicheva
Keyword(s):  
Pregnancy Outcomes ◽  
Biofilm Formation ◽  
Anaerobic Bacteria ◽  
Bacterial Biofilms ◽  
Vitro Fertilization ◽  
Microbial Biofilms ◽  
Ascending Infection ◽  
Adverse Pregnancy

Microbial biofilms are a problem in many areas of medicine. When the vaginal ecological system is disturbed, well-structured polymicrobial biofilm, covering the vaginal epithelium and consisting of anaerobic bacteria, is formed, which may lead to the development of recurrent bacterial vaginosis. During an ascending infection and the development of chronic endometritis, bacterial biofilms are detected in the endometrium. Biofilms formed by bacteria residing in the urogenital tract of woman, may result in dysfunctions of the reproductive system, in-vitro fertilization failures, complications of pregnancy, adverse pregnancy outcomes. In the paper, literature data regarding causes of of biofilm formation, methods of detection and treatment of biofilm infections are reviewed.

Role of Hysteroscopy in Repeated IVF/ICSI – ETs Failure and its Impact Effect on Subsequent Attempts

2021 ◽  
Vol 19 (5) ◽  
pp. 86-94
Author(s):  
Shaima Gaber Mohmeed Gadalla Elgebally ◽  
Mahmoud Salah El Din Hamouda ◽  
Ahmed Tawfeek Soliman ◽  
Dina Gamal El Deen El-Kholi
Keyword(s):  
Prospective Observational Study ◽  
Uterine Cavity ◽  
Clinical Pregnancy ◽  
University Hospital ◽  
Cervical Canal ◽  
Vitro Fertilization ◽  
Reproductive Unit ◽  
Infertile Patients

Background: Recurrent implantation breakdown is characterized as a complication to accomplish a clinical pregnancy subsequent to transfer of 4 or further high-quality embryos in a least amount of 2 in vitro fertilization (IVF) cycles in a woman less than the age of 40. This investigation intended to the responsibility of hysteroscopy in repeated IVF/ICSI failure and its impact on subsequent trials. Methods: Prospective observational study was conducted at assisted reproductive unit in obstetric and gynecology department in Tanta University Hospital from Jan 2018 to Jan 2020. Included 50 infertile patients with more then two IVF/ICSI failure in spite of transmit of as a minimum two better quality embryos. All patients were subjected to 4D US examination with same device (Siemens acuson X300). Results: We found that from the 30 patients who had normal findings in hysteroscopy, 25 had normal findings also in 4DUS, 2 had polyps, 2 had myoma and 1 patient had septum. From the 3 patients who had polyps in hysterectomy, 1 had normal findings in 4DUS, and 2 patients had polyps. Regarding the two patients who had myoma by hysteroscopy, 1 had normal findings in 3DUS and the other had Myoma. While for the 3 considered patients who had septum in hysteroscopy, all had normal findings in 4DUS. Conclusion: According to this study, hysteroscopy is regarded the gold standard not only for envisaging the cervical canal and uterine cavity, however also for healing several types of benign pathologies localized to that area, it is a secure and uncomplicated process.

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